PandemieGrippaleV1, PascalFrancis, Curation, bibRecord, 001C07

Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1

Identifieur interne : 001C07 ( PascalFrancis/Curation ); précédent : 001C06; suivant : 001C08

Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1

Auteurs : Sinthujan Jegaskanda [Australie] ; Karen L. Laurie [Australie] ; Thakshila H. Amarasena [Australie] ; Wendy R. Winnall [Australie] ; Marit Kramski [Australie] ; Robert De Rose [Australie] ; Ian G. Barr [Australie] ; Andrew G. Brooks [Australie] ; Patrick C. Reading [Australie] ; Stephen J. Kent [Australie]

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 2013.

RBID : Pascal:13-0310023

Descripteurs français

Pascal (Inist)
- Age, Réaction ADCC, Soustype, Infection, Virus grippal A(H1N1).

English descriptors

KwdEn :
- Age, Antibody-dependent cell cytotoxicity, Infection, Influenzavirus A(H1N1), Subtype.

Abstract

Background. During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially protected from severe disease. It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed. Methods. We tested serum specimens obtained from 182 individuals aged 1-72 years that were collected either immediately before or after the A(H1N1)pdm09 pandemic for ADCC antibodies to the A(H1N1)pdm09 hemagglutinin (HA) protein. Results. A(H1N1)pdm09 HA-specific ADCC antibodies were detected in almost all individuals aged >45 years (28/31 subjects) before the 2009 A(H1N1) pandemic. Conversely, only approximately half of the individuals aged 1-14 years (11/31) and 15-45 years (17/31) had cross-reactive ADCC antibodies before the 2009 A(H1N1) pandemic. The A(H1N1)pdm09-specific ADCC antibodies were able to efficiently mediate the killing of influenza virus-infected respiratory epithelial cells. Further, subjects >45 years of age had higher ADCC titers to a range of seasonal H1N1 HA proteins, including from the 1918 virus, compared with younger individuals. Conclusions. ADCC antibodies may have contributed to the protection exhibited in older individuals during the 2009 A(H1N1) pandemic. This work has significant implications for improved vaccination strategies for future influenza pandemics.

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A11	`02`	`1`		`@1 LAURIE (Karen L.)`
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A11	`05`	`1`		`@1 KRAMSKI (Marit)`
A11	`06`	`1`		`@1 DE ROSE (Robert)`
A11	`07`	`1`		`@1 BARR (Ian G.)`
A11	`08`	`1`		`@1 BROOKS (Andrew G.)`
A11	`09`	`1`		`@1 READING (Patrick C.)`
A11	`10`	`1`		`@1 KENT (Stephen J.)`
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C01	`01`		`ENG`	@0 Background. During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially protected from severe disease. It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed. Methods. We tested serum specimens obtained from 182 individuals aged 1-72 years that were collected either immediately before or after the A(H1N1)pdm09 pandemic for ADCC antibodies to the A(H1N1)pdm09 hemagglutinin (HA) protein. Results. A(H1N1)pdm09 HA-specific ADCC antibodies were detected in almost all individuals aged >45 years (28/31 subjects) before the 2009 A(H1N1) pandemic. Conversely, only approximately half of the individuals aged 1-14 years (11/31) and 15-45 years (17/31) had cross-reactive ADCC antibodies before the 2009 A(H1N1) pandemic. The A(H1N1)pdm09-specific ADCC antibodies were able to efficiently mediate the killing of influenza virus-infected respiratory epithelial cells. Further, subjects >45 years of age had higher ADCC titers to a range of seasonal H1N1 HA proteins, including from the 1918 virus, compared with younger individuals. Conclusions. ADCC antibodies may have contributed to the protection exhibited in older individuals during the 2009 A(H1N1) pandemic. This work has significant implications for improved vaccination strategies for future influenza pandemics.
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Pascal:13-0310023

Le document en format XML

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<front><div type="abstract" xml:lang="en">Background. During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially protected from severe disease. It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed. Methods. We tested serum specimens obtained from 182 individuals aged 1-72 years that were collected either immediately before or after the A(H1N1)pdm09 pandemic for ADCC antibodies to the A(H1N1)pdm09 hemagglutinin (HA) protein. Results. A(H1N1)pdm09 HA-specific ADCC antibodies were detected in almost all individuals aged >45 years (28/31 subjects) before the 2009 A(H1N1) pandemic. Conversely, only approximately half of the individuals aged 1-14 years (11/31) and 15-45 years (17/31) had cross-reactive ADCC antibodies before the 2009 A(H1N1) pandemic. The A(H1N1)pdm09-specific ADCC antibodies were able to efficiently mediate the killing of influenza virus-infected respiratory epithelial cells. Further, subjects >45 years of age had higher ADCC titers to a range of seasonal H1N1 HA proteins, including from the 1918 virus, compared with younger individuals. Conclusions. ADCC antibodies may have contributed to the protection exhibited in older individuals during the 2009 A(H1N1) pandemic. This work has significant implications for improved vaccination strategies for future influenza pandemics.</div>
</front>
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<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-1899</s0>
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<fA02 i1="01"><s0>JIDIAQ</s0>
</fA02>
<fA03 i2="1"><s0>J. infect. dis.</s0>
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<fA05><s2>208</s2>
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<fA06><s2>7</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>JEGASKANDA (Sinthujan)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>LAURIE (Karen L.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>AMARASENA (Thakshila H.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>WINNALL (Wendy R.)</s1>
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<fA11 i1="05" i2="1"><s1>KRAMSKI (Marit)</s1>
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<fA11 i1="06" i2="1"><s1>DE ROSE (Robert)</s1>
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<fA11 i1="07" i2="1"><s1>BARR (Ian G.)</s1>
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<fA11 i1="08" i2="1"><s1>BROOKS (Andrew G.)</s1>
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<fA11 i1="09" i2="1"><s1>READING (Patrick C.)</s1>
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<fA11 i1="10" i2="1"><s1>KENT (Stephen J.)</s1>
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<fA14 i1="01"><s1>Department of Microbiology and Immunology, University of Melbourne</s1>
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<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<fA14 i1="02"><s1>WHO Collaborating Centre for Reference and Research on Influenza, VIDRL</s1>
<s2>North Melbourne</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
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<fA20><s1>1051-1061</s1>
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<fA21><s1>2013</s1>
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<fA23 i1="01"><s0>ENG</s0>
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<fA47 i1="01" i2="1"><s0>13-0310023</s0>
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<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
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<fA64 i1="01" i2="1"><s0>The Journal of infectious diseases</s0>
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<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background. During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially protected from severe disease. It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed. Methods. We tested serum specimens obtained from 182 individuals aged 1-72 years that were collected either immediately before or after the A(H1N1)pdm09 pandemic for ADCC antibodies to the A(H1N1)pdm09 hemagglutinin (HA) protein. Results. A(H1N1)pdm09 HA-specific ADCC antibodies were detected in almost all individuals aged >45 years (28/31 subjects) before the 2009 A(H1N1) pandemic. Conversely, only approximately half of the individuals aged 1-14 years (11/31) and 15-45 years (17/31) had cross-reactive ADCC antibodies before the 2009 A(H1N1) pandemic. The A(H1N1)pdm09-specific ADCC antibodies were able to efficiently mediate the killing of influenza virus-infected respiratory epithelial cells. Further, subjects >45 years of age had higher ADCC titers to a range of seasonal H1N1 HA proteins, including from the 1918 virus, compared with younger individuals. Conclusions. ADCC antibodies may have contributed to the protection exhibited in older individuals during the 2009 A(H1N1) pandemic. This work has significant implications for improved vaccination strategies for future influenza pandemics.</s0>
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Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1

Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1

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