PandemieGrippaleV1, PascalFrancis, Curation, bibRecord, 001817

Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors

Identifieur interne : 001817 ( PascalFrancis/Curation ); précédent : 001816; suivant : 001818

Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors

Auteurs : Miguel Delgado-Rodriguez [Espagne] ; Jesus Castilla [Espagne] ; Pere Godoy [Espagne] ; Vicente Martin [Espagne] ; Nuria Soldevita [Espagne] ; Jordi Alonso [Espagne] ; Jenaro Astray [Espagne] ; Maretva Baricot [Espagne] ; Rafael Canton [Espagne] ; Ady Castro [Espagne] ; Fernando Gonzalez-Candelas [Espagne] ; Jose María Mayoral [Espagne] ; Jose María Quintana [Espagne] ; Tomás Pumarola [Espagne] ; Sonia Tamames [Espagne] ; Marc Saez [Espagne] ; Angela Dominguez [Espagne]

Source :

Journal of antimicrobial chemotherapy : (Print) [ 0305-7453 ] ; 2012.

RBID : Pascal:12-0261772

Descripteurs français

Pascal (Inist)
- Pronostic, Hospitalisation, Homme, Malade, Espagne, Inhibiteur neuraminidase, Prévention, Complication, Temps séjour, Pandémie, Grippe H1N1.
Wicri :
- geographic : Espagne.
- topic : Hospitalisation, Homme.

English descriptors

KwdEn :
- Complication, H1N1 influenza, Hospitalization, Human, Neuraminidase inhibitor, Patient, Prevention, Prognosis, Residence time, Spain.

Abstract

Background: The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. Methods: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. Results: The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR=2.2₁, 95% CI=₁.2₁-4.₀₂), corticosteroid therapy (OR=3.37, 95% CI₌1.39-8.20) and use of histamine-2 receptor antagonists (OR=2.6₈, 95% CI=1.14-6.36), while the use of neuraminidase inhibitors (OR=0.57, 95% CI₌0.34-0.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95% CI₌4.7-6.6). Conclusions: The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death.

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A02	`01`			`@0 JACHDX`
A03		`1`		`@0 J. antimicrob. chemother. : (Print)`
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A08	`01`	`1`	`ENG`	`@1 Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors`
A11	`01`	`1`		`@1 DELGADO-RODRIGUEZ (Miguel)`
A11	`02`	`1`		`@1 CASTILLA (Jesus)`
A11	`03`	`1`		`@1 GODOY (Pere)`
A11	`04`	`1`		`@1 MARTIN (Vicente)`
A11	`05`	`1`		`@1 SOLDEVITA (Nuria)`
A11	`06`	`1`		`@1 ALONSO (Jordi)`
A11	`07`	`1`		`@1 ASTRAY (Jenaro)`
A11	`08`	`1`		`@1 BARICOT (Maretva)`
A11	`09`	`1`		`@1 CANTON (Rafael)`
A11	`10`	`1`		`@1 CASTRO (Ady)`
A11	`11`	`1`		`@1 GONZALEZ-CANDELAS (Fernando)`
A11	`12`	`1`		`@1 MAYORAL (Jose María)`
A11	`13`	`1`		`@1 QUINTANA (Jose María)`
A11	`14`	`1`		`@1 PUMAROLA (Tomás)`
A11	`15`	`1`		`@1 TAMAMES (Sonia)`
A11	`16`	`1`		`@1 SAEZ (Marc)`
A11	`17`	`1`		`@1 DOMINGUEZ (Angela)`
A14	`01`			`@1 Universidad de Jaén, Campus de las Lagunillas @2 23071 Jaén @3 ESP @Z 1 aut.`
A14	`02`			`@1 CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6 @2 28071 Madrid @3 ESP @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 8 aut. @Z 9 aut. @Z 11 aut. @Z 13 aut. @Z 17 aut.`
A14	`03`			`@1 Instituto de Salud Pública de Navarra, Leyre 15 @2 31003 Pamplona @3 ESP @Z 2 aut.`
A14	`04`			`@1 Departament de Salut, Generalitat de Catalunya, Travessera de les Corts 131 @2 08028 Barcelona @3 ESP @Z 3 aut.`
A14	`05`			`@1 Instituto de Biomedicina, Universidad de Leon, Campus Universitario de Vegazana @2 24071 Leon @3 ESP @Z 4 aut.`
A14	`06`			`@1 Institut Municipal de Investigoció Médica, Barcelona, Dr. Aiguader 80 @2 08003 Barcelona @3 ESP @Z 6 aut.`
A14	`07`			`@1 Area de Epidemiologia, Comunidad de Madrid, Antonio Grilo 10 @2 28029 Madrid @3 ESP @Z 7 aut.`
A14	`08`			`@1 Hospital Universitario Ramon y Cajal, Carretera de Colmenar Viejo km 9.1 @2 28034 Madrid @3 ESP @Z 9 aut.`
A14	`09`			`@1 CIBER Enfermedades Respiratorias, Recinto Hospital Joan March, Carretera Soller km 12, 07110 Bunyola, Mallorca @2 Illes Balears @3 ESP @Z 10 aut.`
A14	`10`			`@1 Centro Superior de Investigación en Salud Pública, Universitat de València, Av. de Cataluña 21 @2 46020 Valencia @3 ESP @Z 11 aut.`
A14	`11`			`@1 Servicio de Vigilancia de Andalucia (Consejería de Salud), Avenida de la Innovación (Edificio Arenas) @2 41020 Sevilla @3 ESP @Z 12 aut.`
A14	`12`			`@1 Unidad de Investigación, Hospital Galdakao-Usansolo, Barrio Labeaga, Galdakao @2 48960 Bizkaia @3 ESP @Z 13 aut.`
A14	`13`			`@1 Red Española de Investigación en Patología Infecciosa (REIPI), ISCIII, Sinesio Delgado 6 @2 28071 Madrid @3 ESP @Z 14 aut.`
A14	`14`			`@1 Dirección General de Salud Pública e Investigación, Desarrollo e Innovación, Junta de Castilla y León, Paseo de Zorrilla 1 @2 47007 Valladolid @3 ESP @Z 15 aut.`
A14	`15`			`@1 Universitat de Girona, Emili Grahit 77 @2 17071 Girona @3 ESP @Z 16 aut.`
A14	`16`			`@1 Universitat de Barcelona, Casanova 143, 4 planta @2 08036 Barcelona @3 ESP @Z 17 aut.`
A17	`01`	`1`		`@1 CIBERESP Cases and Controls in Pandemic Influenza Working Group @3 INC`
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C01	`01`		`ENG`	@0 Background: The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. Methods: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. Results: The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR=2.2₁, 95% CI=₁.2₁-4.₀₂), corticosteroid therapy (OR=3.37, 95% CI₌1.39-8.20) and use of histamine-2 receptor antagonists (OR=2.6₈, 95% CI=1.14-6.36), while the use of neuraminidase inhibitors (OR=0.57, 95% CI₌0.34-0.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95% CI₌4.7-6.6). Conclusions: The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death.
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Pascal:12-0261772

Le document en format XML

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<author><name sortKey="Godoy, Pere" sort="Godoy, Pere" uniqKey="Godoy P" first="Pere" last="Godoy">Pere Godoy</name>
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<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departament de Salut, Generalitat de Catalunya, Travessera de les Corts 131</s1>
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<author><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martin">Vicente Martin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
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<country>Espagne</country>
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<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Instituto de Biomedicina, Universidad de Leon, Campus Universitario de Vegazana</s1>
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<country>Espagne</country>
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<author><name sortKey="Soldevita, Nuria" sort="Soldevita, Nuria" uniqKey="Soldevita N" first="Nuria" last="Soldevita">Nuria Soldevita</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
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<author><name sortKey="Alonso, Jordi" sort="Alonso, Jordi" uniqKey="Alonso J" first="Jordi" last="Alonso">Jordi Alonso</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
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<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institut Municipal de Investigoció Médica, Barcelona, Dr. Aiguader 80</s1>
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<author><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Area de Epidemiologia, Comunidad de Madrid, Antonio Grilo 10</s1>
<s2>28029 Madrid</s2>
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<country>Espagne</country>
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<author><name sortKey="Baricot, Maretva" sort="Baricot, Maretva" uniqKey="Baricot M" first="Maretva" last="Baricot">Maretva Baricot</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
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<author><name sortKey="Canton, Rafael" sort="Canton, Rafael" uniqKey="Canton R" first="Rafael" last="Canton">Rafael Canton</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
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<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Hospital Universitario Ramon y Cajal, Carretera de Colmenar Viejo km 9.1</s1>
<s2>28034 Madrid</s2>
<s3>ESP</s3>
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</author>
<author><name sortKey="Castro, Ady" sort="Castro, Ady" uniqKey="Castro A" first="Ady" last="Castro">Ady Castro</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>CIBER Enfermedades Respiratorias, Recinto Hospital Joan March, Carretera Soller km 12, 07110 Bunyola, Mallorca</s1>
<s2>Illes Balears</s2>
<s3>ESP</s3>
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<country>Espagne</country>
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</author>
<author><name sortKey="Gonzalez Candelas, Fernando" sort="Gonzalez Candelas, Fernando" uniqKey="Gonzalez Candelas F" first="Fernando" last="Gonzalez-Candelas">Fernando Gonzalez-Candelas</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
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<country>Espagne</country>
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<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centro Superior de Investigación en Salud Pública, Universitat de València, Av. de Cataluña 21</s1>
<s2>46020 Valencia</s2>
<s3>ESP</s3>
<sZ>11 aut.</sZ>
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<country>Espagne</country>
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</author>
<author><name sortKey="Mayoral, Jose Maria" sort="Mayoral, Jose Maria" uniqKey="Mayoral J" first="Jose María" last="Mayoral">Jose María Mayoral</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Servicio de Vigilancia de Andalucia (Consejería de Salud), Avenida de la Innovación (Edificio Arenas)</s1>
<s2>41020 Sevilla</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Quintana, Jose Maria" sort="Quintana, Jose Maria" uniqKey="Quintana J" first="Jose María" last="Quintana">Jose María Quintana</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Unidad de Investigación, Hospital Galdakao-Usansolo, Barrio Labeaga, Galdakao</s1>
<s2>48960 Bizkaia</s2>
<s3>ESP</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Pumarola, Tomas" sort="Pumarola, Tomas" uniqKey="Pumarola T" first="Tomás" last="Pumarola">Tomás Pumarola</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Red Española de Investigación en Patología Infecciosa (REIPI), ISCIII, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Tamames, Sonia" sort="Tamames, Sonia" uniqKey="Tamames S" first="Sonia" last="Tamames">Sonia Tamames</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Dirección General de Salud Pública e Investigación, Desarrollo e Innovación, Junta de Castilla y León, Paseo de Zorrilla 1</s1>
<s2>47007 Valladolid</s2>
<s3>ESP</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Saez, Marc" sort="Saez, Marc" uniqKey="Saez M" first="Marc" last="Saez">Marc Saez</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Universitat de Girona, Emili Grahit 77</s1>
<s2>17071 Girona</s2>
<s3>ESP</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Angela" last="Dominguez">Angela Dominguez</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Universitat de Barcelona, Casanova 143, 4 planta</s1>
<s2>08036 Barcelona</s2>
<s3>ESP</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0261772</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0261772 INIST</idno>
<idno type="RBID">Pascal:12-0261772</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000621</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001817</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors</title>
<author><name sortKey="Delgado Rodriguez, Miguel" sort="Delgado Rodriguez, Miguel" uniqKey="Delgado Rodriguez M" first="Miguel" last="Delgado-Rodriguez">Miguel Delgado-Rodriguez</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Universidad de Jaén, Campus de las Lagunillas</s1>
<s2>23071 Jaén</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Castilla, Jesus" sort="Castilla, Jesus" uniqKey="Castilla J" first="Jesus" last="Castilla">Jesus Castilla</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Instituto de Salud Pública de Navarra, Leyre 15</s1>
<s2>31003 Pamplona</s2>
<s3>ESP</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Godoy, Pere" sort="Godoy, Pere" uniqKey="Godoy P" first="Pere" last="Godoy">Pere Godoy</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departament de Salut, Generalitat de Catalunya, Travessera de les Corts 131</s1>
<s2>08028 Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martin">Vicente Martin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Instituto de Biomedicina, Universidad de Leon, Campus Universitario de Vegazana</s1>
<s2>24071 Leon</s2>
<s3>ESP</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Soldevita, Nuria" sort="Soldevita, Nuria" uniqKey="Soldevita N" first="Nuria" last="Soldevita">Nuria Soldevita</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Alonso, Jordi" sort="Alonso, Jordi" uniqKey="Alonso J" first="Jordi" last="Alonso">Jordi Alonso</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institut Municipal de Investigoció Médica, Barcelona, Dr. Aiguader 80</s1>
<s2>08003 Barcelona</s2>
<s3>ESP</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Area de Epidemiologia, Comunidad de Madrid, Antonio Grilo 10</s1>
<s2>28029 Madrid</s2>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Baricot, Maretva" sort="Baricot, Maretva" uniqKey="Baricot M" first="Maretva" last="Baricot">Maretva Baricot</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Canton, Rafael" sort="Canton, Rafael" uniqKey="Canton R" first="Rafael" last="Canton">Rafael Canton</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Hospital Universitario Ramon y Cajal, Carretera de Colmenar Viejo km 9.1</s1>
<s2>28034 Madrid</s2>
<s3>ESP</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Castro, Ady" sort="Castro, Ady" uniqKey="Castro A" first="Ady" last="Castro">Ady Castro</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>CIBER Enfermedades Respiratorias, Recinto Hospital Joan March, Carretera Soller km 12, 07110 Bunyola, Mallorca</s1>
<s2>Illes Balears</s2>
<s3>ESP</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Gonzalez Candelas, Fernando" sort="Gonzalez Candelas, Fernando" uniqKey="Gonzalez Candelas F" first="Fernando" last="Gonzalez-Candelas">Fernando Gonzalez-Candelas</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centro Superior de Investigación en Salud Pública, Universitat de València, Av. de Cataluña 21</s1>
<s2>46020 Valencia</s2>
<s3>ESP</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Mayoral, Jose Maria" sort="Mayoral, Jose Maria" uniqKey="Mayoral J" first="Jose María" last="Mayoral">Jose María Mayoral</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Servicio de Vigilancia de Andalucia (Consejería de Salud), Avenida de la Innovación (Edificio Arenas)</s1>
<s2>41020 Sevilla</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Quintana, Jose Maria" sort="Quintana, Jose Maria" uniqKey="Quintana J" first="Jose María" last="Quintana">Jose María Quintana</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Unidad de Investigación, Hospital Galdakao-Usansolo, Barrio Labeaga, Galdakao</s1>
<s2>48960 Bizkaia</s2>
<s3>ESP</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Pumarola, Tomas" sort="Pumarola, Tomas" uniqKey="Pumarola T" first="Tomás" last="Pumarola">Tomás Pumarola</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Red Española de Investigación en Patología Infecciosa (REIPI), ISCIII, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Tamames, Sonia" sort="Tamames, Sonia" uniqKey="Tamames S" first="Sonia" last="Tamames">Sonia Tamames</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Dirección General de Salud Pública e Investigación, Desarrollo e Innovación, Junta de Castilla y León, Paseo de Zorrilla 1</s1>
<s2>47007 Valladolid</s2>
<s3>ESP</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Saez, Marc" sort="Saez, Marc" uniqKey="Saez M" first="Marc" last="Saez">Marc Saez</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Universitat de Girona, Emili Grahit 77</s1>
<s2>17071 Girona</s2>
<s3>ESP</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Angela" last="Dominguez">Angela Dominguez</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Universitat de Barcelona, Casanova 143, 4 planta</s1>
<s2>08036 Barcelona</s2>
<s3>ESP</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of antimicrobial chemotherapy : (Print)</title>
<title level="j" type="abbreviated">J. antimicrob. chemother. : (Print)</title>
<idno type="ISSN">0305-7453</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of antimicrobial chemotherapy : (Print)</title>
<title level="j" type="abbreviated">J. antimicrob. chemother. : (Print)</title>
<idno type="ISSN">0305-7453</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Complication</term>
<term>H1N1 influenza</term>
<term>Hospitalization</term>
<term>Human</term>
<term>Neuraminidase inhibitor</term>
<term>Patient</term>
<term>Prevention</term>
<term>Prognosis</term>
<term>Residence time</term>
<term>Spain</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pronostic</term>
<term>Hospitalisation</term>
<term>Homme</term>
<term>Malade</term>
<term>Espagne</term>
<term>Inhibiteur neuraminidase</term>
<term>Prévention</term>
<term>Complication</term>
<term>Temps séjour</term>
<term>Pandémie</term>
<term>Grippe H1N1</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Hospitalisation</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. Methods: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. Results: The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR=2.2<sub>1</sub>
, 95% CI=<sub>1</sub>
.2<sub>1</sub>
-4.<sub>02</sub>
), corticosteroid therapy (OR=3.37, 95% CI<sub>=</sub>
1.39-8.20) and use of histamine-2 receptor antagonists (OR=2.6<sub>8</sub>
, 95% CI=1.14-6.36), while the use of neuraminidase inhibitors (OR=0.57, 95% CI<sub>=</sub>
0.34-0.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95% CI<sub>=</sub>
4.7-6.6). Conclusions: The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0305-7453</s0>
</fA01>
<fA02 i1="01"><s0>JACHDX</s0>
</fA02>
<fA03 i2="1"><s0>J. antimicrob. chemother. : (Print)</s0>
</fA03>
<fA05><s2>67</s2>
</fA05>
<fA06><s2>7</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>DELGADO-RODRIGUEZ (Miguel)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>CASTILLA (Jesus)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>GODOY (Pere)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>MARTIN (Vicente)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>SOLDEVITA (Nuria)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>ALONSO (Jordi)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>ASTRAY (Jenaro)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>BARICOT (Maretva)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>CANTON (Rafael)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>CASTRO (Ady)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>GONZALEZ-CANDELAS (Fernando)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>MAYORAL (Jose María)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>QUINTANA (Jose María)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>PUMAROLA (Tomás)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>TAMAMES (Sonia)</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>SAEZ (Marc)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>DOMINGUEZ (Angela)</s1>
</fA11>
<fA14 i1="01"><s1>Universidad de Jaén, Campus de las Lagunillas</s1>
<s2>23071 Jaén</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>CIBERESP, Instituto de Salud Carlos III, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Instituto de Salud Pública de Navarra, Leyre 15</s1>
<s2>31003 Pamplona</s2>
<s3>ESP</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Departament de Salut, Generalitat de Catalunya, Travessera de les Corts 131</s1>
<s2>08028 Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Instituto de Biomedicina, Universidad de Leon, Campus Universitario de Vegazana</s1>
<s2>24071 Leon</s2>
<s3>ESP</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Institut Municipal de Investigoció Médica, Barcelona, Dr. Aiguader 80</s1>
<s2>08003 Barcelona</s2>
<s3>ESP</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Area de Epidemiologia, Comunidad de Madrid, Antonio Grilo 10</s1>
<s2>28029 Madrid</s2>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Hospital Universitario Ramon y Cajal, Carretera de Colmenar Viejo km 9.1</s1>
<s2>28034 Madrid</s2>
<s3>ESP</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>CIBER Enfermedades Respiratorias, Recinto Hospital Joan March, Carretera Soller km 12, 07110 Bunyola, Mallorca</s1>
<s2>Illes Balears</s2>
<s3>ESP</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Centro Superior de Investigación en Salud Pública, Universitat de València, Av. de Cataluña 21</s1>
<s2>46020 Valencia</s2>
<s3>ESP</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Servicio de Vigilancia de Andalucia (Consejería de Salud), Avenida de la Innovación (Edificio Arenas)</s1>
<s2>41020 Sevilla</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>Unidad de Investigación, Hospital Galdakao-Usansolo, Barrio Labeaga, Galdakao</s1>
<s2>48960 Bizkaia</s2>
<s3>ESP</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>Red Española de Investigación en Patología Infecciosa (REIPI), ISCIII, Sinesio Delgado 6</s1>
<s2>28071 Madrid</s2>
<s3>ESP</s3>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="14"><s1>Dirección General de Salud Pública e Investigación, Desarrollo e Innovación, Junta de Castilla y León, Paseo de Zorrilla 1</s1>
<s2>47007 Valladolid</s2>
<s3>ESP</s3>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="15"><s1>Universitat de Girona, Emili Grahit 77</s1>
<s2>17071 Girona</s2>
<s3>ESP</s3>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="16"><s1>Universitat de Barcelona, Casanova 143, 4 planta</s1>
<s2>08036 Barcelona</s2>
<s3>ESP</s3>
<sZ>17 aut.</sZ>
</fA14>
<fA17 i1="01" i2="1"><s1>CIBERESP Cases and Controls in Pandemic Influenza Working Group</s1>
<s3>INC</s3>
</fA17>
<fA20><s1>1739-1745</s1>
</fA20>
<fA21><s1>2012</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>17084</s2>
<s5>354000507970430260</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>22 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>12-0261772</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of antimicrobial chemotherapy : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background: The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. Methods: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. Results: The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR=2.2<sub>1</sub>
, 95% CI=<sub>1</sub>
.2<sub>1</sub>
-4.<sub>02</sub>
), corticosteroid therapy (OR=3.37, 95% CI<sub>=</sub>
1.39-8.20) and use of histamine-2 receptor antagonists (OR=2.6<sub>8</sub>
, 95% CI=1.14-6.36), while the use of neuraminidase inhibitors (OR=0.57, 95% CI<sub>=</sub>
0.34-0.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95% CI<sub>=</sub>
4.7-6.6). Conclusions: The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02S</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Pronostic</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Prognosis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Pronóstico</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Hospitalisation</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Hospitalization</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Hospitalización</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Homme</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Human</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Hombre</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Malade</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Patient</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Enfermo</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Espagne</s0>
<s2>NG</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Spain</s0>
<s2>NG</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>España</s0>
<s2>NG</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Inhibiteur neuraminidase</s0>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Neuraminidase inhibitor</s0>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Inhibidor neuraminidas</s0>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Prévention</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Prevention</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Prevención</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Complication</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Complication</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Complicación</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Temps séjour</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Residence time</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Tiempo estancia</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Pandémie</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Grippe H1N1</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>H1N1 influenza</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Gripe H1N1</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Europe</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Europe</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Europa</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virose</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Viral disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virosis</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fN21><s1>198</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors

Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors

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