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Household Transmission of 2009 Pandemic Influenza A(H1N1): A Systematic Review and Meta-analysis

Identifieur interne : 001816 ( PascalFrancis/Curation ); précédent : 001815; suivant : 001817

Household Transmission of 2009 Pandemic Influenza A(H1N1): A Systematic Review and Meta-analysis

Auteurs : Lincoln L. H. Lau [République populaire de Chine] ; Hiroshi Nishiura [République populaire de Chine, Japon] ; Heath Kelly [Australie] ; Dennis K. M. Ip [République populaire de Chine] ; Gabriel M. Leung [République populaire de Chine] ; Benjamin J. Cowling [République populaire de Chine]

Source :

RBID : Pascal:12-0260908

Descripteurs français

English descriptors

Abstract

Background: During the 2009 influenza A (H1N1) pandemic, household transmission studies were implemented to better understand the characteristics of the transmission of the novel virus in a confined setting. Methods: We conducted a systematic review and meta-analysis to assess and summarize the findings of these studies. We identified 27 articles, around half of which reported studies conducted in May and June 2009. Results: In 13 of the 27 studies (48%) that collected respiratory specimens from household contacts, point estimates of the risk of secondary infection ranged from 3% to 38%, with substantial heterogeneity. Meta-regression analyses revealed that a part of the heterogeneity reflected varying case ascertainment and study designs. The estimates of symptomatic secondary infection risk, based on 20 studies identifying febrile acute respiratory illness among household contacts, also showed substantial variability, with point estimates ranging from 4% to 37%. Conclusions: Transmission of the 2009 pandemic virus in households appeared to vary among countries and settings, with differences in estimates of the secondary infection risk also partly due to differences in study designs.
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A11 01  1    @1 LAU (Lincoln L. H.)
A11 02  1    @1 NISHIURA (Hiroshi)
A11 03  1    @1 KELLY (Heath)
A11 04  1    @1 IP (Dennis K. M.)
A11 05  1    @1 LEUNG (Gabriel M.)
A11 06  1    @1 COWLING (Benjamin J.)
A14 01      @1 School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region @3 CHN @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.
A14 02      @1 PRESTO, Japan Science and Technology Agency @2 Saitama @3 JPN @Z 2 aut.
A14 03      @1 Victorian Infectious Diseases Reference Laboratory, North Melbourne @2 Victoria @3 AUS @Z 3 aut.
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A21       @1 2012
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A44       @0 0000 @1 © 2012 INIST-CNRS. All rights reserved.
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C01 01    ENG  @0 Background: During the 2009 influenza A (H1N1) pandemic, household transmission studies were implemented to better understand the characteristics of the transmission of the novel virus in a confined setting. Methods: We conducted a systematic review and meta-analysis to assess and summarize the findings of these studies. We identified 27 articles, around half of which reported studies conducted in May and June 2009. Results: In 13 of the 27 studies (48%) that collected respiratory specimens from household contacts, point estimates of the risk of secondary infection ranged from 3% to 38%, with substantial heterogeneity. Meta-regression analyses revealed that a part of the heterogeneity reflected varying case ascertainment and study designs. The estimates of symptomatic secondary infection risk, based on 20 studies identifying febrile acute respiratory illness among household contacts, also showed substantial variability, with point estimates ranging from 4% to 37%. Conclusions: Transmission of the 2009 pandemic virus in households appeared to vary among countries and settings, with differences in estimates of the secondary infection risk also partly due to differences in study designs.
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C03 01  X  SPA  @0 Familia @5 02
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C03 06  X  SPA  @0 Meta-análisis @5 09
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C07 01  X  FRE  @0 Pathologie de l'appareil respiratoire @5 37
C07 01  X  ENG  @0 Respiratory disease @5 37
C07 01  X  SPA  @0 Aparato respiratorio patología @5 37
C07 02  X  FRE  @0 Virose @5 38
C07 02  X  ENG  @0 Viral disease @5 38
C07 02  X  SPA  @0 Virosis @5 38
C07 03  X  FRE  @0 Infection
C07 03  X  ENG  @0 Infection
C07 03  X  SPA  @0 Infección
N21       @1 198
N44 01      @1 OTO
N82       @1 OTO

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<div type="abstract" xml:lang="en">Background: During the 2009 influenza A (H1N1) pandemic, household transmission studies were implemented to better understand the characteristics of the transmission of the novel virus in a confined setting. Methods: We conducted a systematic review and meta-analysis to assess and summarize the findings of these studies. We identified 27 articles, around half of which reported studies conducted in May and June 2009. Results: In 13 of the 27 studies (48%) that collected respiratory specimens from household contacts, point estimates of the risk of secondary infection ranged from 3% to 38%, with substantial heterogeneity. Meta-regression analyses revealed that a part of the heterogeneity reflected varying case ascertainment and study designs. The estimates of symptomatic secondary infection risk, based on 20 studies identifying febrile acute respiratory illness among household contacts, also showed substantial variability, with point estimates ranging from 4% to 37%. Conclusions: Transmission of the 2009 pandemic virus in households appeared to vary among countries and settings, with differences in estimates of the secondary infection risk also partly due to differences in study designs.</div>
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<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Revue systématique</s0>
<s2>FM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Systematic review</s0>
<s2>FM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Revisión sistemática</s0>
<s2>FM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Métaanalyse</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Metaanalysis</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Meta-análisis</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Epidémiologie</s0>
<s5>25</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Epidemiology</s0>
<s5>25</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Epidemiología</s0>
<s5>25</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Pandémie</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Grippe H1N1</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>H1N1 influenza</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Gripe H1N1</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE">
<s0>Virus grippal A(H1N1)</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG">
<s0>Influenza A (H1N1)</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Pathologie de l'appareil respiratoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Virose</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Viral disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Virosis</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Infection</s0>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Infection</s0>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Infección</s0>
</fC07>
<fN21>
<s1>198</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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