Influenza A/pandemic 2009/H1N1 in the setting of allogeneic hematopoietic cell transplantation: a potentially catastrophic problem in a vulnerable population
Identifieur interne : 001158 ( PascalFrancis/Checkpoint ); précédent : 001157; suivant : 001159Influenza A/pandemic 2009/H1N1 in the setting of allogeneic hematopoietic cell transplantation: a potentially catastrophic problem in a vulnerable population
Auteurs : Mohamed A. Kharfan-Dabaja [États-Unis] ; Ana Velez [États-Unis] ; Karla Richards [États-Unis] ; John N. Greene [États-Unis] ; Teresa Field [États-Unis] ; Ramon Sandin [États-Unis]Source :
- International journal of hematology [ 0925-5710 ] ; 2010.
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- Pascal (Inist)
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- topic : Cellule souche, Homme.
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Abstract
We describe Influenza A/pandemic 2009/H1N1 in two allogeneic hematopoietic cell transplantation recipients. The main presentation in both cases consisted of flu-like symptoms manifesting as, fever, arthralgias and myalgias. The virus was isolated in one case from a throat swab and in another case following a bronchoalveolar lavage. Both patients received oseltamivir at a dose of 75 mg orally twice day. The dose of oseltamivir was increased to 150 mg twice per day due to the lack of improvement or progression of symptoms. In one case, clinical symptoms resolved without sequelae. In the second case, pulmonary symptomatology continued to deteriorate, despite aggressive polymicrobial treatment, requiring mechanical ventilation and ultimately the patient died from respiratory failure. These cases highlight the potentially serious effect of the ongoing Influenza A/pandemic 2009/ H1N1 pandemic in this very vulnerable population and the urgent need to establish emergency preparedness strategies by oncology and bone marrow transplantation staff to face this serious healthcare challenge.
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Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3</s1><s2>Tampa, FL 33612</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Oncological Sciences, H. Lee Moffitt Cancer Center and Research Institute/University of South Florida</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Hematopathology and Laboratory Medicine, H. 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Kharfan-Dabaja</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3</s1><s2>Tampa, FL 33612</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Oncological Sciences, H. Lee Moffitt Cancer Center and Research Institute/University of South Florida</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation></author><author><name sortKey="Velez, Ana" sort="Velez, Ana" uniqKey="Velez A" first="Ana" last="Velez">Ana Velez</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3</s1><s2>Tampa, FL 33612</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Oncological Sciences, H. Lee Moffitt Cancer Center and Research Institute/University of South Florida</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Infectious Diseases, H. Lee Moffitt Cancer Center and Research Institute/University of South Florida</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation></author><author><name sortKey="Richards, Karla" sort="Richards, Karla" uniqKey="Richards K" first="Karla" last="Richards">Karla Richards</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3</s1><s2>Tampa, FL 33612</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Greene, John N" sort="Greene, John N" uniqKey="Greene J" first="John N." last="Greene">John N. Greene</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3</s1><s2>Tampa, FL 33612</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Oncological Sciences, H. Lee Moffitt Cancer Center and Research Institute/University of South Florida</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Infectious Diseases, H. Lee Moffitt Cancer Center and Research Institute/University of South Florida</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation></author><author><name sortKey="Field, Teresa" sort="Field, Teresa" uniqKey="Field T" first="Teresa" last="Field">Teresa Field</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3</s1><s2>Tampa, FL 33612</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Oncological Sciences, H. Lee Moffitt Cancer Center and Research Institute/University of South Florida</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation></author><author><name sortKey="Sandin, Ramon" sort="Sandin, Ramon" uniqKey="Sandin R" first="Ramon" last="Sandin">Ramon Sandin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3</s1><s2>Tampa, FL 33612</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Oncological Sciences, H. Lee Moffitt Cancer Center and Research Institute/University of South Florida</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><series><title level="j" type="main">International journal of hematology</title><title level="j" type="abbreviated">Int. j. hematol.</title><idno type="ISSN">0925-5710</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of hematology</title><title level="j" type="abbreviated">Int. j. hematol.</title><idno type="ISSN">0925-5710</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Allogeneic hematopoietic stem cell transplantation</term><term>H1N1 influenza</term><term>Hematology</term><term>Hematopoietic cell</term><term>Homograft</term><term>Human</term><term>Influenza A</term><term>Stem cell</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Grippe A</term><term>Homogreffe</term><term>Cellule hématopoïétique</term><term>Cellule souche</term><term>Homme</term><term>Hématologie</term><term>Grippe H1N1</term><term>Allogreffe de cellules souches hématopoïétiques</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cellule souche</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We describe Influenza A/pandemic 2009/H1N1 in two allogeneic hematopoietic cell transplantation recipients. The main presentation in both cases consisted of flu-like symptoms manifesting as, fever, arthralgias and myalgias. The virus was isolated in one case from a throat swab and in another case following a bronchoalveolar lavage. Both patients received oseltamivir at a dose of 75 mg orally twice day. The dose of oseltamivir was increased to 150 mg twice per day due to the lack of improvement or progression of symptoms. In one case, clinical symptoms resolved without sequelae. In the second case, pulmonary symptomatology continued to deteriorate, despite aggressive polymicrobial treatment, requiring mechanical ventilation and ultimately the patient died from respiratory failure. These cases highlight the potentially serious effect of the ongoing Influenza A/pandemic 2009/ H1N1 pandemic in this very vulnerable population and the urgent need to establish emergency preparedness strategies by oncology and bone marrow transplantation staff to face this serious healthcare challenge.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0925-5710</s0></fA01><fA03 i2="1"><s0>Int. j. hematol.</s0></fA03><fA05><s2>91</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Influenza A/pandemic 2009/H1N1 in the setting of allogeneic hematopoietic cell transplantation: a potentially catastrophic problem in a vulnerable population</s1></fA08><fA11 i1="01" i2="1"><s1>KHARFAN-DABAJA (Mohamed A.)</s1></fA11><fA11 i1="02" i2="1"><s1>VELEZ (Ana)</s1></fA11><fA11 i1="03" i2="1"><s1>RICHARDS (Karla)</s1></fA11><fA11 i1="04" i2="1"><s1>GREENE (John N.)</s1></fA11><fA11 i1="05" i2="1"><s1>FIELD (Teresa)</s1></fA11><fA11 i1="06" i2="1"><s1>SANDIN (Ramon)</s1></fA11><fA14 i1="01"><s1>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3</s1><s2>Tampa, FL 33612</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Oncological Sciences, H. Lee Moffitt Cancer Center and Research Institute/University of South Florida</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="03"><s1>Division of Infectious Diseases, H. Lee Moffitt Cancer Center and Research Institute/University of South Florida</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute</s1><s2>Tampa, FL</s2><s3>USA</s3><sZ>6 aut.</sZ></fA14><fA20><s1>124-127</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>19540</s2><s5>354000181634600170</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>18 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>10-0161171</s0></fA47><fA60><s1>P</s1><s3>EC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>International journal of hematology</s0></fA64><fA66 i1="01"><s0>DEU</s0></fA66><fC01 i1="01" l="ENG"><s0>We describe Influenza A/pandemic 2009/H1N1 in two allogeneic hematopoietic cell transplantation recipients. The main presentation in both cases consisted of flu-like symptoms manifesting as, fever, arthralgias and myalgias. The virus was isolated in one case from a throat swab and in another case following a bronchoalveolar lavage. Both patients received oseltamivir at a dose of 75 mg orally twice day. The dose of oseltamivir was increased to 150 mg twice per day due to the lack of improvement or progression of symptoms. In one case, clinical symptoms resolved without sequelae. In the second case, pulmonary symptomatology continued to deteriorate, despite aggressive polymicrobial treatment, requiring mechanical ventilation and ultimately the patient died from respiratory failure. These cases highlight the potentially serious effect of the ongoing Influenza A/pandemic 2009/ H1N1 pandemic in this very vulnerable population and the urgent need to establish emergency preparedness strategies by oncology and bone marrow transplantation staff to face this serious healthcare challenge.</s0></fC01><fC02 i1="01" i2="X"><s0>002B19</s0></fC02><fC02 i1="02" i2="X"><s0>002B05C02C</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Grippe A</s0><s5>09</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Influenza A</s0><s5>09</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Gripe A</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Homogreffe</s0><s5>10</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Homograft</s0><s5>10</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Homoinjerto</s0><s5>10</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Cellule hématopoïétique</s0><s5>11</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Hematopoietic cell</s0><s5>11</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Célula hematopoyética</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Cellule souche</s0><s5>12</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Stem cell</s0><s5>12</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Célula primitiva</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0><s5>13</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Human</s0><s5>13</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Hématologie</s0><s5>14</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Hematology</s0><s5>14</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Hematología</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Grippe H1N1</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>H1N1 influenza</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Allogreffe de cellules souches hématopoïétiques</s0><s4>CD</s4><s5>97</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Allogeneic hematopoietic stem cell transplantation</s0><s4>CD</s4><s5>97</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0><s5>37</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Respiratory disease</s0><s5>37</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0><s5>37</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Greffe</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Graft</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Injerto</s0><s5>39</s5></fC07><fN21><s1>102</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region><settlement><li>Tampa</li></settlement><orgName><li>Université de Floride du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Kharfan Dabaja, Mohamed A" sort="Kharfan Dabaja, Mohamed A" uniqKey="Kharfan Dabaja M" first="Mohamed A." last="Kharfan-Dabaja">Mohamed A. Kharfan-Dabaja</name></region><name sortKey="Field, Teresa" sort="Field, Teresa" uniqKey="Field T" first="Teresa" last="Field">Teresa Field</name><name sortKey="Field, Teresa" sort="Field, Teresa" uniqKey="Field T" first="Teresa" last="Field">Teresa Field</name><name sortKey="Greene, John N" sort="Greene, John N" uniqKey="Greene J" first="John N." last="Greene">John N. Greene</name><name sortKey="Greene, John N" sort="Greene, John N" uniqKey="Greene J" first="John N." last="Greene">John N. Greene</name><name sortKey="Greene, John N" sort="Greene, John N" uniqKey="Greene J" first="John N." last="Greene">John N. Greene</name><name sortKey="Kharfan Dabaja, Mohamed A" sort="Kharfan Dabaja, Mohamed A" uniqKey="Kharfan Dabaja M" first="Mohamed A." last="Kharfan-Dabaja">Mohamed A. Kharfan-Dabaja</name><name sortKey="Richards, Karla" sort="Richards, Karla" uniqKey="Richards K" first="Karla" last="Richards">Karla Richards</name><name sortKey="Sandin, Ramon" sort="Sandin, Ramon" uniqKey="Sandin R" first="Ramon" last="Sandin">Ramon Sandin</name><name sortKey="Sandin, Ramon" sort="Sandin, Ramon" uniqKey="Sandin R" first="Ramon" last="Sandin">Ramon Sandin</name><name sortKey="Sandin, Ramon" sort="Sandin, Ramon" uniqKey="Sandin R" first="Ramon" last="Sandin">Ramon Sandin</name><name sortKey="Velez, Ana" sort="Velez, Ana" uniqKey="Velez A" first="Ana" last="Velez">Ana Velez</name><name sortKey="Velez, Ana" sort="Velez, Ana" uniqKey="Velez A" first="Ana" last="Velez">Ana Velez</name><name sortKey="Velez, Ana" sort="Velez, Ana" uniqKey="Velez A" first="Ana" last="Velez">Ana Velez</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Influenza A/pandemic 2009/H1N1 in the setting of allogeneic hematopoietic cell transplantation: a potentially catastrophic problem in a vulnerable population
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