Obesity and influenza associated mortality: Evidence from an elderly cohort in Hong Kong
Identifieur interne : 000224 ( PascalFrancis/Checkpoint ); précédent : 000223; suivant : 000225Obesity and influenza associated mortality: Evidence from an elderly cohort in Hong Kong
Auteurs : LIN YANG [Hong Kong] ; KING PAN CHAN [Hong Kong] ; Ruby Siu-Yin Lee [Hong Kong] ; WAI MAN CHAN [Hong Kong] ; HAK KAN LAI [Hong Kong] ; THUAN QUOC THACH [Hong Kong] ; KWOK HUNG CHAN [Hong Kong] ; TAI HING LAM [Hong Kong] ; J. S. Malik Peiris [Hong Kong] ; CHIT MING WONG [Hong Kong]Source :
- Preventive medicine : (1972) [ 0091-7435 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Hong Kong.
- topic : Mortalité, Tabagisme, Personne âgée, Santé publique, Tabac.
English descriptors
- KwdEn :
Abstract
Objective. Obesity was not identified as a risk factor for influenza until the recent 2009 H1 N1 pandemic. Based on a cohort of 66,820 subjects aged 65 years and over with the follow-up period from July 1998 to December 2010 in Hong Kong, we assessed the modifying effect of obesity on mortality risks specifically attributable to influenza infections (termed as "influenza associated mortality risks"). Methods. A Cox proportional model with time dependent covariates was adopted to assess the hazard ratio of mortality in each obesity group when influenza activity increased 10% in the community. Results. Hazard ratio of influenza-associated all-cause mortality was 1.081 (95% confidence interval 1.013, 1.154), 1.047 (1.012, 1.084), 0.981 (0.936, 1.028), 1.018 (0.980, 1.058) and 1.062 (0.972, 1.162) in the underweight, normal, overweight, moderate obesity and severe obesity groups, respectively. A similar U shape pattern across the obesity groups was also observed in influenza associated mortality risks of respiratory diseases, pneumonia and influenza. This pattern was more evident among ever smokers, although the influenza effect estimates in each obesity group had overlapping confidence intervals. Conclusion. There is some but limited evidence to suggest that underweight and obesity were associated with higher mortality risks of influenza in old population.
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Pascal:13-0185913Le document en format XML
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<author><name sortKey="Chit Ming Wong" sort="Chit Ming Wong" uniqKey="Chit Ming Wong" last="Chit Ming Wong">CHIT MING WONG</name>
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<term>Hong Kong</term>
<term>Influenza</term>
<term>Mortality</term>
<term>Nutritional status</term>
<term>Obesity</term>
<term>Public health</term>
<term>Respiratory system</term>
<term>Respiratory tract</term>
<term>Tobacco</term>
<term>Tobacco smoking</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Obésité</term>
<term>Grippe</term>
<term>Mortalité</term>
<term>Tabagisme</term>
<term>Epidémiologie</term>
<term>Personne âgée</term>
<term>Etude cohorte</term>
<term>Santé publique</term>
<term>Hong Kong</term>
<term>Appareil respiratoire</term>
<term>Voie respiratoire</term>
<term>Tabac</term>
<term>Etat nutritionnel</term>
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Hong Kong</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Mortalité</term>
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<front><div type="abstract" xml:lang="en">Objective. Obesity was not identified as a risk factor for influenza until the recent 2009 H1 N1 pandemic. Based on a cohort of 66,820 subjects aged 65 years and over with the follow-up period from July 1998 to December 2010 in Hong Kong, we assessed the modifying effect of obesity on mortality risks specifically attributable to influenza infections (termed as "influenza associated mortality risks"). Methods. A Cox proportional model with time dependent covariates was adopted to assess the hazard ratio of mortality in each obesity group when influenza activity increased 10% in the community. Results. Hazard ratio of influenza-associated all-cause mortality was 1.081 (95% confidence interval 1.013, 1.154), 1.047 (1.012, 1.084), 0.981 (0.936, 1.028), 1.018 (0.980, 1.058) and 1.062 (0.972, 1.162) in the underweight, normal, overweight, moderate obesity and severe obesity groups, respectively. A similar U shape pattern across the obesity groups was also observed in influenza associated mortality risks of respiratory diseases, pneumonia and influenza. This pattern was more evident among ever smokers, although the influenza effect estimates in each obesity group had overlapping confidence intervals. Conclusion. There is some but limited evidence to suggest that underweight and obesity were associated with higher mortality risks of influenza in old population.</div>
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<fA66 i1="01"><s0>NLD</s0>
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<fC01 i1="01" l="ENG"><s0>Objective. Obesity was not identified as a risk factor for influenza until the recent 2009 H1 N1 pandemic. Based on a cohort of 66,820 subjects aged 65 years and over with the follow-up period from July 1998 to December 2010 in Hong Kong, we assessed the modifying effect of obesity on mortality risks specifically attributable to influenza infections (termed as "influenza associated mortality risks"). Methods. A Cox proportional model with time dependent covariates was adopted to assess the hazard ratio of mortality in each obesity group when influenza activity increased 10% in the community. Results. Hazard ratio of influenza-associated all-cause mortality was 1.081 (95% confidence interval 1.013, 1.154), 1.047 (1.012, 1.084), 0.981 (0.936, 1.028), 1.018 (0.980, 1.058) and 1.062 (0.972, 1.162) in the underweight, normal, overweight, moderate obesity and severe obesity groups, respectively. A similar U shape pattern across the obesity groups was also observed in influenza associated mortality risks of respiratory diseases, pneumonia and influenza. This pattern was more evident among ever smokers, although the influenza effect estimates in each obesity group had overlapping confidence intervals. Conclusion. There is some but limited evidence to suggest that underweight and obesity were associated with higher mortality risks of influenza in old population.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B30A03C</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B22B</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Obésité</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Obesity</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Obesidad</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Grippe</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Influenza</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Gripe</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Mortalité</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Mortality</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Mortalidad</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Tabagisme</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Tobacco smoking</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Tabaquismo</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Epidémiologie</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Epidemiology</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Epidemiología</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Personne âgée</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Elderly</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Anciano</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Etude cohorte</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Cohort study</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Estudio cohorte</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Santé publique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Public health</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Salud pública</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Appareil respiratoire</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Respiratory system</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Aparato respiratorio</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Voie respiratoire</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Respiratory tract</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Vía respiratoria</s0>
<s5>17</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Tabac</s0>
<s2>FX</s2>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Tobacco</s0>
<s2>FX</s2>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Tabaco</s0>
<s2>FX</s2>
<s5>18</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Etat nutritionnel</s0>
<s5>25</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Nutritional status</s0>
<s5>25</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Estado nutricional</s0>
<s5>25</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Chine</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>China</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>China</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Asie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Trouble de la nutrition</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Nutrition disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Trastorno nutricíon</s0>
<s5>37</s5>
</fC07>
<fN21><s1>168</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Hong Kong</li>
</country>
</list>
<tree><country name="Hong Kong"><noRegion><name sortKey="Lin Yang" sort="Lin Yang" uniqKey="Lin Yang" last="Lin Yang">LIN YANG</name>
</noRegion>
<name sortKey="Chit Ming Wong" sort="Chit Ming Wong" uniqKey="Chit Ming Wong" last="Chit Ming Wong">CHIT MING WONG</name>
<name sortKey="Hak Kan Lai" sort="Hak Kan Lai" uniqKey="Hak Kan Lai" last="Hak Kan Lai">HAK KAN LAI</name>
<name sortKey="King Pan Chan" sort="King Pan Chan" uniqKey="King Pan Chan" last="King Pan Chan">KING PAN CHAN</name>
<name sortKey="Kwok Hung Chan" sort="Kwok Hung Chan" uniqKey="Kwok Hung Chan" last="Kwok Hung Chan">KWOK HUNG CHAN</name>
<name sortKey="Lee, Ruby Siu Yin" sort="Lee, Ruby Siu Yin" uniqKey="Lee R" first="Ruby Siu-Yin" last="Lee">Ruby Siu-Yin Lee</name>
<name sortKey="Malik Peiris, J S" sort="Malik Peiris, J S" uniqKey="Malik Peiris J" first="J. S." last="Malik Peiris">J. S. Malik Peiris</name>
<name sortKey="Malik Peiris, J S" sort="Malik Peiris, J S" uniqKey="Malik Peiris J" first="J. S." last="Malik Peiris">J. S. Malik Peiris</name>
<name sortKey="Tai Hing Lam" sort="Tai Hing Lam" uniqKey="Tai Hing Lam" last="Tai Hing Lam">TAI HING LAM</name>
<name sortKey="Thuan Quoc Thach" sort="Thuan Quoc Thach" uniqKey="Thuan Quoc Thach" last="Thuan Quoc Thach">THUAN QUOC THACH</name>
<name sortKey="Wai Man Chan" sort="Wai Man Chan" uniqKey="Wai Man Chan" last="Wai Man Chan">WAI MAN CHAN</name>
</country>
</tree>
</affiliations>
</record>
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