Protection against a Lethal Avian Influenza A Virus in a Mammalian System
Identifieur interne : 002176 ( Ncbi/Merge ); précédent : 002175; suivant : 002177Protection against a Lethal Avian Influenza A Virus in a Mammalian System
Auteurs : Janice M. Riberdy ; Kirsten J. Flynn ; Juergen Stech ; Robert G. Webster ; John D. Altman ; Peter C. DohertySource :
- Journal of Virology [ 0022-538X ] ; 1999.
Descripteurs français
- KwdFr :
- ADN viral, Animaux, Données de séquences moléculaires, Grippe humaine (), Grippe humaine (immunologie), Humains, Immunoglobulines (immunologie), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD8+ (immunologie), Modèles animaux de maladie humaine, Oiseaux, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Séquence nucléotidique, Vaccins antigrippaux (immunologie), Virus de la grippe A (immunologie).
- MESH :
- immunologie : Grippe humaine, Immunoglobulines, Lymphocytes T CD4+, Lymphocytes T CD8+, Vaccins antigrippaux, Virus de la grippe A.
- ADN viral, Animaux, Données de séquences moléculaires, Grippe humaine, Humains, Modèles animaux de maladie humaine, Oiseaux, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Séquence nucléotidique.
English descriptors
- KwdEn :
- Animals, Base Sequence, Birds, CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), DNA, Viral, Disease Models, Animal, Humans, Immunoglobulins (immunology), Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control), Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data.
- MESH :
- chemical , immunology : Immunoglobulins, Influenza Vaccines.
- chemical : DNA, Viral.
- immunology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Influenza A virus, Influenza, Human.
- prevention & control : Influenza, Human.
- Animals, Base Sequence, Birds, Disease Models, Animal, Humans, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data.
Abstract
The question of how best to protect the human population against a potential influenza pandemic has been raised by the recent outbreak caused by an avian H5N1 virus in Hong Kong. The likely strategy would be to vaccinate with a less virulent, laboratory-adapted H5N1 strain isolated previously from birds. Little attention has been given, however, to dissecting the consequences of sequential exposure to serologically related influenza A viruses using contemporary immunology techniques. Such experiments with the H5N1 viruses are limited by the potential risk to humans. An extremely virulent H3N8 avian influenza A virus has been used to infect both immunoglobulin-expressing (Ig+/+) and Ig−/− mice primed previously with a laboratory-adapted H3N2 virus. The cross-reactive antibody response was very protective, while the recall of CD8+ T-cell memory in the Ig−/− mice provided some small measure of resistance to a low-dose H3N8 challenge. The H3N8 virus also replicated in the respiratory tracts of the H3N2-primed Ig+/+ mice, generating secondary CD8+ and CD4+ T-cell responses that may contribute to recovery. The results indicate that the various components of immune memory operate together to provide optimal protection, and they support the idea that related viruses of nonhuman origin can be used as vaccines.
Url:
PubMed: 9882351
PubMed Central: 103970
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PMC:103970Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>The question of how best to protect the human population against a potential influenza pandemic has been raised by the recent outbreak caused by an avian H5N1 virus in Hong Kong. The likely strategy would be to vaccinate with a less virulent, laboratory-adapted H5N1 strain isolated previously from birds. Little attention has been given, however, to dissecting the consequences of sequential exposure to serologically related influenza A viruses using contemporary immunology techniques. Such experiments with the H5N1 viruses are limited by the potential risk to humans. An extremely virulent H3N8 avian influenza A virus has been used to infect both immunoglobulin-expressing (Ig<sup>+/+</sup>
) and Ig<sup>−/−</sup>
mice primed previously with a laboratory-adapted H3N2 virus. The cross-reactive antibody response was very protective, while the recall of CD8<sup>+</sup>
T-cell memory in the Ig<sup>−/−</sup>
mice provided some small measure of resistance to a low-dose H3N8 challenge. The H3N8 virus also replicated in the respiratory tracts of the H3N2-primed Ig<sup>+/+</sup>
mice, generating secondary CD8<sup>+</sup>
and CD4<sup>+</sup>
T-cell responses that may contribute to recovery. The results indicate that the various components of immune memory operate together to provide optimal protection, and they support the idea that related viruses of nonhuman origin can be used as vaccines.</p>
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<front><div type="abstract" xml:lang="en"><p>The question of how best to protect the human population against a potential influenza pandemic has been raised by the recent outbreak caused by an avian H5N1 virus in Hong Kong. The likely strategy would be to vaccinate with a less virulent, laboratory-adapted H5N1 strain isolated previously from birds. Little attention has been given, however, to dissecting the consequences of sequential exposure to serologically related influenza A viruses using contemporary immunology techniques. Such experiments with the H5N1 viruses are limited by the potential risk to humans. An extremely virulent H3N8 avian influenza A virus has been used to infect both immunoglobulin-expressing (Ig<sup>+/+</sup>
) and Ig<sup>−/−</sup>
mice primed previously with a laboratory-adapted H3N2 virus. The cross-reactive antibody response was very protective, while the recall of CD8<sup>+</sup>
T-cell memory in the Ig<sup>−/−</sup>
mice provided some small measure of resistance to a low-dose H3N8 challenge. The H3N8 virus also replicated in the respiratory tracts of the H3N2-primed Ig<sup>+/+</sup>
mice, generating secondary CD8<sup>+</sup>
and CD4<sup>+</sup>
T-cell responses that may contribute to recovery. The results indicate that the various components of immune memory operate together to provide optimal protection, and they support the idea that related viruses of nonhuman origin can be used as vaccines.</p>
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<term>Influenza, Human (prevention & control)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Inbred C57BL</term>
<term>Molecular Sequence Data</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (immunologie)</term>
<term>Humains</term>
<term>Immunoglobulines (immunologie)</term>
<term>Lymphocytes T CD4+ (immunologie)</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Oiseaux</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Souris de lignée C57BL</term>
<term>Séquence nucléotidique</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Virus de la grippe A (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Immunoglobulins</term>
<term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>DNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Immunoglobulines</term>
<term>Lymphocytes T CD4+</term>
<term>Lymphocytes T CD8+</term>
<term>Vaccins antigrippaux</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>CD8-Positive T-Lymphocytes</term>
<term>Influenza A virus</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Base Sequence</term>
<term>Birds</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Inbred C57BL</term>
<term>Molecular Sequence Data</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>ADN viral</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Grippe humaine</term>
<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Oiseaux</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Souris de lignée C57BL</term>
<term>Séquence nucléotidique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The question of how best to protect the human population against a potential influenza pandemic has been raised by the recent outbreak caused by an avian H5N1 virus in Hong Kong. The likely strategy would be to vaccinate with a less virulent, laboratory-adapted H5N1 strain isolated previously from birds. Little attention has been given, however, to dissecting the consequences of sequential exposure to serologically related influenza A viruses using contemporary immunology techniques. Such experiments with the H5N1 viruses are limited by the potential risk to humans. An extremely virulent H3N8 avian influenza A virus has been used to infect both immunoglobulin-expressing (Ig+/+) and Ig-/- mice primed previously with a laboratory-adapted H3N2 virus. The cross-reactive antibody response was very protective, while the recall of CD8(+) T-cell memory in the Ig-/- mice provided some small measure of resistance to a low-dose H3N8 challenge. The H3N8 virus also replicated in the respiratory tracts of the H3N2-primed Ig+/+ mice, generating secondary CD8(+) and CD4(+) T-cell responses that may contribute to recovery. The results indicate that the various components of immune memory operate together to provide optimal protection, and they support the idea that related viruses of nonhuman origin can be used as vaccines.</div>
</front>
</TEI>
</pubmed>
</double>
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