PandemieGrippaleV1, Ncbi, Merge, bibRecord, 001E40

Comparative effectiveness of H7N9 vaccines in healthy individuals

Identifieur interne : 001E40 ( Ncbi/Merge ); précédent : 001E39; suivant : 001E41

Comparative effectiveness of H7N9 vaccines in healthy individuals

Auteurs : Dan Zheng [République populaire de Chine] ; Feixia Gao [République populaire de Chine] ; Cheng Zhao [République populaire de Chine] ; Yahong Ding [République populaire de Chine] ; Yemin Cao [République populaire de Chine] ; Tianhan Yang [République populaire de Chine] ; Xuesong Xu [République populaire de Chine] ; Ze Chen [République populaire de Chine]

Source :

Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2018.

RBID : PMC:6363152

Descripteurs français

KwdFr :
- Adjuvants immunologiques (administration et posologie), Adjuvants immunologiques (normes), Essais contrôlés randomisés comme sujet, Femelle, Grippe humaine (), Humains, Immunogénicité des vaccins, Mâle, Sous-type H7N9 du virus de la grippe A, Vaccins antigrippaux (immunologie), Vaccins antigrippaux (normes).
MESH :
- administration et posologie : Adjuvants immunologiques.
- immunologie : Vaccins antigrippaux.
- normes : Adjuvants immunologiques, Vaccins antigrippaux.
- Essais contrôlés randomisés comme sujet, Femelle, Grippe humaine, Humains, Immunogénicité des vaccins, Mâle, Sous-type H7N9 du virus de la grippe A.

English descriptors

KwdEn :
- Adjuvants, Immunologic (administration & dosage), Adjuvants, Immunologic (standards), Female, Humans, Immunogenicity, Vaccine, Influenza A Virus, H7N9 Subtype, Influenza Vaccines (immunology), Influenza Vaccines (standards), Influenza, Human (prevention & control), Male, Randomized Controlled Trials as Topic.
MESH :
- chemical , administration & dosage : Adjuvants, Immunologic.
- chemical , immunology : Influenza Vaccines.
- chemical , standards : Adjuvants, Immunologic, Influenza Vaccines.
- prevention & control : Influenza, Human.
- Female, Humans, Immunogenicity, Vaccine, Influenza A Virus, H7N9 Subtype, Male, Randomized Controlled Trials as Topic.

Abstract

ABSTRACT

Background: Avian H7N9 influenza viruses possess a potential pandemic threat to public health worldwide, and have caused severe infection and high mortality in humans. A series of clinical trials of H7N9 vaccines have been completed. Meta-analyses need to be performed to assess the immunogenicity and safety of H7N9 vaccines.

Methods: Database research with defined selection criteria was conducted in PubMed, Cochrane Central Register of Controlled Trials, the World Health Organization’s International Clinical Trials Registry Platform, ClinicalTrials.gov, etc. Data from randomized clinical trials regarding the immunogenicity and safety of H7N9 vaccines were collected and meta-analyzed.

Results: For non-adjuvanted H7N9 vaccines, high dose formulations induced limited immunogenicity and increased the risk of local and systemic adverse events, simultaneously. For adjuvanted H7N9 vaccines, on the one hand, ISCOMATRIX, MF59, AS03 and aluminium adjuvants applied in H7N9 vaccines could improve immune responses effectively, and non-aluminium adjuvants had superior performance in saving vaccine dose; on the other hand, aluminium adjuvant had the advantages of safety amongst these adjuvants applied in H7N9 vaccines.

Conclusion: H7N9 influenza vaccines with adjuvant might represent the optimal available option in an influenza pandemic, at present.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363152

DOI: 10.1080/21645515.2018.1515454
PubMed: 30148691
PubMed Central: 6363152

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PMC:6363152

Le document en format XML

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<term>Female</term>
<term>Humans</term>
<term>Immunogenicity, Vaccine</term>
<term>Influenza A Virus, H7N9 Subtype</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza Vaccines (standards)</term>
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<term>Adjuvants immunologiques (normes)</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Femelle</term>
<term>Grippe humaine ()</term>
<term>Humains</term>
<term>Immunogénicité des vaccins</term>
<term>Mâle</term>
<term>Sous-type H7N9 du virus de la grippe A</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins antigrippaux (normes)</term>
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<term>Influenza Vaccines</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term>
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<term>Humans</term>
<term>Immunogenicity, Vaccine</term>
<term>Influenza A Virus, H7N9 Subtype</term>
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<term>Randomized Controlled Trials as Topic</term>
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<term>Grippe humaine</term>
<term>Humains</term>
<term>Immunogénicité des vaccins</term>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p><bold>Background</bold>
: Avian H7N9 influenza viruses possess a potential pandemic threat to public health worldwide, and have caused severe infection and high mortality in humans. A series of clinical trials of H7N9 vaccines have been completed. Meta-analyses need to be performed to assess the immunogenicity and safety of H7N9 vaccines.</p>
<p><bold>Methods</bold>
: Database research with defined selection criteria was conducted in PubMed, Cochrane Central Register of Controlled Trials, the World Health Organization’s International Clinical Trials Registry Platform, ClinicalTrials.gov, etc. Data from randomized clinical trials regarding the immunogenicity and safety of H7N9 vaccines were collected and meta-analyzed.</p>
<p><bold>Results</bold>
: For non-adjuvanted H7N9 vaccines, high dose formulations induced limited immunogenicity and increased the risk of local and systemic adverse events, simultaneously. For adjuvanted H7N9 vaccines, on the one hand, ISCOMATRIX, MF59, AS03 and aluminium adjuvants applied in H7N9 vaccines could improve immune responses effectively, and non-aluminium adjuvants had superior performance in saving vaccine dose; on the other hand, aluminium adjuvant had the advantages of safety amongst these adjuvants applied in H7N9 vaccines.</p>
<p><bold>Conclusion</bold>
: H7N9 influenza vaccines with adjuvant might represent the optimal available option in an influenza pandemic, at present.</p>
</div>
</front>
</TEI>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Cao, Yemin" sort="Cao, Yemin" uniqKey="Cao Y" first="Yemin" last="Cao">Yemin Cao</name>
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, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AFF0003"><institution>Department of Vascular Disease, Shanghai TCM-Integrated Institute of Vascular Disease</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Tianhan" sort="Yang, Tianhan" uniqKey="Yang T" first="Tianhan" last="Yang">Tianhan Yang</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Research and Development, Shanghai Institute of Biological Products</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Xu, Xuesong" sort="Xu, Xuesong" uniqKey="Xu X" first="Xuesong" last="Xu">Xuesong Xu</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0004"><institution>Huadong Hospital Affiliated to Fudan University</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Research and Development, Shanghai Institute of Biological Products</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">30148691</idno>
<idno type="pmc">6363152</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363152</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparative effectiveness of H7N9 vaccines in healthy individuals</title>
<author><name sortKey="Zheng, Dan" sort="Zheng, Dan" uniqKey="Zheng D" first="Dan" last="Zheng">Dan Zheng</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Research and Development, Shanghai Institute of Biological Products</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AFF0003"><institution>Department of Vascular Disease, Shanghai TCM-Integrated Institute of Vascular Disease</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gao, Feixia" sort="Gao, Feixia" uniqKey="Gao F" first="Feixia" last="Gao">Feixia Gao</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Research and Development, Shanghai Institute of Biological Products</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Cheng" sort="Zhao, Cheng" uniqKey="Zhao C" first="Cheng" last="Zhao">Cheng Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AFF0003"><institution>Department of Vascular Disease, Shanghai TCM-Integrated Institute of Vascular Disease</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ding, Yahong" sort="Ding, Yahong" uniqKey="Ding Y" first="Yahong" last="Ding">Yahong Ding</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Research and Development, Shanghai Institute of Biological Products</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cao, Yemin" sort="Cao, Yemin" uniqKey="Cao Y" first="Yemin" last="Cao">Yemin Cao</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AFF0003"><institution>Department of Vascular Disease, Shanghai TCM-Integrated Institute of Vascular Disease</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Tianhan" sort="Yang, Tianhan" uniqKey="Yang T" first="Tianhan" last="Yang">Tianhan Yang</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Research and Development, Shanghai Institute of Biological Products</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Xu, Xuesong" sort="Xu, Xuesong" uniqKey="Xu X" first="Xuesong" last="Xu">Xuesong Xu</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0004"><institution>Huadong Hospital Affiliated to Fudan University</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Research and Development, Shanghai Institute of Biological Products</institution>
, Shanghai,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Human Vaccines & Immunotherapeutics</title>
<idno type="ISSN">2164-5515</idno>
<idno type="eISSN">2164-554X</idno>
<imprint><date when="2018">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p><bold>Background</bold>
: Avian H7N9 influenza viruses possess a potential pandemic threat to public health worldwide, and have caused severe infection and high mortality in humans. A series of clinical trials of H7N9 vaccines have been completed. Meta-analyses need to be performed to assess the immunogenicity and safety of H7N9 vaccines.</p>
<p><bold>Methods</bold>
: Database research with defined selection criteria was conducted in PubMed, Cochrane Central Register of Controlled Trials, the World Health Organization’s International Clinical Trials Registry Platform, ClinicalTrials.gov, etc. Data from randomized clinical trials regarding the immunogenicity and safety of H7N9 vaccines were collected and meta-analyzed.</p>
<p><bold>Results</bold>
: For non-adjuvanted H7N9 vaccines, high dose formulations induced limited immunogenicity and increased the risk of local and systemic adverse events, simultaneously. For adjuvanted H7N9 vaccines, on the one hand, ISCOMATRIX, MF59, AS03 and aluminium adjuvants applied in H7N9 vaccines could improve immune responses effectively, and non-aluminium adjuvants had superior performance in saving vaccine dose; on the other hand, aluminium adjuvant had the advantages of safety amongst these adjuvants applied in H7N9 vaccines.</p>
<p><bold>Conclusion</bold>
: H7N9 influenza vaccines with adjuvant might represent the optimal available option in an influenza pandemic, at present.</p>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative effectiveness of H7N9 vaccines in healthy individuals.</title>
<author><name sortKey="Zheng, Dan" sort="Zheng, Dan" uniqKey="Zheng D" first="Dan" last="Zheng">Dan Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Feixia" sort="Gao, Feixia" uniqKey="Gao F" first="Feixia" last="Gao">Feixia Gao</name>
<affiliation wicri:level="1"><nlm:affiliation>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Cheng" sort="Zhao, Cheng" uniqKey="Zhao C" first="Cheng" last="Zhao">Cheng Zhao</name>
<affiliation wicri:level="1"><nlm:affiliation>b Shanghai TCM-Integrated Hospital , Shanghai University of Traditional Chinese Medicine , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Shanghai TCM-Integrated Hospital , Shanghai University of Traditional Chinese Medicine , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ding, Yahong" sort="Ding, Yahong" uniqKey="Ding Y" first="Yahong" last="Ding">Yahong Ding</name>
<affiliation wicri:level="1"><nlm:affiliation>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cao, Yemin" sort="Cao, Yemin" uniqKey="Cao Y" first="Yemin" last="Cao">Yemin Cao</name>
<affiliation wicri:level="1"><nlm:affiliation>b Shanghai TCM-Integrated Hospital , Shanghai University of Traditional Chinese Medicine , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Shanghai TCM-Integrated Hospital , Shanghai University of Traditional Chinese Medicine , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Tianhan" sort="Yang, Tianhan" uniqKey="Yang T" first="Tianhan" last="Yang">Tianhan Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Xuesong" sort="Xu, Xuesong" uniqKey="Xu X" first="Xuesong" last="Xu">Xuesong Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>d Huadong Hospital Affiliated to Fudan University , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>d Huadong Hospital Affiliated to Fudan University , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:30148691</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Comparative effectiveness of H7N9 vaccines in healthy individuals.</title>
<author><name sortKey="Zheng, Dan" sort="Zheng, Dan" uniqKey="Zheng D" first="Dan" last="Zheng">Dan Zheng</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Feixia" sort="Gao, Feixia" uniqKey="Gao F" first="Feixia" last="Gao">Feixia Gao</name>
<affiliation wicri:level="1"><nlm:affiliation>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Cheng" sort="Zhao, Cheng" uniqKey="Zhao C" first="Cheng" last="Zhao">Cheng Zhao</name>
<affiliation wicri:level="1"><nlm:affiliation>b Shanghai TCM-Integrated Hospital , Shanghai University of Traditional Chinese Medicine , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Shanghai TCM-Integrated Hospital , Shanghai University of Traditional Chinese Medicine , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ding, Yahong" sort="Ding, Yahong" uniqKey="Ding Y" first="Yahong" last="Ding">Yahong Ding</name>
<affiliation wicri:level="1"><nlm:affiliation>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a Department of Research and Development , Shanghai Institute of Biological Products , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cao, Yemin" sort="Cao, Yemin" uniqKey="Cao Y" first="Yemin" last="Cao">Yemin Cao</name>
<affiliation wicri:level="1"><nlm:affiliation>b Shanghai TCM-Integrated Hospital , Shanghai University of Traditional Chinese Medicine , Shanghai , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Shanghai TCM-Integrated Hospital , Shanghai University of Traditional Chinese Medicine , Shanghai </wicri:regionArea>
<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Tianhan" sort="Yang, Tianhan" uniqKey="Yang T" first="Tianhan" last="Yang">Tianhan Yang</name>
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<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Xuesong" sort="Xu, Xuesong" uniqKey="Xu X" first="Xuesong" last="Xu">Xuesong Xu</name>
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<wicri:noRegion>Shanghai </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<wicri:noRegion>Shanghai </wicri:noRegion>
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<series><title level="j">Human vaccines & immunotherapeutics</title>
<idno type="eISSN">2164-554X</idno>
<imprint><date when="2019" type="published">2019</date>
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<term>Adjuvants, Immunologic (standards)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunogenicity, Vaccine</term>
<term>Influenza A Virus, H7N9 Subtype</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza Vaccines (standards)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Male</term>
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</keywords>
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<term>Essais contrôlés randomisés comme sujet</term>
<term>Femelle</term>
<term>Grippe humaine ()</term>
<term>Humains</term>
<term>Immunogénicité des vaccins</term>
<term>Mâle</term>
<term>Sous-type H7N9 du virus de la grippe A</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins antigrippaux (normes)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adjuvants, Immunologic</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="standards" xml:lang="en"><term>Adjuvants, Immunologic</term>
<term>Influenza Vaccines</term>
</keywords>
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</keywords>
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<term>Randomized Controlled Trials as Topic</term>
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<term>Femelle</term>
<term>Grippe humaine</term>
<term>Humains</term>
<term>Immunogénicité des vaccins</term>
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<front><div type="abstract" xml:lang="en">Avian H7N9 influenza viruses possess a potential pandemic threat to public health worldwide, and have caused severe infection and high mortality in humans. A series of clinical trials of H7N9 vaccines have been completed. Meta-analyses need to be performed to assess the immunogenicity and safety of H7N9 vaccines.</div>
</front>
</TEI>
</pubmed>
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Comparative effectiveness of H7N9 vaccines in healthy individuals

Comparative effectiveness of H7N9 vaccines in healthy individuals

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