Passive Broad-Spectrum Influenza Immunoprophylaxis
Identifieur interne : 001937 ( Ncbi/Merge ); précédent : 001936; suivant : 001938Passive Broad-Spectrum Influenza Immunoprophylaxis
Auteurs : Cassandra M. Berry [Australie] ; William J. Penhale [Australie] ; Mark Y. Sangster [États-Unis]Source :
- Influenza Research and Treatment [ 2090-1380 ] ; 2014.
Abstract
Influenza is a perennial problem affecting millions of people annually with the everpresent threat of devastating pandemics. Active prophylaxis by vaccination against influenza virus is currently the main countermeasure supplemented with antivirals. However, disadvantages of this strategy include the impact of antigenic drift, necessitating constant updating of vaccine strain composition, and emerging antiviral drug resistance. The development of other options for influenza prophylaxis, particularly with broad acting agents able to provide protection in the period between the onset of a pandemic and the development of a strain specific vaccine, is of great interest. Exploitation of broad-spectrum mediators could provide barricade protection in the early critical phase of influenza virus outbreaks. Passive immunity has the potential to provide immediate antiviral effects, inhibiting virus replication, reducing virus shedding, and thereby protecting vulnerable populations in the event of an impending influenza pandemic. Here, we review passive broad-spectrum influenza prophylaxis options with a focus on harnessing natural host defenses, including interferons and antibodies.
Url:
DOI: 10.1155/2014/267594
PubMed: 25328697
PubMed Central: 4190013
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Penhale</name><affiliation wicri:level="1"><nlm:aff id="I1">Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150</wicri:regionArea><wicri:noRegion>WA 6150</wicri:noRegion></affiliation></author><author><name sortKey="Sangster, Mark Y" sort="Sangster, Mark Y" uniqKey="Sangster M" first="Mark Y." last="Sangster">Mark Y. Sangster</name><affiliation wicri:level="2"><nlm:aff id="I2">Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25328697</idno><idno type="pmc">4190013</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190013</idno><idno type="RBID">PMC:4190013</idno><idno type="doi">10.1155/2014/267594</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000A94</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A94</idno><idno type="wicri:Area/Pmc/Curation">000A94</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A94</idno><idno type="wicri:Area/Pmc/Checkpoint">000449</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000449</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:25328697</idno><idno type="wicri:Area/PubMed/Corpus">000749</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000749</idno><idno type="wicri:Area/PubMed/Curation">000749</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000749</idno><idno type="wicri:Area/PubMed/Checkpoint">000766</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000766</idno><idno type="wicri:Area/Ncbi/Merge">001937</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Passive Broad-Spectrum Influenza Immunoprophylaxis</title><author><name sortKey="Berry, Cassandra M" sort="Berry, Cassandra M" uniqKey="Berry C" first="Cassandra M." last="Berry">Cassandra M. Berry</name><affiliation wicri:level="1"><nlm:aff id="I1">Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150</wicri:regionArea><wicri:noRegion>WA 6150</wicri:noRegion></affiliation></author><author><name sortKey="Penhale, William J" sort="Penhale, William J" uniqKey="Penhale W" first="William J." last="Penhale">William J. Penhale</name><affiliation wicri:level="1"><nlm:aff id="I1">Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150</wicri:regionArea><wicri:noRegion>WA 6150</wicri:noRegion></affiliation></author><author><name sortKey="Sangster, Mark Y" sort="Sangster, Mark Y" uniqKey="Sangster M" first="Mark Y." last="Sangster">Mark Y. Sangster</name><affiliation wicri:level="2"><nlm:aff id="I2">Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Influenza Research and Treatment</title><idno type="ISSN">2090-1380</idno><idno type="eISSN">2090-1399</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza is a perennial problem affecting millions of people annually with the everpresent threat of devastating pandemics. Active prophylaxis by vaccination against influenza virus is currently the main countermeasure supplemented with antivirals. However, disadvantages of this strategy include the impact of antigenic drift, necessitating constant updating of vaccine strain composition, and emerging antiviral drug resistance. The development of other options for influenza prophylaxis, particularly with broad acting agents able to provide protection in the period between the onset of a pandemic and the development of a strain specific vaccine, is of great interest. Exploitation of broad-spectrum mediators could provide barricade protection in the early critical phase of influenza virus outbreaks. Passive immunity has the potential to provide immediate antiviral effects, inhibiting virus replication, reducing virus shedding, and thereby protecting vulnerable populations in the event of an impending influenza pandemic. 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Tay</name></author><author><name sortKey="Berry, Cm" uniqKey="Berry C">CM Berry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author><author><name sortKey="Skountzou, I" uniqKey="Skountzou I">I Skountzou</name></author><author><name sortKey="Compans, R" uniqKey="Compans R">R Compans</name></author><author><name sortKey="Jacob, J" uniqKey="Jacob J">J Jacob</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="25328697"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Passive Broad-Spectrum Influenza Immunoprophylaxis</title><author><name sortKey="Berry, Cassandra M" sort="Berry, Cassandra M" uniqKey="Berry C" first="Cassandra M." last="Berry">Cassandra M. Berry</name><affiliation wicri:level="1"><nlm:aff id="I1">Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150</wicri:regionArea><wicri:noRegion>WA 6150</wicri:noRegion></affiliation></author><author><name sortKey="Penhale, William J" sort="Penhale, William J" uniqKey="Penhale W" first="William J." last="Penhale">William J. Penhale</name><affiliation wicri:level="1"><nlm:aff id="I1">Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150</wicri:regionArea><wicri:noRegion>WA 6150</wicri:noRegion></affiliation></author><author><name sortKey="Sangster, Mark Y" sort="Sangster, Mark Y" uniqKey="Sangster M" first="Mark Y." last="Sangster">Mark Y. Sangster</name><affiliation wicri:level="2"><nlm:aff id="I2">Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25328697</idno><idno type="pmc">4190013</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190013</idno><idno type="RBID">PMC:4190013</idno><idno type="doi">10.1155/2014/267594</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000A94</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A94</idno><idno type="wicri:Area/Pmc/Curation">000A94</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A94</idno><idno type="wicri:Area/Pmc/Checkpoint">000449</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000449</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Passive Broad-Spectrum Influenza Immunoprophylaxis</title><author><name sortKey="Berry, Cassandra M" sort="Berry, Cassandra M" uniqKey="Berry C" first="Cassandra M." last="Berry">Cassandra M. Berry</name><affiliation wicri:level="1"><nlm:aff id="I1">Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150</wicri:regionArea><wicri:noRegion>WA 6150</wicri:noRegion></affiliation></author><author><name sortKey="Penhale, William J" sort="Penhale, William J" uniqKey="Penhale W" first="William J." last="Penhale">William J. Penhale</name><affiliation wicri:level="1"><nlm:aff id="I1">Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150</wicri:regionArea><wicri:noRegion>WA 6150</wicri:noRegion></affiliation></author><author><name sortKey="Sangster, Mark Y" sort="Sangster, Mark Y" uniqKey="Sangster M" first="Mark Y." last="Sangster">Mark Y. Sangster</name><affiliation wicri:level="2"><nlm:aff id="I2">Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Influenza Research and Treatment</title><idno type="ISSN">2090-1380</idno><idno type="eISSN">2090-1399</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza is a perennial problem affecting millions of people annually with the everpresent threat of devastating pandemics. Active prophylaxis by vaccination against influenza virus is currently the main countermeasure supplemented with antivirals. However, disadvantages of this strategy include the impact of antigenic drift, necessitating constant updating of vaccine strain composition, and emerging antiviral drug resistance. The development of other options for influenza prophylaxis, particularly with broad acting agents able to provide protection in the period between the onset of a pandemic and the development of a strain specific vaccine, is of great interest. Exploitation of broad-spectrum mediators could provide barricade protection in the early critical phase of influenza virus outbreaks. Passive immunity has the potential to provide immediate antiviral effects, inhibiting virus replication, reducing virus shedding, and thereby protecting vulnerable populations in the event of an impending influenza pandemic. 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last="Berry">Cassandra M. Berry</name><affiliation wicri:level="1"><nlm:affiliation>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150</wicri:regionArea><wicri:noRegion>WA 6150</wicri:noRegion></affiliation></author><author><name sortKey="Penhale, William J" sort="Penhale, William J" uniqKey="Penhale W" first="William J" last="Penhale">William J. Penhale</name><affiliation wicri:level="1"><nlm:affiliation>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150</wicri:regionArea><wicri:noRegion>WA 6150</wicri:noRegion></affiliation></author><author><name sortKey="Sangster, Mark Y" sort="Sangster, Mark Y" uniqKey="Sangster M" first="Mark Y" last="Sangster">Mark Y. Sangster</name><affiliation wicri:level="2"><nlm:affiliation>Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25328697</idno><idno type="pmid">25328697</idno><idno type="doi">10.1155/2014/267594</idno><idno type="wicri:Area/PubMed/Corpus">000749</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000749</idno><idno type="wicri:Area/PubMed/Curation">000749</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000749</idno><idno type="wicri:Area/PubMed/Checkpoint">000766</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000766</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Passive broad-spectrum influenza immunoprophylaxis.</title><author><name sortKey="Berry, Cassandra M" sort="Berry, Cassandra M" uniqKey="Berry C" first="Cassandra M" last="Berry">Cassandra M. Berry</name><affiliation wicri:level="1"><nlm:affiliation>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150</wicri:regionArea><wicri:noRegion>WA 6150</wicri:noRegion></affiliation></author><author><name sortKey="Penhale, William J" sort="Penhale, William J" uniqKey="Penhale W" first="William J" last="Penhale">William J. Penhale</name><affiliation wicri:level="1"><nlm:affiliation>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular and Biomedical Sciences, School of Veterinary and Life Sciences, Murdoch University, Perth, WA 6150</wicri:regionArea><wicri:noRegion>WA 6150</wicri:noRegion></affiliation></author><author><name sortKey="Sangster, Mark Y" sort="Sangster, Mark Y" uniqKey="Sangster M" first="Mark Y" last="Sangster">Mark Y. Sangster</name><affiliation wicri:level="2"><nlm:affiliation>Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Influenza research and treatment</title><idno type="ISSN">2090-1380</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza is a perennial problem affecting millions of people annually with the everpresent threat of devastating pandemics. Active prophylaxis by vaccination against influenza virus is currently the main countermeasure supplemented with antivirals. However, disadvantages of this strategy include the impact of antigenic drift, necessitating constant updating of vaccine strain composition, and emerging antiviral drug resistance. The development of other options for influenza prophylaxis, particularly with broad acting agents able to provide protection in the period between the onset of a pandemic and the development of a strain specific vaccine, is of great interest. Exploitation of broad-spectrum mediators could provide barricade protection in the early critical phase of influenza virus outbreaks. Passive immunity has the potential to provide immediate antiviral effects, inhibiting virus replication, reducing virus shedding, and thereby protecting vulnerable populations in the event of an impending influenza pandemic. Here, we review passive broad-spectrum influenza prophylaxis options with a focus on harnessing natural host defenses, including interferons and antibodies. </div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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