Microarray analysis of MicroRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1)
Identifieur interne : 001664 ( Ncbi/Merge ); précédent : 001663; suivant : 001665Microarray analysis of MicroRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1)
Auteurs : Hao Song [République populaire de Chine] ; Qi Wang [République populaire de Chine] ; Yang Guo ; Shunai Liu [République populaire de Chine] ; Rui Song [République populaire de Chine] ; Xuesong Gao [République populaire de Chine] ; Li Dai ; Baoshun Li [République populaire de Chine] ; Deli Zhang [République populaire de Chine] ; Jun Cheng [République populaire de Chine]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Agranulocytes (métabolisme), Analyse de profil d'expression de gènes, Analyse de regroupements, Courbe ROC, Femelle, Grippe humaine (génétique), Grippe humaine (métabolisme), Grippe humaine (virologie), Humains, Interactions hôte-pathogène, Maladie grave, Mâle, Reproductibilité des résultats, Réaction de polymérisation en chaine en temps réel, Réseaux de régulation génique, Sous-type H1N1 du virus de la grippe A (isolement et purification), Séquençage par oligonucléotides en batterie, microARN (biosynthèse), microARN (génétique), microARN (métabolisme).
- MESH :
- biosynthèse : microARN.
- génétique : Grippe humaine, microARN.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- métabolisme : Agranulocytes, Grippe humaine, microARN.
- virologie : Grippe humaine.
- Adulte, Analyse de profil d'expression de gènes, Analyse de regroupements, Courbe ROC, Femelle, Humains, Interactions hôte-pathogène, Maladie grave, Mâle, Reproductibilité des résultats, Réaction de polymérisation en chaine en temps réel, Réseaux de régulation génique, Séquençage par oligonucléotides en batterie.
English descriptors
- KwdEn :
- Adult, Cluster Analysis, Critical Illness, Female, Gene Expression Profiling, Gene Regulatory Networks, Host-Pathogen Interactions, Humans, Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (genetics), Influenza, Human (metabolism), Influenza, Human (virology), Leukocytes, Mononuclear (metabolism), Male, MicroRNAs (biosynthesis), MicroRNAs (genetics), MicroRNAs (metabolism), Oligonucleotide Array Sequence Analysis, ROC Curve, Real-Time Polymerase Chain Reaction, Reproducibility of Results.
- MESH :
- chemical , biosynthesis : MicroRNAs.
- genetics : Influenza, Human, MicroRNAs.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- metabolism : Influenza, Human, Leukocytes, Mononuclear, MicroRNAs.
- virology : Influenza, Human.
- Adult, Cluster Analysis, Critical Illness, Female, Gene Expression Profiling, Gene Regulatory Networks, Host-Pathogen Interactions, Humans, Male, Oligonucleotide Array Sequence Analysis, ROC Curve, Real-Time Polymerase Chain Reaction, Reproducibility of Results.
Abstract
With concerns about the disastrous health and economic consequences caused by the influenza pandemic, comprehensively understanding the global host response to influenza virus infection is urgent. The role of microRNA (miRNA) has recently been highlighted in pathogen-host interactions. However, the precise role of miRNAs in the pathogenesis of influenza virus infection in humans, especially in critically ill patients is still unclear.
We identified cellular miRNAs involved in the host response to influenza virus infection by performing comprehensive miRNA profiling in peripheral blood mononuclear cells (PBMCs) from critically ill patients with swine-origin influenza pandemic H1N1 (2009) virus infection via miRNA microarray and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) assays. Receiver operator characteristic (ROC) curve analysis was conducted and area under the ROC curve (AUC) was calculated to evaluate the diagnostic accuracy of severe H1N1 influenza virus infection. Furthermore, an integrative network of miRNA-mediated host-influenza virus protein interactions was constructed by integrating the predicted and validated miRNA-gene interaction data with influenza virus and host-protein-protein interaction information using Cytoscape software. Moreover, several hub genes in the network were selected and validated by qRT-PCR.
Forty-one significantly differentially expressed miRNAs were found by miRNA microarray; nine were selected and validated by qRT-PCR. QRT-PCR assay and ROC curve analyses revealed that miR-31, miR-29a and miR-148a all had significant potential diagnostic value for critically ill patients infected with H1N1 influenza virus, which yielded AUC of 0.9510, 0.8951 and 0.8811, respectively. We subsequently constructed an integrative network of miRNA-mediated host-influenza virus protein interactions, wherein we found that miRNAs are involved in regulating important pathways, such as mitogen-activated protein kinase signaling pathway, epidermal growth factor receptor signaling pathway, and Toll-like receptor signaling pathway, during influenza virus infection. Some of differentially expressed miRNAs via in silico analysis targeted mRNAs of several key genes in these pathways. The mRNA expression level of tumor protein T53 and transforming growth factor beta receptor 1 were found significantly reduced in critically ill patients, whereas the expression of Janus kinase 2, caspase 3 apoptosis-related cysteine peptidase, interleukin 10, and myxovirus resistance 1 were extremely increased in critically ill patients.
Our data suggest that the dysregulation of miRNAs in the PBMCs of H1N1 critically ill patients can regulate a number of key genes in the major signaling pathways associated with influenza virus infection. These differentially expressed miRNAs could be potential therapeutic targets or biomarkers for severe influenza virus infection.
The online version of this article (doi:10.1186/1471-2334-13-257) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1471-2334-13-257
PubMed: 23731466
PubMed Central: 3679792
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PMC:3679792Le document en format XML
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</author>
<author><name sortKey="Li, Baoshun" sort="Li, Baoshun" uniqKey="Li B" first="Baoshun" last="Li">Baoshun Li</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution-id institution-id-type="ISNI">000000040369153X</institution-id>
<institution>Department of Infectious Diseases, Beijing Ditan Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, 100015 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Deli" sort="Zhang, Deli" uniqKey="Zhang D" first="Deli" last="Zhang">Deli Zhang</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.144022.1</institution-id>
<institution-id institution-id-type="ISNI">0000000417604150</institution-id>
<institution>MOA Key Laboratory of Animal Biotechnology of National Ministry of Agriculture, Institute of Veterinary Immunology, and Research Laboratory of Virology, Immunology & Bioinformatics, Division of Veterinary Microbiology & Virology, Department of Preventive Veterinary Medicine, College of Veterinary Medicine,</institution>
<institution>Northwest A & F University,</institution>
</institution-wrap>
Yangling, Xi’an City, Shaanxi Province 712100 China</nlm:aff>
<wicri:noCountry code="subfield">Shaanxi Province 712100 China</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution-id institution-id-type="ISNI">000000040369153X</institution-id>
<institution>Institute of Infectious Diseases, Beijing Ditan Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, 100015 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cheng, Jun" sort="Cheng, Jun" uniqKey="Cheng J" first="Jun" last="Cheng">Jun Cheng</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution-id institution-id-type="ISNI">000000040369153X</institution-id>
<institution>Institute of Infectious Diseases, Beijing Ditan Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, 100015 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, 100015 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Key Laboratory of Emerging Infectious Diseases, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Infectious Diseases</title>
<idno type="eISSN">1471-2334</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Cluster Analysis</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Gene Regulatory Networks</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term>
<term>Influenza, Human (genetics)</term>
<term>Influenza, Human (metabolism)</term>
<term>Influenza, Human (virology)</term>
<term>Leukocytes, Mononuclear (metabolism)</term>
<term>Male</term>
<term>MicroRNAs (biosynthesis)</term>
<term>MicroRNAs (genetics)</term>
<term>MicroRNAs (metabolism)</term>
<term>Oligonucleotide Array Sequence Analysis</term>
<term>ROC Curve</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Agranulocytes (métabolisme)</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Analyse de regroupements</term>
<term>Courbe ROC</term>
<term>Femelle</term>
<term>Grippe humaine (génétique)</term>
<term>Grippe humaine (métabolisme)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Reproductibilité des résultats</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Réseaux de régulation génique</term>
<term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term>
<term>Séquençage par oligonucléotides en batterie</term>
<term>microARN (biosynthèse)</term>
<term>microARN (génétique)</term>
<term>microARN (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>MicroRNAs</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza, Human</term>
<term>MicroRNAs</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Grippe humaine</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza, Human</term>
<term>Leukocytes, Mononuclear</term>
<term>MicroRNAs</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Agranulocytes</term>
<term>Grippe humaine</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Cluster Analysis</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Gene Regulatory Networks</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Male</term>
<term>Oligonucleotide Array Sequence Analysis</term>
<term>ROC Curve</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Analyse de regroupements</term>
<term>Courbe ROC</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Reproductibilité des résultats</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Réseaux de régulation génique</term>
<term>Séquençage par oligonucléotides en batterie</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>With concerns about the disastrous health and economic consequences caused by the influenza pandemic, comprehensively understanding the global host response to influenza virus infection is urgent. The role of microRNA (miRNA) has recently been highlighted in pathogen-host interactions. However, the precise role of miRNAs in the pathogenesis of influenza virus infection in humans, especially in critically ill patients is still unclear.</p>
</sec>
<sec><title>Methods</title>
<p>We identified cellular miRNAs involved in the host response to influenza virus infection by performing comprehensive miRNA profiling in peripheral blood mononuclear cells (PBMCs) from critically ill patients with swine-origin influenza pandemic H1N1 (2009) virus infection via miRNA microarray and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) assays. Receiver operator characteristic (ROC) curve analysis was conducted and area under the ROC curve (AUC) was calculated to evaluate the diagnostic accuracy of severe H1N1 influenza virus infection. Furthermore, an integrative network of miRNA-mediated host-influenza virus protein interactions was constructed by integrating the predicted and validated miRNA-gene interaction data with influenza virus and host-protein-protein interaction information using Cytoscape software. Moreover, several hub genes in the network were selected and validated by qRT-PCR.</p>
</sec>
<sec><title>Results</title>
<p>Forty-one significantly differentially expressed miRNAs were found by miRNA microarray; nine were selected and validated by qRT-PCR. QRT-PCR assay and ROC curve analyses revealed that miR-31, miR-29a and miR-148a all had significant potential diagnostic value for critically ill patients infected with H1N1 influenza virus, which yielded AUC of 0.9510, 0.8951 and 0.8811, respectively. We subsequently constructed an integrative network of miRNA-mediated host-influenza virus protein interactions, wherein we found that miRNAs are involved in regulating important pathways, such as mitogen-activated protein kinase signaling pathway, epidermal growth factor receptor signaling pathway, and Toll-like receptor signaling pathway, during influenza virus infection. Some of differentially expressed miRNAs via in silico analysis targeted mRNAs of several key genes in these pathways. The mRNA expression level of tumor protein T53 and transforming growth factor beta receptor 1 were found significantly reduced in critically ill patients, whereas the expression of Janus kinase 2, caspase 3 apoptosis-related cysteine peptidase, interleukin 10, and myxovirus resistance 1 were extremely increased in critically ill patients.</p>
</sec>
<sec><title>Conclusions</title>
<p>Our data suggest that the dysregulation of miRNAs in the PBMCs of H1N1 critically ill patients can regulate a number of key genes in the major signaling pathways associated with influenza virus infection. These differentially expressed miRNAs could be potential therapeutic targets or biomarkers for severe influenza virus infection.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/1471-2334-13-257) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Butler, D" uniqKey="Butler D">D Butler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huarte, M" uniqKey="Huarte M">M Huarte</name>
</author>
<author><name sortKey="Sanz Ezquerro, Jj" uniqKey="Sanz Ezquerro J">JJ Sanz-Ezquerro</name>
</author>
<author><name sortKey="Roncal, F" uniqKey="Roncal F">F Roncal</name>
</author>
<author><name sortKey="Ortin, J" uniqKey="Ortin J">J Ortin</name>
</author>
<author><name sortKey="Nieto, A" uniqKey="Nieto A">A Nieto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hao, L" uniqKey="Hao L">L Hao</name>
</author>
<author><name sortKey="Sakurai, A" uniqKey="Sakurai A">A Sakurai</name>
</author>
<author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name>
</author>
<author><name sortKey="Sorensen, E" uniqKey="Sorensen E">E Sorensen</name>
</author>
<author><name sortKey="Nidom, Ca" uniqKey="Nidom C">CA Nidom</name>
</author>
<author><name sortKey="Newton, Ma" uniqKey="Newton M">MA Newton</name>
</author>
<author><name sortKey="Ahlquist, P" uniqKey="Ahlquist P">P Ahlquist</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karlas, A" uniqKey="Karlas A">A Karlas</name>
</author>
<author><name sortKey="Machuy, N" uniqKey="Machuy N">N Machuy</name>
</author>
<author><name sortKey="Shin, Y" uniqKey="Shin Y">Y Shin</name>
</author>
<author><name sortKey="Pleissner, Kp" uniqKey="Pleissner K">KP Pleissner</name>
</author>
<author><name sortKey="Artarini, A" uniqKey="Artarini A">A Artarini</name>
</author>
<author><name sortKey="Heuer, D" uniqKey="Heuer D">D Heuer</name>
</author>
<author><name sortKey="Becker, D" uniqKey="Becker D">D Becker</name>
</author>
<author><name sortKey="Khalil, H" uniqKey="Khalil H">H Khalil</name>
</author>
<author><name sortKey="Ogilvie, La" uniqKey="Ogilvie L">LA Ogilvie</name>
</author>
<author><name sortKey="Hess, S" uniqKey="Hess S">S Hess</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brass, Al" uniqKey="Brass A">AL Brass</name>
</author>
<author><name sortKey="Huang, Ic" uniqKey="Huang I">IC Huang</name>
</author>
<author><name sortKey="Benita, Y" uniqKey="Benita Y">Y Benita</name>
</author>
<author><name sortKey="John, Sp" uniqKey="John S">SP John</name>
</author>
<author><name sortKey="Krishnan, Mn" uniqKey="Krishnan M">MN Krishnan</name>
</author>
<author><name sortKey="Feeley, Em" uniqKey="Feeley E">EM Feeley</name>
</author>
<author><name sortKey="Ryan, Bj" uniqKey="Ryan B">BJ Ryan</name>
</author>
<author><name sortKey="Weyer, Jl" uniqKey="Weyer J">JL Weyer</name>
</author>
<author><name sortKey="Van Der Weyden, L" uniqKey="Van Der Weyden L">L van der Weyden</name>
</author>
<author><name sortKey="Fikrig, E" uniqKey="Fikrig E">E Fikrig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Konig, R" uniqKey="Konig R">R Konig</name>
</author>
<author><name sortKey="Stertz, S" uniqKey="Stertz S">S Stertz</name>
</author>
<author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name>
</author>
<author><name sortKey="Inoue, A" uniqKey="Inoue A">A Inoue</name>
</author>
<author><name sortKey="Hoffmann, Hh" uniqKey="Hoffmann H">HH Hoffmann</name>
</author>
<author><name sortKey="Bhattacharyya, S" uniqKey="Bhattacharyya S">S Bhattacharyya</name>
</author>
<author><name sortKey="Alamares, Jg" uniqKey="Alamares J">JG Alamares</name>
</author>
<author><name sortKey="Tscherne, Dm" uniqKey="Tscherne D">DM Tscherne</name>
</author>
<author><name sortKey="Ortigoza, Mb" uniqKey="Ortigoza M">MB Ortigoza</name>
</author>
<author><name sortKey="Liang, Yh" uniqKey="Liang Y">YH Liang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shapira, Sd" uniqKey="Shapira S">SD Shapira</name>
</author>
<author><name sortKey="Gat Viks, I" uniqKey="Gat Viks I">I Gat-Viks</name>
</author>
<author><name sortKey="Shum, Bov" uniqKey="Shum B">BOV Shum</name>
</author>
<author><name sortKey="Dricot, A" uniqKey="Dricot A">A Dricot</name>
</author>
<author><name sortKey="De Grace, Mm" uniqKey="De Grace M">MM de Grace</name>
</author>
<author><name sortKey="Wu, Lg" uniqKey="Wu L">LG Wu</name>
</author>
<author><name sortKey="Gupta, Pb" uniqKey="Gupta P">PB Gupta</name>
</author>
<author><name sortKey="Hao, T" uniqKey="Hao T">T Hao</name>
</author>
<author><name sortKey="Silver, Sj" uniqKey="Silver S">SJ Silver</name>
</author>
<author><name sortKey="Root, De" uniqKey="Root D">DE Root</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Onnell, Rm" uniqKey="O Onnell R">RM O’Connell</name>
</author>
<author><name sortKey="Rao, Ds" uniqKey="Rao D">DS Rao</name>
</author>
<author><name sortKey="Chaudhuri, Aa" uniqKey="Chaudhuri A">AA Chaudhuri</name>
</author>
<author><name sortKey="Baltimore, D" uniqKey="Baltimore D">D Baltimore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ren, Jq" uniqKey="Ren J">JQ Ren</name>
</author>
<author><name sortKey="Jin, P" uniqKey="Jin P">P Jin</name>
</author>
<author><name sortKey="Wang, E" uniqKey="Wang E">E Wang</name>
</author>
<author><name sortKey="Marincola, Fm" uniqKey="Marincola F">FM Marincola</name>
</author>
<author><name sortKey="Stroncek, Df" uniqKey="Stroncek D">DF Stroncek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ji, Jf" uniqKey="Ji J">JF Ji</name>
</author>
<author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name>
</author>
<author><name sortKey="Budhu, A" uniqKey="Budhu A">A Budhu</name>
</author>
<author><name sortKey="Yu, Zp" uniqKey="Yu Z">ZP Yu</name>
</author>
<author><name sortKey="Forgues, M" uniqKey="Forgues M">M Forgues</name>
</author>
<author><name sortKey="Roessler, S" uniqKey="Roessler S">S Roessler</name>
</author>
<author><name sortKey="Ambs, S" uniqKey="Ambs S">S Ambs</name>
</author>
<author><name sortKey="Chen, Yd" uniqKey="Chen Y">YD Chen</name>
</author>
<author><name sortKey="Meltzer, Ps" uniqKey="Meltzer P">PS Meltzer</name>
</author>
<author><name sortKey="Croce, Cm" uniqKey="Croce C">CM Croce</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lodish, Hf" uniqKey="Lodish H">HF Lodish</name>
</author>
<author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name>
</author>
<author><name sortKey="Liu, G" uniqKey="Liu G">G Liu</name>
</author>
<author><name sortKey="Chen, Cz" uniqKey="Chen C">CZ Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Umbach, Jl" uniqKey="Umbach J">JL Umbach</name>
</author>
<author><name sortKey="Cullen, Br" uniqKey="Cullen B">BR Cullen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouellet, Dl" uniqKey="Ouellet D">DL Ouellet</name>
</author>
<author><name sortKey="Provost, P" uniqKey="Provost P">P Provost</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cullen, Br" uniqKey="Cullen B">BR Cullen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Brahmakshatriya, V" uniqKey="Brahmakshatriya V">V Brahmakshatriya</name>
</author>
<author><name sortKey="Zhu, Hf" uniqKey="Zhu H">HF Zhu</name>
</author>
<author><name sortKey="Lupiani, B" uniqKey="Lupiani B">B Lupiani</name>
</author>
<author><name sortKey="Reddy, Sm" uniqKey="Reddy S">SM Reddy</name>
</author>
<author><name sortKey="Yoon, Bj" uniqKey="Yoon B">BJ Yoon</name>
</author>
<author><name sortKey="Gunaratne, Ph" uniqKey="Gunaratne P">PH Gunaratne</name>
</author>
<author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
<author><name sortKey="Chen, R" uniqKey="Chen R">R Chen</name>
</author>
<author><name sortKey="Wang, Jj" uniqKey="Wang J">JJ Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Brahmakshatriya, V" uniqKey="Brahmakshatriya V">V Brahmakshatriya</name>
</author>
<author><name sortKey="Lupiani, B" uniqKey="Lupiani B">B Lupiani</name>
</author>
<author><name sortKey="Reddy, Sm" uniqKey="Reddy S">SM Reddy</name>
</author>
<author><name sortKey="Soibam, B" uniqKey="Soibam B">B Soibam</name>
</author>
<author><name sortKey="Benham, Al" uniqKey="Benham A">AL Benham</name>
</author>
<author><name sortKey="Gunaratne, P" uniqKey="Gunaratne P">P Gunaratne</name>
</author>
<author><name sortKey="Liu, Hc" uniqKey="Liu H">HC Liu</name>
</author>
<author><name sortKey="Trakooljul, M" uniqKey="Trakooljul M">M Trakooljul</name>
</author>
<author><name sortKey="Ing, N" uniqKey="Ing N">N Ing</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Chan, Ey" uniqKey="Chan E">EY Chan</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Ni, C" uniqKey="Ni C">C Ni</name>
</author>
<author><name sortKey="Peng, X" uniqKey="Peng X">X Peng</name>
</author>
<author><name sortKey="Rosenzweig, E" uniqKey="Rosenzweig E">E Rosenzweig</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogers, Jv" uniqKey="Rogers J">JV Rogers</name>
</author>
<author><name sortKey="Price, Ja" uniqKey="Price J">JA Price</name>
</author>
<author><name sortKey="Wendling, Mq" uniqKey="Wendling M">MQ Wendling</name>
</author>
<author><name sortKey="Long, Jp" uniqKey="Long J">JP Long</name>
</author>
<author><name sortKey="Bresler, Hs" uniqKey="Bresler H">HS Bresler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, Lp" uniqKey="Song L">LP Song</name>
</author>
<author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name>
</author>
<author><name sortKey="Gao, Sj" uniqKey="Gao S">SJ Gao</name>
</author>
<author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name>
</author>
<author><name sortKey="Huang, Wl" uniqKey="Huang W">WL Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meliopoulos, Va" uniqKey="Meliopoulos V">VA Meliopoulos</name>
</author>
<author><name sortKey="Andersen, Le" uniqKey="Andersen L">LE Andersen</name>
</author>
<author><name sortKey="Brooks, P" uniqKey="Brooks P">P Brooks</name>
</author>
<author><name sortKey="Yan, X" uniqKey="Yan X">X Yan</name>
</author>
<author><name sortKey="Bakre, A" uniqKey="Bakre A">A Bakre</name>
</author>
<author><name sortKey="Coleman, Jk" uniqKey="Coleman J">JK Coleman</name>
</author>
<author><name sortKey="Tompkins, Sm" uniqKey="Tompkins S">SM Tompkins</name>
</author>
<author><name sortKey="Tripp, Ra" uniqKey="Tripp R">RA Tripp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loveday, Ek" uniqKey="Loveday E">EK Loveday</name>
</author>
<author><name sortKey="Svinti, V" uniqKey="Svinti V">V Svinti</name>
</author>
<author><name sortKey="Diederich, S" uniqKey="Diederich S">S Diederich</name>
</author>
<author><name sortKey="Pasick, J" uniqKey="Pasick J">J Pasick</name>
</author>
<author><name sortKey="Jean, F" uniqKey="Jean F">F Jean</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shou, Jy" uniqKey="Shou J">JY Shou</name>
</author>
<author><name sortKey="Bull, Cm" uniqKey="Bull C">CM Bull</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Qian, Hr" uniqKey="Qian H">HR Qian</name>
</author>
<author><name sortKey="Wei, T" uniqKey="Wei T">T Wei</name>
</author>
<author><name sortKey="Luo, Sa" uniqKey="Luo S">SA Luo</name>
</author>
<author><name sortKey="Perkins, D" uniqKey="Perkins D">D Perkins</name>
</author>
<author><name sortKey="Solenberg, Pj" uniqKey="Solenberg P">PJ Solenberg</name>
</author>
<author><name sortKey="Tan, Sl" uniqKey="Tan S">SL Tan</name>
</author>
<author><name sortKey="Chen, Xyc" uniqKey="Chen X">XYC Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Otaegui, D" uniqKey="Otaegui D">D Otaegui</name>
</author>
<author><name sortKey="Baranzini, Se" uniqKey="Baranzini S">SE Baranzini</name>
</author>
<author><name sortKey="Armananzas, R" uniqKey="Armananzas R">R Armananzas</name>
</author>
<author><name sortKey="Calvo, B" uniqKey="Calvo B">B Calvo</name>
</author>
<author><name sortKey="Munoz Culla, M" uniqKey="Munoz Culla M">M Munoz-Culla</name>
</author>
<author><name sortKey="Khankhanian, P" uniqKey="Khankhanian P">P Khankhanian</name>
</author>
<author><name sortKey="Inza, I" uniqKey="Inza I">I Inza</name>
</author>
<author><name sortKey="Lozano, Ja" uniqKey="Lozano J">JA Lozano</name>
</author>
<author><name sortKey="Castillo Trivino, T" uniqKey="Castillo Trivino T">T Castillo-Trivino</name>
</author>
<author><name sortKey="Asensio, A" uniqKey="Asensio A">A Asensio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shao, Hw" uniqKey="Shao H">HW Shao</name>
</author>
<author><name sortKey="Lan, Dm" uniqKey="Lan D">DM Lan</name>
</author>
<author><name sortKey="Duan, Zh" uniqKey="Duan Z">ZH Duan</name>
</author>
<author><name sortKey="Liu, Zh" uniqKey="Liu Z">ZH Liu</name>
</author>
<author><name sortKey="Min, J" uniqKey="Min J">J Min</name>
</author>
<author><name sortKey="Zhang, Lc" uniqKey="Zhang L">LC Zhang</name>
</author>
<author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name>
</author>
<author><name sortKey="Su, J" uniqKey="Su J">J Su</name>
</author>
<author><name sortKey="Chen, Sw" uniqKey="Chen S">SW Chen</name>
</author>
<author><name sortKey="Xu, Al" uniqKey="Xu A">AL Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rollins, B" uniqKey="Rollins B">B Rollins</name>
</author>
<author><name sortKey="Martin, Mv" uniqKey="Martin M">MV Martin</name>
</author>
<author><name sortKey="Morgan, L" uniqKey="Morgan L">L Morgan</name>
</author>
<author><name sortKey="Vawter, Mp" uniqKey="Vawter M">MP Vawter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Monaco, A" uniqKey="Monaco A">A Monaco</name>
</author>
<author><name sortKey="Marincola, Fm" uniqKey="Marincola F">FM Marincola</name>
</author>
<author><name sortKey="Sabatino, M" uniqKey="Sabatino M">M Sabatino</name>
</author>
<author><name sortKey="Pos, Z" uniqKey="Pos Z">Z Pos</name>
</author>
<author><name sortKey="Tornesello, Ml" uniqKey="Tornesello M">ML Tornesello</name>
</author>
<author><name sortKey="Stroncek, Df" uniqKey="Stroncek D">DF Stroncek</name>
</author>
<author><name sortKey="Wang, E" uniqKey="Wang E">E Wang</name>
</author>
<author><name sortKey="Lewis, Gk" uniqKey="Lewis G">GK Lewis</name>
</author>
<author><name sortKey="Buonaguro, Fm" uniqKey="Buonaguro F">FM Buonaguro</name>
</author>
<author><name sortKey="Buonaguro, L" uniqKey="Buonaguro L">L Buonaguro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Yu, Yj" uniqKey="Yu Y">YJ Yu</name>
</author>
<author><name sortKey="Feng, L" uniqKey="Feng L">L Feng</name>
</author>
<author><name sortKey="Cai, Xb" uniqKey="Cai X">XB Cai</name>
</author>
<author><name sortKey="Tang, Hb" uniqKey="Tang H">HB Tang</name>
</author>
<author><name sortKey="Sun, Sk" uniqKey="Sun S">SK Sun</name>
</author>
<author><name sortKey="Zhang, Hy" uniqKey="Zhang H">HY Zhang</name>
</author>
<author><name sortKey="Liang, Jj" uniqKey="Liang J">JJ Liang</name>
</author>
<author><name sortKey="Luo, Tr" uniqKey="Luo T">TR Luo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name>
</author>
<author><name sortKey="Chen, Hg" uniqKey="Chen H">HG Chen</name>
</author>
<author><name sortKey="Cassidy, W" uniqKey="Cassidy W">W Cassidy</name>
</author>
<author><name sortKey="Howell, Cd" uniqKey="Howell C">CD Howell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramilo, O" uniqKey="Ramilo O">O Ramilo</name>
</author>
<author><name sortKey="Allman, W" uniqKey="Allman W">W Allman</name>
</author>
<author><name sortKey="Chung, W" uniqKey="Chung W">W Chung</name>
</author>
<author><name sortKey="Mejias, A" uniqKey="Mejias A">A Mejias</name>
</author>
<author><name sortKey="Ardura, M" uniqKey="Ardura M">M Ardura</name>
</author>
<author><name sortKey="Glaser, C" uniqKey="Glaser C">C Glaser</name>
</author>
<author><name sortKey="Wittkowski, Km" uniqKey="Wittkowski K">KM Wittkowski</name>
</author>
<author><name sortKey="Piqueras, B" uniqKey="Piqueras B">B Piqueras</name>
</author>
<author><name sortKey="Banchereau, J" uniqKey="Banchereau J">J Banchereau</name>
</author>
<author><name sortKey="Palucka, Ak" uniqKey="Palucka A">AK Palucka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zaas, Ak" uniqKey="Zaas A">AK Zaas</name>
</author>
<author><name sortKey="Chen, Mh" uniqKey="Chen M">MH Chen</name>
</author>
<author><name sortKey="Varkey, J" uniqKey="Varkey J">J Varkey</name>
</author>
<author><name sortKey="Veldman, T" uniqKey="Veldman T">T Veldman</name>
</author>
<author><name sortKey="Hero, Ao" uniqKey="Hero A">AO Hero</name>
</author>
<author><name sortKey="Lucas, J" uniqKey="Lucas J">J Lucas</name>
</author>
<author><name sortKey="Huang, Ys" uniqKey="Huang Y">YS Huang</name>
</author>
<author><name sortKey="Tumer, R" uniqKey="Tumer R">R Tumer</name>
</author>
<author><name sortKey="Gilbert, A" uniqKey="Gilbert A">A Gilbert</name>
</author>
<author><name sortKey="Lambkin Williams, R" uniqKey="Lambkin Williams R">R Lambkin-Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zaas, Ak" uniqKey="Zaas A">AK Zaas</name>
</author>
<author><name sortKey="Aziz, H" uniqKey="Aziz H">H Aziz</name>
</author>
<author><name sortKey="Lucas, J" uniqKey="Lucas J">J Lucas</name>
</author>
<author><name sortKey="Perfect, Jr" uniqKey="Perfect J">JR Perfect</name>
</author>
<author><name sortKey="Ginsburg, Gs" uniqKey="Ginsburg G">GS Ginsburg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aziz, H" uniqKey="Aziz H">H Aziz</name>
</author>
<author><name sortKey="Zaas, A" uniqKey="Zaas A">A Zaas</name>
</author>
<author><name sortKey="Ginsburg, Gs" uniqKey="Ginsburg G">GS Ginsburg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taurino, C" uniqKey="Taurino C">C Taurino</name>
</author>
<author><name sortKey="Miller, Wh" uniqKey="Miller W">WH Miller</name>
</author>
<author><name sortKey="Mcbride, Mw" uniqKey="Mcbride M">MW McBride</name>
</author>
<author><name sortKey="Mcclure, Jd" uniqKey="Mcclure J">JD McClure</name>
</author>
<author><name sortKey="Khanin, R" uniqKey="Khanin R">R Khanin</name>
</author>
<author><name sortKey="Moreno, Mu" uniqKey="Moreno M">MU Moreno</name>
</author>
<author><name sortKey="Dymott, Ja" uniqKey="Dymott J">JA Dymott</name>
</author>
<author><name sortKey="Delles, C" uniqKey="Delles C">C Delles</name>
</author>
<author><name sortKey="Dominiczak, Af" uniqKey="Dominiczak A">AF Dominiczak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Osterlund, P" uniqKey="Osterlund P">P Osterlund</name>
</author>
<author><name sortKey="Pirhonen, J" uniqKey="Pirhonen J">J Pirhonen</name>
</author>
<author><name sortKey="Ikonen, N" uniqKey="Ikonen N">N Ikonen</name>
</author>
<author><name sortKey="Ronkko, E" uniqKey="Ronkko E">E Ronkko</name>
</author>
<author><name sortKey="Strengell, M" uniqKey="Strengell M">M Strengell</name>
</author>
<author><name sortKey="Makela, Sm" uniqKey="Makela S">SM Makela</name>
</author>
<author><name sortKey="Broman, M" uniqKey="Broman M">M Broman</name>
</author>
<author><name sortKey="Hamming, Oj" uniqKey="Hamming O">OJ Hamming</name>
</author>
<author><name sortKey="Hartmann, R" uniqKey="Hartmann R">R Hartmann</name>
</author>
<author><name sortKey="Ziegler, T" uniqKey="Ziegler T">T Ziegler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name>
</author>
<author><name sortKey="Cheung, Cy" uniqKey="Cheung C">CY Cheung</name>
</author>
<author><name sortKey="Leung, Cyh" uniqKey="Leung C">CYH Leung</name>
</author>
<author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arankalle, Va" uniqKey="Arankalle V">VA Arankalle</name>
</author>
<author><name sortKey="Lole, Ks" uniqKey="Lole K">KS Lole</name>
</author>
<author><name sortKey="Arya, Rp" uniqKey="Arya R">RP Arya</name>
</author>
<author><name sortKey="Tripathy, As" uniqKey="Tripathy A">AS Tripathy</name>
</author>
<author><name sortKey="Ramdasi, Ay" uniqKey="Ramdasi A">AY Ramdasi</name>
</author>
<author><name sortKey="Chadha, Ms" uniqKey="Chadha M">MS Chadha</name>
</author>
<author><name sortKey="Sangle, Sa" uniqKey="Sangle S">SA Sangle</name>
</author>
<author><name sortKey="Kadam, Db" uniqKey="Kadam D">DB Kadam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name>
</author>
<author><name sortKey="Zhang, Rf" uniqKey="Zhang R">RF Zhang</name>
</author>
<author><name sortKey="Lu, Hz" uniqKey="Lu H">HZ Lu</name>
</author>
<author><name sortKey="Lu, Sh" uniqKey="Lu S">SH Lu</name>
</author>
<author><name sortKey="Huang, Q" uniqKey="Huang Q">Q Huang</name>
</author>
<author><name sortKey="Xiong, Yy" uniqKey="Xiong Y">YY Xiong</name>
</author>
<author><name sortKey="Xi, Xh" uniqKey="Xi X">XH Xi</name>
</author>
<author><name sortKey="Zhang, Zy" uniqKey="Zhang Z">ZY Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Griffiths Jones, S" uniqKey="Griffiths Jones S">S Griffiths-Jones</name>
</author>
<author><name sortKey="Saini, Hk" uniqKey="Saini H">HK Saini</name>
</author>
<author><name sortKey="Van Dongen, S" uniqKey="Van Dongen S">S van Dongen</name>
</author>
<author><name sortKey="Enright, Aj" uniqKey="Enright A">AJ Enright</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tusher, Vg" uniqKey="Tusher V">VG Tusher</name>
</author>
<author><name sortKey="Tibshirani, R" uniqKey="Tibshirani R">R Tibshirani</name>
</author>
<author><name sortKey="Chu, G" uniqKey="Chu G">G Chu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Hoon, Mjl" uniqKey="De Hoon M">MJL de Hoon</name>
</author>
<author><name sortKey="Imoto, S" uniqKey="Imoto S">S Imoto</name>
</author>
<author><name sortKey="Nolan, J" uniqKey="Nolan J">J Nolan</name>
</author>
<author><name sortKey="Miyano, S" uniqKey="Miyano S">S Miyano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saldanha, Aj" uniqKey="Saldanha A">AJ Saldanha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barrett, T" uniqKey="Barrett T">T Barrett</name>
</author>
<author><name sortKey="Troup, Db" uniqKey="Troup D">DB Troup</name>
</author>
<author><name sortKey="Wilhite, Se" uniqKey="Wilhite S">SE Wilhite</name>
</author>
<author><name sortKey="Ledoux, P" uniqKey="Ledoux P">P Ledoux</name>
</author>
<author><name sortKey="Rudnev, D" uniqKey="Rudnev D">D Rudnev</name>
</author>
<author><name sortKey="Evangelista, C" uniqKey="Evangelista C">C Evangelista</name>
</author>
<author><name sortKey="Kim, If" uniqKey="Kim I">IF Kim</name>
</author>
<author><name sortKey="Soboleva, A" uniqKey="Soboleva A">A Soboleva</name>
</author>
<author><name sortKey="Tomashevsky, M" uniqKey="Tomashevsky M">M Tomashevsky</name>
</author>
<author><name sortKey="Marshall, Ka" uniqKey="Marshall K">KA Marshall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="John, B" uniqKey="John B">B John</name>
</author>
<author><name sortKey="Enright, Aj" uniqKey="Enright A">AJ Enright</name>
</author>
<author><name sortKey="Aravin, A" uniqKey="Aravin A">A Aravin</name>
</author>
<author><name sortKey="Tuschl, T" uniqKey="Tuschl T">T Tuschl</name>
</author>
<author><name sortKey="Sander, C" uniqKey="Sander C">C Sander</name>
</author>
<author><name sortKey="Marks, Ds" uniqKey="Marks D">DS Marks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Friedman, Rc" uniqKey="Friedman R">RC Friedman</name>
</author>
<author><name sortKey="Farh, Kk H" uniqKey="Farh K">KK-H Farh</name>
</author>
<author><name sortKey="Burge, Cb" uniqKey="Burge C">CB Burge</name>
</author>
<author><name sortKey="Bartel, Dp" uniqKey="Bartel D">DP Bartel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Xw" uniqKey="Wang X">XW Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miranda, Kc" uniqKey="Miranda K">KC Miranda</name>
</author>
<author><name sortKey="Huynh, T" uniqKey="Huynh T">T Huynh</name>
</author>
<author><name sortKey="Tay, Y" uniqKey="Tay Y">Y Tay</name>
</author>
<author><name sortKey="Ang, Ys" uniqKey="Ang Y">YS Ang</name>
</author>
<author><name sortKey="Tam, Wl" uniqKey="Tam W">WL Tam</name>
</author>
<author><name sortKey="Thomson, Am" uniqKey="Thomson A">AM Thomson</name>
</author>
<author><name sortKey="Lim, B" uniqKey="Lim B">B Lim</name>
</author>
<author><name sortKey="Rigoutsos, I" uniqKey="Rigoutsos I">I Rigoutsos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krek, A" uniqKey="Krek A">A Krek</name>
</author>
<author><name sortKey="Grun, D" uniqKey="Grun D">D Grun</name>
</author>
<author><name sortKey="Poy, Mn" uniqKey="Poy M">MN Poy</name>
</author>
<author><name sortKey="Wolf, R" uniqKey="Wolf R">R Wolf</name>
</author>
<author><name sortKey="Rosenberg, L" uniqKey="Rosenberg L">L Rosenberg</name>
</author>
<author><name sortKey="Epstein, Ej" uniqKey="Epstein E">EJ Epstein</name>
</author>
<author><name sortKey="Macmenamin, P" uniqKey="Macmenamin P">P MacMenamin</name>
</author>
<author><name sortKey="Da Piedade, I" uniqKey="Da Piedade I">I da Piedade</name>
</author>
<author><name sortKey="Gunsalus, Kc" uniqKey="Gunsalus K">KC Gunsalus</name>
</author>
<author><name sortKey="Stoffel, M" uniqKey="Stoffel M">M Stoffel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dweep, H" uniqKey="Dweep H">H Dweep</name>
</author>
<author><name sortKey="Sticht, C" uniqKey="Sticht C">C Sticht</name>
</author>
<author><name sortKey="Pandey, P" uniqKey="Pandey P">P Pandey</name>
</author>
<author><name sortKey="Gretz, N" uniqKey="Gretz N">N Gretz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Szklarczyk, D" uniqKey="Szklarczyk D">D Szklarczyk</name>
</author>
<author><name sortKey="Franceschini, A" uniqKey="Franceschini A">A Franceschini</name>
</author>
<author><name sortKey="Kuhn, M" uniqKey="Kuhn M">M Kuhn</name>
</author>
<author><name sortKey="Simonovic, M" uniqKey="Simonovic M">M Simonovic</name>
</author>
<author><name sortKey="Roth, A" uniqKey="Roth A">A Roth</name>
</author>
<author><name sortKey="Minguez, P" uniqKey="Minguez P">P Minguez</name>
</author>
<author><name sortKey="Doerks, T" uniqKey="Doerks T">T Doerks</name>
</author>
<author><name sortKey="Stark, M" uniqKey="Stark M">M Stark</name>
</author>
<author><name sortKey="Muller, J" uniqKey="Muller J">J Muller</name>
</author>
<author><name sortKey="Bork, P" uniqKey="Bork P">P Bork</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Von Mering, C" uniqKey="Von Mering C">C von Mering</name>
</author>
<author><name sortKey="Jensen, Lj" uniqKey="Jensen L">LJ Jensen</name>
</author>
<author><name sortKey="Snel, B" uniqKey="Snel B">B Snel</name>
</author>
<author><name sortKey="Hooper, Sd" uniqKey="Hooper S">SD Hooper</name>
</author>
<author><name sortKey="Krupp, M" uniqKey="Krupp M">M Krupp</name>
</author>
<author><name sortKey="Foglierini, M" uniqKey="Foglierini M">M Foglierini</name>
</author>
<author><name sortKey="Jouffre, N" uniqKey="Jouffre N">N Jouffre</name>
</author>
<author><name sortKey="Huynen, Ma" uniqKey="Huynen M">MA Huynen</name>
</author>
<author><name sortKey="Bork, P" uniqKey="Bork P">P Bork</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dennis, G" uniqKey="Dennis G">G Dennis</name>
</author>
<author><name sortKey="Sherman, Bt" uniqKey="Sherman B">BT Sherman</name>
</author>
<author><name sortKey="Hosack, Da" uniqKey="Hosack D">DA Hosack</name>
</author>
<author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name>
</author>
<author><name sortKey="Gao, W" uniqKey="Gao W">W Gao</name>
</author>
<author><name sortKey="Lane, Hc" uniqKey="Lane H">HC Lane</name>
</author>
<author><name sortKey="Lempicki, Ra" uniqKey="Lempicki R">RA Lempicki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kanehisa, M" uniqKey="Kanehisa M">M Kanehisa</name>
</author>
<author><name sortKey="Goto, S" uniqKey="Goto S">S Goto</name>
</author>
<author><name sortKey="Furumichi, M" uniqKey="Furumichi M">M Furumichi</name>
</author>
<author><name sortKey="Tanabe, M" uniqKey="Tanabe M">M Tanabe</name>
</author>
<author><name sortKey="Hirakawa, M" uniqKey="Hirakawa M">M Hirakawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="D Ustachio, P" uniqKey="D Ustachio P">P D’Eustachio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cline, Ms" uniqKey="Cline M">MS Cline</name>
</author>
<author><name sortKey="Smoot, M" uniqKey="Smoot M">M Smoot</name>
</author>
<author><name sortKey="Cerami, E" uniqKey="Cerami E">E Cerami</name>
</author>
<author><name sortKey="Kuchinsky, A" uniqKey="Kuchinsky A">A Kuchinsky</name>
</author>
<author><name sortKey="Landys, N" uniqKey="Landys N">N Landys</name>
</author>
<author><name sortKey="Workman, C" uniqKey="Workman C">C Workman</name>
</author>
<author><name sortKey="Christmas, R" uniqKey="Christmas R">R Christmas</name>
</author>
<author><name sortKey="Avila Campilo, I" uniqKey="Avila Campilo I">I Avila-Campilo</name>
</author>
<author><name sortKey="Creech, M" uniqKey="Creech M">M Creech</name>
</author>
<author><name sortKey="Gross, B" uniqKey="Gross B">B Gross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name>
</author>
<author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nathans, R" uniqKey="Nathans R">R Nathans</name>
</author>
<author><name sortKey="Chu, Cy" uniqKey="Chu C">CY Chu</name>
</author>
<author><name sortKey="Serquina, Ak" uniqKey="Serquina A">AK Serquina</name>
</author>
<author><name sortKey="Lu, Cc" uniqKey="Lu C">CC Lu</name>
</author>
<author><name sortKey="Cao, H" uniqKey="Cao H">H Cao</name>
</author>
<author><name sortKey="Rana, Tm" uniqKey="Rana T">TM Rana</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lecellier, Ch" uniqKey="Lecellier C">CH Lecellier</name>
</author>
<author><name sortKey="Dunoyer, P" uniqKey="Dunoyer P">P Dunoyer</name>
</author>
<author><name sortKey="Arar, K" uniqKey="Arar K">K Arar</name>
</author>
<author><name sortKey="Lehmann Che, J" uniqKey="Lehmann Che J">J Lehmann-Che</name>
</author>
<author><name sortKey="Eyquem, S" uniqKey="Eyquem S">S Eyquem</name>
</author>
<author><name sortKey="Himber, C" uniqKey="Himber C">C Himber</name>
</author>
<author><name sortKey="Saib, A" uniqKey="Saib A">A Saib</name>
</author>
<author><name sortKey="Voinnet, O" uniqKey="Voinnet O">O Voinnet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jopling, Cl" uniqKey="Jopling C">CL Jopling</name>
</author>
<author><name sortKey="Schuetz, S" uniqKey="Schuetz S">S Schuetz</name>
</author>
<author><name sortKey="Sarnow, P" uniqKey="Sarnow P">P Sarnow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jangra, Rk" uniqKey="Jangra R">RK Jangra</name>
</author>
<author><name sortKey="Yi, M" uniqKey="Yi M">M Yi</name>
</author>
<author><name sortKey="Lemon, Sm" uniqKey="Lemon S">SM Lemon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, Jh" uniqKey="Chang J">JH Chang</name>
</author>
<author><name sortKey="Cruo, Jt" uniqKey="Cruo J">JT Cruo</name>
</author>
<author><name sortKey="Jiang, D" uniqKey="Jiang D">D Jiang</name>
</author>
<author><name sortKey="Guo, Ht" uniqKey="Guo H">HT Guo</name>
</author>
<author><name sortKey="Taylor, Jm" uniqKey="Taylor J">JM Taylor</name>
</author>
<author><name sortKey="Block, Tm" uniqKey="Block T">TM Block</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steiner, Df" uniqKey="Steiner D">DF Steiner</name>
</author>
<author><name sortKey="Thomas, Mf" uniqKey="Thomas M">MF Thomas</name>
</author>
<author><name sortKey="Hu, Jk" uniqKey="Hu J">JK Hu</name>
</author>
<author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name>
</author>
<author><name sortKey="Babiarz, Je" uniqKey="Babiarz J">JE Babiarz</name>
</author>
<author><name sortKey="Allen, Cdc" uniqKey="Allen C">CDC Allen</name>
</author>
<author><name sortKey="Matloubian, M" uniqKey="Matloubian M">M Matloubian</name>
</author>
<author><name sortKey="Blelloch, R" uniqKey="Blelloch R">R Blelloch</name>
</author>
<author><name sortKey="Ansel, Km" uniqKey="Ansel K">KM Ansel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, Z" uniqKey="Ding Z">Z Ding</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Khaidakov, M" uniqKey="Khaidakov M">M Khaidakov</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name>
</author>
<author><name sortKey="Mehta, Jl" uniqKey="Mehta J">JL Mehta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, M" uniqKey="Kumar M">M Kumar</name>
</author>
<author><name sortKey="Ahmad, T" uniqKey="Ahmad T">T Ahmad</name>
</author>
<author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name>
</author>
<author><name sortKey="Mabalirajan, U" uniqKey="Mabalirajan U">U Mabalirajan</name>
</author>
<author><name sortKey="Kulshreshtha, A" uniqKey="Kulshreshtha A">A Kulshreshtha</name>
</author>
<author><name sortKey="Agrawal, A" uniqKey="Agrawal A">A Agrawal</name>
</author>
<author><name sortKey="Ghosh, B" uniqKey="Ghosh B">B Ghosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name>
</author>
<author><name sortKey="Homer, Rj" uniqKey="Homer R">RJ Homer</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name>
</author>
<author><name sortKey="Geba, Gp" uniqKey="Geba G">GP Geba</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Elias, Ja" uniqKey="Elias J">JA Elias</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fezeu, L" uniqKey="Fezeu L">L Fezeu</name>
</author>
<author><name sortKey="Julia, C" uniqKey="Julia C">C Julia</name>
</author>
<author><name sortKey="Henegar, A" uniqKey="Henegar A">A Henegar</name>
</author>
<author><name sortKey="Bitu, J" uniqKey="Bitu J">J Bitu</name>
</author>
<author><name sortKey="Hu, Fb" uniqKey="Hu F">FB Hu</name>
</author>
<author><name sortKey="Grobbee, De" uniqKey="Grobbee D">DE Grobbee</name>
</author>
<author><name sortKey="Kengne, Ap" uniqKey="Kengne A">AP Kengne</name>
</author>
<author><name sortKey="Hercberg, S" uniqKey="Hercberg S">S Hercberg</name>
</author>
<author><name sortKey="Czernichow, S" uniqKey="Czernichow S">S Czernichow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Louie, Jk" uniqKey="Louie J">JK Louie</name>
</author>
<author><name sortKey="Acosta, M" uniqKey="Acosta M">M Acosta</name>
</author>
<author><name sortKey="Samuel, Mc" uniqKey="Samuel M">MC Samuel</name>
</author>
<author><name sortKey="Schechter, R" uniqKey="Schechter R">R Schechter</name>
</author>
<author><name sortKey="Vugia, Dj" uniqKey="Vugia D">DJ Vugia</name>
</author>
<author><name sortKey="Harriman, K" uniqKey="Harriman K">K Harriman</name>
</author>
<author><name sortKey="Matyas, Bt" uniqKey="Matyas B">BT Matyas</name>
</author>
<author><name sortKey="Calif Pandem, Hnwg" uniqKey="Calif Pandem H">HNWG Calif Pandem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name>
</author>
<author><name sortKey="Chaves, Ss" uniqKey="Chaves S">SS Chaves</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kornum, Jb" uniqKey="Kornum J">JB Kornum</name>
</author>
<author><name sortKey="Norgaard, M" uniqKey="Norgaard M">M Norgaard</name>
</author>
<author><name sortKey="Dethlefsen, C" uniqKey="Dethlefsen C">C Dethlefsen</name>
</author>
<author><name sortKey="Due, Km" uniqKey="Due K">KM Due</name>
</author>
<author><name sortKey="Thomsen, Rw" uniqKey="Thomsen R">RW Thomsen</name>
</author>
<author><name sortKey="Tjonneland, A" uniqKey="Tjonneland A">A Tjonneland</name>
</author>
<author><name sortKey="Sorensen, Ht" uniqKey="Sorensen H">HT Sorensen</name>
</author>
<author><name sortKey="Overvad, K" uniqKey="Overvad K">K Overvad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hingston, Cd" uniqKey="Hingston C">CD Hingston</name>
</author>
<author><name sortKey="Holmes, Tw" uniqKey="Holmes T">TW Holmes</name>
</author>
<author><name sortKey="Saayman, Ag" uniqKey="Saayman A">AG Saayman</name>
</author>
<author><name sortKey="Wise, Mp" uniqKey="Wise M">MP Wise</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kok, J" uniqKey="Kok J">J Kok</name>
</author>
<author><name sortKey="Blyth, Cc" uniqKey="Blyth C">CC Blyth</name>
</author>
<author><name sortKey="Foo, H" uniqKey="Foo H">H Foo</name>
</author>
<author><name sortKey="Bailey, Mj" uniqKey="Bailey M">MJ Bailey</name>
</author>
<author><name sortKey="Pilcher, Dv" uniqKey="Pilcher D">DV Pilcher</name>
</author>
<author><name sortKey="Webb, Sa" uniqKey="Webb S">SA Webb</name>
</author>
<author><name sortKey="Seppelt, Im" uniqKey="Seppelt I">IM Seppelt</name>
</author>
<author><name sortKey="Dwyer, De" uniqKey="Dwyer D">DE Dwyer</name>
</author>
<author><name sortKey="Iredell, Jr" uniqKey="Iredell J">JR Iredell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Ag" uniqKey="Smith A">AG Smith</name>
</author>
<author><name sortKey="Sheridan, Pa" uniqKey="Sheridan P">PA Sheridan</name>
</author>
<author><name sortKey="Tseng, Rj" uniqKey="Tseng R">RJ Tseng</name>
</author>
<author><name sortKey="Sheridan, Jf" uniqKey="Sheridan J">JF Sheridan</name>
</author>
<author><name sortKey="Beck, Ma" uniqKey="Beck M">MA Beck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Ag" uniqKey="Smith A">AG Smith</name>
</author>
<author><name sortKey="Sheridan, Pa" uniqKey="Sheridan P">PA Sheridan</name>
</author>
<author><name sortKey="Harp, Jb" uniqKey="Harp J">JB Harp</name>
</author>
<author><name sortKey="Beck, Ma" uniqKey="Beck M">MA Beck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karlsson, Ea" uniqKey="Karlsson E">EA Karlsson</name>
</author>
<author><name sortKey="Sheridan, Pa" uniqKey="Sheridan P">PA Sheridan</name>
</author>
<author><name sortKey="Beck, Ma" uniqKey="Beck M">MA Beck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hulsmans, M" uniqKey="Hulsmans M">M Hulsmans</name>
</author>
<author><name sortKey="Van Dooren, E" uniqKey="Van Dooren E">E Van Dooren</name>
</author>
<author><name sortKey="Mathieu, C" uniqKey="Mathieu C">C Mathieu</name>
</author>
<author><name sortKey="Holvoet, P" uniqKey="Holvoet P">P Holvoet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yan, X" uniqKey="Yan X">X Yan</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Zhao, Jx" uniqKey="Zhao J">JX Zhao</name>
</author>
<author><name sortKey="Rogers, Cj" uniqKey="Rogers C">CJ Rogers</name>
</author>
<author><name sortKey="Zhu, Mj" uniqKey="Zhu M">MJ Zhu</name>
</author>
<author><name sortKey="Ford, Sp" uniqKey="Ford S">SP Ford</name>
</author>
<author><name sortKey="Nathanielsz, Pw" uniqKey="Nathanielsz P">PW Nathanielsz</name>
</author>
<author><name sortKey="Du, M" uniqKey="Du M">M Du</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schmidt, Wm" uniqKey="Schmidt W">WM Schmidt</name>
</author>
<author><name sortKey="Spiel, Ao" uniqKey="Spiel A">AO Spiel</name>
</author>
<author><name sortKey="Jilma, B" uniqKey="Jilma B">B Jilma</name>
</author>
<author><name sortKey="Wolzt, M" uniqKey="Wolzt M">M Wolzt</name>
</author>
<author><name sortKey="Wuller, M" uniqKey="Wuller M">M Wuller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giamarellos Bourboulis, Ej" uniqKey="Giamarellos Bourboulis E">EJ Giamarellos-Bourboulis</name>
</author>
<author><name sortKey="Raftogiannis, M" uniqKey="Raftogiannis M">M Raftogiannis</name>
</author>
<author><name sortKey="Antonopoulou, A" uniqKey="Antonopoulou A">A Antonopoulou</name>
</author>
<author><name sortKey="Baziaka, F" uniqKey="Baziaka F">F Baziaka</name>
</author>
<author><name sortKey="Koutoukas, P" uniqKey="Koutoukas P">P Koutoukas</name>
</author>
<author><name sortKey="Savva, A" uniqKey="Savva A">A Savva</name>
</author>
<author><name sortKey="Kanni, T" uniqKey="Kanni T">T Kanni</name>
</author>
<author><name sortKey="Georgitsi, M" uniqKey="Georgitsi M">M Georgitsi</name>
</author>
<author><name sortKey="Pistiki, A" uniqKey="Pistiki A">A Pistiki</name>
</author>
<author><name sortKey="Tsaganos, T" uniqKey="Tsaganos T">T Tsaganos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Palacios, G" uniqKey="Palacios G">G Palacios</name>
</author>
<author><name sortKey="Hornig, M" uniqKey="Hornig M">M Hornig</name>
</author>
<author><name sortKey="Cisterna, D" uniqKey="Cisterna D">D Cisterna</name>
</author>
<author><name sortKey="Savji, N" uniqKey="Savji N">N Savji</name>
</author>
<author><name sortKey="Bussetti, Av" uniqKey="Bussetti A">AV Bussetti</name>
</author>
<author><name sortKey="Kapoor, V" uniqKey="Kapoor V">V Kapoor</name>
</author>
<author><name sortKey="Hui, J" uniqKey="Hui J">J Hui</name>
</author>
<author><name sortKey="Tokarz, R" uniqKey="Tokarz R">R Tokarz</name>
</author>
<author><name sortKey="Briese, T" uniqKey="Briese T">T Briese</name>
</author>
<author><name sortKey="Baumeister, E" uniqKey="Baumeister E">E Baumeister</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cuadrado, A" uniqKey="Cuadrado A">A Cuadrado</name>
</author>
<author><name sortKey="Nebreda, Ar" uniqKey="Nebreda A">AR Nebreda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xing, Z" uniqKey="Xing Z">Z Xing</name>
</author>
<author><name sortKey="Cardona, Cj" uniqKey="Cardona C">CJ Cardona</name>
</author>
<author><name sortKey="Anunciacion, J" uniqKey="Anunciacion J">J Anunciacion</name>
</author>
<author><name sortKey="Adams, S" uniqKey="Adams S">S Adams</name>
</author>
<author><name sortKey="Dao, N" uniqKey="Dao N">N Dao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marchant, D" uniqKey="Marchant D">D Marchant</name>
</author>
<author><name sortKey="Singhera, Gk" uniqKey="Singhera G">GK Singhera</name>
</author>
<author><name sortKey="Utokaparch, S" uniqKey="Utokaparch S">S Utokaparch</name>
</author>
<author><name sortKey="Hackett, Tl" uniqKey="Hackett T">TL Hackett</name>
</author>
<author><name sortKey="Boyd, Jh" uniqKey="Boyd J">JH Boyd</name>
</author>
<author><name sortKey="Luo, Zs" uniqKey="Luo Z">ZS Luo</name>
</author>
<author><name sortKey="Si, Xn" uniqKey="Si X">XN Si</name>
</author>
<author><name sortKey="Dorscheid, Dr" uniqKey="Dorscheid D">DR Dorscheid</name>
</author>
<author><name sortKey="Mcmanus, Bm" uniqKey="Mcmanus B">BM McManus</name>
</author>
<author><name sortKey="Hegele, Rg" uniqKey="Hegele R">RG Hegele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eierhoff, T" uniqKey="Eierhoff T">T Eierhoff</name>
</author>
<author><name sortKey="Hrincius, Er" uniqKey="Hrincius E">ER Hrincius</name>
</author>
<author><name sortKey="Rescher, U" uniqKey="Rescher U">U Rescher</name>
</author>
<author><name sortKey="Ludwig, S" uniqKey="Ludwig S">S Ludwig</name>
</author>
<author><name sortKey="Ehrhardt, C" uniqKey="Ehrhardt C">C Ehrhardt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wurzer, Wj" uniqKey="Wurzer W">WJ Wurzer</name>
</author>
<author><name sortKey="Planz, O" uniqKey="Planz O">O Planz</name>
</author>
<author><name sortKey="Ehrhardt, C" uniqKey="Ehrhardt C">C Ehrhardt</name>
</author>
<author><name sortKey="Giner, M" uniqKey="Giner M">M Giner</name>
</author>
<author><name sortKey="Silberzahn, T" uniqKey="Silberzahn T">T Silberzahn</name>
</author>
<author><name sortKey="Pleschka, S" uniqKey="Pleschka S">S Pleschka</name>
</author>
<author><name sortKey="Ludwig, S" uniqKey="Ludwig S">S Ludwig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schultzcherry, S" uniqKey="Schultzcherry S">S SchultzCherry</name>
</author>
<author><name sortKey="Hinshaw, Vs" uniqKey="Hinshaw V">VS Hinshaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bloomston, M" uniqKey="Bloomston M">M Bloomston</name>
</author>
<author><name sortKey="Frankel, Wl" uniqKey="Frankel W">WL Frankel</name>
</author>
<author><name sortKey="Petrocca, F" uniqKey="Petrocca F">F Petrocca</name>
</author>
<author><name sortKey="Volinia, S" uniqKey="Volinia S">S Volinia</name>
</author>
<author><name sortKey="Alder, H" uniqKey="Alder H">H Alder</name>
</author>
<author><name sortKey="Hagan, Jp" uniqKey="Hagan J">JP Hagan</name>
</author>
<author><name sortKey="Liu, Cg" uniqKey="Liu C">CG Liu</name>
</author>
<author><name sortKey="Bhatt, D" uniqKey="Bhatt D">D Bhatt</name>
</author>
<author><name sortKey="Taccioli, C" uniqKey="Taccioli C">C Taccioli</name>
</author>
<author><name sortKey="Croce, Cm" uniqKey="Croce C">CM Croce</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lehmann, U" uniqKey="Lehmann U">U Lehmann</name>
</author>
<author><name sortKey="Hasemeier, B" uniqKey="Hasemeier B">B Hasemeier</name>
</author>
<author><name sortKey="Romermann, D" uniqKey="Romermann D">D Romermann</name>
</author>
<author><name sortKey="Muller, M" uniqKey="Muller M">M Muller</name>
</author>
<author><name sortKey="Langer, F" uniqKey="Langer F">F Langer</name>
</author>
<author><name sortKey="Kreipe, H" uniqKey="Kreipe H">H Kreipe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tan, Z" uniqKey="Tan Z">Z Tan</name>
</author>
<author><name sortKey="Randall, G" uniqKey="Randall G">G Randall</name>
</author>
<author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name>
</author>
<author><name sortKey="Camoretti Mercado, B" uniqKey="Camoretti Mercado B">B Camoretti-Mercado</name>
</author>
<author><name sortKey="Brockman Schneider, R" uniqKey="Brockman Schneider R">R Brockman-Schneider</name>
</author>
<author><name sortKey="Pan, L" uniqKey="Pan L">L Pan</name>
</author>
<author><name sortKey="Solway, J" uniqKey="Solway J">J Solway</name>
</author>
<author><name sortKey="Gern, Je" uniqKey="Gern J">JE Gern</name>
</author>
<author><name sortKey="Lemanske, Rf" uniqKey="Lemanske R">RF Lemanske</name>
</author>
<author><name sortKey="Nicolae, D" uniqKey="Nicolae D">D Nicolae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pan, W" uniqKey="Pan W">W Pan</name>
</author>
<author><name sortKey="Zhu, S" uniqKey="Zhu S">S Zhu</name>
</author>
<author><name sortKey="Yuan, M" uniqKey="Yuan M">M Yuan</name>
</author>
<author><name sortKey="Cui, Hj" uniqKey="Cui H">HJ Cui</name>
</author>
<author><name sortKey="Wang, Lj" uniqKey="Wang L">LJ Wang</name>
</author>
<author><name sortKey="Luo, Xb" uniqKey="Luo X">XB Luo</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Zhou, Hb" uniqKey="Zhou H">HB Zhou</name>
</author>
<author><name sortKey="Tang, Yj" uniqKey="Tang Y">YJ Tang</name>
</author>
<author><name sortKey="Shen, N" uniqKey="Shen N">N Shen</name>
</author>
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<biblStruct><analytic><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Zhan, Z" uniqKey="Zhan Z">Z Zhan</name>
</author>
<author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name>
</author>
<author><name sortKey="Ma, F" uniqKey="Ma F">F Ma</name>
</author>
<author><name sortKey="Li, D" uniqKey="Li D">D Li</name>
</author>
<author><name sortKey="Guo, Z" uniqKey="Guo Z">Z Guo</name>
</author>
<author><name sortKey="Li, N" uniqKey="Li N">N Li</name>
</author>
<author><name sortKey="Cao, X" uniqKey="Cao X">X Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rouas, R" uniqKey="Rouas R">R Rouas</name>
</author>
<author><name sortKey="Fawad Kazan, H" uniqKey="Fawad Kazan H">H Fawad-Kazan</name>
</author>
<author><name sortKey="El Zein, N" uniqKey="El Zein N">N El Zein</name>
</author>
<author><name sortKey="Lewalle, P" uniqKey="Lewalle P">P Lewalle</name>
</author>
<author><name sortKey="Rothe, F" uniqKey="Rothe F">F Rothe</name>
</author>
<author><name sortKey="Simion, A" uniqKey="Simion A">A Simion</name>
</author>
<author><name sortKey="Akl, H" uniqKey="Akl H">H Akl</name>
</author>
<author><name sortKey="Mourtada, M" uniqKey="Mourtada M">M Mourtada</name>
</author>
<author><name sortKey="El Rifai, M" uniqKey="El Rifai M">M El Rifai</name>
</author>
<author><name sortKey="Burny, A" uniqKey="Burny A">A Burny</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wieckiewicz, J" uniqKey="Wieckiewicz J">J Wieckiewicz</name>
</author>
<author><name sortKey="Goto, R" uniqKey="Goto R">R Goto</name>
</author>
<author><name sortKey="Wood, Kj" uniqKey="Wood K">KJ Wood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Hx" uniqKey="Chen H">HX Chen</name>
</author>
<author><name sortKey="Chen, Bg" uniqKey="Chen B">BG Chen</name>
</author>
<author><name sortKey="Shi, Ww" uniqKey="Shi W">WW Shi</name>
</author>
<author><name sortKey="Zhen, R" uniqKey="Zhen R">R Zhen</name>
</author>
<author><name sortKey="Xu, Dp" uniqKey="Xu D">DP Xu</name>
</author>
<author><name sortKey="Lin, Af" uniqKey="Lin A">AF Lin</name>
</author>
<author><name sortKey="Yan, Wh" uniqKey="Yan W">WH Yan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pavlovic, J" uniqKey="Pavlovic J">J Pavlovic</name>
</author>
<author><name sortKey="Haller, O" uniqKey="Haller O">O Haller</name>
</author>
<author><name sortKey="Staeheli, P" uniqKey="Staeheli P">P Staeheli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haller, O" uniqKey="Haller O">O Haller</name>
</author>
<author><name sortKey="Staeheli, P" uniqKey="Staeheli P">P Staeheli</name>
</author>
<author><name sortKey="Kochs, G" uniqKey="Kochs G">G Kochs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Szretter, Kj" uniqKey="Szretter K">KJ Szretter</name>
</author>
<author><name sortKey="Van Hoeven, N" uniqKey="Van Hoeven N">N Van Hoeven</name>
</author>
<author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name>
</author>
<author><name sortKey="Kochs, G" uniqKey="Kochs G">G Kochs</name>
</author>
<author><name sortKey="Haller, O" uniqKey="Haller O">O Haller</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name>
</author>
<author><name sortKey="Staeheli, P" uniqKey="Staeheli P">P Staeheli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cilloniz, C" uniqKey="Cilloniz C">C Cilloniz</name>
</author>
<author><name sortKey="Pantin Jackwood, Mj" uniqKey="Pantin Jackwood M">MJ Pantin-Jackwood</name>
</author>
<author><name sortKey="Ni, C" uniqKey="Ni C">C Ni</name>
</author>
<author><name sortKey="Carter, Vs" uniqKey="Carter V">VS Carter</name>
</author>
<author><name sortKey="Korth, Mj" uniqKey="Korth M">MJ Korth</name>
</author>
<author><name sortKey="Swayne, De" uniqKey="Swayne D">DE Swayne</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
</analytic>
</biblStruct>
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<author><name sortKey="Song, Rui" sort="Song, Rui" uniqKey="Song R" first="Rui" last="Song">Rui Song</name>
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<author><name sortKey="Li, Baoshun" sort="Li, Baoshun" uniqKey="Li B" first="Baoshun" last="Li">Baoshun Li</name>
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Beijing, 100015 China</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Microarray analysis of MicroRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1)</title>
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<wicri:noCountry code="subfield">Shaanxi Province 712100 China</wicri:noCountry>
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Beijing, 100015 China</nlm:aff>
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<author><name sortKey="Wang, Qi" sort="Wang, Qi" uniqKey="Wang Q" first="Qi" last="Wang">Qi Wang</name>
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<author><name sortKey="Liu, Shunai" sort="Liu, Shunai" uniqKey="Liu S" first="Shunai" last="Liu">Shunai Liu</name>
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<author><name sortKey="Song, Rui" sort="Song, Rui" uniqKey="Song R" first="Rui" last="Song">Rui Song</name>
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<author><name sortKey="Gao, Xuesong" sort="Gao, Xuesong" uniqKey="Gao X" first="Xuesong" last="Gao">Xuesong Gao</name>
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</affiliation>
</author>
<author><name sortKey="Dai, Li" sort="Dai, Li" uniqKey="Dai L" first="Li" last="Dai">Li Dai</name>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.144022.1</institution-id>
<institution-id institution-id-type="ISNI">0000000417604150</institution-id>
<institution>Investigation Group of Molecular Virology, Immunology, Oncology & Systems Biology, Center for Bioinformatics, College of Life Sciences,</institution>
<institution>Northwest A & F University,</institution>
</institution-wrap>
Yangling, Xi’an City, Shaanxi Province 712100 China</nlm:aff>
<wicri:noCountry code="subfield">Shaanxi Province 712100 China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Li, Baoshun" sort="Li, Baoshun" uniqKey="Li B" first="Baoshun" last="Li">Baoshun Li</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution-id institution-id-type="ISNI">000000040369153X</institution-id>
<institution>Department of Infectious Diseases, Beijing Ditan Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, 100015 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Deli" sort="Zhang, Deli" uniqKey="Zhang D" first="Deli" last="Zhang">Deli Zhang</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.144022.1</institution-id>
<institution-id institution-id-type="ISNI">0000000417604150</institution-id>
<institution>MOA Key Laboratory of Animal Biotechnology of National Ministry of Agriculture, Institute of Veterinary Immunology, and Research Laboratory of Virology, Immunology & Bioinformatics, Division of Veterinary Microbiology & Virology, Department of Preventive Veterinary Medicine, College of Veterinary Medicine,</institution>
<institution>Northwest A & F University,</institution>
</institution-wrap>
Yangling, Xi’an City, Shaanxi Province 712100 China</nlm:aff>
<wicri:noCountry code="subfield">Shaanxi Province 712100 China</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution-id institution-id-type="ISNI">000000040369153X</institution-id>
<institution>Institute of Infectious Diseases, Beijing Ditan Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, 100015 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cheng, Jun" sort="Cheng, Jun" uniqKey="Cheng J" first="Jun" last="Cheng">Jun Cheng</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution-id institution-id-type="ISNI">000000040369153X</institution-id>
<institution>Institute of Infectious Diseases, Beijing Ditan Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, 100015 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, 100015 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Key Laboratory of Emerging Infectious Diseases, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Infectious Diseases</title>
<idno type="eISSN">1471-2334</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>With concerns about the disastrous health and economic consequences caused by the influenza pandemic, comprehensively understanding the global host response to influenza virus infection is urgent. The role of microRNA (miRNA) has recently been highlighted in pathogen-host interactions. However, the precise role of miRNAs in the pathogenesis of influenza virus infection in humans, especially in critically ill patients is still unclear.</p>
</sec>
<sec><title>Methods</title>
<p>We identified cellular miRNAs involved in the host response to influenza virus infection by performing comprehensive miRNA profiling in peripheral blood mononuclear cells (PBMCs) from critically ill patients with swine-origin influenza pandemic H1N1 (2009) virus infection via miRNA microarray and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) assays. Receiver operator characteristic (ROC) curve analysis was conducted and area under the ROC curve (AUC) was calculated to evaluate the diagnostic accuracy of severe H1N1 influenza virus infection. Furthermore, an integrative network of miRNA-mediated host-influenza virus protein interactions was constructed by integrating the predicted and validated miRNA-gene interaction data with influenza virus and host-protein-protein interaction information using Cytoscape software. Moreover, several hub genes in the network were selected and validated by qRT-PCR.</p>
</sec>
<sec><title>Results</title>
<p>Forty-one significantly differentially expressed miRNAs were found by miRNA microarray; nine were selected and validated by qRT-PCR. QRT-PCR assay and ROC curve analyses revealed that miR-31, miR-29a and miR-148a all had significant potential diagnostic value for critically ill patients infected with H1N1 influenza virus, which yielded AUC of 0.9510, 0.8951 and 0.8811, respectively. We subsequently constructed an integrative network of miRNA-mediated host-influenza virus protein interactions, wherein we found that miRNAs are involved in regulating important pathways, such as mitogen-activated protein kinase signaling pathway, epidermal growth factor receptor signaling pathway, and Toll-like receptor signaling pathway, during influenza virus infection. Some of differentially expressed miRNAs via in silico analysis targeted mRNAs of several key genes in these pathways. The mRNA expression level of tumor protein T53 and transforming growth factor beta receptor 1 were found significantly reduced in critically ill patients, whereas the expression of Janus kinase 2, caspase 3 apoptosis-related cysteine peptidase, interleukin 10, and myxovirus resistance 1 were extremely increased in critically ill patients.</p>
</sec>
<sec><title>Conclusions</title>
<p>Our data suggest that the dysregulation of miRNAs in the PBMCs of H1N1 critically ill patients can regulate a number of key genes in the major signaling pathways associated with influenza virus infection. These differentially expressed miRNAs could be potential therapeutic targets or biomarkers for severe influenza virus infection.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/1471-2334-13-257) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Butler, D" uniqKey="Butler D">D Butler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huarte, M" uniqKey="Huarte M">M Huarte</name>
</author>
<author><name sortKey="Sanz Ezquerro, Jj" uniqKey="Sanz Ezquerro J">JJ Sanz-Ezquerro</name>
</author>
<author><name sortKey="Roncal, F" uniqKey="Roncal F">F Roncal</name>
</author>
<author><name sortKey="Ortin, J" uniqKey="Ortin J">J Ortin</name>
</author>
<author><name sortKey="Nieto, A" uniqKey="Nieto A">A Nieto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hao, L" uniqKey="Hao L">L Hao</name>
</author>
<author><name sortKey="Sakurai, A" uniqKey="Sakurai A">A Sakurai</name>
</author>
<author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name>
</author>
<author><name sortKey="Sorensen, E" uniqKey="Sorensen E">E Sorensen</name>
</author>
<author><name sortKey="Nidom, Ca" uniqKey="Nidom C">CA Nidom</name>
</author>
<author><name sortKey="Newton, Ma" uniqKey="Newton M">MA Newton</name>
</author>
<author><name sortKey="Ahlquist, P" uniqKey="Ahlquist P">P Ahlquist</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karlas, A" uniqKey="Karlas A">A Karlas</name>
</author>
<author><name sortKey="Machuy, N" uniqKey="Machuy N">N Machuy</name>
</author>
<author><name sortKey="Shin, Y" uniqKey="Shin Y">Y Shin</name>
</author>
<author><name sortKey="Pleissner, Kp" uniqKey="Pleissner K">KP Pleissner</name>
</author>
<author><name sortKey="Artarini, A" uniqKey="Artarini A">A Artarini</name>
</author>
<author><name sortKey="Heuer, D" uniqKey="Heuer D">D Heuer</name>
</author>
<author><name sortKey="Becker, D" uniqKey="Becker D">D Becker</name>
</author>
<author><name sortKey="Khalil, H" uniqKey="Khalil H">H Khalil</name>
</author>
<author><name sortKey="Ogilvie, La" uniqKey="Ogilvie L">LA Ogilvie</name>
</author>
<author><name sortKey="Hess, S" uniqKey="Hess S">S Hess</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brass, Al" uniqKey="Brass A">AL Brass</name>
</author>
<author><name sortKey="Huang, Ic" uniqKey="Huang I">IC Huang</name>
</author>
<author><name sortKey="Benita, Y" uniqKey="Benita Y">Y Benita</name>
</author>
<author><name sortKey="John, Sp" uniqKey="John S">SP John</name>
</author>
<author><name sortKey="Krishnan, Mn" uniqKey="Krishnan M">MN Krishnan</name>
</author>
<author><name sortKey="Feeley, Em" uniqKey="Feeley E">EM Feeley</name>
</author>
<author><name sortKey="Ryan, Bj" uniqKey="Ryan B">BJ Ryan</name>
</author>
<author><name sortKey="Weyer, Jl" uniqKey="Weyer J">JL Weyer</name>
</author>
<author><name sortKey="Van Der Weyden, L" uniqKey="Van Der Weyden L">L van der Weyden</name>
</author>
<author><name sortKey="Fikrig, E" uniqKey="Fikrig E">E Fikrig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Konig, R" uniqKey="Konig R">R Konig</name>
</author>
<author><name sortKey="Stertz, S" uniqKey="Stertz S">S Stertz</name>
</author>
<author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name>
</author>
<author><name sortKey="Inoue, A" uniqKey="Inoue A">A Inoue</name>
</author>
<author><name sortKey="Hoffmann, Hh" uniqKey="Hoffmann H">HH Hoffmann</name>
</author>
<author><name sortKey="Bhattacharyya, S" uniqKey="Bhattacharyya S">S Bhattacharyya</name>
</author>
<author><name sortKey="Alamares, Jg" uniqKey="Alamares J">JG Alamares</name>
</author>
<author><name sortKey="Tscherne, Dm" uniqKey="Tscherne D">DM Tscherne</name>
</author>
<author><name sortKey="Ortigoza, Mb" uniqKey="Ortigoza M">MB Ortigoza</name>
</author>
<author><name sortKey="Liang, Yh" uniqKey="Liang Y">YH Liang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shapira, Sd" uniqKey="Shapira S">SD Shapira</name>
</author>
<author><name sortKey="Gat Viks, I" uniqKey="Gat Viks I">I Gat-Viks</name>
</author>
<author><name sortKey="Shum, Bov" uniqKey="Shum B">BOV Shum</name>
</author>
<author><name sortKey="Dricot, A" uniqKey="Dricot A">A Dricot</name>
</author>
<author><name sortKey="De Grace, Mm" uniqKey="De Grace M">MM de Grace</name>
</author>
<author><name sortKey="Wu, Lg" uniqKey="Wu L">LG Wu</name>
</author>
<author><name sortKey="Gupta, Pb" uniqKey="Gupta P">PB Gupta</name>
</author>
<author><name sortKey="Hao, T" uniqKey="Hao T">T Hao</name>
</author>
<author><name sortKey="Silver, Sj" uniqKey="Silver S">SJ Silver</name>
</author>
<author><name sortKey="Root, De" uniqKey="Root D">DE Root</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Onnell, Rm" uniqKey="O Onnell R">RM O’Connell</name>
</author>
<author><name sortKey="Rao, Ds" uniqKey="Rao D">DS Rao</name>
</author>
<author><name sortKey="Chaudhuri, Aa" uniqKey="Chaudhuri A">AA Chaudhuri</name>
</author>
<author><name sortKey="Baltimore, D" uniqKey="Baltimore D">D Baltimore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ren, Jq" uniqKey="Ren J">JQ Ren</name>
</author>
<author><name sortKey="Jin, P" uniqKey="Jin P">P Jin</name>
</author>
<author><name sortKey="Wang, E" uniqKey="Wang E">E Wang</name>
</author>
<author><name sortKey="Marincola, Fm" uniqKey="Marincola F">FM Marincola</name>
</author>
<author><name sortKey="Stroncek, Df" uniqKey="Stroncek D">DF Stroncek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ji, Jf" uniqKey="Ji J">JF Ji</name>
</author>
<author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name>
</author>
<author><name sortKey="Budhu, A" uniqKey="Budhu A">A Budhu</name>
</author>
<author><name sortKey="Yu, Zp" uniqKey="Yu Z">ZP Yu</name>
</author>
<author><name sortKey="Forgues, M" uniqKey="Forgues M">M Forgues</name>
</author>
<author><name sortKey="Roessler, S" uniqKey="Roessler S">S Roessler</name>
</author>
<author><name sortKey="Ambs, S" uniqKey="Ambs S">S Ambs</name>
</author>
<author><name sortKey="Chen, Yd" uniqKey="Chen Y">YD Chen</name>
</author>
<author><name sortKey="Meltzer, Ps" uniqKey="Meltzer P">PS Meltzer</name>
</author>
<author><name sortKey="Croce, Cm" uniqKey="Croce C">CM Croce</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lodish, Hf" uniqKey="Lodish H">HF Lodish</name>
</author>
<author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name>
</author>
<author><name sortKey="Liu, G" uniqKey="Liu G">G Liu</name>
</author>
<author><name sortKey="Chen, Cz" uniqKey="Chen C">CZ Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Umbach, Jl" uniqKey="Umbach J">JL Umbach</name>
</author>
<author><name sortKey="Cullen, Br" uniqKey="Cullen B">BR Cullen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouellet, Dl" uniqKey="Ouellet D">DL Ouellet</name>
</author>
<author><name sortKey="Provost, P" uniqKey="Provost P">P Provost</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cullen, Br" uniqKey="Cullen B">BR Cullen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Brahmakshatriya, V" uniqKey="Brahmakshatriya V">V Brahmakshatriya</name>
</author>
<author><name sortKey="Zhu, Hf" uniqKey="Zhu H">HF Zhu</name>
</author>
<author><name sortKey="Lupiani, B" uniqKey="Lupiani B">B Lupiani</name>
</author>
<author><name sortKey="Reddy, Sm" uniqKey="Reddy S">SM Reddy</name>
</author>
<author><name sortKey="Yoon, Bj" uniqKey="Yoon B">BJ Yoon</name>
</author>
<author><name sortKey="Gunaratne, Ph" uniqKey="Gunaratne P">PH Gunaratne</name>
</author>
<author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
<author><name sortKey="Chen, R" uniqKey="Chen R">R Chen</name>
</author>
<author><name sortKey="Wang, Jj" uniqKey="Wang J">JJ Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Brahmakshatriya, V" uniqKey="Brahmakshatriya V">V Brahmakshatriya</name>
</author>
<author><name sortKey="Lupiani, B" uniqKey="Lupiani B">B Lupiani</name>
</author>
<author><name sortKey="Reddy, Sm" uniqKey="Reddy S">SM Reddy</name>
</author>
<author><name sortKey="Soibam, B" uniqKey="Soibam B">B Soibam</name>
</author>
<author><name sortKey="Benham, Al" uniqKey="Benham A">AL Benham</name>
</author>
<author><name sortKey="Gunaratne, P" uniqKey="Gunaratne P">P Gunaratne</name>
</author>
<author><name sortKey="Liu, Hc" uniqKey="Liu H">HC Liu</name>
</author>
<author><name sortKey="Trakooljul, M" uniqKey="Trakooljul M">M Trakooljul</name>
</author>
<author><name sortKey="Ing, N" uniqKey="Ing N">N Ing</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Chan, Ey" uniqKey="Chan E">EY Chan</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Ni, C" uniqKey="Ni C">C Ni</name>
</author>
<author><name sortKey="Peng, X" uniqKey="Peng X">X Peng</name>
</author>
<author><name sortKey="Rosenzweig, E" uniqKey="Rosenzweig E">E Rosenzweig</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogers, Jv" uniqKey="Rogers J">JV Rogers</name>
</author>
<author><name sortKey="Price, Ja" uniqKey="Price J">JA Price</name>
</author>
<author><name sortKey="Wendling, Mq" uniqKey="Wendling M">MQ Wendling</name>
</author>
<author><name sortKey="Long, Jp" uniqKey="Long J">JP Long</name>
</author>
<author><name sortKey="Bresler, Hs" uniqKey="Bresler H">HS Bresler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, Lp" uniqKey="Song L">LP Song</name>
</author>
<author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name>
</author>
<author><name sortKey="Gao, Sj" uniqKey="Gao S">SJ Gao</name>
</author>
<author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name>
</author>
<author><name sortKey="Huang, Wl" uniqKey="Huang W">WL Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meliopoulos, Va" uniqKey="Meliopoulos V">VA Meliopoulos</name>
</author>
<author><name sortKey="Andersen, Le" uniqKey="Andersen L">LE Andersen</name>
</author>
<author><name sortKey="Brooks, P" uniqKey="Brooks P">P Brooks</name>
</author>
<author><name sortKey="Yan, X" uniqKey="Yan X">X Yan</name>
</author>
<author><name sortKey="Bakre, A" uniqKey="Bakre A">A Bakre</name>
</author>
<author><name sortKey="Coleman, Jk" uniqKey="Coleman J">JK Coleman</name>
</author>
<author><name sortKey="Tompkins, Sm" uniqKey="Tompkins S">SM Tompkins</name>
</author>
<author><name sortKey="Tripp, Ra" uniqKey="Tripp R">RA Tripp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loveday, Ek" uniqKey="Loveday E">EK Loveday</name>
</author>
<author><name sortKey="Svinti, V" uniqKey="Svinti V">V Svinti</name>
</author>
<author><name sortKey="Diederich, S" uniqKey="Diederich S">S Diederich</name>
</author>
<author><name sortKey="Pasick, J" uniqKey="Pasick J">J Pasick</name>
</author>
<author><name sortKey="Jean, F" uniqKey="Jean F">F Jean</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shou, Jy" uniqKey="Shou J">JY Shou</name>
</author>
<author><name sortKey="Bull, Cm" uniqKey="Bull C">CM Bull</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Qian, Hr" uniqKey="Qian H">HR Qian</name>
</author>
<author><name sortKey="Wei, T" uniqKey="Wei T">T Wei</name>
</author>
<author><name sortKey="Luo, Sa" uniqKey="Luo S">SA Luo</name>
</author>
<author><name sortKey="Perkins, D" uniqKey="Perkins D">D Perkins</name>
</author>
<author><name sortKey="Solenberg, Pj" uniqKey="Solenberg P">PJ Solenberg</name>
</author>
<author><name sortKey="Tan, Sl" uniqKey="Tan S">SL Tan</name>
</author>
<author><name sortKey="Chen, Xyc" uniqKey="Chen X">XYC Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Otaegui, D" uniqKey="Otaegui D">D Otaegui</name>
</author>
<author><name sortKey="Baranzini, Se" uniqKey="Baranzini S">SE Baranzini</name>
</author>
<author><name sortKey="Armananzas, R" uniqKey="Armananzas R">R Armananzas</name>
</author>
<author><name sortKey="Calvo, B" uniqKey="Calvo B">B Calvo</name>
</author>
<author><name sortKey="Munoz Culla, M" uniqKey="Munoz Culla M">M Munoz-Culla</name>
</author>
<author><name sortKey="Khankhanian, P" uniqKey="Khankhanian P">P Khankhanian</name>
</author>
<author><name sortKey="Inza, I" uniqKey="Inza I">I Inza</name>
</author>
<author><name sortKey="Lozano, Ja" uniqKey="Lozano J">JA Lozano</name>
</author>
<author><name sortKey="Castillo Trivino, T" uniqKey="Castillo Trivino T">T Castillo-Trivino</name>
</author>
<author><name sortKey="Asensio, A" uniqKey="Asensio A">A Asensio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shao, Hw" uniqKey="Shao H">HW Shao</name>
</author>
<author><name sortKey="Lan, Dm" uniqKey="Lan D">DM Lan</name>
</author>
<author><name sortKey="Duan, Zh" uniqKey="Duan Z">ZH Duan</name>
</author>
<author><name sortKey="Liu, Zh" uniqKey="Liu Z">ZH Liu</name>
</author>
<author><name sortKey="Min, J" uniqKey="Min J">J Min</name>
</author>
<author><name sortKey="Zhang, Lc" uniqKey="Zhang L">LC Zhang</name>
</author>
<author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name>
</author>
<author><name sortKey="Su, J" uniqKey="Su J">J Su</name>
</author>
<author><name sortKey="Chen, Sw" uniqKey="Chen S">SW Chen</name>
</author>
<author><name sortKey="Xu, Al" uniqKey="Xu A">AL Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rollins, B" uniqKey="Rollins B">B Rollins</name>
</author>
<author><name sortKey="Martin, Mv" uniqKey="Martin M">MV Martin</name>
</author>
<author><name sortKey="Morgan, L" uniqKey="Morgan L">L Morgan</name>
</author>
<author><name sortKey="Vawter, Mp" uniqKey="Vawter M">MP Vawter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Monaco, A" uniqKey="Monaco A">A Monaco</name>
</author>
<author><name sortKey="Marincola, Fm" uniqKey="Marincola F">FM Marincola</name>
</author>
<author><name sortKey="Sabatino, M" uniqKey="Sabatino M">M Sabatino</name>
</author>
<author><name sortKey="Pos, Z" uniqKey="Pos Z">Z Pos</name>
</author>
<author><name sortKey="Tornesello, Ml" uniqKey="Tornesello M">ML Tornesello</name>
</author>
<author><name sortKey="Stroncek, Df" uniqKey="Stroncek D">DF Stroncek</name>
</author>
<author><name sortKey="Wang, E" uniqKey="Wang E">E Wang</name>
</author>
<author><name sortKey="Lewis, Gk" uniqKey="Lewis G">GK Lewis</name>
</author>
<author><name sortKey="Buonaguro, Fm" uniqKey="Buonaguro F">FM Buonaguro</name>
</author>
<author><name sortKey="Buonaguro, L" uniqKey="Buonaguro L">L Buonaguro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Yu, Yj" uniqKey="Yu Y">YJ Yu</name>
</author>
<author><name sortKey="Feng, L" uniqKey="Feng L">L Feng</name>
</author>
<author><name sortKey="Cai, Xb" uniqKey="Cai X">XB Cai</name>
</author>
<author><name sortKey="Tang, Hb" uniqKey="Tang H">HB Tang</name>
</author>
<author><name sortKey="Sun, Sk" uniqKey="Sun S">SK Sun</name>
</author>
<author><name sortKey="Zhang, Hy" uniqKey="Zhang H">HY Zhang</name>
</author>
<author><name sortKey="Liang, Jj" uniqKey="Liang J">JJ Liang</name>
</author>
<author><name sortKey="Luo, Tr" uniqKey="Luo T">TR Luo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name>
</author>
<author><name sortKey="Chen, Hg" uniqKey="Chen H">HG Chen</name>
</author>
<author><name sortKey="Cassidy, W" uniqKey="Cassidy W">W Cassidy</name>
</author>
<author><name sortKey="Howell, Cd" uniqKey="Howell C">CD Howell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramilo, O" uniqKey="Ramilo O">O Ramilo</name>
</author>
<author><name sortKey="Allman, W" uniqKey="Allman W">W Allman</name>
</author>
<author><name sortKey="Chung, W" uniqKey="Chung W">W Chung</name>
</author>
<author><name sortKey="Mejias, A" uniqKey="Mejias A">A Mejias</name>
</author>
<author><name sortKey="Ardura, M" uniqKey="Ardura M">M Ardura</name>
</author>
<author><name sortKey="Glaser, C" uniqKey="Glaser C">C Glaser</name>
</author>
<author><name sortKey="Wittkowski, Km" uniqKey="Wittkowski K">KM Wittkowski</name>
</author>
<author><name sortKey="Piqueras, B" uniqKey="Piqueras B">B Piqueras</name>
</author>
<author><name sortKey="Banchereau, J" uniqKey="Banchereau J">J Banchereau</name>
</author>
<author><name sortKey="Palucka, Ak" uniqKey="Palucka A">AK Palucka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zaas, Ak" uniqKey="Zaas A">AK Zaas</name>
</author>
<author><name sortKey="Chen, Mh" uniqKey="Chen M">MH Chen</name>
</author>
<author><name sortKey="Varkey, J" uniqKey="Varkey J">J Varkey</name>
</author>
<author><name sortKey="Veldman, T" uniqKey="Veldman T">T Veldman</name>
</author>
<author><name sortKey="Hero, Ao" uniqKey="Hero A">AO Hero</name>
</author>
<author><name sortKey="Lucas, J" uniqKey="Lucas J">J Lucas</name>
</author>
<author><name sortKey="Huang, Ys" uniqKey="Huang Y">YS Huang</name>
</author>
<author><name sortKey="Tumer, R" uniqKey="Tumer R">R Tumer</name>
</author>
<author><name sortKey="Gilbert, A" uniqKey="Gilbert A">A Gilbert</name>
</author>
<author><name sortKey="Lambkin Williams, R" uniqKey="Lambkin Williams R">R Lambkin-Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zaas, Ak" uniqKey="Zaas A">AK Zaas</name>
</author>
<author><name sortKey="Aziz, H" uniqKey="Aziz H">H Aziz</name>
</author>
<author><name sortKey="Lucas, J" uniqKey="Lucas J">J Lucas</name>
</author>
<author><name sortKey="Perfect, Jr" uniqKey="Perfect J">JR Perfect</name>
</author>
<author><name sortKey="Ginsburg, Gs" uniqKey="Ginsburg G">GS Ginsburg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aziz, H" uniqKey="Aziz H">H Aziz</name>
</author>
<author><name sortKey="Zaas, A" uniqKey="Zaas A">A Zaas</name>
</author>
<author><name sortKey="Ginsburg, Gs" uniqKey="Ginsburg G">GS Ginsburg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taurino, C" uniqKey="Taurino C">C Taurino</name>
</author>
<author><name sortKey="Miller, Wh" uniqKey="Miller W">WH Miller</name>
</author>
<author><name sortKey="Mcbride, Mw" uniqKey="Mcbride M">MW McBride</name>
</author>
<author><name sortKey="Mcclure, Jd" uniqKey="Mcclure J">JD McClure</name>
</author>
<author><name sortKey="Khanin, R" uniqKey="Khanin R">R Khanin</name>
</author>
<author><name sortKey="Moreno, Mu" uniqKey="Moreno M">MU Moreno</name>
</author>
<author><name sortKey="Dymott, Ja" uniqKey="Dymott J">JA Dymott</name>
</author>
<author><name sortKey="Delles, C" uniqKey="Delles C">C Delles</name>
</author>
<author><name sortKey="Dominiczak, Af" uniqKey="Dominiczak A">AF Dominiczak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Osterlund, P" uniqKey="Osterlund P">P Osterlund</name>
</author>
<author><name sortKey="Pirhonen, J" uniqKey="Pirhonen J">J Pirhonen</name>
</author>
<author><name sortKey="Ikonen, N" uniqKey="Ikonen N">N Ikonen</name>
</author>
<author><name sortKey="Ronkko, E" uniqKey="Ronkko E">E Ronkko</name>
</author>
<author><name sortKey="Strengell, M" uniqKey="Strengell M">M Strengell</name>
</author>
<author><name sortKey="Makela, Sm" uniqKey="Makela S">SM Makela</name>
</author>
<author><name sortKey="Broman, M" uniqKey="Broman M">M Broman</name>
</author>
<author><name sortKey="Hamming, Oj" uniqKey="Hamming O">OJ Hamming</name>
</author>
<author><name sortKey="Hartmann, R" uniqKey="Hartmann R">R Hartmann</name>
</author>
<author><name sortKey="Ziegler, T" uniqKey="Ziegler T">T Ziegler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name>
</author>
<author><name sortKey="Cheung, Cy" uniqKey="Cheung C">CY Cheung</name>
</author>
<author><name sortKey="Leung, Cyh" uniqKey="Leung C">CYH Leung</name>
</author>
<author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arankalle, Va" uniqKey="Arankalle V">VA Arankalle</name>
</author>
<author><name sortKey="Lole, Ks" uniqKey="Lole K">KS Lole</name>
</author>
<author><name sortKey="Arya, Rp" uniqKey="Arya R">RP Arya</name>
</author>
<author><name sortKey="Tripathy, As" uniqKey="Tripathy A">AS Tripathy</name>
</author>
<author><name sortKey="Ramdasi, Ay" uniqKey="Ramdasi A">AY Ramdasi</name>
</author>
<author><name sortKey="Chadha, Ms" uniqKey="Chadha M">MS Chadha</name>
</author>
<author><name sortKey="Sangle, Sa" uniqKey="Sangle S">SA Sangle</name>
</author>
<author><name sortKey="Kadam, Db" uniqKey="Kadam D">DB Kadam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name>
</author>
<author><name sortKey="Zhang, Rf" uniqKey="Zhang R">RF Zhang</name>
</author>
<author><name sortKey="Lu, Hz" uniqKey="Lu H">HZ Lu</name>
</author>
<author><name sortKey="Lu, Sh" uniqKey="Lu S">SH Lu</name>
</author>
<author><name sortKey="Huang, Q" uniqKey="Huang Q">Q Huang</name>
</author>
<author><name sortKey="Xiong, Yy" uniqKey="Xiong Y">YY Xiong</name>
</author>
<author><name sortKey="Xi, Xh" uniqKey="Xi X">XH Xi</name>
</author>
<author><name sortKey="Zhang, Zy" uniqKey="Zhang Z">ZY Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Griffiths Jones, S" uniqKey="Griffiths Jones S">S Griffiths-Jones</name>
</author>
<author><name sortKey="Saini, Hk" uniqKey="Saini H">HK Saini</name>
</author>
<author><name sortKey="Van Dongen, S" uniqKey="Van Dongen S">S van Dongen</name>
</author>
<author><name sortKey="Enright, Aj" uniqKey="Enright A">AJ Enright</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tusher, Vg" uniqKey="Tusher V">VG Tusher</name>
</author>
<author><name sortKey="Tibshirani, R" uniqKey="Tibshirani R">R Tibshirani</name>
</author>
<author><name sortKey="Chu, G" uniqKey="Chu G">G Chu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Hoon, Mjl" uniqKey="De Hoon M">MJL de Hoon</name>
</author>
<author><name sortKey="Imoto, S" uniqKey="Imoto S">S Imoto</name>
</author>
<author><name sortKey="Nolan, J" uniqKey="Nolan J">J Nolan</name>
</author>
<author><name sortKey="Miyano, S" uniqKey="Miyano S">S Miyano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saldanha, Aj" uniqKey="Saldanha A">AJ Saldanha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barrett, T" uniqKey="Barrett T">T Barrett</name>
</author>
<author><name sortKey="Troup, Db" uniqKey="Troup D">DB Troup</name>
</author>
<author><name sortKey="Wilhite, Se" uniqKey="Wilhite S">SE Wilhite</name>
</author>
<author><name sortKey="Ledoux, P" uniqKey="Ledoux P">P Ledoux</name>
</author>
<author><name sortKey="Rudnev, D" uniqKey="Rudnev D">D Rudnev</name>
</author>
<author><name sortKey="Evangelista, C" uniqKey="Evangelista C">C Evangelista</name>
</author>
<author><name sortKey="Kim, If" uniqKey="Kim I">IF Kim</name>
</author>
<author><name sortKey="Soboleva, A" uniqKey="Soboleva A">A Soboleva</name>
</author>
<author><name sortKey="Tomashevsky, M" uniqKey="Tomashevsky M">M Tomashevsky</name>
</author>
<author><name sortKey="Marshall, Ka" uniqKey="Marshall K">KA Marshall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="John, B" uniqKey="John B">B John</name>
</author>
<author><name sortKey="Enright, Aj" uniqKey="Enright A">AJ Enright</name>
</author>
<author><name sortKey="Aravin, A" uniqKey="Aravin A">A Aravin</name>
</author>
<author><name sortKey="Tuschl, T" uniqKey="Tuschl T">T Tuschl</name>
</author>
<author><name sortKey="Sander, C" uniqKey="Sander C">C Sander</name>
</author>
<author><name sortKey="Marks, Ds" uniqKey="Marks D">DS Marks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Friedman, Rc" uniqKey="Friedman R">RC Friedman</name>
</author>
<author><name sortKey="Farh, Kk H" uniqKey="Farh K">KK-H Farh</name>
</author>
<author><name sortKey="Burge, Cb" uniqKey="Burge C">CB Burge</name>
</author>
<author><name sortKey="Bartel, Dp" uniqKey="Bartel D">DP Bartel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Xw" uniqKey="Wang X">XW Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miranda, Kc" uniqKey="Miranda K">KC Miranda</name>
</author>
<author><name sortKey="Huynh, T" uniqKey="Huynh T">T Huynh</name>
</author>
<author><name sortKey="Tay, Y" uniqKey="Tay Y">Y Tay</name>
</author>
<author><name sortKey="Ang, Ys" uniqKey="Ang Y">YS Ang</name>
</author>
<author><name sortKey="Tam, Wl" uniqKey="Tam W">WL Tam</name>
</author>
<author><name sortKey="Thomson, Am" uniqKey="Thomson A">AM Thomson</name>
</author>
<author><name sortKey="Lim, B" uniqKey="Lim B">B Lim</name>
</author>
<author><name sortKey="Rigoutsos, I" uniqKey="Rigoutsos I">I Rigoutsos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krek, A" uniqKey="Krek A">A Krek</name>
</author>
<author><name sortKey="Grun, D" uniqKey="Grun D">D Grun</name>
</author>
<author><name sortKey="Poy, Mn" uniqKey="Poy M">MN Poy</name>
</author>
<author><name sortKey="Wolf, R" uniqKey="Wolf R">R Wolf</name>
</author>
<author><name sortKey="Rosenberg, L" uniqKey="Rosenberg L">L Rosenberg</name>
</author>
<author><name sortKey="Epstein, Ej" uniqKey="Epstein E">EJ Epstein</name>
</author>
<author><name sortKey="Macmenamin, P" uniqKey="Macmenamin P">P MacMenamin</name>
</author>
<author><name sortKey="Da Piedade, I" uniqKey="Da Piedade I">I da Piedade</name>
</author>
<author><name sortKey="Gunsalus, Kc" uniqKey="Gunsalus K">KC Gunsalus</name>
</author>
<author><name sortKey="Stoffel, M" uniqKey="Stoffel M">M Stoffel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dweep, H" uniqKey="Dweep H">H Dweep</name>
</author>
<author><name sortKey="Sticht, C" uniqKey="Sticht C">C Sticht</name>
</author>
<author><name sortKey="Pandey, P" uniqKey="Pandey P">P Pandey</name>
</author>
<author><name sortKey="Gretz, N" uniqKey="Gretz N">N Gretz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Szklarczyk, D" uniqKey="Szklarczyk D">D Szklarczyk</name>
</author>
<author><name sortKey="Franceschini, A" uniqKey="Franceschini A">A Franceschini</name>
</author>
<author><name sortKey="Kuhn, M" uniqKey="Kuhn M">M Kuhn</name>
</author>
<author><name sortKey="Simonovic, M" uniqKey="Simonovic M">M Simonovic</name>
</author>
<author><name sortKey="Roth, A" uniqKey="Roth A">A Roth</name>
</author>
<author><name sortKey="Minguez, P" uniqKey="Minguez P">P Minguez</name>
</author>
<author><name sortKey="Doerks, T" uniqKey="Doerks T">T Doerks</name>
</author>
<author><name sortKey="Stark, M" uniqKey="Stark M">M Stark</name>
</author>
<author><name sortKey="Muller, J" uniqKey="Muller J">J Muller</name>
</author>
<author><name sortKey="Bork, P" uniqKey="Bork P">P Bork</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Von Mering, C" uniqKey="Von Mering C">C von Mering</name>
</author>
<author><name sortKey="Jensen, Lj" uniqKey="Jensen L">LJ Jensen</name>
</author>
<author><name sortKey="Snel, B" uniqKey="Snel B">B Snel</name>
</author>
<author><name sortKey="Hooper, Sd" uniqKey="Hooper S">SD Hooper</name>
</author>
<author><name sortKey="Krupp, M" uniqKey="Krupp M">M Krupp</name>
</author>
<author><name sortKey="Foglierini, M" uniqKey="Foglierini M">M Foglierini</name>
</author>
<author><name sortKey="Jouffre, N" uniqKey="Jouffre N">N Jouffre</name>
</author>
<author><name sortKey="Huynen, Ma" uniqKey="Huynen M">MA Huynen</name>
</author>
<author><name sortKey="Bork, P" uniqKey="Bork P">P Bork</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dennis, G" uniqKey="Dennis G">G Dennis</name>
</author>
<author><name sortKey="Sherman, Bt" uniqKey="Sherman B">BT Sherman</name>
</author>
<author><name sortKey="Hosack, Da" uniqKey="Hosack D">DA Hosack</name>
</author>
<author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name>
</author>
<author><name sortKey="Gao, W" uniqKey="Gao W">W Gao</name>
</author>
<author><name sortKey="Lane, Hc" uniqKey="Lane H">HC Lane</name>
</author>
<author><name sortKey="Lempicki, Ra" uniqKey="Lempicki R">RA Lempicki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kanehisa, M" uniqKey="Kanehisa M">M Kanehisa</name>
</author>
<author><name sortKey="Goto, S" uniqKey="Goto S">S Goto</name>
</author>
<author><name sortKey="Furumichi, M" uniqKey="Furumichi M">M Furumichi</name>
</author>
<author><name sortKey="Tanabe, M" uniqKey="Tanabe M">M Tanabe</name>
</author>
<author><name sortKey="Hirakawa, M" uniqKey="Hirakawa M">M Hirakawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="D Ustachio, P" uniqKey="D Ustachio P">P D’Eustachio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cline, Ms" uniqKey="Cline M">MS Cline</name>
</author>
<author><name sortKey="Smoot, M" uniqKey="Smoot M">M Smoot</name>
</author>
<author><name sortKey="Cerami, E" uniqKey="Cerami E">E Cerami</name>
</author>
<author><name sortKey="Kuchinsky, A" uniqKey="Kuchinsky A">A Kuchinsky</name>
</author>
<author><name sortKey="Landys, N" uniqKey="Landys N">N Landys</name>
</author>
<author><name sortKey="Workman, C" uniqKey="Workman C">C Workman</name>
</author>
<author><name sortKey="Christmas, R" uniqKey="Christmas R">R Christmas</name>
</author>
<author><name sortKey="Avila Campilo, I" uniqKey="Avila Campilo I">I Avila-Campilo</name>
</author>
<author><name sortKey="Creech, M" uniqKey="Creech M">M Creech</name>
</author>
<author><name sortKey="Gross, B" uniqKey="Gross B">B Gross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name>
</author>
<author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nathans, R" uniqKey="Nathans R">R Nathans</name>
</author>
<author><name sortKey="Chu, Cy" uniqKey="Chu C">CY Chu</name>
</author>
<author><name sortKey="Serquina, Ak" uniqKey="Serquina A">AK Serquina</name>
</author>
<author><name sortKey="Lu, Cc" uniqKey="Lu C">CC Lu</name>
</author>
<author><name sortKey="Cao, H" uniqKey="Cao H">H Cao</name>
</author>
<author><name sortKey="Rana, Tm" uniqKey="Rana T">TM Rana</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lecellier, Ch" uniqKey="Lecellier C">CH Lecellier</name>
</author>
<author><name sortKey="Dunoyer, P" uniqKey="Dunoyer P">P Dunoyer</name>
</author>
<author><name sortKey="Arar, K" uniqKey="Arar K">K Arar</name>
</author>
<author><name sortKey="Lehmann Che, J" uniqKey="Lehmann Che J">J Lehmann-Che</name>
</author>
<author><name sortKey="Eyquem, S" uniqKey="Eyquem S">S Eyquem</name>
</author>
<author><name sortKey="Himber, C" uniqKey="Himber C">C Himber</name>
</author>
<author><name sortKey="Saib, A" uniqKey="Saib A">A Saib</name>
</author>
<author><name sortKey="Voinnet, O" uniqKey="Voinnet O">O Voinnet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jopling, Cl" uniqKey="Jopling C">CL Jopling</name>
</author>
<author><name sortKey="Schuetz, S" uniqKey="Schuetz S">S Schuetz</name>
</author>
<author><name sortKey="Sarnow, P" uniqKey="Sarnow P">P Sarnow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jangra, Rk" uniqKey="Jangra R">RK Jangra</name>
</author>
<author><name sortKey="Yi, M" uniqKey="Yi M">M Yi</name>
</author>
<author><name sortKey="Lemon, Sm" uniqKey="Lemon S">SM Lemon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, Jh" uniqKey="Chang J">JH Chang</name>
</author>
<author><name sortKey="Cruo, Jt" uniqKey="Cruo J">JT Cruo</name>
</author>
<author><name sortKey="Jiang, D" uniqKey="Jiang D">D Jiang</name>
</author>
<author><name sortKey="Guo, Ht" uniqKey="Guo H">HT Guo</name>
</author>
<author><name sortKey="Taylor, Jm" uniqKey="Taylor J">JM Taylor</name>
</author>
<author><name sortKey="Block, Tm" uniqKey="Block T">TM Block</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steiner, Df" uniqKey="Steiner D">DF Steiner</name>
</author>
<author><name sortKey="Thomas, Mf" uniqKey="Thomas M">MF Thomas</name>
</author>
<author><name sortKey="Hu, Jk" uniqKey="Hu J">JK Hu</name>
</author>
<author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name>
</author>
<author><name sortKey="Babiarz, Je" uniqKey="Babiarz J">JE Babiarz</name>
</author>
<author><name sortKey="Allen, Cdc" uniqKey="Allen C">CDC Allen</name>
</author>
<author><name sortKey="Matloubian, M" uniqKey="Matloubian M">M Matloubian</name>
</author>
<author><name sortKey="Blelloch, R" uniqKey="Blelloch R">R Blelloch</name>
</author>
<author><name sortKey="Ansel, Km" uniqKey="Ansel K">KM Ansel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, Z" uniqKey="Ding Z">Z Ding</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Khaidakov, M" uniqKey="Khaidakov M">M Khaidakov</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name>
</author>
<author><name sortKey="Mehta, Jl" uniqKey="Mehta J">JL Mehta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, M" uniqKey="Kumar M">M Kumar</name>
</author>
<author><name sortKey="Ahmad, T" uniqKey="Ahmad T">T Ahmad</name>
</author>
<author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name>
</author>
<author><name sortKey="Mabalirajan, U" uniqKey="Mabalirajan U">U Mabalirajan</name>
</author>
<author><name sortKey="Kulshreshtha, A" uniqKey="Kulshreshtha A">A Kulshreshtha</name>
</author>
<author><name sortKey="Agrawal, A" uniqKey="Agrawal A">A Agrawal</name>
</author>
<author><name sortKey="Ghosh, B" uniqKey="Ghosh B">B Ghosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name>
</author>
<author><name sortKey="Homer, Rj" uniqKey="Homer R">RJ Homer</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name>
</author>
<author><name sortKey="Geba, Gp" uniqKey="Geba G">GP Geba</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Elias, Ja" uniqKey="Elias J">JA Elias</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fezeu, L" uniqKey="Fezeu L">L Fezeu</name>
</author>
<author><name sortKey="Julia, C" uniqKey="Julia C">C Julia</name>
</author>
<author><name sortKey="Henegar, A" uniqKey="Henegar A">A Henegar</name>
</author>
<author><name sortKey="Bitu, J" uniqKey="Bitu J">J Bitu</name>
</author>
<author><name sortKey="Hu, Fb" uniqKey="Hu F">FB Hu</name>
</author>
<author><name sortKey="Grobbee, De" uniqKey="Grobbee D">DE Grobbee</name>
</author>
<author><name sortKey="Kengne, Ap" uniqKey="Kengne A">AP Kengne</name>
</author>
<author><name sortKey="Hercberg, S" uniqKey="Hercberg S">S Hercberg</name>
</author>
<author><name sortKey="Czernichow, S" uniqKey="Czernichow S">S Czernichow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Louie, Jk" uniqKey="Louie J">JK Louie</name>
</author>
<author><name sortKey="Acosta, M" uniqKey="Acosta M">M Acosta</name>
</author>
<author><name sortKey="Samuel, Mc" uniqKey="Samuel M">MC Samuel</name>
</author>
<author><name sortKey="Schechter, R" uniqKey="Schechter R">R Schechter</name>
</author>
<author><name sortKey="Vugia, Dj" uniqKey="Vugia D">DJ Vugia</name>
</author>
<author><name sortKey="Harriman, K" uniqKey="Harriman K">K Harriman</name>
</author>
<author><name sortKey="Matyas, Bt" uniqKey="Matyas B">BT Matyas</name>
</author>
<author><name sortKey="Calif Pandem, Hnwg" uniqKey="Calif Pandem H">HNWG Calif Pandem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name>
</author>
<author><name sortKey="Chaves, Ss" uniqKey="Chaves S">SS Chaves</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kornum, Jb" uniqKey="Kornum J">JB Kornum</name>
</author>
<author><name sortKey="Norgaard, M" uniqKey="Norgaard M">M Norgaard</name>
</author>
<author><name sortKey="Dethlefsen, C" uniqKey="Dethlefsen C">C Dethlefsen</name>
</author>
<author><name sortKey="Due, Km" uniqKey="Due K">KM Due</name>
</author>
<author><name sortKey="Thomsen, Rw" uniqKey="Thomsen R">RW Thomsen</name>
</author>
<author><name sortKey="Tjonneland, A" uniqKey="Tjonneland A">A Tjonneland</name>
</author>
<author><name sortKey="Sorensen, Ht" uniqKey="Sorensen H">HT Sorensen</name>
</author>
<author><name sortKey="Overvad, K" uniqKey="Overvad K">K Overvad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hingston, Cd" uniqKey="Hingston C">CD Hingston</name>
</author>
<author><name sortKey="Holmes, Tw" uniqKey="Holmes T">TW Holmes</name>
</author>
<author><name sortKey="Saayman, Ag" uniqKey="Saayman A">AG Saayman</name>
</author>
<author><name sortKey="Wise, Mp" uniqKey="Wise M">MP Wise</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kok, J" uniqKey="Kok J">J Kok</name>
</author>
<author><name sortKey="Blyth, Cc" uniqKey="Blyth C">CC Blyth</name>
</author>
<author><name sortKey="Foo, H" uniqKey="Foo H">H Foo</name>
</author>
<author><name sortKey="Bailey, Mj" uniqKey="Bailey M">MJ Bailey</name>
</author>
<author><name sortKey="Pilcher, Dv" uniqKey="Pilcher D">DV Pilcher</name>
</author>
<author><name sortKey="Webb, Sa" uniqKey="Webb S">SA Webb</name>
</author>
<author><name sortKey="Seppelt, Im" uniqKey="Seppelt I">IM Seppelt</name>
</author>
<author><name sortKey="Dwyer, De" uniqKey="Dwyer D">DE Dwyer</name>
</author>
<author><name sortKey="Iredell, Jr" uniqKey="Iredell J">JR Iredell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Ag" uniqKey="Smith A">AG Smith</name>
</author>
<author><name sortKey="Sheridan, Pa" uniqKey="Sheridan P">PA Sheridan</name>
</author>
<author><name sortKey="Tseng, Rj" uniqKey="Tseng R">RJ Tseng</name>
</author>
<author><name sortKey="Sheridan, Jf" uniqKey="Sheridan J">JF Sheridan</name>
</author>
<author><name sortKey="Beck, Ma" uniqKey="Beck M">MA Beck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Ag" uniqKey="Smith A">AG Smith</name>
</author>
<author><name sortKey="Sheridan, Pa" uniqKey="Sheridan P">PA Sheridan</name>
</author>
<author><name sortKey="Harp, Jb" uniqKey="Harp J">JB Harp</name>
</author>
<author><name sortKey="Beck, Ma" uniqKey="Beck M">MA Beck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karlsson, Ea" uniqKey="Karlsson E">EA Karlsson</name>
</author>
<author><name sortKey="Sheridan, Pa" uniqKey="Sheridan P">PA Sheridan</name>
</author>
<author><name sortKey="Beck, Ma" uniqKey="Beck M">MA Beck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hulsmans, M" uniqKey="Hulsmans M">M Hulsmans</name>
</author>
<author><name sortKey="Van Dooren, E" uniqKey="Van Dooren E">E Van Dooren</name>
</author>
<author><name sortKey="Mathieu, C" uniqKey="Mathieu C">C Mathieu</name>
</author>
<author><name sortKey="Holvoet, P" uniqKey="Holvoet P">P Holvoet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yan, X" uniqKey="Yan X">X Yan</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Zhao, Jx" uniqKey="Zhao J">JX Zhao</name>
</author>
<author><name sortKey="Rogers, Cj" uniqKey="Rogers C">CJ Rogers</name>
</author>
<author><name sortKey="Zhu, Mj" uniqKey="Zhu M">MJ Zhu</name>
</author>
<author><name sortKey="Ford, Sp" uniqKey="Ford S">SP Ford</name>
</author>
<author><name sortKey="Nathanielsz, Pw" uniqKey="Nathanielsz P">PW Nathanielsz</name>
</author>
<author><name sortKey="Du, M" uniqKey="Du M">M Du</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schmidt, Wm" uniqKey="Schmidt W">WM Schmidt</name>
</author>
<author><name sortKey="Spiel, Ao" uniqKey="Spiel A">AO Spiel</name>
</author>
<author><name sortKey="Jilma, B" uniqKey="Jilma B">B Jilma</name>
</author>
<author><name sortKey="Wolzt, M" uniqKey="Wolzt M">M Wolzt</name>
</author>
<author><name sortKey="Wuller, M" uniqKey="Wuller M">M Wuller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giamarellos Bourboulis, Ej" uniqKey="Giamarellos Bourboulis E">EJ Giamarellos-Bourboulis</name>
</author>
<author><name sortKey="Raftogiannis, M" uniqKey="Raftogiannis M">M Raftogiannis</name>
</author>
<author><name sortKey="Antonopoulou, A" uniqKey="Antonopoulou A">A Antonopoulou</name>
</author>
<author><name sortKey="Baziaka, F" uniqKey="Baziaka F">F Baziaka</name>
</author>
<author><name sortKey="Koutoukas, P" uniqKey="Koutoukas P">P Koutoukas</name>
</author>
<author><name sortKey="Savva, A" uniqKey="Savva A">A Savva</name>
</author>
<author><name sortKey="Kanni, T" uniqKey="Kanni T">T Kanni</name>
</author>
<author><name sortKey="Georgitsi, M" uniqKey="Georgitsi M">M Georgitsi</name>
</author>
<author><name sortKey="Pistiki, A" uniqKey="Pistiki A">A Pistiki</name>
</author>
<author><name sortKey="Tsaganos, T" uniqKey="Tsaganos T">T Tsaganos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Palacios, G" uniqKey="Palacios G">G Palacios</name>
</author>
<author><name sortKey="Hornig, M" uniqKey="Hornig M">M Hornig</name>
</author>
<author><name sortKey="Cisterna, D" uniqKey="Cisterna D">D Cisterna</name>
</author>
<author><name sortKey="Savji, N" uniqKey="Savji N">N Savji</name>
</author>
<author><name sortKey="Bussetti, Av" uniqKey="Bussetti A">AV Bussetti</name>
</author>
<author><name sortKey="Kapoor, V" uniqKey="Kapoor V">V Kapoor</name>
</author>
<author><name sortKey="Hui, J" uniqKey="Hui J">J Hui</name>
</author>
<author><name sortKey="Tokarz, R" uniqKey="Tokarz R">R Tokarz</name>
</author>
<author><name sortKey="Briese, T" uniqKey="Briese T">T Briese</name>
</author>
<author><name sortKey="Baumeister, E" uniqKey="Baumeister E">E Baumeister</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cuadrado, A" uniqKey="Cuadrado A">A Cuadrado</name>
</author>
<author><name sortKey="Nebreda, Ar" uniqKey="Nebreda A">AR Nebreda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xing, Z" uniqKey="Xing Z">Z Xing</name>
</author>
<author><name sortKey="Cardona, Cj" uniqKey="Cardona C">CJ Cardona</name>
</author>
<author><name sortKey="Anunciacion, J" uniqKey="Anunciacion J">J Anunciacion</name>
</author>
<author><name sortKey="Adams, S" uniqKey="Adams S">S Adams</name>
</author>
<author><name sortKey="Dao, N" uniqKey="Dao N">N Dao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marchant, D" uniqKey="Marchant D">D Marchant</name>
</author>
<author><name sortKey="Singhera, Gk" uniqKey="Singhera G">GK Singhera</name>
</author>
<author><name sortKey="Utokaparch, S" uniqKey="Utokaparch S">S Utokaparch</name>
</author>
<author><name sortKey="Hackett, Tl" uniqKey="Hackett T">TL Hackett</name>
</author>
<author><name sortKey="Boyd, Jh" uniqKey="Boyd J">JH Boyd</name>
</author>
<author><name sortKey="Luo, Zs" uniqKey="Luo Z">ZS Luo</name>
</author>
<author><name sortKey="Si, Xn" uniqKey="Si X">XN Si</name>
</author>
<author><name sortKey="Dorscheid, Dr" uniqKey="Dorscheid D">DR Dorscheid</name>
</author>
<author><name sortKey="Mcmanus, Bm" uniqKey="Mcmanus B">BM McManus</name>
</author>
<author><name sortKey="Hegele, Rg" uniqKey="Hegele R">RG Hegele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eierhoff, T" uniqKey="Eierhoff T">T Eierhoff</name>
</author>
<author><name sortKey="Hrincius, Er" uniqKey="Hrincius E">ER Hrincius</name>
</author>
<author><name sortKey="Rescher, U" uniqKey="Rescher U">U Rescher</name>
</author>
<author><name sortKey="Ludwig, S" uniqKey="Ludwig S">S Ludwig</name>
</author>
<author><name sortKey="Ehrhardt, C" uniqKey="Ehrhardt C">C Ehrhardt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wurzer, Wj" uniqKey="Wurzer W">WJ Wurzer</name>
</author>
<author><name sortKey="Planz, O" uniqKey="Planz O">O Planz</name>
</author>
<author><name sortKey="Ehrhardt, C" uniqKey="Ehrhardt C">C Ehrhardt</name>
</author>
<author><name sortKey="Giner, M" uniqKey="Giner M">M Giner</name>
</author>
<author><name sortKey="Silberzahn, T" uniqKey="Silberzahn T">T Silberzahn</name>
</author>
<author><name sortKey="Pleschka, S" uniqKey="Pleschka S">S Pleschka</name>
</author>
<author><name sortKey="Ludwig, S" uniqKey="Ludwig S">S Ludwig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schultzcherry, S" uniqKey="Schultzcherry S">S SchultzCherry</name>
</author>
<author><name sortKey="Hinshaw, Vs" uniqKey="Hinshaw V">VS Hinshaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bloomston, M" uniqKey="Bloomston M">M Bloomston</name>
</author>
<author><name sortKey="Frankel, Wl" uniqKey="Frankel W">WL Frankel</name>
</author>
<author><name sortKey="Petrocca, F" uniqKey="Petrocca F">F Petrocca</name>
</author>
<author><name sortKey="Volinia, S" uniqKey="Volinia S">S Volinia</name>
</author>
<author><name sortKey="Alder, H" uniqKey="Alder H">H Alder</name>
</author>
<author><name sortKey="Hagan, Jp" uniqKey="Hagan J">JP Hagan</name>
</author>
<author><name sortKey="Liu, Cg" uniqKey="Liu C">CG Liu</name>
</author>
<author><name sortKey="Bhatt, D" uniqKey="Bhatt D">D Bhatt</name>
</author>
<author><name sortKey="Taccioli, C" uniqKey="Taccioli C">C Taccioli</name>
</author>
<author><name sortKey="Croce, Cm" uniqKey="Croce C">CM Croce</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lehmann, U" uniqKey="Lehmann U">U Lehmann</name>
</author>
<author><name sortKey="Hasemeier, B" uniqKey="Hasemeier B">B Hasemeier</name>
</author>
<author><name sortKey="Romermann, D" uniqKey="Romermann D">D Romermann</name>
</author>
<author><name sortKey="Muller, M" uniqKey="Muller M">M Muller</name>
</author>
<author><name sortKey="Langer, F" uniqKey="Langer F">F Langer</name>
</author>
<author><name sortKey="Kreipe, H" uniqKey="Kreipe H">H Kreipe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tan, Z" uniqKey="Tan Z">Z Tan</name>
</author>
<author><name sortKey="Randall, G" uniqKey="Randall G">G Randall</name>
</author>
<author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name>
</author>
<author><name sortKey="Camoretti Mercado, B" uniqKey="Camoretti Mercado B">B Camoretti-Mercado</name>
</author>
<author><name sortKey="Brockman Schneider, R" uniqKey="Brockman Schneider R">R Brockman-Schneider</name>
</author>
<author><name sortKey="Pan, L" uniqKey="Pan L">L Pan</name>
</author>
<author><name sortKey="Solway, J" uniqKey="Solway J">J Solway</name>
</author>
<author><name sortKey="Gern, Je" uniqKey="Gern J">JE Gern</name>
</author>
<author><name sortKey="Lemanske, Rf" uniqKey="Lemanske R">RF Lemanske</name>
</author>
<author><name sortKey="Nicolae, D" uniqKey="Nicolae D">D Nicolae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pan, W" uniqKey="Pan W">W Pan</name>
</author>
<author><name sortKey="Zhu, S" uniqKey="Zhu S">S Zhu</name>
</author>
<author><name sortKey="Yuan, M" uniqKey="Yuan M">M Yuan</name>
</author>
<author><name sortKey="Cui, Hj" uniqKey="Cui H">HJ Cui</name>
</author>
<author><name sortKey="Wang, Lj" uniqKey="Wang L">LJ Wang</name>
</author>
<author><name sortKey="Luo, Xb" uniqKey="Luo X">XB Luo</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Zhou, Hb" uniqKey="Zhou H">HB Zhou</name>
</author>
<author><name sortKey="Tang, Yj" uniqKey="Tang Y">YJ Tang</name>
</author>
<author><name sortKey="Shen, N" uniqKey="Shen N">N Shen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Zhan, Z" uniqKey="Zhan Z">Z Zhan</name>
</author>
<author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name>
</author>
<author><name sortKey="Ma, F" uniqKey="Ma F">F Ma</name>
</author>
<author><name sortKey="Li, D" uniqKey="Li D">D Li</name>
</author>
<author><name sortKey="Guo, Z" uniqKey="Guo Z">Z Guo</name>
</author>
<author><name sortKey="Li, N" uniqKey="Li N">N Li</name>
</author>
<author><name sortKey="Cao, X" uniqKey="Cao X">X Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rouas, R" uniqKey="Rouas R">R Rouas</name>
</author>
<author><name sortKey="Fawad Kazan, H" uniqKey="Fawad Kazan H">H Fawad-Kazan</name>
</author>
<author><name sortKey="El Zein, N" uniqKey="El Zein N">N El Zein</name>
</author>
<author><name sortKey="Lewalle, P" uniqKey="Lewalle P">P Lewalle</name>
</author>
<author><name sortKey="Rothe, F" uniqKey="Rothe F">F Rothe</name>
</author>
<author><name sortKey="Simion, A" uniqKey="Simion A">A Simion</name>
</author>
<author><name sortKey="Akl, H" uniqKey="Akl H">H Akl</name>
</author>
<author><name sortKey="Mourtada, M" uniqKey="Mourtada M">M Mourtada</name>
</author>
<author><name sortKey="El Rifai, M" uniqKey="El Rifai M">M El Rifai</name>
</author>
<author><name sortKey="Burny, A" uniqKey="Burny A">A Burny</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wieckiewicz, J" uniqKey="Wieckiewicz J">J Wieckiewicz</name>
</author>
<author><name sortKey="Goto, R" uniqKey="Goto R">R Goto</name>
</author>
<author><name sortKey="Wood, Kj" uniqKey="Wood K">KJ Wood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Hx" uniqKey="Chen H">HX Chen</name>
</author>
<author><name sortKey="Chen, Bg" uniqKey="Chen B">BG Chen</name>
</author>
<author><name sortKey="Shi, Ww" uniqKey="Shi W">WW Shi</name>
</author>
<author><name sortKey="Zhen, R" uniqKey="Zhen R">R Zhen</name>
</author>
<author><name sortKey="Xu, Dp" uniqKey="Xu D">DP Xu</name>
</author>
<author><name sortKey="Lin, Af" uniqKey="Lin A">AF Lin</name>
</author>
<author><name sortKey="Yan, Wh" uniqKey="Yan W">WH Yan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pavlovic, J" uniqKey="Pavlovic J">J Pavlovic</name>
</author>
<author><name sortKey="Haller, O" uniqKey="Haller O">O Haller</name>
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</author>
<author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name>
</author>
<author><name sortKey="Kochs, G" uniqKey="Kochs G">G Kochs</name>
</author>
<author><name sortKey="Haller, O" uniqKey="Haller O">O Haller</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name>
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</author>
<author><name sortKey="Ni, C" uniqKey="Ni C">C Ni</name>
</author>
<author><name sortKey="Carter, Vs" uniqKey="Carter V">VS Carter</name>
</author>
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</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Microarray analysis of microRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1).</title>
<author><name sortKey="Song, Hao" sort="Song, Hao" uniqKey="Song H" first="Hao" last="Song">Hao Song</name>
<affiliation wicri:level="1"><nlm:affiliation>MOA Key Laboratory of Animal Biotechnology of National Ministry of Agriculture, Institute of Veterinary Immunology, and Research Laboratory of Virology, Immunology & Bioinformatics, Division of Veterinary Microbiology & Virology, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A & F University, Yangling, Xi'an City, Shaanxi Province, 712100, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>MOA Key Laboratory of Animal Biotechnology of National Ministry of Agriculture, Institute of Veterinary Immunology, and Research Laboratory of Virology, Immunology & Bioinformatics, Division of Veterinary Microbiology & Virology, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A & F University, Yangling, Xi'an City, Shaanxi Province, 712100</wicri:regionArea>
<wicri:noRegion>712100</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Qi" sort="Wang, Qi" uniqKey="Wang Q" first="Qi" last="Wang">Qi Wang</name>
</author>
<author><name sortKey="Guo, Yang" sort="Guo, Yang" uniqKey="Guo Y" first="Yang" last="Guo">Yang Guo</name>
</author>
<author><name sortKey="Liu, Shunai" sort="Liu, Shunai" uniqKey="Liu S" first="Shunai" last="Liu">Shunai Liu</name>
</author>
<author><name sortKey="Song, Rui" sort="Song, Rui" uniqKey="Song R" first="Rui" last="Song">Rui Song</name>
</author>
<author><name sortKey="Gao, Xuesong" sort="Gao, Xuesong" uniqKey="Gao X" first="Xuesong" last="Gao">Xuesong Gao</name>
</author>
<author><name sortKey="Dai, Li" sort="Dai, Li" uniqKey="Dai L" first="Li" last="Dai">Li Dai</name>
</author>
<author><name sortKey="Li, Baoshun" sort="Li, Baoshun" uniqKey="Li B" first="Baoshun" last="Li">Baoshun Li</name>
</author>
<author><name sortKey="Zhang, Deli" sort="Zhang, Deli" uniqKey="Zhang D" first="Deli" last="Zhang">Deli Zhang</name>
</author>
<author><name sortKey="Cheng, Jun" sort="Cheng, Jun" uniqKey="Cheng J" first="Jun" last="Cheng">Jun Cheng</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23731466</idno>
<idno type="pmid">23731466</idno>
<idno type="doi">10.1186/1471-2334-13-257</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Microarray analysis of microRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1).</title>
<author><name sortKey="Song, Hao" sort="Song, Hao" uniqKey="Song H" first="Hao" last="Song">Hao Song</name>
<affiliation wicri:level="1"><nlm:affiliation>MOA Key Laboratory of Animal Biotechnology of National Ministry of Agriculture, Institute of Veterinary Immunology, and Research Laboratory of Virology, Immunology & Bioinformatics, Division of Veterinary Microbiology & Virology, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A & F University, Yangling, Xi'an City, Shaanxi Province, 712100, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>MOA Key Laboratory of Animal Biotechnology of National Ministry of Agriculture, Institute of Veterinary Immunology, and Research Laboratory of Virology, Immunology & Bioinformatics, Division of Veterinary Microbiology & Virology, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A & F University, Yangling, Xi'an City, Shaanxi Province, 712100</wicri:regionArea>
<wicri:noRegion>712100</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Qi" sort="Wang, Qi" uniqKey="Wang Q" first="Qi" last="Wang">Qi Wang</name>
</author>
<author><name sortKey="Guo, Yang" sort="Guo, Yang" uniqKey="Guo Y" first="Yang" last="Guo">Yang Guo</name>
</author>
<author><name sortKey="Liu, Shunai" sort="Liu, Shunai" uniqKey="Liu S" first="Shunai" last="Liu">Shunai Liu</name>
</author>
<author><name sortKey="Song, Rui" sort="Song, Rui" uniqKey="Song R" first="Rui" last="Song">Rui Song</name>
</author>
<author><name sortKey="Gao, Xuesong" sort="Gao, Xuesong" uniqKey="Gao X" first="Xuesong" last="Gao">Xuesong Gao</name>
</author>
<author><name sortKey="Dai, Li" sort="Dai, Li" uniqKey="Dai L" first="Li" last="Dai">Li Dai</name>
</author>
<author><name sortKey="Li, Baoshun" sort="Li, Baoshun" uniqKey="Li B" first="Baoshun" last="Li">Baoshun Li</name>
</author>
<author><name sortKey="Zhang, Deli" sort="Zhang, Deli" uniqKey="Zhang D" first="Deli" last="Zhang">Deli Zhang</name>
</author>
<author><name sortKey="Cheng, Jun" sort="Cheng, Jun" uniqKey="Cheng J" first="Jun" last="Cheng">Jun Cheng</name>
</author>
</analytic>
<series><title level="j">BMC infectious diseases</title>
<idno type="eISSN">1471-2334</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Cluster Analysis</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Gene Regulatory Networks</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term>
<term>Influenza, Human (genetics)</term>
<term>Influenza, Human (metabolism)</term>
<term>Influenza, Human (virology)</term>
<term>Leukocytes, Mononuclear (metabolism)</term>
<term>Male</term>
<term>MicroRNAs (biosynthesis)</term>
<term>MicroRNAs (genetics)</term>
<term>MicroRNAs (metabolism)</term>
<term>Oligonucleotide Array Sequence Analysis</term>
<term>ROC Curve</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Agranulocytes (métabolisme)</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Analyse de regroupements</term>
<term>Courbe ROC</term>
<term>Femelle</term>
<term>Grippe humaine (génétique)</term>
<term>Grippe humaine (métabolisme)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Reproductibilité des résultats</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Réseaux de régulation génique</term>
<term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term>
<term>Séquençage par oligonucléotides en batterie</term>
<term>microARN (biosynthèse)</term>
<term>microARN (génétique)</term>
<term>microARN (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>MicroRNAs</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza, Human</term>
<term>MicroRNAs</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Grippe humaine</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza, Human</term>
<term>Leukocytes, Mononuclear</term>
<term>MicroRNAs</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Agranulocytes</term>
<term>Grippe humaine</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Cluster Analysis</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Gene Regulatory Networks</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Male</term>
<term>Oligonucleotide Array Sequence Analysis</term>
<term>ROC Curve</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Analyse de regroupements</term>
<term>Courbe ROC</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Reproductibilité des résultats</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Réseaux de régulation génique</term>
<term>Séquençage par oligonucléotides en batterie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">With concerns about the disastrous health and economic consequences caused by the influenza pandemic, comprehensively understanding the global host response to influenza virus infection is urgent. The role of microRNA (miRNA) has recently been highlighted in pathogen-host interactions. However, the precise role of miRNAs in the pathogenesis of influenza virus infection in humans, especially in critically ill patients is still unclear.</div>
</front>
</TEI>
</pubmed>
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