Corticosteroid Treatment Ameliorates Acute Lung Injury Induced by 2009 Swine Origin Influenza A (H1N1) Virus in Mice
Identifieur interne : 001462 ( Ncbi/Merge ); précédent : 001461; suivant : 001463Corticosteroid Treatment Ameliorates Acute Lung Injury Induced by 2009 Swine Origin Influenza A (H1N1) Virus in Mice
Auteurs : Chenggang Li [République populaire de Chine] ; Penghui Yang [République populaire de Chine] ; Yanli Zhang [République populaire de Chine] ; Yang Sun [République populaire de Chine] ; Wei Wang [République populaire de Chine] ; Zhen Zou [République populaire de Chine] ; Li Xing [République populaire de Chine] ; Zhongwei Chen [République populaire de Chine] ; Chong Tang [République populaire de Chine] ; Feng Guo [République populaire de Chine] ; Jiejie Deng [République populaire de Chine] ; Yan Zhao [République populaire de Chine] ; Yiwu Yan [République populaire de Chine] ; Jun Tang [République populaire de Chine] ; Xiliang Wang [République populaire de Chine] ; Chengyu Jiang [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Cytokines (métabolisme), Dexaméthasone (administration et posologie), Dexaméthasone (pharmacologie), Dexaméthasone (usage thérapeutique), Hormones corticosurrénaliennes (administration et posologie), Hormones corticosurrénaliennes (pharmacologie), Hormones corticosurrénaliennes (usage thérapeutique), Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (traitement médicamenteux), Infections à Orthomyxoviridae (virologie), Inflammation (), Inflammation (anatomopathologie), Inflammation (virologie), Lésion pulmonaire aigüe (anatomopathologie), Lésion pulmonaire aigüe (immunologie), Lésion pulmonaire aigüe (traitement médicamenteux), Lésion pulmonaire aigüe (virologie), Modèles animaux de maladie humaine, Sevrage, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (physiologie), Sus scrofa (virologie).
- MESH :
- administration et posologie : Dexaméthasone, Hormones corticosurrénaliennes.
- anatomopathologie : Infections à Orthomyxoviridae, Inflammation, Lésion pulmonaire aigüe.
- immunologie : Infections à Orthomyxoviridae, Lésion pulmonaire aigüe.
- métabolisme : Cytokines.
- pharmacologie : Dexaméthasone, Hormones corticosurrénaliennes.
- physiologie : Sous-type H1N1 du virus de la grippe A.
- traitement médicamenteux : Infections à Orthomyxoviridae, Lésion pulmonaire aigüe.
- usage thérapeutique : Dexaméthasone, Hormones corticosurrénaliennes.
- virologie : Infections à Orthomyxoviridae, Inflammation, Lésion pulmonaire aigüe, Sus scrofa.
- Animaux, Inflammation, Modèles animaux de maladie humaine, Sevrage, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A.
English descriptors
- KwdEn :
- Acute Lung Injury (drug therapy), Acute Lung Injury (immunology), Acute Lung Injury (pathology), Acute Lung Injury (virology), Adrenal Cortex Hormones (administration & dosage), Adrenal Cortex Hormones (pharmacology), Adrenal Cortex Hormones (therapeutic use), Animals, Cytokines (metabolism), Dexamethasone (administration & dosage), Dexamethasone (pharmacology), Dexamethasone (therapeutic use), Disease Models, Animal, Inflammation (complications), Inflammation (pathology), Inflammation (virology), Influenza A Virus, H1N1 Subtype (drug effects), Influenza A Virus, H1N1 Subtype (physiology), Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Orthomyxoviridae Infections (drug therapy), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (virology), Sus scrofa (virology), Weaning.
- MESH :
- chemical , administration & dosage : Adrenal Cortex Hormones, Dexamethasone.
- complications : Inflammation.
- drug effects : Influenza A Virus, H1N1 Subtype.
- drug therapy : Acute Lung Injury, Orthomyxoviridae Infections.
- immunology : Acute Lung Injury, Orthomyxoviridae Infections.
- chemical , metabolism : Cytokines.
- pathology : Acute Lung Injury, Inflammation, Orthomyxoviridae Infections.
- chemical , pharmacology : Adrenal Cortex Hormones, Dexamethasone.
- physiology : Influenza A Virus, H1N1 Subtype.
- chemical , therapeutic use : Adrenal Cortex Hormones, Dexamethasone.
- virology : Acute Lung Injury, Inflammation, Orthomyxoviridae Infections, Sus scrofa.
- Animals, Disease Models, Animal, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Weaning.
Abstract
The 2009 influenza pandemic affected people in almost all countries in the world, especially in younger age groups. During this time, the debate over whether to use corticosteroid treatment in severe influenza H1N1 infections patients resurfaced and was disputed by clinicians. There is an urgent need for a susceptible animal model of 2009 H1N1 infection that can be used to evaluate the pathogenesis and the therapeutic effect of corticosteroid treatment during infection.
We intranasally inoculated two groups of C57BL/6 and BALB/c mice (using 4- or 6-to 8-week-old mice) to compare the pathogenesis of several different H1N1 strains in mice of different ages. Based on the results, a very susceptible 4-week-old C57BL/6 mouse model of Beijing 501 strain of 2009 H1N1 virus infection was established, showing significantly elevated lung edema and cytokine levels compared to controls. Using our established animal model, the cytokine production profile and lung histology were assessed at different times post-infection, revealing increased lung lesions in a time-dependent manner. In additional,the mice were also treated with dexamethasone, which significantly improved survival rate and lung lesions in infected mice compared to those in control mice. Our data showed that corticosteroid treatment ameliorated acute lung injury induced by the 2009 A/H1N1 virus in mice and suggested that corticosteroids are valid drugs for treating 2009 A/H1N1 infection.
Using the established, very susceptible 2009 Pandemic Influenza A (H1N1) mouse model, our studies indicate that corticosteroids are a potential therapeutic remedy that may address the increasing concerns over future 2009 A/H1N1pandemics.
Url:
DOI: 10.1371/journal.pone.0044110
PubMed: 22952892
PubMed Central: 3430649
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PMC:3430649Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Corticosteroid Treatment Ameliorates Acute Lung Injury Induced by 2009 Swine Origin Influenza A (H1N1) Virus in Mice</title>
<author><name sortKey="Li, Chenggang" sort="Li, Chenggang" uniqKey="Li C" first="Chenggang" last="Li">Chenggang Li</name>
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<author><name sortKey="Yang, Penghui" sort="Yang, Penghui" uniqKey="Yang P" first="Penghui" last="Yang">Penghui Yang</name>
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<author><name sortKey="Zhang, Yanli" sort="Zhang, Yanli" uniqKey="Zhang Y" first="Yanli" last="Zhang">Yanli Zhang</name>
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<author><name sortKey="Sun, Yang" sort="Sun, Yang" uniqKey="Sun Y" first="Yang" last="Sun">Yang Sun</name>
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</nlm:aff>
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<author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
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<author><name sortKey="Zou, Zhen" sort="Zou, Zhen" uniqKey="Zou Z" first="Zhen" last="Zou">Zhen Zou</name>
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<author><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name>
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<author><name sortKey="Chen, Zhongwei" sort="Chen, Zhongwei" uniqKey="Chen Z" first="Zhongwei" last="Chen">Zhongwei Chen</name>
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<author><name sortKey="Tang, Chong" sort="Tang, Chong" uniqKey="Tang C" first="Chong" last="Tang">Chong Tang</name>
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<author><name sortKey="Guo, Feng" sort="Guo, Feng" uniqKey="Guo F" first="Feng" last="Guo">Feng Guo</name>
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</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Deng, Jiejie" sort="Deng, Jiejie" uniqKey="Deng J" first="Jiejie" last="Deng">Jiejie Deng</name>
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</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Zhao, Yan" sort="Zhao, Yan" uniqKey="Zhao Y" first="Yan" last="Zhao">Yan Zhao</name>
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</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Yan, Yiwu" sort="Yan, Yiwu" uniqKey="Yan Y" first="Yiwu" last="Yan">Yiwu Yan</name>
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</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Tang, Jun" sort="Tang, Jun" uniqKey="Tang J" first="Jun" last="Tang">Jun Tang</name>
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<country xml:lang="fr">République populaire de Chine</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name>
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</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
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<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College; Tsinghua University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
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</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012">2012</date>
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<term>Acute Lung Injury (immunology)</term>
<term>Acute Lung Injury (pathology)</term>
<term>Acute Lung Injury (virology)</term>
<term>Adrenal Cortex Hormones (administration & dosage)</term>
<term>Adrenal Cortex Hormones (pharmacology)</term>
<term>Adrenal Cortex Hormones (therapeutic use)</term>
<term>Animals</term>
<term>Cytokines (metabolism)</term>
<term>Dexamethasone (administration & dosage)</term>
<term>Dexamethasone (pharmacology)</term>
<term>Dexamethasone (therapeutic use)</term>
<term>Disease Models, Animal</term>
<term>Inflammation (complications)</term>
<term>Inflammation (pathology)</term>
<term>Inflammation (virology)</term>
<term>Influenza A Virus, H1N1 Subtype (drug effects)</term>
<term>Influenza A Virus, H1N1 Subtype (physiology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Inbred C57BL</term>
<term>Orthomyxoviridae Infections (drug therapy)</term>
<term>Orthomyxoviridae Infections (immunology)</term>
<term>Orthomyxoviridae Infections (pathology)</term>
<term>Orthomyxoviridae Infections (virology)</term>
<term>Sus scrofa (virology)</term>
<term>Weaning</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cytokines (métabolisme)</term>
<term>Dexaméthasone (administration et posologie)</term>
<term>Dexaméthasone (pharmacologie)</term>
<term>Dexaméthasone (usage thérapeutique)</term>
<term>Hormones corticosurrénaliennes (administration et posologie)</term>
<term>Hormones corticosurrénaliennes (pharmacologie)</term>
<term>Hormones corticosurrénaliennes (usage thérapeutique)</term>
<term>Infections à Orthomyxoviridae (anatomopathologie)</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Infections à Orthomyxoviridae (traitement médicamenteux)</term>
<term>Infections à Orthomyxoviridae (virologie)</term>
<term>Inflammation ()</term>
<term>Inflammation (anatomopathologie)</term>
<term>Inflammation (virologie)</term>
<term>Lésion pulmonaire aigüe (anatomopathologie)</term>
<term>Lésion pulmonaire aigüe (immunologie)</term>
<term>Lésion pulmonaire aigüe (traitement médicamenteux)</term>
<term>Lésion pulmonaire aigüe (virologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Sevrage</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Souris de lignée C57BL</term>
<term>Sous-type H1N1 du virus de la grippe A ()</term>
<term>Sous-type H1N1 du virus de la grippe A (physiologie)</term>
<term>Sus scrofa (virologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adrenal Cortex Hormones</term>
<term>Dexamethasone</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Dexaméthasone</term>
<term>Hormones corticosurrénaliennes</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
<term>Inflammation</term>
<term>Lésion pulmonaire aigüe</term>
</keywords>
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</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Acute Lung Injury</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
<term>Lésion pulmonaire aigüe</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Acute Lung Injury</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Acute Lung Injury</term>
<term>Inflammation</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Dexaméthasone</term>
<term>Hormones corticosurrénaliennes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adrenal Cortex Hormones</term>
<term>Dexamethasone</term>
</keywords>
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</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term>
<term>Dexamethasone</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
<term>Lésion pulmonaire aigüe</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Dexaméthasone</term>
<term>Hormones corticosurrénaliennes</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
<term>Inflammation</term>
<term>Lésion pulmonaire aigüe</term>
<term>Sus scrofa</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Acute Lung Injury</term>
<term>Inflammation</term>
<term>Orthomyxoviridae Infections</term>
<term>Sus scrofa</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Inbred C57BL</term>
<term>Weaning</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Inflammation</term>
<term>Modèles animaux de maladie humaine</term>
<term>Sevrage</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Souris de lignée C57BL</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The 2009 influenza pandemic affected people in almost all countries in the world, especially in younger age groups. During this time, the debate over whether to use corticosteroid treatment in severe influenza H1N1 infections patients resurfaced and was disputed by clinicians. There is an urgent need for a susceptible animal model of 2009 H1N1 infection that can be used to evaluate the pathogenesis and the therapeutic effect of corticosteroid treatment during infection.</p>
</sec>
<sec><title>Methodology/Principal Findings</title>
<p>We intranasally inoculated two groups of C57BL/6 and BALB/c mice (using 4- or 6-to 8-week-old mice) to compare the pathogenesis of several different H1N1 strains in mice of different ages. Based on the results, a very susceptible 4-week-old C57BL/6 mouse model of Beijing 501 strain of 2009 H1N1 virus infection was established, showing significantly elevated lung edema and cytokine levels compared to controls. Using our established animal model, the cytokine production profile and lung histology were assessed at different times post-infection, revealing increased lung lesions in a time-dependent manner. In additional,the mice were also treated with dexamethasone, which significantly improved survival rate and lung lesions in infected mice compared to those in control mice. Our data showed that corticosteroid treatment ameliorated acute lung injury induced by the 2009 A/H1N1 virus in mice and suggested that corticosteroids are valid drugs for treating 2009 A/H1N1 infection.</p>
</sec>
<sec><title>Conclusions/Significance</title>
<p>Using the established, very susceptible 2009 Pandemic Influenza A (H1N1) mouse model, our studies indicate that corticosteroids are a potential therapeutic remedy that may address the increasing concerns over future 2009 A/H1N1pandemics.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="De Vries, Rp" uniqKey="De Vries R">RP de Vries</name>
</author>
<author><name sortKey="De Vries, E" uniqKey="De Vries E">E de Vries</name>
</author>
<author><name sortKey="Moore, Ks" uniqKey="Moore K">KS Moore</name>
</author>
<author><name sortKey="Rigter, A" uniqKey="Rigter A">A Rigter</name>
</author>
<author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Louie, Jk" uniqKey="Louie J">JK Louie</name>
</author>
<author><name sortKey="Acosta, M" uniqKey="Acosta M">M Acosta</name>
</author>
<author><name sortKey="Winter, K" uniqKey="Winter K">K Winter</name>
</author>
<author><name sortKey="Jean, C" uniqKey="Jean C">C Jean</name>
</author>
<author><name sortKey="Gavali, S" uniqKey="Gavali S">S Gavali</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Ashbaugh, Dg" uniqKey="Ashbaugh D">DG Ashbaugh</name>
</author>
<author><name sortKey="Bigelow, Db" uniqKey="Bigelow D">DB Bigelow</name>
</author>
<author><name sortKey="Petty, Tl" uniqKey="Petty T">TL Petty</name>
</author>
<author><name sortKey="Levine, Be" uniqKey="Levine B">BE Levine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name>
</author>
<author><name sortKey="Bertozzi, Sm" uniqKey="Bertozzi S">SM Bertozzi</name>
</author>
<author><name sortKey="Colchero, Ma" uniqKey="Colchero M">MA Colchero</name>
</author>
<author><name sortKey="Lopez Gatell, H" uniqKey="Lopez Gatell H">H Lopez-Gatell</name>
</author>
<author><name sortKey="Alpuche Aranda, C" uniqKey="Alpuche Aranda C">C Alpuche-Aranda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, N" uniqKey="Yang N">N Yang</name>
</author>
<author><name sortKey="Hong, X" uniqKey="Hong X">X Hong</name>
</author>
<author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name>
</author>
<author><name sortKey="Ju, X" uniqKey="Ju X">X Ju</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nencioni, L" uniqKey="Nencioni L">L Nencioni</name>
</author>
<author><name sortKey="De Chiara, G" uniqKey="De Chiara G">G De Chiara</name>
</author>
<author><name sortKey="Sgarbanti, R" uniqKey="Sgarbanti R">R Sgarbanti</name>
</author>
<author><name sortKey="Amatore, D" uniqKey="Amatore D">D Amatore</name>
</author>
<author><name sortKey="Aquilano, K" uniqKey="Aquilano K">K Aquilano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name>
</author>
<author><name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name>
</author>
<author><name sortKey="Ju, X" uniqKey="Ju X">X Ju</name>
</author>
<author><name sortKey="Zou, Z" uniqKey="Zou Z">Z Zou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sauerzapf, V" uniqKey="Sauerzapf V">V Sauerzapf</name>
</author>
<author><name sortKey="Jones, Ap" uniqKey="Jones A">AP Jones</name>
</author>
<author><name sortKey="Cross, J" uniqKey="Cross J">J Cross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Wong, Ck" uniqKey="Wong C">CK Wong</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
<author><name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name>
</author>
<author><name sortKey="Wong, Ry" uniqKey="Wong R">RY Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name>
</author>
<author><name sortKey="Li, Iw" uniqKey="Li I">IW Li</name>
</author>
<author><name sortKey="Lee, Kl" uniqKey="Lee K">KL Lee</name>
</author>
<author><name sortKey="Koo, Ck" uniqKey="Koo C">CK Koo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quispe Laime, Am" uniqKey="Quispe Laime A">AM Quispe-Laime</name>
</author>
<author><name sortKey="Bracco, Jd" uniqKey="Bracco J">JD Bracco</name>
</author>
<author><name sortKey="Barberio, Pa" uniqKey="Barberio P">PA Barberio</name>
</author>
<author><name sortKey="Campagne, Cg" uniqKey="Campagne C">CG Campagne</name>
</author>
<author><name sortKey="Rolfo, Ve" uniqKey="Rolfo V">VE Rolfo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brun Buisson, C" uniqKey="Brun Buisson C">C Brun-Buisson</name>
</author>
<author><name sortKey="Richard, Jc" uniqKey="Richard J">JC Richard</name>
</author>
<author><name sortKey="Mercat, A" uniqKey="Mercat A">A Mercat</name>
</author>
<author><name sortKey="Thiebaut, Ac" uniqKey="Thiebaut A">AC Thiebaut</name>
</author>
<author><name sortKey="Brochard, L" uniqKey="Brochard L">L Brochard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name>
</author>
<author><name sortKey="Hong, Sb" uniqKey="Hong S">SB Hong</name>
</author>
<author><name sortKey="Yun, Sc" uniqKey="Yun S">SC Yun</name>
</author>
<author><name sortKey="Choi, Wi" uniqKey="Choi W">WI Choi</name>
</author>
<author><name sortKey="Ahn, Jj" uniqKey="Ahn J">JJ Ahn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name>
</author>
<author><name sortKey="Liu, Kd" uniqKey="Liu K">KD Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Annane, D" uniqKey="Annane D">D Annane</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Salomon, R" uniqKey="Salomon R">R Salomon</name>
</author>
<author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mauad, T" uniqKey="Mauad T">T Mauad</name>
</author>
<author><name sortKey="Hajjar, La" uniqKey="Hajjar L">LA Hajjar</name>
</author>
<author><name sortKey="Callegari, Gd" uniqKey="Callegari G">GD Callegari</name>
</author>
<author><name sortKey="Da Silva, Lf" uniqKey="Da Silva L">LF da Silva</name>
</author>
<author><name sortKey="Schout, D" uniqKey="Schout D">D Schout</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin Loeches, I" uniqKey="Martin Loeches I">I Martin-Loeches</name>
</author>
<author><name sortKey="Lisboa, T" uniqKey="Lisboa T">T Lisboa</name>
</author>
<author><name sortKey="Rhodes, A" uniqKey="Rhodes A">A Rhodes</name>
</author>
<author><name sortKey="Moreno, Rp" uniqKey="Moreno R">RP Moreno</name>
</author>
<author><name sortKey="Silva, E" uniqKey="Silva E">E Silva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maines, Tr" uniqKey="Maines T">TR Maines</name>
</author>
<author><name sortKey="Jayaraman, A" uniqKey="Jayaraman A">A Jayaraman</name>
</author>
<author><name sortKey="Belser, Ja" uniqKey="Belser J">JA Belser</name>
</author>
<author><name sortKey="Wadford, Da" uniqKey="Wadford D">DA Wadford</name>
</author>
<author><name sortKey="Pappas, C" uniqKey="Pappas C">C Pappas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ye, J" uniqKey="Ye J">J Ye</name>
</author>
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</author>
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</author>
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</author>
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</author>
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</author>
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</author>
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</author>
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</author>
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</author>
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</author>
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</author>
<author><name sortKey="Moreno, Rp" uniqKey="Moreno R">RP Moreno</name>
</author>
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</author>
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</author>
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</author>
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<author><name sortKey="Zhao, Yan" sort="Zhao, Yan" uniqKey="Zhao Y" first="Yan" last="Zhao">Yan Zhao</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College; Tsinghua University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College; Tsinghua University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yan, Yiwu" sort="Yan, Yiwu" uniqKey="Yan Y" first="Yiwu" last="Yan">Yiwu Yan</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College; Tsinghua University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College; Tsinghua University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tang, Jun" sort="Tang, Jun" uniqKey="Tang J" first="Jun" last="Tang">Jun Tang</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College; Tsinghua University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College; Tsinghua University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name>
<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College; Tsinghua University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College; Tsinghua University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The 2009 influenza pandemic affected people in almost all countries in the world, especially in younger age groups. During this time, the debate over whether to use corticosteroid treatment in severe influenza H1N1 infections patients resurfaced and was disputed by clinicians. There is an urgent need for a susceptible animal model of 2009 H1N1 infection that can be used to evaluate the pathogenesis and the therapeutic effect of corticosteroid treatment during infection.</p>
</sec>
<sec><title>Methodology/Principal Findings</title>
<p>We intranasally inoculated two groups of C57BL/6 and BALB/c mice (using 4- or 6-to 8-week-old mice) to compare the pathogenesis of several different H1N1 strains in mice of different ages. Based on the results, a very susceptible 4-week-old C57BL/6 mouse model of Beijing 501 strain of 2009 H1N1 virus infection was established, showing significantly elevated lung edema and cytokine levels compared to controls. Using our established animal model, the cytokine production profile and lung histology were assessed at different times post-infection, revealing increased lung lesions in a time-dependent manner. In additional,the mice were also treated with dexamethasone, which significantly improved survival rate and lung lesions in infected mice compared to those in control mice. Our data showed that corticosteroid treatment ameliorated acute lung injury induced by the 2009 A/H1N1 virus in mice and suggested that corticosteroids are valid drugs for treating 2009 A/H1N1 infection.</p>
</sec>
<sec><title>Conclusions/Significance</title>
<p>Using the established, very susceptible 2009 Pandemic Influenza A (H1N1) mouse model, our studies indicate that corticosteroids are a potential therapeutic remedy that may address the increasing concerns over future 2009 A/H1N1pandemics.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="De Vries, Rp" uniqKey="De Vries R">RP de Vries</name>
</author>
<author><name sortKey="De Vries, E" uniqKey="De Vries E">E de Vries</name>
</author>
<author><name sortKey="Moore, Ks" uniqKey="Moore K">KS Moore</name>
</author>
<author><name sortKey="Rigter, A" uniqKey="Rigter A">A Rigter</name>
</author>
<author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Louie, Jk" uniqKey="Louie J">JK Louie</name>
</author>
<author><name sortKey="Acosta, M" uniqKey="Acosta M">M Acosta</name>
</author>
<author><name sortKey="Winter, K" uniqKey="Winter K">K Winter</name>
</author>
<author><name sortKey="Jean, C" uniqKey="Jean C">C Jean</name>
</author>
<author><name sortKey="Gavali, S" uniqKey="Gavali S">S Gavali</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Ashbaugh, Dg" uniqKey="Ashbaugh D">DG Ashbaugh</name>
</author>
<author><name sortKey="Bigelow, Db" uniqKey="Bigelow D">DB Bigelow</name>
</author>
<author><name sortKey="Petty, Tl" uniqKey="Petty T">TL Petty</name>
</author>
<author><name sortKey="Levine, Be" uniqKey="Levine B">BE Levine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name>
</author>
<author><name sortKey="Bertozzi, Sm" uniqKey="Bertozzi S">SM Bertozzi</name>
</author>
<author><name sortKey="Colchero, Ma" uniqKey="Colchero M">MA Colchero</name>
</author>
<author><name sortKey="Lopez Gatell, H" uniqKey="Lopez Gatell H">H Lopez-Gatell</name>
</author>
<author><name sortKey="Alpuche Aranda, C" uniqKey="Alpuche Aranda C">C Alpuche-Aranda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, N" uniqKey="Yang N">N Yang</name>
</author>
<author><name sortKey="Hong, X" uniqKey="Hong X">X Hong</name>
</author>
<author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name>
</author>
<author><name sortKey="Ju, X" uniqKey="Ju X">X Ju</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nencioni, L" uniqKey="Nencioni L">L Nencioni</name>
</author>
<author><name sortKey="De Chiara, G" uniqKey="De Chiara G">G De Chiara</name>
</author>
<author><name sortKey="Sgarbanti, R" uniqKey="Sgarbanti R">R Sgarbanti</name>
</author>
<author><name sortKey="Amatore, D" uniqKey="Amatore D">D Amatore</name>
</author>
<author><name sortKey="Aquilano, K" uniqKey="Aquilano K">K Aquilano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name>
</author>
<author><name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name>
</author>
<author><name sortKey="Ju, X" uniqKey="Ju X">X Ju</name>
</author>
<author><name sortKey="Zou, Z" uniqKey="Zou Z">Z Zou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sauerzapf, V" uniqKey="Sauerzapf V">V Sauerzapf</name>
</author>
<author><name sortKey="Jones, Ap" uniqKey="Jones A">AP Jones</name>
</author>
<author><name sortKey="Cross, J" uniqKey="Cross J">J Cross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Wong, Ck" uniqKey="Wong C">CK Wong</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
<author><name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name>
</author>
<author><name sortKey="Wong, Ry" uniqKey="Wong R">RY Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name>
</author>
<author><name sortKey="Li, Iw" uniqKey="Li I">IW Li</name>
</author>
<author><name sortKey="Lee, Kl" uniqKey="Lee K">KL Lee</name>
</author>
<author><name sortKey="Koo, Ck" uniqKey="Koo C">CK Koo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quispe Laime, Am" uniqKey="Quispe Laime A">AM Quispe-Laime</name>
</author>
<author><name sortKey="Bracco, Jd" uniqKey="Bracco J">JD Bracco</name>
</author>
<author><name sortKey="Barberio, Pa" uniqKey="Barberio P">PA Barberio</name>
</author>
<author><name sortKey="Campagne, Cg" uniqKey="Campagne C">CG Campagne</name>
</author>
<author><name sortKey="Rolfo, Ve" uniqKey="Rolfo V">VE Rolfo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brun Buisson, C" uniqKey="Brun Buisson C">C Brun-Buisson</name>
</author>
<author><name sortKey="Richard, Jc" uniqKey="Richard J">JC Richard</name>
</author>
<author><name sortKey="Mercat, A" uniqKey="Mercat A">A Mercat</name>
</author>
<author><name sortKey="Thiebaut, Ac" uniqKey="Thiebaut A">AC Thiebaut</name>
</author>
<author><name sortKey="Brochard, L" uniqKey="Brochard L">L Brochard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name>
</author>
<author><name sortKey="Hong, Sb" uniqKey="Hong S">SB Hong</name>
</author>
<author><name sortKey="Yun, Sc" uniqKey="Yun S">SC Yun</name>
</author>
<author><name sortKey="Choi, Wi" uniqKey="Choi W">WI Choi</name>
</author>
<author><name sortKey="Ahn, Jj" uniqKey="Ahn J">JJ Ahn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name>
</author>
<author><name sortKey="Liu, Kd" uniqKey="Liu K">KD Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Annane, D" uniqKey="Annane D">D Annane</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Salomon, R" uniqKey="Salomon R">R Salomon</name>
</author>
<author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mauad, T" uniqKey="Mauad T">T Mauad</name>
</author>
<author><name sortKey="Hajjar, La" uniqKey="Hajjar L">LA Hajjar</name>
</author>
<author><name sortKey="Callegari, Gd" uniqKey="Callegari G">GD Callegari</name>
</author>
<author><name sortKey="Da Silva, Lf" uniqKey="Da Silva L">LF da Silva</name>
</author>
<author><name sortKey="Schout, D" uniqKey="Schout D">D Schout</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin Loeches, I" uniqKey="Martin Loeches I">I Martin-Loeches</name>
</author>
<author><name sortKey="Lisboa, T" uniqKey="Lisboa T">T Lisboa</name>
</author>
<author><name sortKey="Rhodes, A" uniqKey="Rhodes A">A Rhodes</name>
</author>
<author><name sortKey="Moreno, Rp" uniqKey="Moreno R">RP Moreno</name>
</author>
<author><name sortKey="Silva, E" uniqKey="Silva E">E Silva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maines, Tr" uniqKey="Maines T">TR Maines</name>
</author>
<author><name sortKey="Jayaraman, A" uniqKey="Jayaraman A">A Jayaraman</name>
</author>
<author><name sortKey="Belser, Ja" uniqKey="Belser J">JA Belser</name>
</author>
<author><name sortKey="Wadford, Da" uniqKey="Wadford D">DA Wadford</name>
</author>
<author><name sortKey="Pappas, C" uniqKey="Pappas C">C Pappas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ye, J" uniqKey="Ye J">J Ye</name>
</author>
<author><name sortKey="Sorrell, Em" uniqKey="Sorrell E">EM Sorrell</name>
</author>
<author><name sortKey="Cai, Y" uniqKey="Cai Y">Y Cai</name>
</author>
<author><name sortKey="Shao, H" uniqKey="Shao H">H Shao</name>
</author>
<author><name sortKey="Xu, K" uniqKey="Xu K">K Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Sun, H" uniqKey="Sun H">H Sun</name>
</author>
<author><name sortKey="Fan, L" uniqKey="Fan L">L Fan</name>
</author>
<author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name>
</author>
<author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Zhang, Aj" uniqKey="Zhang A">AJ Zhang</name>
</author>
<author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Chan, Cc" uniqKey="Chan C">CC Chan</name>
</author>
<author><name sortKey="Poon, Vk" uniqKey="Poon V">VK Poon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hagau, N" uniqKey="Hagau N">N Hagau</name>
</author>
<author><name sortKey="Slavcovici, A" uniqKey="Slavcovici A">A Slavcovici</name>
</author>
<author><name sortKey="Gonganau, Dn" uniqKey="Gonganau D">DN Gonganau</name>
</author>
<author><name sortKey="Oltean, S" uniqKey="Oltean S">S Oltean</name>
</author>
<author><name sortKey="Dirzu, Ds" uniqKey="Dirzu D">DS Dirzu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adcock, Im" uniqKey="Adcock I">IM Adcock</name>
</author>
<author><name sortKey="Caramori, G" uniqKey="Caramori G">G Caramori</name>
</author>
<author><name sortKey="Ito, K" uniqKey="Ito K">K Ito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bautista, E" uniqKey="Bautista E">E Bautista</name>
</author>
<author><name sortKey="Chotpitayasunondh, T" uniqKey="Chotpitayasunondh T">T Chotpitayasunondh</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name>
</author>
<author><name sortKey="Harper, Sa" uniqKey="Harper S">SA Harper</name>
</author>
<author><name sortKey="Shaw, M" uniqKey="Shaw M">M Shaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin Loeches, I" uniqKey="Martin Loeches I">I Martin-Loeches</name>
</author>
<author><name sortKey="Lisboa, T" uniqKey="Lisboa T">T Lisboa</name>
</author>
<author><name sortKey="Rhodes, A" uniqKey="Rhodes A">A Rhodes</name>
</author>
<author><name sortKey="Moreno, Rp" uniqKey="Moreno R">RP Moreno</name>
</author>
<author><name sortKey="Silva, E" uniqKey="Silva E">E Silva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Confalonieri, M" uniqKey="Confalonieri M">M Confalonieri</name>
</author>
<author><name sortKey="D Garo, P" uniqKey="D Garo P">P D’Agaro</name>
</author>
<author><name sortKey="Campello, C" uniqKey="Campello C">C Campello</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Corticosteroid treatment ameliorates acute lung injury induced by 2009 swine origin influenza A (H1N1) virus in mice.</title>
<author><name sortKey="Li, Chenggang" sort="Li, Chenggang" uniqKey="Li C" first="Chenggang" last="Li">Chenggang Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College, Tsinghua University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College, Tsinghua University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Penghui" sort="Yang, Penghui" uniqKey="Yang P" first="Penghui" last="Yang">Penghui Yang</name>
</author>
<author><name sortKey="Zhang, Yanli" sort="Zhang, Yanli" uniqKey="Zhang Y" first="Yanli" last="Zhang">Yanli Zhang</name>
</author>
<author><name sortKey="Sun, Yang" sort="Sun, Yang" uniqKey="Sun Y" first="Yang" last="Sun">Yang Sun</name>
</author>
<author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
</author>
<author><name sortKey="Zou, Zhen" sort="Zou, Zhen" uniqKey="Zou Z" first="Zhen" last="Zou">Zhen Zou</name>
</author>
<author><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name>
</author>
<author><name sortKey="Chen, Zhongwei" sort="Chen, Zhongwei" uniqKey="Chen Z" first="Zhongwei" last="Chen">Zhongwei Chen</name>
</author>
<author><name sortKey="Tang, Chong" sort="Tang, Chong" uniqKey="Tang C" first="Chong" last="Tang">Chong Tang</name>
</author>
<author><name sortKey="Guo, Feng" sort="Guo, Feng" uniqKey="Guo F" first="Feng" last="Guo">Feng Guo</name>
</author>
<author><name sortKey="Deng, Jiejie" sort="Deng, Jiejie" uniqKey="Deng J" first="Jiejie" last="Deng">Jiejie Deng</name>
</author>
<author><name sortKey="Zhao, Yan" sort="Zhao, Yan" uniqKey="Zhao Y" first="Yan" last="Zhao">Yan Zhao</name>
</author>
<author><name sortKey="Yan, Yiwu" sort="Yan, Yiwu" uniqKey="Yan Y" first="Yiwu" last="Yan">Yiwu Yan</name>
</author>
<author><name sortKey="Tang, Jun" sort="Tang, Jun" uniqKey="Tang J" first="Jun" last="Tang">Jun Tang</name>
</author>
<author><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name>
</author>
<author><name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="RBID">pubmed:22952892</idno>
<idno type="pmid">22952892</idno>
<idno type="doi">10.1371/journal.pone.0044110</idno>
<idno type="wicri:Area/PubMed/Corpus">000C11</idno>
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<idno type="wicri:Area/PubMed/Checkpoint">000D15</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D15</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Corticosteroid treatment ameliorates acute lung injury induced by 2009 swine origin influenza A (H1N1) virus in mice.</title>
<author><name sortKey="Li, Chenggang" sort="Li, Chenggang" uniqKey="Li C" first="Chenggang" last="Li">Chenggang Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College, Tsinghua University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College, Tsinghua University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Penghui" sort="Yang, Penghui" uniqKey="Yang P" first="Penghui" last="Yang">Penghui Yang</name>
</author>
<author><name sortKey="Zhang, Yanli" sort="Zhang, Yanli" uniqKey="Zhang Y" first="Yanli" last="Zhang">Yanli Zhang</name>
</author>
<author><name sortKey="Sun, Yang" sort="Sun, Yang" uniqKey="Sun Y" first="Yang" last="Sun">Yang Sun</name>
</author>
<author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
</author>
<author><name sortKey="Zou, Zhen" sort="Zou, Zhen" uniqKey="Zou Z" first="Zhen" last="Zou">Zhen Zou</name>
</author>
<author><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name>
</author>
<author><name sortKey="Chen, Zhongwei" sort="Chen, Zhongwei" uniqKey="Chen Z" first="Zhongwei" last="Chen">Zhongwei Chen</name>
</author>
<author><name sortKey="Tang, Chong" sort="Tang, Chong" uniqKey="Tang C" first="Chong" last="Tang">Chong Tang</name>
</author>
<author><name sortKey="Guo, Feng" sort="Guo, Feng" uniqKey="Guo F" first="Feng" last="Guo">Feng Guo</name>
</author>
<author><name sortKey="Deng, Jiejie" sort="Deng, Jiejie" uniqKey="Deng J" first="Jiejie" last="Deng">Jiejie Deng</name>
</author>
<author><name sortKey="Zhao, Yan" sort="Zhao, Yan" uniqKey="Zhao Y" first="Yan" last="Zhao">Yan Zhao</name>
</author>
<author><name sortKey="Yan, Yiwu" sort="Yan, Yiwu" uniqKey="Yan Y" first="Yiwu" last="Yan">Yiwu Yan</name>
</author>
<author><name sortKey="Tang, Jun" sort="Tang, Jun" uniqKey="Tang J" first="Jun" last="Tang">Jun Tang</name>
</author>
<author><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name>
</author>
<author><name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name>
</author>
</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012" type="published">2012</date>
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<term>Mice, Inbred BALB C</term>
<term>Mice, Inbred C57BL</term>
<term>Orthomyxoviridae Infections (drug therapy)</term>
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<term>Cytokines (métabolisme)</term>
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<term>Dexaméthasone (pharmacologie)</term>
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<term>Modèles animaux de maladie humaine</term>
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<front><div type="abstract" xml:lang="en">The 2009 influenza pandemic affected people in almost all countries in the world, especially in younger age groups. During this time, the debate over whether to use corticosteroid treatment in severe influenza H1N1 infections patients resurfaced and was disputed by clinicians. There is an urgent need for a susceptible animal model of 2009 H1N1 infection that can be used to evaluate the pathogenesis and the therapeutic effect of corticosteroid treatment during infection.</div>
</front>
</TEI>
</pubmed>
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