Corticosteroid treatment ameliorates acute lung injury induced by 2009 swine origin influenza A (H1N1) virus in mice.
Identifieur interne : 000C11 ( PubMed/Curation ); précédent : 000C10; suivant : 000C12Corticosteroid treatment ameliorates acute lung injury induced by 2009 swine origin influenza A (H1N1) virus in mice.
Auteurs : Chenggang Li [République populaire de Chine] ; Penghui Yang ; Yanli Zhang ; Yang Sun ; Wei Wang ; Zhen Zou ; Li Xing ; Zhongwei Chen ; Chong Tang ; Feng Guo ; Jiejie Deng ; Yan Zhao ; Yiwu Yan ; Jun Tang ; Xiliang Wang ; Chengyu JiangSource :
- PloS one [ 1932-6203 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Cytokines (métabolisme), Dexaméthasone (administration et posologie), Dexaméthasone (pharmacologie), Dexaméthasone (usage thérapeutique), Hormones corticosurrénaliennes (administration et posologie), Hormones corticosurrénaliennes (pharmacologie), Hormones corticosurrénaliennes (usage thérapeutique), Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (traitement médicamenteux), Infections à Orthomyxoviridae (virologie), Inflammation (), Inflammation (anatomopathologie), Inflammation (virologie), Lésion pulmonaire aigüe (anatomopathologie), Lésion pulmonaire aigüe (immunologie), Lésion pulmonaire aigüe (traitement médicamenteux), Lésion pulmonaire aigüe (virologie), Modèles animaux de maladie humaine, Sevrage, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (physiologie), Sus scrofa (virologie).
- MESH :
- administration et posologie : Dexaméthasone, Hormones corticosurrénaliennes.
- anatomopathologie : Infections à Orthomyxoviridae, Inflammation, Lésion pulmonaire aigüe.
- immunologie : Infections à Orthomyxoviridae, Lésion pulmonaire aigüe.
- métabolisme : Cytokines.
- pharmacologie : Dexaméthasone, Hormones corticosurrénaliennes.
- physiologie : Sous-type H1N1 du virus de la grippe A.
- traitement médicamenteux : Infections à Orthomyxoviridae, Lésion pulmonaire aigüe.
- usage thérapeutique : Dexaméthasone, Hormones corticosurrénaliennes.
- virologie : Infections à Orthomyxoviridae, Inflammation, Lésion pulmonaire aigüe, Sus scrofa.
- Animaux, Inflammation, Modèles animaux de maladie humaine, Sevrage, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A.
English descriptors
- KwdEn :
- Acute Lung Injury (drug therapy), Acute Lung Injury (immunology), Acute Lung Injury (pathology), Acute Lung Injury (virology), Adrenal Cortex Hormones (administration & dosage), Adrenal Cortex Hormones (pharmacology), Adrenal Cortex Hormones (therapeutic use), Animals, Cytokines (metabolism), Dexamethasone (administration & dosage), Dexamethasone (pharmacology), Dexamethasone (therapeutic use), Disease Models, Animal, Inflammation (complications), Inflammation (pathology), Inflammation (virology), Influenza A Virus, H1N1 Subtype (drug effects), Influenza A Virus, H1N1 Subtype (physiology), Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Orthomyxoviridae Infections (drug therapy), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (virology), Sus scrofa (virology), Weaning.
- MESH :
- chemical , administration & dosage : Adrenal Cortex Hormones, Dexamethasone.
- complications : Inflammation.
- drug effects : Influenza A Virus, H1N1 Subtype.
- drug therapy : Acute Lung Injury, Orthomyxoviridae Infections.
- immunology : Acute Lung Injury, Orthomyxoviridae Infections.
- chemical , metabolism : Cytokines.
- pathology : Acute Lung Injury, Inflammation, Orthomyxoviridae Infections.
- chemical , pharmacology : Adrenal Cortex Hormones, Dexamethasone.
- physiology : Influenza A Virus, H1N1 Subtype.
- chemical , therapeutic use : Adrenal Cortex Hormones, Dexamethasone.
- virology : Acute Lung Injury, Inflammation, Orthomyxoviridae Infections, Sus scrofa.
- Animals, Disease Models, Animal, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Weaning.
Abstract
The 2009 influenza pandemic affected people in almost all countries in the world, especially in younger age groups. During this time, the debate over whether to use corticosteroid treatment in severe influenza H1N1 infections patients resurfaced and was disputed by clinicians. There is an urgent need for a susceptible animal model of 2009 H1N1 infection that can be used to evaluate the pathogenesis and the therapeutic effect of corticosteroid treatment during infection.
DOI: 10.1371/journal.pone.0044110
PubMed: 22952892
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C</term><term>Mice, Inbred C57BL</term><term>Orthomyxoviridae Infections (drug therapy)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (pathology)</term><term>Orthomyxoviridae Infections (virology)</term><term>Sus scrofa (virology)</term><term>Weaning</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cytokines (métabolisme)</term><term>Dexaméthasone (administration et posologie)</term><term>Dexaméthasone (pharmacologie)</term><term>Dexaméthasone (usage thérapeutique)</term><term>Hormones corticosurrénaliennes (administration et posologie)</term><term>Hormones corticosurrénaliennes (pharmacologie)</term><term>Hormones corticosurrénaliennes (usage thérapeutique)</term><term>Infections à Orthomyxoviridae (anatomopathologie)</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (traitement médicamenteux)</term><term>Infections à Orthomyxoviridae 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BALB C</term><term>Souris de lignée C57BL</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The 2009 influenza pandemic affected people in almost all countries in the world, especially in younger age groups. During this time, the debate over whether to use corticosteroid treatment in severe influenza H1N1 infections patients resurfaced and was disputed by clinicians. There is an urgent need for a susceptible animal model of 2009 H1N1 infection that can be used to evaluate the pathogenesis and the therapeutic effect of corticosteroid treatment during infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22952892</PMID><DateCompleted><Year>2013</Year><Month>02</Month><Day>07</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>8</Issue><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Corticosteroid treatment ameliorates acute lung injury induced by 2009 swine origin influenza A (H1N1) virus in mice.</ArticleTitle><Pagination><MedlinePgn>e44110</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0044110</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The 2009 influenza pandemic affected people in almost all countries in the world, especially in younger age groups. During this time, the debate over whether to use corticosteroid treatment in severe influenza H1N1 infections patients resurfaced and was disputed by clinicians. There is an urgent need for a susceptible animal model of 2009 H1N1 infection that can be used to evaluate the pathogenesis and the therapeutic effect of corticosteroid treatment during infection.</AbstractText><AbstractText Label="METHODOLOGY/PRINCIPAL FINDINGS" NlmCategory="RESULTS">We intranasally inoculated two groups of C57BL/6 and BALB/c mice (using 4- or 6-to 8-week-old mice) to compare the pathogenesis of several different H1N1 strains in mice of different ages. Based on the results, a very susceptible 4-week-old C57BL/6 mouse model of Beijing 501 strain of 2009 H1N1 virus infection was established, showing significantly elevated lung edema and cytokine levels compared to controls. Using our established animal model, the cytokine production profile and lung histology were assessed at different times post-infection, revealing increased lung lesions in a time-dependent manner. In additional,the mice were also treated with dexamethasone, which significantly improved survival rate and lung lesions in infected mice compared to those in control mice. Our data showed that corticosteroid treatment ameliorated acute lung injury induced by the 2009 A/H1N1 virus in mice and suggested that corticosteroids are valid drugs for treating 2009 A/H1N1 infection.</AbstractText><AbstractText Label="CONCLUSIONS/SIGNIFICANCE" NlmCategory="CONCLUSIONS">Using the established, very susceptible 2009 Pandemic Influenza A (H1N1) mouse model, our studies indicate that corticosteroids are a potential therapeutic remedy that may address the increasing concerns over future 2009 A/H1N1 pandemics.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Chenggang</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College, Tsinghua University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Penghui</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yanli</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Yang</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Wei</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Zou</LastName><ForeName>Zhen</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Xing</LastName><ForeName>Li</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Zhongwei</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Chong</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Feng</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Jiejie</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Yan</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Yiwu</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Jun</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xiliang</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Chengyu</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>08</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>7S5I7G3JQL</RegistryNumber><NameOfSubstance UI="D003907">Dexamethasone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D055371" MajorTopicYN="N">Acute Lung Injury</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000305" MajorTopicYN="N">Adrenal Cortex Hormones</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003907" MajorTopicYN="N">Dexamethasone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, 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MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D034421" MajorTopicYN="N">Sus scrofa</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014886" MajorTopicYN="N">Weaning</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>03</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>07</Month><Day>30</Day></PubMedPubDate><PubMedPubDate 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