PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments
Identifieur interne : 001325 ( Ncbi/Merge ); précédent : 001324; suivant : 001326PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments
Auteurs : David S. Deluca [États-Unis] ; Derin B. Keskin [États-Unis] ; Guang Lan Zhang [États-Unis] ; Ellis L. Reinherz [États-Unis] ; Vladimir Brusic [États-Unis]Source :
- BMC Bioinformatics [ 1471-2105 ] ; 2011.
Descripteurs français
- KwdFr :
- Algorithmes, Analyse de séquence d'ARN, Facteurs de virulence (génétique), Grippe humaine (virologie), Humains, Protéines virales (génétique), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (pathogénicité), Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité).
- MESH :
- génétique : Facteurs de virulence, Protéines virales, Sous-type H1N1 du virus de la grippe A, Virus de la grippe A.
- pathogénicité : Sous-type H1N1 du virus de la grippe A, Virus de la grippe A.
- virologie : Grippe humaine.
- Algorithmes, Analyse de séquence d'ARN, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Viral Proteins, Virulence Factors.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A virus.
- pathogenicity : Influenza A Virus, H1N1 Subtype, Influenza A virus.
- virology : Influenza, Human.
- Algorithms, Humans, Sequence Analysis, RNA.
Abstract
PB1-F2 is a major virulence factor of influenza A. This protein is a product of an alternative reading frame in the PB1-encoding RNA segment 2. Its presence of is dictated by the presence or absence of premature stop codons. This virulence factor is present in every influenza pandemic and major epidemic of the 20th century. Absence of PB1-F2 is associated with mild disease, such as the 2009 H1N1 (“swine flu”).
The analysis of 8608 segment 2 sequences showed that only 8.5% have been annotated for the presence of PB1-F2. Our analysis indicates that 75% of segment 2 sequences are likely to encode PB1-F2. Two major populations of PB1-F2 are of lengths 90 and 57 while minor populations include lengths 52, 63, 79, 81, 87, and 101. Additional possible populations include the lengths of 59, 69, 81, 95, and 106. Previously described sequences include only lengths 57, 87, and 90. We observed substantial variation in PB1-F2 sequences where certain variants show up to 35% difference to well-defined reference sequences. Therefore this dataset indicates that there are many more variants that need to be functionally characterized.
Our web-accessible tool PB1-F2 Finder enables scanning of influenza sequences for potential PB1-F2 protein products. It provides an initial screen and annotation of PB1-F2 products. It is accessible at
Url:
DOI: 10.1186/1471-2105-12-S13-S6
PubMed: 22373288
PubMed Central: 3278846
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Links to Exploration step
PMC:3278846Le document en format XML
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Deluca</name><affiliation wicri:level="2"><nlm:aff id="I1">Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I2">Broad Institute, 301 Binney Street, Cambridge, MA 02142, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute, 301 Binney Street, Cambridge, MA 02142</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Keskin, Derin B" sort="Keskin, Derin B" uniqKey="Keskin D" first="Derin B" last="Keskin">Derin B. 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This protein is a product of an alternative reading frame in the PB1-encoding RNA segment 2. Its presence of is dictated by the presence or absence of premature stop codons. This virulence factor is present in every influenza pandemic and major epidemic of the 20th century. Absence of PB1-F2 is associated with mild disease, such as the 2009 H1N1 (“swine flu”).</p></sec><sec><title>Results</title><p>The analysis of 8608 segment 2 sequences showed that only 8.5% have been annotated for the presence of PB1-F2. Our analysis indicates that 75% of segment 2 sequences are likely to encode PB1-F2. Two major populations of PB1-F2 are of lengths 90 and 57 while minor populations include lengths 52, 63, 79, 81, 87, and 101. Additional possible populations include the lengths of 59, 69, 81, 95, and 106. Previously described sequences include only lengths 57, 87, and 90. We observed substantial variation in PB1-F2 sequences where certain variants show up to 35% difference to well-defined reference sequences. Therefore this dataset indicates that there are many more variants that need to be functionally characterized.</p></sec><sec><title>Conclusions</title><p>Our web-accessible tool PB1-F2 Finder enables scanning of influenza sequences for potential PB1-F2 protein products. It provides an initial screen and annotation of PB1-F2 products. It is accessible at <ext-link ext-link-type="uri" xlink:href="http://cvc.dfci.harvard.edu/pb1-f2">http://cvc.dfci.harvard.edu/pb1-f2</ext-link>.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author><author><name sortKey="Calvo, Pa" uniqKey="Calvo P">PA Calvo</name></author><author><name sortKey="Malide, D" uniqKey="Malide D">D Malide</name></author><author><name sortKey="Gibbs, J" uniqKey="Gibbs J">J Gibbs</name></author><author><name sortKey="Schubert, U" uniqKey="Schubert U">U Schubert</name></author><author><name sortKey="Bacik, I" uniqKey="Bacik I">I Bacik</name></author><author><name sortKey="Basta, S" uniqKey="Basta S">S Basta</name></author><author><name sortKey="O Neill, R" uniqKey="O Neill R">R O'Neill</name></author><author><name sortKey="Schickli, J" uniqKey="Schickli J">J Schickli</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author><author><name sortKey="Henklein, P" uniqKey="Henklein P">P Henklein</name></author><author><name sortKey="Bennink, Jr" uniqKey="Bennink J">JR Bennink</name></author><author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, Jr" uniqKey="Coleman J">JR Coleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamada, H" uniqKey="Yamada H">H Yamada</name></author><author><name sortKey="Chounan, R" uniqKey="Chounan R">R Chounan</name></author><author><name sortKey="Higashi, Y" uniqKey="Higashi Y">Y Higashi</name></author><author><name sortKey="Kurihara, N" uniqKey="Kurihara N">N Kurihara</name></author><author><name sortKey="Kido, H" uniqKey="Kido H">H Kido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zell, R" uniqKey="Zell R">R Zell</name></author><author><name sortKey="Krumbholz, A" uniqKey="Krumbholz A">A Krumbholz</name></author><author><name sortKey="Eitner, A" uniqKey="Eitner A">A Eitner</name></author><author><name sortKey="Krieg, R" uniqKey="Krieg R">R Krieg</name></author><author><name sortKey="Halbhuber, Kj" uniqKey="Halbhuber K">KJ Halbhuber</name></author><author><name sortKey="Wutzler, P" uniqKey="Wutzler P">P Wutzler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcauley, Jl" uniqKey="Mcauley J">JL McAuley</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K Zhang</name></author><author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bao, Y" uniqKey="Bao Y">Y Bao</name></author><author><name sortKey="Bolotov, P" uniqKey="Bolotov P">P Bolotov</name></author><author><name sortKey="Dernovoy, D" uniqKey="Dernovoy D">D Dernovoy</name></author><author><name sortKey="Kiryutin, B" uniqKey="Kiryutin B">B Kiryutin</name></author><author><name sortKey="Zaslavsky, L" uniqKey="Zaslavsky L">L Zaslavsky</name></author><author><name sortKey="Tatusova, T" uniqKey="Tatusova T">T Tatusova</name></author><author><name sortKey="Ostell, J" uniqKey="Ostell J">J Ostell</name></author><author><name sortKey="Lipman, D" uniqKey="Lipman D">D Lipman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noble, S" uniqKey="Noble S">S Noble</name></author><author><name sortKey="Dimmock, Nj" uniqKey="Dimmock N">NJ Dimmock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Hm" uniqKey="Kim H">HM Kim</name></author><author><name sortKey="Oh, Jh" uniqKey="Oh J">JH Oh</name></author><author><name sortKey="Seo, Sh" uniqKey="Seo S">SH Seo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heiny, At" uniqKey="Heiny A">AT Heiny</name></author><author><name sortKey="Miotto, O" uniqKey="Miotto O">O Miotto</name></author><author><name sortKey="Srinivasan, Kn" uniqKey="Srinivasan K">KN Srinivasan</name></author><author><name sortKey="Khan, Am" uniqKey="Khan A">AM Khan</name></author><author><name sortKey="Zhang, Gl" uniqKey="Zhang G">GL Zhang</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V Brusic</name></author><author><name sortKey="Tan, Tw" uniqKey="Tan T">TW Tan</name></author><author><name sortKey="August, Jt" uniqKey="August J">JT August</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="22373288"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments</title><author><name sortKey="Deluca, David S" sort="Deluca, David S" uniqKey="Deluca D" first="David S" last="Deluca">David S. Deluca</name><affiliation wicri:level="2"><nlm:aff id="I1">Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I2">Broad Institute, 301 Binney Street, Cambridge, MA 02142, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute, 301 Binney Street, Cambridge, MA 02142</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Keskin, Derin B" sort="Keskin, Derin B" uniqKey="Keskin D" first="Derin B" last="Keskin">Derin B. Keskin</name><affiliation wicri:level="2"><nlm:aff id="I1">Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zhang, Guang Lan" sort="Zhang, Guang Lan" uniqKey="Zhang G" first="Guang Lan" last="Zhang">Guang Lan Zhang</name><affiliation wicri:level="2"><nlm:aff id="I1">Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Reinherz, Ellis L" sort="Reinherz, Ellis L" uniqKey="Reinherz E" first="Ellis L" last="Reinherz">Ellis L. Reinherz</name><affiliation wicri:level="2"><nlm:aff id="I1">Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Brusic, Vladimir" sort="Brusic, Vladimir" uniqKey="Brusic V" first="Vladimir" last="Brusic">Vladimir Brusic</name><affiliation wicri:level="2"><nlm:aff id="I1">Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22373288</idno><idno type="pmc">3278846</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278846</idno><idno type="RBID">PMC:3278846</idno><idno type="doi">10.1186/1471-2105-12-S13-S6</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000918</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000918</idno><idno type="wicri:Area/Pmc/Curation">000918</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000918</idno><idno type="wicri:Area/Pmc/Checkpoint">000841</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000841</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments</title><author><name sortKey="Deluca, David S" sort="Deluca, David S" uniqKey="Deluca D" first="David S" last="Deluca">David S. Deluca</name><affiliation wicri:level="2"><nlm:aff id="I1">Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I2">Broad Institute, 301 Binney Street, Cambridge, MA 02142, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute, 301 Binney Street, Cambridge, MA 02142</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Keskin, Derin B" sort="Keskin, Derin B" uniqKey="Keskin D" first="Derin B" last="Keskin">Derin B. Keskin</name><affiliation wicri:level="2"><nlm:aff id="I1">Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zhang, Guang Lan" sort="Zhang, Guang Lan" uniqKey="Zhang G" first="Guang Lan" last="Zhang">Guang Lan Zhang</name><affiliation wicri:level="2"><nlm:aff id="I1">Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Reinherz, Ellis L" sort="Reinherz, Ellis L" uniqKey="Reinherz E" first="Ellis L" last="Reinherz">Ellis L. Reinherz</name><affiliation wicri:level="2"><nlm:aff id="I1">Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Brusic, Vladimir" sort="Brusic, Vladimir" uniqKey="Brusic V" first="Vladimir" last="Brusic">Vladimir Brusic</name><affiliation wicri:level="2"><nlm:aff id="I1">Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">BMC Bioinformatics</title><idno type="eISSN">1471-2105</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>PB1-F2 is a major virulence factor of influenza A. This protein is a product of an alternative reading frame in the PB1-encoding RNA segment 2. Its presence of is dictated by the presence or absence of premature stop codons. This virulence factor is present in every influenza pandemic and major epidemic of the 20th century. Absence of PB1-F2 is associated with mild disease, such as the 2009 H1N1 (“swine flu”).</p></sec><sec><title>Results</title><p>The analysis of 8608 segment 2 sequences showed that only 8.5% have been annotated for the presence of PB1-F2. Our analysis indicates that 75% of segment 2 sequences are likely to encode PB1-F2. Two major populations of PB1-F2 are of lengths 90 and 57 while minor populations include lengths 52, 63, 79, 81, 87, and 101. Additional possible populations include the lengths of 59, 69, 81, 95, and 106. Previously described sequences include only lengths 57, 87, and 90. We observed substantial variation in PB1-F2 sequences where certain variants show up to 35% difference to well-defined reference sequences. Therefore this dataset indicates that there are many more variants that need to be functionally characterized.</p></sec><sec><title>Conclusions</title><p>Our web-accessible tool PB1-F2 Finder enables scanning of influenza sequences for potential PB1-F2 protein products. It provides an initial screen and annotation of PB1-F2 products. It is accessible at <ext-link ext-link-type="uri" xlink:href="http://cvc.dfci.harvard.edu/pb1-f2">http://cvc.dfci.harvard.edu/pb1-f2</ext-link>.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author><author><name sortKey="Calvo, Pa" uniqKey="Calvo P">PA Calvo</name></author><author><name sortKey="Malide, D" uniqKey="Malide D">D Malide</name></author><author><name sortKey="Gibbs, J" uniqKey="Gibbs J">J Gibbs</name></author><author><name sortKey="Schubert, U" uniqKey="Schubert U">U Schubert</name></author><author><name sortKey="Bacik, I" uniqKey="Bacik I">I Bacik</name></author><author><name sortKey="Basta, S" uniqKey="Basta S">S Basta</name></author><author><name sortKey="O Neill, R" uniqKey="O Neill R">R O'Neill</name></author><author><name sortKey="Schickli, J" uniqKey="Schickli J">J Schickli</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author><author><name sortKey="Henklein, P" uniqKey="Henklein P">P Henklein</name></author><author><name sortKey="Bennink, Jr" uniqKey="Bennink J">JR Bennink</name></author><author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, Jr" uniqKey="Coleman J">JR Coleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamada, H" uniqKey="Yamada H">H Yamada</name></author><author><name sortKey="Chounan, R" uniqKey="Chounan R">R Chounan</name></author><author><name sortKey="Higashi, Y" uniqKey="Higashi Y">Y Higashi</name></author><author><name sortKey="Kurihara, N" uniqKey="Kurihara N">N Kurihara</name></author><author><name sortKey="Kido, H" uniqKey="Kido H">H Kido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zell, R" uniqKey="Zell R">R Zell</name></author><author><name sortKey="Krumbholz, A" uniqKey="Krumbholz A">A Krumbholz</name></author><author><name sortKey="Eitner, A" uniqKey="Eitner A">A Eitner</name></author><author><name sortKey="Krieg, R" uniqKey="Krieg R">R Krieg</name></author><author><name sortKey="Halbhuber, Kj" uniqKey="Halbhuber K">KJ Halbhuber</name></author><author><name sortKey="Wutzler, P" uniqKey="Wutzler P">P Wutzler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcauley, Jl" uniqKey="Mcauley J">JL McAuley</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K Zhang</name></author><author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bao, Y" uniqKey="Bao Y">Y Bao</name></author><author><name sortKey="Bolotov, P" uniqKey="Bolotov P">P Bolotov</name></author><author><name sortKey="Dernovoy, D" uniqKey="Dernovoy D">D Dernovoy</name></author><author><name sortKey="Kiryutin, B" uniqKey="Kiryutin B">B Kiryutin</name></author><author><name sortKey="Zaslavsky, L" uniqKey="Zaslavsky L">L Zaslavsky</name></author><author><name sortKey="Tatusova, T" uniqKey="Tatusova T">T Tatusova</name></author><author><name sortKey="Ostell, J" uniqKey="Ostell J">J Ostell</name></author><author><name sortKey="Lipman, D" uniqKey="Lipman D">D Lipman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noble, S" uniqKey="Noble S">S Noble</name></author><author><name sortKey="Dimmock, Nj" uniqKey="Dimmock N">NJ Dimmock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Hm" uniqKey="Kim H">HM Kim</name></author><author><name sortKey="Oh, Jh" uniqKey="Oh J">JH Oh</name></author><author><name sortKey="Seo, Sh" uniqKey="Seo S">SH Seo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heiny, At" uniqKey="Heiny A">AT Heiny</name></author><author><name sortKey="Miotto, O" uniqKey="Miotto O">O Miotto</name></author><author><name sortKey="Srinivasan, Kn" uniqKey="Srinivasan K">KN Srinivasan</name></author><author><name sortKey="Khan, Am" uniqKey="Khan A">AM Khan</name></author><author><name sortKey="Zhang, Gl" uniqKey="Zhang G">GL Zhang</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V Brusic</name></author><author><name sortKey="Tan, Tw" uniqKey="Tan T">TW Tan</name></author><author><name sortKey="August, Jt" uniqKey="August J">JT August</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.</title><author><name sortKey="Deluca, David S" sort="Deluca, David S" uniqKey="Deluca D" first="David S" last="Deluca">David S. Deluca</name><affiliation wicri:level="2"><nlm:affiliation>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Keskin, Derin B" sort="Keskin, Derin B" uniqKey="Keskin D" first="Derin B" last="Keskin">Derin B. Keskin</name></author><author><name sortKey="Zhang, Guang Lan" sort="Zhang, Guang Lan" uniqKey="Zhang G" first="Guang Lan" last="Zhang">Guang Lan Zhang</name></author><author><name sortKey="Reinherz, Ellis L" sort="Reinherz, Ellis L" uniqKey="Reinherz E" first="Ellis L" last="Reinherz">Ellis L. Reinherz</name></author><author><name sortKey="Brusic, Vladimir" sort="Brusic, Vladimir" uniqKey="Brusic V" first="Vladimir" last="Brusic">Vladimir Brusic</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:22373288</idno><idno type="pmid">22373288</idno><idno type="doi">10.1186/1471-2105-12-S13-S6</idno><idno type="wicri:Area/PubMed/Corpus">000D38</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D38</idno><idno type="wicri:Area/PubMed/Curation">000D38</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D38</idno><idno type="wicri:Area/PubMed/Checkpoint">000F00</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.</title><author><name sortKey="Deluca, David S" sort="Deluca, David S" uniqKey="Deluca D" first="David S" last="Deluca">David S. Deluca</name><affiliation wicri:level="2"><nlm:affiliation>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Keskin, Derin B" sort="Keskin, Derin B" uniqKey="Keskin D" first="Derin B" last="Keskin">Derin B. Keskin</name></author><author><name sortKey="Zhang, Guang Lan" sort="Zhang, Guang Lan" uniqKey="Zhang G" first="Guang Lan" last="Zhang">Guang Lan Zhang</name></author><author><name sortKey="Reinherz, Ellis L" sort="Reinherz, Ellis L" uniqKey="Reinherz E" first="Ellis L" last="Reinherz">Ellis L. Reinherz</name></author><author><name sortKey="Brusic, Vladimir" sort="Brusic, Vladimir" uniqKey="Brusic V" first="Vladimir" last="Brusic">Vladimir Brusic</name></author></analytic><series><title level="j">BMC bioinformatics</title><idno type="eISSN">1471-2105</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza, Human (virology)</term><term>Sequence Analysis, RNA</term><term>Viral Proteins (genetics)</term><term>Virulence Factors (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Algorithmes</term><term>Analyse de séquence d'ARN</term><term>Facteurs de virulence (génétique)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Protéines virales (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Proteins</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de virulence</term><term>Protéines virales</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Humans</term><term>Sequence Analysis, RNA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Algorithmes</term><term>Analyse de séquence d'ARN</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">PB1-F2 is a major virulence factor of influenza A. This protein is a product of an alternative reading frame in the PB1-encoding RNA segment 2. Its presence of is dictated by the presence or absence of premature stop codons. This virulence factor is present in every influenza pandemic and major epidemic of the 20th century. Absence of PB1-F2 is associated with mild disease, such as the 2009 H1N1 ("swine flu").</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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