PandemieGrippaleV1, PubMed, Curation, bibRecord, 000D38

PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.

Identifieur interne : 000D38 ( PubMed/Curation ); précédent : 000D37; suivant : 000D39

PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.

Auteurs : David S. Deluca [États-Unis] ; Derin B. Keskin ; Guang Lan Zhang ; Ellis L. Reinherz ; Vladimir Brusic

Source :

BMC bioinformatics [ 1471-2105 ] ; 2011.

RBID : pubmed:22373288

Descripteurs français

KwdFr :
- Algorithmes, Analyse de séquence d'ARN, Facteurs de virulence (génétique), Grippe humaine (virologie), Humains, Protéines virales (génétique), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (pathogénicité), Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité).
MESH :
- génétique : Facteurs de virulence, Protéines virales, Sous-type H1N1 du virus de la grippe A, Virus de la grippe A.
- pathogénicité : Sous-type H1N1 du virus de la grippe A, Virus de la grippe A.
- virologie : Grippe humaine.
- Algorithmes, Analyse de séquence d'ARN, Humains.

English descriptors

KwdEn :
- Algorithms, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza A virus (genetics), Influenza A virus (pathogenicity), Influenza, Human (virology), Sequence Analysis, RNA, Viral Proteins (genetics), Virulence Factors (genetics).
MESH :
- chemical , genetics : Viral Proteins, Virulence Factors.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A virus.
- pathogenicity : Influenza A Virus, H1N1 Subtype, Influenza A virus.
- virology : Influenza, Human.
- Algorithms, Humans, Sequence Analysis, RNA.

Abstract

PB1-F2 is a major virulence factor of influenza A. This protein is a product of an alternative reading frame in the PB1-encoding RNA segment 2. Its presence of is dictated by the presence or absence of premature stop codons. This virulence factor is present in every influenza pandemic and major epidemic of the 20th century. Absence of PB1-F2 is associated with mild disease, such as the 2009 H1N1 ("swine flu").

DOI: 10.1186/1471-2105-12-S13-S6
PubMed: 22373288

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pubmed:22373288

Le document en format XML

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<author><name sortKey="Deluca, David S" sort="Deluca, David S" uniqKey="Deluca D" first="David S" last="Deluca">David S. Deluca</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Keskin, Derin B" sort="Keskin, Derin B" uniqKey="Keskin D" first="Derin B" last="Keskin">Derin B. Keskin</name>
</author>
<author><name sortKey="Zhang, Guang Lan" sort="Zhang, Guang Lan" uniqKey="Zhang G" first="Guang Lan" last="Zhang">Guang Lan Zhang</name>
</author>
<author><name sortKey="Reinherz, Ellis L" sort="Reinherz, Ellis L" uniqKey="Reinherz E" first="Ellis L" last="Reinherz">Ellis L. Reinherz</name>
</author>
<author><name sortKey="Brusic, Vladimir" sort="Brusic, Vladimir" uniqKey="Brusic V" first="Vladimir" last="Brusic">Vladimir Brusic</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.</title>
<author><name sortKey="Deluca, David S" sort="Deluca, David S" uniqKey="Deluca D" first="David S" last="Deluca">David S. Deluca</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea>
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<author><name sortKey="Keskin, Derin B" sort="Keskin, Derin B" uniqKey="Keskin D" first="Derin B" last="Keskin">Derin B. Keskin</name>
</author>
<author><name sortKey="Zhang, Guang Lan" sort="Zhang, Guang Lan" uniqKey="Zhang G" first="Guang Lan" last="Zhang">Guang Lan Zhang</name>
</author>
<author><name sortKey="Reinherz, Ellis L" sort="Reinherz, Ellis L" uniqKey="Reinherz E" first="Ellis L" last="Reinherz">Ellis L. Reinherz</name>
</author>
<author><name sortKey="Brusic, Vladimir" sort="Brusic, Vladimir" uniqKey="Brusic V" first="Vladimir" last="Brusic">Vladimir Brusic</name>
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<series><title level="j">BMC bioinformatics</title>
<idno type="eISSN">1471-2105</idno>
<imprint><date when="2011" type="published">2011</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (pathogenicity)</term>
<term>Influenza, Human (virology)</term>
<term>Sequence Analysis, RNA</term>
<term>Viral Proteins (genetics)</term>
<term>Virulence Factors (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Algorithmes</term>
<term>Analyse de séquence d'ARN</term>
<term>Facteurs de virulence (génétique)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Protéines virales (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Proteins</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de virulence</term>
<term>Protéines virales</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Algorithms</term>
<term>Humans</term>
<term>Sequence Analysis, RNA</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Algorithmes</term>
<term>Analyse de séquence d'ARN</term>
<term>Humains</term>
</keywords>
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<front><div type="abstract" xml:lang="en">PB1-F2 is a major virulence factor of influenza A. This protein is a product of an alternative reading frame in the PB1-encoding RNA segment 2. Its presence of is dictated by the presence or absence of premature stop codons. This virulence factor is present in every influenza pandemic and major epidemic of the 20th century. Absence of PB1-F2 is associated with mild disease, such as the 2009 H1N1 ("swine flu").</div>
</front>
</TEI>
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<DateCompleted><Year>2012</Year>
<Month>08</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>01</Day>
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<JournalIssue CitedMedium="Internet"><Volume>12 Suppl 13</Volume>
<PubDate><Year>2011</Year>
</PubDate>
</JournalIssue>
<Title>BMC bioinformatics</Title>
<ISOAbbreviation>BMC Bioinformatics</ISOAbbreviation>
</Journal>
<ArticleTitle>PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.</ArticleTitle>
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<ELocationID EIdType="doi" ValidYN="Y">10.1186/1471-2105-12-S13-S6</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">PB1-F2 is a major virulence factor of influenza A. This protein is a product of an alternative reading frame in the PB1-encoding RNA segment 2. Its presence of is dictated by the presence or absence of premature stop codons. This virulence factor is present in every influenza pandemic and major epidemic of the 20th century. Absence of PB1-F2 is associated with mild disease, such as the 2009 H1N1 ("swine flu").</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The analysis of 8608 segment 2 sequences showed that only 8.5% have been annotated for the presence of PB1-F2. Our analysis indicates that 75% of segment 2 sequences are likely to encode PB1-F2. Two major populations of PB1-F2 are of lengths 90 and 57 while minor populations include lengths 52, 63, 79, 81, 87, and 101. Additional possible populations include the lengths of 59, 69, 81, 95, and 106. Previously described sequences include only lengths 57, 87, and 90. We observed substantial variation in PB1-F2 sequences where certain variants show up to 35% difference to well-defined reference sequences. Therefore this dataset indicates that there are many more variants that need to be functionally characterized.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our web-accessible tool PB1-F2 Finder enables scanning of influenza sequences for potential PB1-F2 protein products. It provides an initial screen and annotation of PB1-F2 products. It is accessible at http://cvc.dfci.harvard.edu/pb1-f2.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>DeLuca</LastName>
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<AffiliationInfo><Affiliation>Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Zhang</LastName>
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<Author ValidYN="Y"><LastName>Brusic</LastName>
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<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P30 AI060354</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
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<Grant><GrantID>U01 AI 90043</GrantID>
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PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.

PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki