Novel Influenza A (H1N1) infection vs. common Influenza-Like Illness: A prospective study
Identifieur interne : 001009 ( Ncbi/Merge ); précédent : 001008; suivant : 001010Novel Influenza A (H1N1) infection vs. common Influenza-Like Illness: A prospective study
Auteurs : Evangelos Voudoukis [Grèce] ; Apostolos Pappas [Grèce] ; Athanasios Panoutsopoulos [Grèce] ; Konstantinos Xynos [Grèce] ; Fotini Rozi [Grèce] ; Konstantina Giannakopoulou [Grèce] ; Maria Paulaki [Grèce] ; Euthimia Stofa [Grèce] ; Charalampos Seretis [Grèce] ; Emmanouil Lagoudianakis [Grèce] ; George Andrianopoulos [Grèce]Source :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research [ 1234-1010 ] ; 2011.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Sous-type H1N1 du virus de la grippe A.
- virologie : Grippe humaine.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Études prospectives.
English descriptors
- KwdEn :
- MESH :
- physiology : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adult, Female, Humans, Male, Middle Aged, Prospective Studies, Young Adult.
Abstract
On June 11th, 2009 the World Health Organization (WHO) declared the first influenza pandemic of the 21st century. Data regarding the clinical characteristics and course of this viral infectious disease are still being assessed. The aim of this study was to investigate and compare the possible differences in clinical course and outcome between H1N1-positive [H1N1(+)] and negative [H1N1(−)] patients.
This prospective study was conducted between July 2009 and January 2010 in a regional hospital in Greece. The study population consisted of 165 patients aged 14 years or older, with influenza-like illness (ILI) who, according to CDC recommendations, fulfilled the criteria for diagnostic influenza testing. Enrolled patients underwent a detailed diagnostic work-up. Infection by the H1N1 virus was diagnosed using real-time reverse transcriptase polymerase chain reaction, from pharyngeal swab specimens.
We identified 81 H1N1 (+) (49%) patients. Statistical analysis revealed that H1N1(+) patients were significantly younger (median age 27
The clinical characteristics of the new influenza virus appear to be mild and to resemble those of common influenza-like illnesses (ILI). The patients who tested positive for the H1N1 virus were younger and had an increased percentage of monocytes compared to the H1N1-negative patients.
Url:
DOI: 10.12659/MSM.881713
PubMed: 21455103
PubMed Central: 3539528
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PMC:3539528Le document en format XML
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<author><name sortKey="Panoutsopoulos, Athanasios" sort="Panoutsopoulos, Athanasios" uniqKey="Panoutsopoulos A" first="Athanasios" last="Panoutsopoulos">Athanasios Panoutsopoulos</name>
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<author><name sortKey="Giannakopoulou, Konstantina" sort="Giannakopoulou, Konstantina" uniqKey="Giannakopoulou K" first="Konstantina" last="Giannakopoulou">Konstantina Giannakopoulou</name>
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<author><name sortKey="Paulaki, Maria" sort="Paulaki, Maria" uniqKey="Paulaki M" first="Maria" last="Paulaki">Maria Paulaki</name>
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<author><name sortKey="Stofa, Euthimia" sort="Stofa, Euthimia" uniqKey="Stofa E" first="Euthimia" last="Stofa">Euthimia Stofa</name>
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<author><name sortKey="Seretis, Charalampos" sort="Seretis, Charalampos" uniqKey="Seretis C" first="Charalampos" last="Seretis">Charalampos Seretis</name>
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Department of Surgery, 401 Army General Hospital, Athens, Greece</nlm:aff>
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<author><name sortKey="Lagoudianakis, Emmanouil" sort="Lagoudianakis, Emmanouil" uniqKey="Lagoudianakis E" first="Emmanouil" last="Lagoudianakis">Emmanouil Lagoudianakis</name>
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Department of Surgery, 401 Army General Hospital, Athens, Greece</nlm:aff>
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<author><name sortKey="Andrianopoulos, George" sort="Andrianopoulos, George" uniqKey="Andrianopoulos G" first="George" last="Andrianopoulos">George Andrianopoulos</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (physiology)</term>
<term>Influenza, Human (virology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Sous-type H1N1 du virus de la grippe A (physiologie)</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<sec><title>Background</title>
<p>On June 11<sup>th</sup>
, 2009 the World Health Organization (WHO) declared the first influenza pandemic of the 21<sup>st</sup>
century. Data regarding the clinical characteristics and course of this viral infectious disease are still being assessed. The aim of this study was to investigate and compare the possible differences in clinical course and outcome between H1N1-positive [H1N1(+)] and negative [H1N1(−)] patients.</p>
</sec>
<sec><title>Material/Methods</title>
<p>This prospective study was conducted between July 2009 and January 2010 in a regional hospital in Greece. The study population consisted of 165 patients aged 14 years or older, with influenza-like illness (ILI) who, according to CDC recommendations, fulfilled the criteria for diagnostic influenza testing. Enrolled patients underwent a detailed diagnostic work-up. Infection by the H1N1 virus was diagnosed using real-time reverse transcriptase polymerase chain reaction, from pharyngeal swab specimens.</p>
</sec>
<sec><title>Results</title>
<p>We identified 81 H1N1 (+) (49%) patients. Statistical analysis revealed that H1N1(+) patients were significantly younger (median age 27 <italic>vs.</italic>
35 years, p<0.05), had a decreased white blood cell count (median 7.200 <italic>vs.</italic>
8.415, p<0.05) and an increased percentage of monocytes (55.6% <italic>vs.</italic>
27.4%, p<0.05) compared to the H1N1(−) patients. The clinical presentation at the emergency department, as well as the hospital admission and disease complication rate, were not significantly different between the 2 groups.</p>
</sec>
<sec><title>Conclusions</title>
<p>The clinical characteristics of the new influenza virus appear to be mild and to resemble those of common influenza-like illnesses (ILI). The patients who tested positive for the H1N1 virus were younger and had an increased percentage of monocytes compared to the H1N1-negative patients.</p>
</sec>
</div>
</front>
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<biblStruct><analytic><author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name>
</author>
<author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name>
</author>
</analytic>
</biblStruct>
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</author>
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</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giamarellos Bourboulis, Ej" uniqKey="Giamarellos Bourboulis E">EJ Giamarellos-Bourboulis</name>
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<author><name sortKey="Raftogiannis, M" uniqKey="Raftogiannis M">M Raftogiannis</name>
</author>
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</analytic>
</biblStruct>
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</analytic>
</biblStruct>
</listBibl>
</div1>
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</TEI>
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. common Influenza-Like Illness: A prospective study</title>
<author><name sortKey="Voudoukis, Evangelos" sort="Voudoukis, Evangelos" uniqKey="Voudoukis E" first="Evangelos" last="Voudoukis">Evangelos Voudoukis</name>
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</author>
<author><name sortKey="Pappas, Apostolos" sort="Pappas, Apostolos" uniqKey="Pappas A" first="Apostolos" last="Pappas">Apostolos Pappas</name>
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<country xml:lang="fr">Grèce</country>
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</author>
<author><name sortKey="Panoutsopoulos, Athanasios" sort="Panoutsopoulos, Athanasios" uniqKey="Panoutsopoulos A" first="Athanasios" last="Panoutsopoulos">Athanasios Panoutsopoulos</name>
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<country xml:lang="fr">Grèce</country>
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<author><name sortKey="Xynos, Konstantinos" sort="Xynos, Konstantinos" uniqKey="Xynos K" first="Konstantinos" last="Xynos">Konstantinos Xynos</name>
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<country xml:lang="fr">Grèce</country>
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<author><name sortKey="Rozi, Fotini" sort="Rozi, Fotini" uniqKey="Rozi F" first="Fotini" last="Rozi">Fotini Rozi</name>
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<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
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</author>
<author><name sortKey="Giannakopoulou, Konstantina" sort="Giannakopoulou, Konstantina" uniqKey="Giannakopoulou K" first="Konstantina" last="Giannakopoulou">Konstantina Giannakopoulou</name>
<affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-17-4-cr185">Department of Internal Medicine of General Hospital of Argos, Argos, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Paulaki, Maria" sort="Paulaki, Maria" uniqKey="Paulaki M" first="Maria" last="Paulaki">Maria Paulaki</name>
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<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
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</author>
<author><name sortKey="Stofa, Euthimia" sort="Stofa, Euthimia" uniqKey="Stofa E" first="Euthimia" last="Stofa">Euthimia Stofa</name>
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<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
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</author>
<author><name sortKey="Seretis, Charalampos" sort="Seretis, Charalampos" uniqKey="Seretis C" first="Charalampos" last="Seretis">Charalampos Seretis</name>
<affiliation wicri:level="3"><nlm:aff id="af2-medscimonit-17-4-cr185">2<sup>nd</sup>
Department of Surgery, 401 Army General Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
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<placeName><settlement type="city">Athènes</settlement>
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</affiliation>
</author>
<author><name sortKey="Lagoudianakis, Emmanouil" sort="Lagoudianakis, Emmanouil" uniqKey="Lagoudianakis E" first="Emmanouil" last="Lagoudianakis">Emmanouil Lagoudianakis</name>
<affiliation wicri:level="3"><nlm:aff id="af2-medscimonit-17-4-cr185">2<sup>nd</sup>
Department of Surgery, 401 Army General Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Department of Surgery, 401 Army General Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Andrianopoulos, George" sort="Andrianopoulos, George" uniqKey="Andrianopoulos G" first="George" last="Andrianopoulos">George Andrianopoulos</name>
<affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-17-4-cr185">Department of Internal Medicine of General Hospital of Argos, Argos, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Novel Influenza A (H1N1) infection <italic>vs</italic>
. common Influenza-Like Illness: A prospective study</title>
<author><name sortKey="Voudoukis, Evangelos" sort="Voudoukis, Evangelos" uniqKey="Voudoukis E" first="Evangelos" last="Voudoukis">Evangelos Voudoukis</name>
<affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-17-4-cr185">Department of Internal Medicine of General Hospital of Argos, Argos, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pappas, Apostolos" sort="Pappas, Apostolos" uniqKey="Pappas A" first="Apostolos" last="Pappas">Apostolos Pappas</name>
<affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-17-4-cr185">Department of Internal Medicine of General Hospital of Argos, Argos, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Panoutsopoulos, Athanasios" sort="Panoutsopoulos, Athanasios" uniqKey="Panoutsopoulos A" first="Athanasios" last="Panoutsopoulos">Athanasios Panoutsopoulos</name>
<affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-17-4-cr185">Department of Internal Medicine of General Hospital of Argos, Argos, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xynos, Konstantinos" sort="Xynos, Konstantinos" uniqKey="Xynos K" first="Konstantinos" last="Xynos">Konstantinos Xynos</name>
<affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-17-4-cr185">Department of Internal Medicine of General Hospital of Argos, Argos, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rozi, Fotini" sort="Rozi, Fotini" uniqKey="Rozi F" first="Fotini" last="Rozi">Fotini Rozi</name>
<affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-17-4-cr185">Department of Internal Medicine of General Hospital of Argos, Argos, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Giannakopoulou, Konstantina" sort="Giannakopoulou, Konstantina" uniqKey="Giannakopoulou K" first="Konstantina" last="Giannakopoulou">Konstantina Giannakopoulou</name>
<affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-17-4-cr185">Department of Internal Medicine of General Hospital of Argos, Argos, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Paulaki, Maria" sort="Paulaki, Maria" uniqKey="Paulaki M" first="Maria" last="Paulaki">Maria Paulaki</name>
<affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-17-4-cr185">Department of Internal Medicine of General Hospital of Argos, Argos, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stofa, Euthimia" sort="Stofa, Euthimia" uniqKey="Stofa E" first="Euthimia" last="Stofa">Euthimia Stofa</name>
<affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-17-4-cr185">Department of Internal Medicine of General Hospital of Argos, Argos, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seretis, Charalampos" sort="Seretis, Charalampos" uniqKey="Seretis C" first="Charalampos" last="Seretis">Charalampos Seretis</name>
<affiliation wicri:level="3"><nlm:aff id="af2-medscimonit-17-4-cr185">2<sup>nd</sup>
Department of Surgery, 401 Army General Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Department of Surgery, 401 Army General Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lagoudianakis, Emmanouil" sort="Lagoudianakis, Emmanouil" uniqKey="Lagoudianakis E" first="Emmanouil" last="Lagoudianakis">Emmanouil Lagoudianakis</name>
<affiliation wicri:level="3"><nlm:aff id="af2-medscimonit-17-4-cr185">2<sup>nd</sup>
Department of Surgery, 401 Army General Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Department of Surgery, 401 Army General Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Andrianopoulos, George" sort="Andrianopoulos, George" uniqKey="Andrianopoulos G" first="George" last="Andrianopoulos">George Andrianopoulos</name>
<affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-17-4-cr185">Department of Internal Medicine of General Hospital of Argos, Argos, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Medical Science Monitor : International Medical Journal of Experimental and Clinical Research</title>
<idno type="ISSN">1234-1010</idno>
<idno type="eISSN">1643-3750</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<sec><title>Background</title>
<p>On June 11<sup>th</sup>
, 2009 the World Health Organization (WHO) declared the first influenza pandemic of the 21<sup>st</sup>
century. Data regarding the clinical characteristics and course of this viral infectious disease are still being assessed. The aim of this study was to investigate and compare the possible differences in clinical course and outcome between H1N1-positive [H1N1(+)] and negative [H1N1(−)] patients.</p>
</sec>
<sec><title>Material/Methods</title>
<p>This prospective study was conducted between July 2009 and January 2010 in a regional hospital in Greece. The study population consisted of 165 patients aged 14 years or older, with influenza-like illness (ILI) who, according to CDC recommendations, fulfilled the criteria for diagnostic influenza testing. Enrolled patients underwent a detailed diagnostic work-up. Infection by the H1N1 virus was diagnosed using real-time reverse transcriptase polymerase chain reaction, from pharyngeal swab specimens.</p>
</sec>
<sec><title>Results</title>
<p>We identified 81 H1N1 (+) (49%) patients. Statistical analysis revealed that H1N1(+) patients were significantly younger (median age 27 <italic>vs.</italic>
35 years, p<0.05), had a decreased white blood cell count (median 7.200 <italic>vs.</italic>
8.415, p<0.05) and an increased percentage of monocytes (55.6% <italic>vs.</italic>
27.4%, p<0.05) compared to the H1N1(−) patients. The clinical presentation at the emergency department, as well as the hospital admission and disease complication rate, were not significantly different between the 2 groups.</p>
</sec>
<sec><title>Conclusions</title>
<p>The clinical characteristics of the new influenza virus appear to be mild and to resemble those of common influenza-like illnesses (ILI). The patients who tested positive for the H1N1 virus were younger and had an increased percentage of monocytes compared to the H1N1-negative patients.</p>
</sec>
</div>
</front>
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</analytic>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Novel influenza A (H1N1) infection vs. common influenza-like illness: a prospective study.</title>
<author><name sortKey="Voudoukis, Evangelos" sort="Voudoukis, Evangelos" uniqKey="Voudoukis E" first="Evangelos" last="Voudoukis">Evangelos Voudoukis</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine of General Hospital of Argos, Argos, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pappas, Apostolos" sort="Pappas, Apostolos" uniqKey="Pappas A" first="Apostolos" last="Pappas">Apostolos Pappas</name>
</author>
<author><name sortKey="Panoutsopoulos, Athanasios" sort="Panoutsopoulos, Athanasios" uniqKey="Panoutsopoulos A" first="Athanasios" last="Panoutsopoulos">Athanasios Panoutsopoulos</name>
</author>
<author><name sortKey="Xynos, Konstantinos" sort="Xynos, Konstantinos" uniqKey="Xynos K" first="Konstantinos" last="Xynos">Konstantinos Xynos</name>
</author>
<author><name sortKey="Rozi, Fotini" sort="Rozi, Fotini" uniqKey="Rozi F" first="Fotini" last="Rozi">Fotini Rozi</name>
</author>
<author><name sortKey="Giannakopoulou, Konstantina" sort="Giannakopoulou, Konstantina" uniqKey="Giannakopoulou K" first="Konstantina" last="Giannakopoulou">Konstantina Giannakopoulou</name>
</author>
<author><name sortKey="Paulaki, Maria" sort="Paulaki, Maria" uniqKey="Paulaki M" first="Maria" last="Paulaki">Maria Paulaki</name>
</author>
<author><name sortKey="Stofa, Euthimia" sort="Stofa, Euthimia" uniqKey="Stofa E" first="Euthimia" last="Stofa">Euthimia Stofa</name>
</author>
<author><name sortKey="Seretis, Charalampos" sort="Seretis, Charalampos" uniqKey="Seretis C" first="Charalampos" last="Seretis">Charalampos Seretis</name>
</author>
<author><name sortKey="Lagoudianakis, Emmanouil" sort="Lagoudianakis, Emmanouil" uniqKey="Lagoudianakis E" first="Emmanouil" last="Lagoudianakis">Emmanouil Lagoudianakis</name>
</author>
<author><name sortKey="Andrianopoulos, George" sort="Andrianopoulos, George" uniqKey="Andrianopoulos G" first="George" last="Andrianopoulos">George Andrianopoulos</name>
</author>
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<date when="2011">2011</date>
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<idno type="pmid">21455103</idno>
<idno type="doi">10.12659/msm.881713</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Novel influenza A (H1N1) infection vs. common influenza-like illness: a prospective study.</title>
<author><name sortKey="Voudoukis, Evangelos" sort="Voudoukis, Evangelos" uniqKey="Voudoukis E" first="Evangelos" last="Voudoukis">Evangelos Voudoukis</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine of General Hospital of Argos, Argos, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine of General Hospital of Argos, Argos</wicri:regionArea>
<wicri:noRegion>Argos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pappas, Apostolos" sort="Pappas, Apostolos" uniqKey="Pappas A" first="Apostolos" last="Pappas">Apostolos Pappas</name>
</author>
<author><name sortKey="Panoutsopoulos, Athanasios" sort="Panoutsopoulos, Athanasios" uniqKey="Panoutsopoulos A" first="Athanasios" last="Panoutsopoulos">Athanasios Panoutsopoulos</name>
</author>
<author><name sortKey="Xynos, Konstantinos" sort="Xynos, Konstantinos" uniqKey="Xynos K" first="Konstantinos" last="Xynos">Konstantinos Xynos</name>
</author>
<author><name sortKey="Rozi, Fotini" sort="Rozi, Fotini" uniqKey="Rozi F" first="Fotini" last="Rozi">Fotini Rozi</name>
</author>
<author><name sortKey="Giannakopoulou, Konstantina" sort="Giannakopoulou, Konstantina" uniqKey="Giannakopoulou K" first="Konstantina" last="Giannakopoulou">Konstantina Giannakopoulou</name>
</author>
<author><name sortKey="Paulaki, Maria" sort="Paulaki, Maria" uniqKey="Paulaki M" first="Maria" last="Paulaki">Maria Paulaki</name>
</author>
<author><name sortKey="Stofa, Euthimia" sort="Stofa, Euthimia" uniqKey="Stofa E" first="Euthimia" last="Stofa">Euthimia Stofa</name>
</author>
<author><name sortKey="Seretis, Charalampos" sort="Seretis, Charalampos" uniqKey="Seretis C" first="Charalampos" last="Seretis">Charalampos Seretis</name>
</author>
<author><name sortKey="Lagoudianakis, Emmanouil" sort="Lagoudianakis, Emmanouil" uniqKey="Lagoudianakis E" first="Emmanouil" last="Lagoudianakis">Emmanouil Lagoudianakis</name>
</author>
<author><name sortKey="Andrianopoulos, George" sort="Andrianopoulos, George" uniqKey="Andrianopoulos G" first="George" last="Andrianopoulos">George Andrianopoulos</name>
</author>
</analytic>
<series><title level="j">Medical science monitor : international medical journal of experimental and clinical research</title>
<idno type="eISSN">1643-3750</idno>
<imprint><date when="2011" type="published">2011</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (physiology)</term>
<term>Influenza, Human (virology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Sous-type H1N1 du virus de la grippe A (physiologie)</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Études prospectives</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">On June 11th, 2009 the World Health Organization (WHO) declared the first influenza pandemic of the 21st century. Data regarding the clinical characteristics and course of this viral infectious disease are still being assessed. The aim of this study was to investigate and compare the possible differences in clinical course and outcome between H1N1-positive [H1N1(+)] and negative [H1N1(-)] patients.</div>
</front>
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