Biochemistry and computer generated graph comparison of the structural and nonstructural proteins of spanish-1918 Influenza, pandemic-2009, and bird flu viruses.
Identifieur interne : 002001 ( Ncbi/Curation ); précédent : 002000; suivant : 002002Biochemistry and computer generated graph comparison of the structural and nonstructural proteins of spanish-1918 Influenza, pandemic-2009, and bird flu viruses.
Auteurs : Gusti Ngurah Mahardika [Indonésie] ; Nyoman I. Suartha [Indonésie] ; Gusti A Y. Kencana [Indonésie] ; Ida B K. Suardana [Indonésie] ; Wisnu W. Mahardika [Indonésie] ; Nyoman S. Budayanti [Indonésie]Source :
- Acta biochimica Polonica [ 1734-154X ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Grippe chez les oiseaux (), Grippe chez les oiseaux (virologie), Grippe chez les oiseaux (épidémiologie), Grippe humaine (), Grippe humaine (virologie), Grippe humaine (épidémiologie), Génome viral, Humains, Oiseaux, Pandémie de grippe de 1918-1919, Pandémies, Protéines virales (), Protéines virales (génétique), Simulation numérique, Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H5N1 du virus de la grippe A (génétique), Structure en hélice alpha, Transmission de maladie infectieuse, Vaccins antigrippaux.
- MESH :
- génétique : Protéines virales, Sous-type H1N1 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A.
- virologie : Grippe chez les oiseaux, Grippe humaine.
- épidémiologie : Grippe chez les oiseaux, Grippe humaine.
- Animaux, Grippe chez les oiseaux, Grippe humaine, Génome viral, Humains, Oiseaux, Pandémie de grippe de 1918-1919, Pandémies, Protéines virales, Simulation numérique, Structure en hélice alpha, Transmission de maladie infectieuse, Vaccins antigrippaux.
English descriptors
- KwdEn :
- Animals, Birds, Computer Simulation, Disease Transmission, Infectious, Genome, Viral, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (genetics), Influenza Pandemic, 1918-1919, Influenza Vaccines, Influenza in Birds (epidemiology), Influenza in Birds (prevention & control), Influenza in Birds (virology), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Influenza, Human (virology), Pandemics, Protein Conformation, alpha-Helical, Viral Proteins (chemistry), Viral Proteins (genetics).
- MESH :
- chemical , chemistry : Viral Proteins.
- chemical , genetics : Viral Proteins.
- chemical : Influenza Vaccines.
- epidemiology : Influenza in Birds, Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype.
- prevention & control : Influenza in Birds, Influenza, Human.
- virology : Influenza in Birds, Influenza, Human.
- Animals, Birds, Computer Simulation, Disease Transmission, Infectious, Genome, Viral, Humans, Influenza Pandemic, 1918-1919, Pandemics, Protein Conformation, alpha-Helical.
Abstract
The potential emergence of deadly pandemic influenza viruses is unpredictable and most have emerged with no forewarning. The distinct epidemiological and pathological patterns of the Spanish (H1N1), pandemic-2009 (H1N1), and avian influenza (H5N1), known as bird flu, viruses may allow us to develop a 'template' for possible emergence of devastating pandemic strains. Here, we provide a detailed molecular dissection of the structural and nonstructural proteins of this triad of viruses. GenBank data for three representative strains were analyzed to determine the polymorphic amino acids, genetic distances, and isoelectric points, hydrophobicity plot, and protein modeling of various proteins. We propose that the most devastating pandemic strains may have full-length PB1-F2 protein with unique residues, highly cleavable HA, and a basic NS1. Any newly emerging strain should be compared with these three strains, so that resources can be directed appropriately.
DOI: 10.18388/abp.2019_2795
PubMed: 31531422
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The distinct epidemiological and pathological patterns of the Spanish (H1N1), pandemic-2009 (H1N1), and avian influenza (H5N1), known as bird flu, viruses may allow us to develop a 'template' for possible emergence of devastating pandemic strains. Here, we provide a detailed molecular dissection of the structural and nonstructural proteins of this triad of viruses. GenBank data for three representative strains were analyzed to determine the polymorphic amino acids, genetic distances, and isoelectric points, hydrophobicity plot, and protein modeling of various proteins. We propose that the most devastating pandemic strains may have full-length PB1-F2 protein with unique residues, highly cleavable HA, and a basic NS1. Any newly emerging strain should be compared with these three strains, so that resources can be directed appropriately.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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