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Biochemistry and computer generated graph comparison of the structural and nonstructural proteins of spanish-1918 Influenza, pandemic-2009, and bird flu viruses.

Identifieur interne : 000094 ( PubMed/Corpus ); précédent : 000093; suivant : 000095

Biochemistry and computer generated graph comparison of the structural and nonstructural proteins of spanish-1918 Influenza, pandemic-2009, and bird flu viruses.

Auteurs : Gusti Ngurah Mahardika ; Nyoman I. Suartha ; Gusti A Y. Kencana ; Ida B K. Suardana ; Wisnu W. Mahardika ; Nyoman S. Budayanti

Source :

RBID : pubmed:31531422

English descriptors

Abstract

The potential emergence of deadly pandemic influenza viruses is unpredictable and most have emerged with no forewarning. The distinct epidemiological and pathological patterns of the Spanish (H1N1), pandemic-2009 (H1N1), and avian influenza (H5N1), known as bird flu, viruses may allow us to develop a 'template' for possible emergence of devastating pandemic strains. Here, we provide a detailed molecular dissection of the structural and nonstructural proteins of this triad of viruses. GenBank data for three representative strains were analyzed to determine the polymorphic amino acids, genetic distances, and isoelectric points, hydrophobicity plot, and protein modeling of various proteins. We propose that the most devastating pandemic strains may have full-length PB1-F2 protein with unique residues, highly cleavable HA, and a basic NS1. Any newly emerging strain should be compared with these three strains, so that resources can be directed appropriately.

DOI: 10.18388/abp.2019_2795
PubMed: 31531422

Links to Exploration step

pubmed:31531422

Le document en format XML

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