Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic
Identifieur interne : 001871 ( Ncbi/Curation ); précédent : 001870; suivant : 001872Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic
Auteurs : Isabelle Magalhaes [Suède] ; Mikael Eriksson [Suède] ; Charlotte Linde [Suède] ; Rashid Muhammad [Suède] ; Lalit Rane [Suède] ; Aditya Ambati [Suède] ; Rebecca Axelsson-Robertson [Suède] ; Bahareh Khalaj [Suède] ; Nancy Alvarez-Corrales [Suède] ; Giulia Lapini [Italie] ; Emanuele Montomoli [Italie] ; Annika Linde [Suède] ; Nancy L. Pedersen [Suède] ; Markus Maeurer [Suède]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Femelle, Grippe humaine (immunologie), Grippe humaine (épidémiologie), Humains, Immunité cellulaire (immunologie), Immunité humorale (immunologie), Interféron gamma (métabolisme), Jeune adulte, Lymphocytes T (immunologie), Mâle, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H1N1 du virus de la grippe A (pathogénicité), Sujet âgé, Suède (épidémiologie), Vaccination, Vaccins antigrippaux (immunologie), Études longitudinales, Études prospectives.
- MESH :
- immunologie : Grippe humaine, Immunité cellulaire, Immunité humorale, Lymphocytes T, Sous-type H1N1 du virus de la grippe A, Vaccins antigrippaux.
- métabolisme : Interféron gamma.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- sang : Anticorps antiviraux.
- épidémiologie : Grippe humaine, Suède.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Sujet âgé, Vaccination, Études longitudinales, Études prospectives.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Antibodies, Viral (blood), Female, Humans, Immunity, Cellular (immunology), Immunity, Humoral (immunology), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Interferon-gamma (metabolism), Longitudinal Studies, Male, Middle Aged, Prospective Studies, Sweden (epidemiology), T-Lymphocytes (immunology), Vaccination, Young Adult.
- MESH :
- chemical , blood : Antibodies, Viral.
- epidemiology : Influenza, Human, Sweden.
- immunology : Immunity, Cellular, Immunity, Humoral, Influenza A Virus, H1N1 Subtype, Influenza Vaccines, Influenza, Human, T-Lymphocytes.
- chemical , metabolism : Interferon-gamma.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- Adolescent, Adult, Aged, Female, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Vaccination, Young Adult.
Abstract
Previous exposures to flu and subsequent immune responses may impact on 2009/2010 pandemic flu vaccine responses and clinical symptoms upon infection with the 2009 pandemic H1N1 influenza strain. Qualitative and quantitative differences in humoral and cellular immune responses associated with the flu vaccination in 2009/2010 (pandemic H1N1 vaccine) and natural infection have not yet been described in detail. We designed a longitudinal study to examine influenza- (flu-) specific immune responses and the association between pre-existing flu responses, symptoms of influenza-like illness (ILI), impact of pandemic flu infection, and pandemic flu vaccination in a cohort of 2,040 individuals in Sweden in 2009–2010.
Cellular flu-specific immune responses were assessed by whole-blood antigen stimulation assay, and humoral responses by a single radial hemolysis test.
Previous seasonal flu vaccination was associated with significantly lower flu-specific IFN-γ responses (using a whole-blood assay) at study entry. Pandemic flu vaccination induced long-lived T-cell responses (measured by IFN-γ production) to influenza A strains, influenza B strains, and the matrix (M1) antigen. In contrast, individuals with pandemic flu infection (PCR positive) exhibited increased flu-specific T-cell responses shortly after onset of ILI symptoms but the immune response decreased after the flu season (spring 2010). We identified non-pandemic-flu vaccinated participants without ILI symptoms who showed an IFN-γ production profile similar to pandemic-flu infected participants, suggesting exposure without experiencing clinical symptoms.
Strong and long-lived flu-M1 specific immune responses, defined by IFN-γ production, in individuals after vaccination suggest that M1-responses may contribute to protective cellular immune responses. Silent flu infections appeared to be frequent in 2009/2010. The pandemic flu vaccine induced qualitatively and quantitatively different humoral and cellular immune responses as compared to infection with the 2009 H1N1 pandemic H1N1 influenza strain.
The online version of this article (doi:10.1186/1471-2334-14-319) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1471-2334-14-319
PubMed: 24916787
PubMed Central: 4067073
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PMC:4067073Le document en format XML
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id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4714.6</institution-id><institution-id institution-id-type="ISNI">0000000419370626</institution-id><institution>Department of Laboratory Medicine, Division of Therapeutic Immunology,</institution><institution>Karolinska Institute,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.4714.6</institution-id><institution-id institution-id-type="ISNI">0000000419370626</institution-id><institution>Department of Medical Epidemiology and Biostatistics,</institution><institution>Karolinska Institute,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Linde, Charlotte" sort="Linde, Charlotte" uniqKey="Linde C" first="Charlotte" last="Linde">Charlotte Linde</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.4714.6</institution-id><institution-id institution-id-type="ISNI">0000000419370626</institution-id><institution>Microbiology, Tumor and Cell Biology, MTB,</institution><institution>Karolinska Institutet,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Muhammad, Rashid" sort="Muhammad, Rashid" uniqKey="Muhammad R" first="Rashid" last="Muhammad">Rashid Muhammad</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id 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xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Ambati, Aditya" sort="Ambati, Aditya" uniqKey="Ambati A" first="Aditya" last="Ambati">Aditya Ambati</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.24381.3c</institution-id><institution-id institution-id-type="ISNI">0000000092415705</institution-id><institution>Center for allogeneic stem cell transplantation,</institution><institution>Karolinska University Hospital,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4714.6</institution-id><institution-id institution-id-type="ISNI">0000000419370626</institution-id><institution>Department of Laboratory Medicine, Division of Therapeutic Immunology,</institution><institution>Karolinska Institute,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Axelsson Robertson, Rebecca" sort="Axelsson Robertson, Rebecca" uniqKey="Axelsson Robertson R" first="Rebecca" last="Axelsson-Robertson">Rebecca Axelsson-Robertson</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.24381.3c</institution-id><institution-id institution-id-type="ISNI">0000000092415705</institution-id><institution>Center for allogeneic stem cell transplantation,</institution><institution>Karolinska University Hospital,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4714.6</institution-id><institution-id institution-id-type="ISNI">0000000419370626</institution-id><institution>Department of Laboratory Medicine, Division of Therapeutic Immunology,</institution><institution>Karolinska Institute,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Khalaj, Bahareh" sort="Khalaj, Bahareh" uniqKey="Khalaj B" first="Bahareh" last="Khalaj">Bahareh Khalaj</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.4714.6</institution-id><institution-id institution-id-type="ISNI">0000000419370626</institution-id><institution>Microbiology, Tumor and Cell Biology, MTB,</institution><institution>Karolinska Institutet,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Alvarez Corrales, Nancy" sort="Alvarez Corrales, Nancy" uniqKey="Alvarez Corrales N" first="Nancy" last="Alvarez-Corrales">Nancy Alvarez-Corrales</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.4714.6</institution-id><institution-id institution-id-type="ISNI">0000000419370626</institution-id><institution>Microbiology, Tumor and Cell Biology, MTB,</institution><institution>Karolinska Institutet,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Lapini, Giulia" sort="Lapini, Giulia" uniqKey="Lapini G" first="Giulia" last="Lapini">Giulia Lapini</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000000417574641</institution-id><institution>Department of Physiopathology, Molecular Epidemiology Research Division, Experimental Medicine and Public Health,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Montomoli, Emanuele" sort="Montomoli, Emanuele" uniqKey="Montomoli E" first="Emanuele" last="Montomoli">Emanuele Montomoli</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000000417574641</institution-id><institution>Department of Physiopathology, Molecular Epidemiology Research Division, Experimental Medicine and Public Health,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Linde, Annika" sort="Linde, Annika" uniqKey="Linde A" first="Annika" last="Linde">Annika Linde</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.419734.c</institution-id><institution-id institution-id-type="ISNI">0000000095803113</institution-id><institution>Swedish Institute for Communicable Disease Control Stockholm,</institution><institution>Smittskyddsinstitutet,</institution></institution-wrap>Solna, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Solna</wicri:regionArea></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.4714.6</institution-id><institution-id institution-id-type="ISNI">0000000419370626</institution-id><institution>Department of Medical Epidemiology and Biostatistics,</institution><institution>Karolinska Institute,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Maeurer, Markus" sort="Maeurer, Markus" uniqKey="Maeurer M" first="Markus" last="Maeurer">Markus Maeurer</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.24381.3c</institution-id><institution-id institution-id-type="ISNI">0000000092415705</institution-id><institution>Center for allogeneic stem cell transplantation,</institution><institution>Karolinska University Hospital,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.4714.6</institution-id><institution-id institution-id-type="ISNI">0000000419370626</institution-id><institution>Department of Laboratory Medicine, Division of Therapeutic Immunology,</institution><institution>Karolinska Institute,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.4714.6</institution-id><institution-id institution-id-type="ISNI">0000000419370626</institution-id><institution>Microbiology, Tumor and Cell Biology, MTB,</institution><institution>Karolinska Institutet,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.24381.3c</institution-id><institution-id institution-id-type="ISNI">0000000092415705</institution-id><institution>Therapeutic Immunology, F79, LabMed, Hälsovägen,</institution><institution>Karolinska University Hospital Huddinge,</institution></institution-wrap>SE-14186 Huddinge, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>SE-14186 Huddinge</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Antibodies, Viral (blood)</term><term>Female</term><term>Humans</term><term>Immunity, Cellular (immunology)</term><term>Immunity, Humoral (immunology)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (immunology)</term><term>Interferon-gamma (metabolism)</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Sweden (epidemiology)</term><term>T-Lymphocytes (immunology)</term><term>Vaccination</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Femelle</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Immunité cellulaire (immunologie)</term><term>Immunité humorale (immunologie)</term><term>Interféron gamma (métabolisme)</term><term>Jeune adulte</term><term>Lymphocytes T (immunologie)</term><term>Mâle</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term><term>Sujet âgé</term><term>Suède (épidémiologie)</term><term>Vaccination</term><term>Vaccins antigrippaux (immunologie)</term><term>Études longitudinales</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term><term>Sweden</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Lymphocytes T</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza Vaccines</term><term>Influenza, Human</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interferon-gamma</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Interféron gamma</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Suède</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Vaccination</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Sujet âgé</term><term>Vaccination</term><term>Études longitudinales</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Previous exposures to flu and subsequent immune responses may impact on 2009/2010 pandemic flu vaccine responses and clinical symptoms upon infection with the 2009 pandemic H1N1 influenza strain. Qualitative and quantitative differences in humoral and cellular immune responses associated with the flu vaccination in 2009/2010 (pandemic H1N1 vaccine) and natural infection have not yet been described in detail. We designed a longitudinal study to examine influenza- (flu-) specific immune responses and the association between pre-existing flu responses, symptoms of influenza-like illness (ILI), impact of pandemic flu infection, and pandemic flu vaccination in a cohort of 2,040 individuals in Sweden in 2009–2010.</p></sec><sec><title>Methods</title><p>Cellular flu-specific immune responses were assessed by whole-blood antigen stimulation assay, and humoral responses by a single radial hemolysis test.</p></sec><sec><title>Results</title><p>Previous seasonal flu vaccination was associated with significantly lower flu-specific IFN-γ responses (using a whole-blood assay) at study entry. Pandemic flu vaccination induced long-lived T-cell responses (measured by IFN-γ production) to influenza A strains, influenza B strains, and the matrix (M1) antigen. In contrast, individuals with pandemic flu infection (PCR positive) exhibited increased flu-specific T-cell responses shortly after onset of ILI symptoms but the immune response decreased after the flu season (spring 2010). We identified non-pandemic-flu vaccinated participants without ILI symptoms who showed an IFN-γ production profile similar to pandemic-flu infected participants, suggesting exposure without experiencing clinical symptoms.</p></sec><sec><title>Conclusions</title><p>Strong and long-lived flu-M1 specific immune responses, defined by IFN-γ production, in individuals after vaccination suggest that M1-responses may contribute to protective cellular immune responses. Silent flu infections appeared to be frequent in 2009/2010. The pandemic flu vaccine induced qualitatively and quantitatively different humoral and cellular immune responses as compared to infection with the 2009 H1N1 pandemic H1N1 influenza strain.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/1471-2334-14-319) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name></author><author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name></author><author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name></author><author><name sortKey="Shaw, Mw" uniqKey="Shaw M">MW Shaw</name></author><author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name></author><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name></author><author><name sortKey="Gubareva, Lv" 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