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Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity in intravenous immunoglobulin as a potential therapeutic against emerging influenza viruses.

Identifieur interne : 001870 ( Ncbi/Curation ); précédent : 001869; suivant : 001871

Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity in intravenous immunoglobulin as a potential therapeutic against emerging influenza viruses.

Auteurs : Sinthujan Jegaskanda [Australie] ; Kirsten Vandenberg ; Karen L. Laurie [Australie] ; Liyen Loh [Australie] ; Marit Kramski [Australie] ; Wendy R. Winnall [Australie] ; Katherine Kedzierska [Australie] ; Steven Rockman ; Stephen J. Kent [Australie]

Source :

RBID : pubmed:24916185

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English descriptors

Abstract

Intravenous immunoglobulin (IVIG) is a purified pool of human antibodies from thousands of donors that is used to prevent or treat primary immune deficiency, several infectious diseases, and autoimmune diseases. The antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) against heterologous influenza strains may be present in IVIG preparations.

DOI: 10.1093/infdis/jiu334
PubMed: 24916185

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Kirsten Vandenberg
<affiliation>
<nlm:affiliation>BioCSL Ltd, Parkville, Victoria.</nlm:affiliation>
<wicri:noCountry code="subField">Victoria</wicri:noCountry>
</affiliation>
Steven Rockman
<affiliation>
<nlm:affiliation>Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne BioCSL Ltd, Parkville, Victoria.</nlm:affiliation>
<wicri:noCountry code="subField">Victoria</wicri:noCountry>
</affiliation>

Le document en format XML

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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antibody-Dependent Cell Cytotoxicity (immunology)</term>
<term>Cross Reactions (immunology)</term>
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<term>Middle Aged</term>
<term>Young Adult</term>
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<term>Cellules tueuses naturelles (immunologie)</term>
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<term>Antibodies, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
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<term>Cellules tueuses naturelles</term>
<term>Cytotoxicité à médiation cellulaire dépendante des anticorps</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Grippe humaine</term>
<term>Réactions croisées</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H7N9 du virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Antibody-Dependent Cell Cytotoxicity</term>
<term>Cross Reactions</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H7N9 Subtype</term>
<term>Influenza, Human</term>
<term>Killer Cells, Natural</term>
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<term>Anticorps antiviraux</term>
</keywords>
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<term>Immunoglobulins, Intravenous</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Influenza, Human</term>
</keywords>
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<term>Immunoglobulines par voie veineuse</term>
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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
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<term>Middle Aged</term>
<term>Young Adult</term>
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<term>Grippe humaine</term>
<term>Humains</term>
<term>Jeune adulte</term>
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<front>
<div type="abstract" xml:lang="en">Intravenous immunoglobulin (IVIG) is a purified pool of human antibodies from thousands of donors that is used to prevent or treat primary immune deficiency, several infectious diseases, and autoimmune diseases. The antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) against heterologous influenza strains may be present in IVIG preparations.</div>
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