Age-Specific Mortality During the 1918 Influenza Pandemic: Unravelling the Mystery of High Young Adult Mortality
Identifieur interne : 001709 ( Ncbi/Curation ); précédent : 001708; suivant : 001710Age-Specific Mortality During the 1918 Influenza Pandemic: Unravelling the Mystery of High Young Adult Mortality
Auteurs : Alain Gagnon [Canada] ; Matthew S. Miller [États-Unis] ; Stacey A. Hallman [Canada] ; Robert Bourbeau [Canada] ; D. Ann Herring [Canada] ; David Jd. Earn [Canada] ; Joaquín Madrenas [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Canada (épidémiologie), Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine (mortalité), Grippe humaine (épidémiologie), Humains, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Pandémies (), Répartition par âge, Sujet âgé, Sujet âgé de 80 ans ou plus, États-Unis d'Amérique (épidémiologie).
- MESH :
- mortalité : Grippe humaine.
- épidémiologie : Canada, Grippe humaine, États-Unis d'Amérique.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Pandémies, Répartition par âge, Sujet âgé, Sujet âgé de 80 ans ou plus.
- Wicri :
- geographic : Canada, États-Unis.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Canada (epidemiology), Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Influenza, Human (epidemiology), Influenza, Human (mortality), Male, Middle Aged, Pandemics (statistics & numerical data), United States (epidemiology), Young Adult.
- MESH :
- geographic , epidemiology : Canada, United States.
- epidemiology : Influenza, Human.
- mortality : Influenza, Human.
- statistics & numerical data : Pandemics.
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Young Adult.
Abstract
The worldwide spread of a novel influenza A (H1N1) virus in 2009 showed that influenza remains a significant health threat, even for individuals in the prime of life. This paper focuses on the unusually high young adult mortality observed during the Spanish flu pandemic of 1918. Using historical records from Canada and the U.S., we report a peak of mortality at the exact age of 28 during the pandemic and argue that this increased mortality resulted from an early life exposure to influenza during the previous Russian flu pandemic of 1889–90. We posit that in specific instances, development of immunological memory to an influenza virus strain in early life may lead to a dysregulated immune response to antigenically novel strains encountered in later life, thereby increasing the risk of death. Exposure during critical periods of development could also create holes in the T cell repertoire and impair fetal maturation in general, thereby increasing mortality from infectious diseases later in life. Knowledge of the age-pattern of susceptibility to mortality from influenza could improve crisis management during future influenza pandemics.
Url:
DOI: 10.1371/journal.pone.0069586
PubMed: 23940526
PubMed Central: 3734171
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PMC:3734171Le document en format XML
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DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Madrenas, Joaquin" sort="Madrenas, Joaquin" uniqKey="Madrenas J" first="Joaquín" last="Madrenas">Joaquín Madrenas</name><affiliation wicri:level="4"><nlm:aff id="aff7"><addr-line>Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Microbiology and Immunology, McGill University, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Aged, 80 and over</term><term>Canada (epidemiology)</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (mortality)</term><term>Male</term><term>Middle Aged</term><term>Pandemics (statistics & numerical data)</term><term>United States (epidemiology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Canada (épidémiologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Grippe humaine (mortalité)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Pandémies ()</term><term>Répartition par âge</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>États-Unis d'Amérique (épidémiologie)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Canada</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Canada</term><term>Grippe humaine</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Pandémies</term><term>Répartition par âge</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The worldwide spread of a novel influenza A (H1N1) virus in 2009 showed that influenza remains a significant health threat, even for individuals in the prime of life. This paper focuses on the unusually high young adult mortality observed during the Spanish flu pandemic of 1918. Using historical records from Canada and the U.S., we report a peak of mortality at the exact age of 28 during the pandemic and argue that this increased mortality resulted from an early life exposure to influenza during the previous Russian flu pandemic of 1889–90. We posit that in specific instances, development of immunological memory to an influenza virus strain in early life may lead to a dysregulated immune response to antigenically novel strains encountered in later life, thereby increasing the risk of death. Exposure during critical periods of development could also create holes in the T cell repertoire and impair fetal maturation in general, thereby increasing mortality from infectious diseases later in life. Knowledge of the age-pattern of susceptibility to mortality from influenza could improve crisis management during future influenza pandemics.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name></author><author><name sortKey="Eisenstein, J" uniqKey="Eisenstein J">J Eisenstein</name></author><author><name sortKey="Reid, Ah" uniqKey="Reid A">AH Reid</name></author><author><name sortKey="Janczewski, Ta" uniqKey="Janczewski T">TA Janczewski</name></author><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Francis, T" uniqKey="Francis T">T Francis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reichert, T" uniqKey="Reichert T">T Reichert</name></author><author><name sortKey="Chowell, G" uniqKey="Chowell G">G 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Lindstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bengtsson, T" uniqKey="Bengtsson T">T Bengtsson</name></author><author><name sortKey="Brostrom, G" uniqKey="Brostrom G">G Broström</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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