Induction of Long-Term Protective Immune Responses by Influenza H5N1 Virus-Like Particles
Identifieur interne : 000839 ( Ncbi/Curation ); précédent : 000838; suivant : 000840Induction of Long-Term Protective Immune Responses by Influenza H5N1 Virus-Like Particles
Auteurs : Sang-Moo Kang [États-Unis] ; Dae-Goon Yoo [États-Unis] ; Aleksandr S. Lipatov [États-Unis] ; Jae-Min Song [États-Unis] ; C. Todd Davis [États-Unis] ; Fu-Shi Quan [États-Unis] ; Li-Mei Chen [États-Unis] ; Ruben O. Donis [États-Unis] ; Richard W. Compans [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2009.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : Anticorps antiviraux, Cytokines.
- immunologie : Sous-type H5N1 du virus de la grippe A, Virion.
- Amorces ADN, Animaux, Femelle, Immunité cellulaire, Immunité muqueuse, Mémoire immunologique, Souris, Souris de lignée BALB C, Séquence nucléotidique.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Antibodies, Viral, Cytokines.
- immunology : Influenza A Virus, H5N1 Subtype, Virion.
- Animals, Base Sequence, DNA Primers, Female, Immunity, Cellular, Immunity, Mucosal, Immunologic Memory, Mice, Mice, Inbred BALB C.
Abstract
Recurrent outbreaks of highly pathogenic H5N1 avian influenza virus pose a threat of eventually causing a pandemic. Early vaccination of the population would be the single most effective measure for the control of an emerging influenza pandemic.
Influenza virus-like particles (VLPs) produced in insect cell-culture substrates do not depend on the availability of fertile eggs for vaccine manufacturing. We produced VLPs containing influenza A/Viet Nam1203/04 (H5N1) hemagglutinin, neuraminidase, and matrix proteins, and investigated their preclinical immunogenicity and protective efficacy. Mice immunized intranasally with H5N1 VLPs developed high levels of H5N1 specific antibodies and were 100% protected against a high dose of homologous H5N1 virus infection at 30 weeks after immunization. Protection is likely to be correlated with humoral and cellular immunologic memory at systemic and mucosal sites as evidenced by rapid anamnestic responses to re-stimulation with viral antigen in vivo and
These results provide support for clinical evaluation of H5N1 VLP vaccination as a public health intervention to mitigate a possible pandemic of H5N1 influenza.
Url:
DOI: 10.1371/journal.pone.0004667
PubMed: 19252744
PubMed Central: 2646145
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PMC:2646145Le document en format XML
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Compans</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19252744</idno><idno type="pmc">2646145</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646145</idno><idno type="RBID">PMC:2646145</idno><idno type="doi">10.1371/journal.pone.0004667</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000C78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C78</idno><idno type="wicri:Area/Pmc/Curation">000C78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C78</idno><idno type="wicri:Area/Pmc/Checkpoint">000B98</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B98</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:19252744</idno><idno type="wicri:Area/PubMed/Corpus">001801</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001801</idno><idno type="wicri:Area/PubMed/Curation">001801</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001801</idno><idno type="wicri:Area/PubMed/Checkpoint">001581</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001581</idno><idno type="wicri:Area/Ncbi/Merge">000839</idno><idno type="wicri:Area/Ncbi/Curation">000839</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Induction of Long-Term Protective Immune Responses by Influenza H5N1 Virus-Like Particles</title><author><name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Yoo, Dae Goon" sort="Yoo, Dae Goon" uniqKey="Yoo D" first="Dae-Goon" last="Yoo">Dae-Goon Yoo</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Lipatov, Aleksandr S" sort="Lipatov, Aleksandr S" uniqKey="Lipatov A" first="Aleksandr S." last="Lipatov">Aleksandr S. Lipatov</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Song, Jae Min" sort="Song, Jae Min" uniqKey="Song J" first="Jae-Min" last="Song">Jae-Min Song</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Davis, C Todd" sort="Davis, C Todd" uniqKey="Davis C" first="C. Todd" last="Davis">C. Todd Davis</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Quan, Fu Shi" sort="Quan, Fu Shi" uniqKey="Quan F" first="Fu-Shi" last="Quan">Fu-Shi Quan</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O." last="Donis">Ruben O. Donis</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W." last="Compans">Richard W. Compans</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (biosynthesis)</term><term>Base Sequence</term><term>Cytokines (biosynthesis)</term><term>DNA Primers</term><term>Female</term><term>Immunity, Cellular</term><term>Immunity, Mucosal</term><term>Immunologic Memory</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Virion (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amorces ADN</term><term>Animaux</term><term>Anticorps antiviraux (biosynthèse)</term><term>Cytokines (biosynthèse)</term><term>Femelle</term><term>Immunité cellulaire</term><term>Immunité muqueuse</term><term>Mémoire immunologique</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term><term>Séquence nucléotidique</term><term>Virion (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term><term>Virion</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term><term>Virion</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>DNA Primers</term><term>Female</term><term>Immunity, Cellular</term><term>Immunity, Mucosal</term><term>Immunologic Memory</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Amorces ADN</term><term>Animaux</term><term>Femelle</term><term>Immunité cellulaire</term><term>Immunité muqueuse</term><term>Mémoire immunologique</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Recurrent outbreaks of highly pathogenic H5N1 avian influenza virus pose a threat of eventually causing a pandemic. Early vaccination of the population would be the single most effective measure for the control of an emerging influenza pandemic.</p></sec><sec><title>Methodology/Principal Findings</title><p>Influenza virus-like particles (VLPs) produced in insect cell-culture substrates do not depend on the availability of fertile eggs for vaccine manufacturing. We produced VLPs containing influenza A/Viet Nam1203/04 (H5N1) hemagglutinin, neuraminidase, and matrix proteins, and investigated their preclinical immunogenicity and protective efficacy. Mice immunized intranasally with H5N1 VLPs developed high levels of H5N1 specific antibodies and were 100% protected against a high dose of homologous H5N1 virus infection at 30 weeks after immunization. Protection is likely to be correlated with humoral and cellular immunologic memory at systemic and mucosal sites as evidenced by rapid anamnestic responses to re-stimulation with viral antigen in vivo and <italic>in vitro</italic>.</p></sec><sec><title>Conclusions/Significance</title><p>These results provide support for clinical evaluation of H5N1 VLP vaccination as a public health intervention to mitigate a possible pandemic of H5N1 influenza.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Germann, Tc" uniqKey="Germann T">TC Germann</name></author><author><name sortKey="Kadau, K" uniqKey="Kadau K">K Kadau</name></author><author><name sortKey="Longini, Im" uniqKey="Longini I">IM Longini</name></author><author><name sortKey="Macken, Ca" uniqKey="Macken C">CA Macken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cintra, Oa" uniqKey="Cintra O">OA Cintra</name></author><author><name 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