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The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights

Identifieur interne : 002047 ( Ncbi/Checkpoint ); précédent : 002046; suivant : 002048

The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights

Auteurs : Hiroshi Nishiura [Japon] ; Tetsuro Kobayashi ; Yichi Yang ; Katsuma Hayashi ; Takeshi Miyama ; Ryo Kinoshita ; Natalie M. Linton ; Sung-Mok Jung ; Baoyin Yuan ; Ayako Suzuki ; Andrei R. Akhmetzhanov

Source :

RBID : PMC:7074297

Abstract

From 29 to 31 January 2020, a total of 565 Japanese citizens were evacuated from Wuhan, China on three chartered flights. All passengers were screened upon arrival in Japan for symptoms consistent with novel coronavirus (2019-nCoV) infection and tested for presence of the virus. Assuming that the mean detection window of the virus can be informed by the mean serial interval (estimated at 7.5 days), the ascertainment rate of infection was estimated at 9.2% (95% confidence interval: 5.0, 20.0). This indicates that the incidence of infection in Wuhan can be estimated at 20,767 infected individuals, including those with asymptomatic and mildly symptomatic infections. The infection fatality risk (IFR)—the actual risk of death among all infected individuals—is therefore 0.3% to 0.6%, which may be comparable to Asian influenza pandemic of 1957–1958.


Url:
DOI: 10.3390/jcm9020419
PubMed: 32033064
PubMed Central: 7074297


Affiliations:


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PMC:7074297

Le document en format XML

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<name sortKey="Suzuki, Ayako" sort="Suzuki, Ayako" uniqKey="Suzuki A" first="Ayako" last="Suzuki">Ayako Suzuki</name>
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<title xml:lang="en" level="a" type="main">The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights</title>
<author>
<name sortKey="Nishiura, Hiroshi" sort="Nishiura, Hiroshi" uniqKey="Nishiura H" first="Hiroshi" last="Nishiura">Hiroshi Nishiura</name>
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<nlm:aff id="af1-jcm-09-00419">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;
<email>tootsieroll2910@gmail.com</email>
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<name sortKey="Kobayashi, Tetsuro" sort="Kobayashi, Tetsuro" uniqKey="Kobayashi T" first="Tetsuro" last="Kobayashi">Tetsuro Kobayashi</name>
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<name sortKey="Yang, Yichi" sort="Yang, Yichi" uniqKey="Yang Y" first="Yichi" last="Yang">Yichi Yang</name>
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<name sortKey="Hayashi, Katsuma" sort="Hayashi, Katsuma" uniqKey="Hayashi K" first="Katsuma" last="Hayashi">Katsuma Hayashi</name>
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<email>tootsieroll2910@gmail.com</email>
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<name sortKey="Miyama, Takeshi" sort="Miyama, Takeshi" uniqKey="Miyama T" first="Takeshi" last="Miyama">Takeshi Miyama</name>
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<name sortKey="Kinoshita, Ryo" sort="Kinoshita, Ryo" uniqKey="Kinoshita R" first="Ryo" last="Kinoshita">Ryo Kinoshita</name>
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<nlm:aff id="af1-jcm-09-00419">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;
<email>tootsieroll2910@gmail.com</email>
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<name sortKey="Linton, Natalie M" sort="Linton, Natalie M" uniqKey="Linton N" first="Natalie M." last="Linton">Natalie M. Linton</name>
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<nlm:aff id="af1-jcm-09-00419">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;
<email>tootsieroll2910@gmail.com</email>
(T.K.);
<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);
<email>katsuma5miffy@gmail.com</email>
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<email>ryokinoshita@med.hokudai.ac.jp</email>
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<email>nlinton@gmail.com</email>
(N.M.L.);
<email>seductmd@med.hokudai.ac.jp</email>
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<email>baoyinyuan@outlook.com</email>
(B.Y.);
<email>akmskorokoro@gmail.com</email>
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<author>
<name sortKey="Jung, Sung Mok" sort="Jung, Sung Mok" uniqKey="Jung S" first="Sung-Mok" last="Jung">Sung-Mok Jung</name>
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<nlm:aff id="af1-jcm-09-00419">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;
<email>tootsieroll2910@gmail.com</email>
(T.K.);
<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);
<email>katsuma5miffy@gmail.com</email>
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<email>ryokinoshita@med.hokudai.ac.jp</email>
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<name sortKey="Yuan, Baoyin" sort="Yuan, Baoyin" uniqKey="Yuan B" first="Baoyin" last="Yuan">Baoyin Yuan</name>
<affiliation>
<nlm:aff id="af1-jcm-09-00419">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;
<email>tootsieroll2910@gmail.com</email>
(T.K.);
<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);
<email>katsuma5miffy@gmail.com</email>
(K.H.);
<email>ryokinoshita@med.hokudai.ac.jp</email>
(R.K.);
<email>nlinton@gmail.com</email>
(N.M.L.);
<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);
<email>baoyinyuan@outlook.com</email>
(B.Y.);
<email>akmskorokoro@gmail.com</email>
(A.S.);</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Suzuki, Ayako" sort="Suzuki, Ayako" uniqKey="Suzuki A" first="Ayako" last="Suzuki">Ayako Suzuki</name>
<affiliation>
<nlm:aff id="af1-jcm-09-00419">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;
<email>tootsieroll2910@gmail.com</email>
(T.K.);
<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);
<email>katsuma5miffy@gmail.com</email>
(K.H.);
<email>ryokinoshita@med.hokudai.ac.jp</email>
(R.K.);
<email>nlinton@gmail.com</email>
(N.M.L.);
<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);
<email>baoyinyuan@outlook.com</email>
(B.Y.);
<email>akmskorokoro@gmail.com</email>
(A.S.);</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Akhmetzhanov, Andrei R" sort="Akhmetzhanov, Andrei R" uniqKey="Akhmetzhanov A" first="Andrei R." last="Akhmetzhanov">Andrei R. Akhmetzhanov</name>
<affiliation>
<nlm:aff id="af1-jcm-09-00419">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;
<email>tootsieroll2910@gmail.com</email>
(T.K.);
<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);
<email>katsuma5miffy@gmail.com</email>
(K.H.);
<email>ryokinoshita@med.hokudai.ac.jp</email>
(R.K.);
<email>nlinton@gmail.com</email>
(N.M.L.);
<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);
<email>baoyinyuan@outlook.com</email>
(B.Y.);
<email>akmskorokoro@gmail.com</email>
(A.S.);</nlm:aff>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Journal of Clinical Medicine</title>
<idno type="eISSN">2077-0383</idno>
<imprint>
<date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>From 29 to 31 January 2020, a total of 565 Japanese citizens were evacuated from Wuhan, China on three chartered flights. All passengers were screened upon arrival in Japan for symptoms consistent with novel coronavirus (2019-nCoV) infection and tested for presence of the virus. Assuming that the mean detection window of the virus can be informed by the mean serial interval (estimated at 7.5 days), the ascertainment rate of infection was estimated at 9.2% (95% confidence interval: 5.0, 20.0). This indicates that the incidence of infection in Wuhan can be estimated at 20,767 infected individuals, including those with asymptomatic and mildly symptomatic infections. The infection fatality risk (IFR)—the actual risk of death among all infected individuals—is therefore 0.3% to 0.6%, which may be comparable to Asian influenza pandemic of 1957–1958.</p>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct>
<analytic>
<author>
<name sortKey="Nishiura, H" uniqKey="Nishiura H">H. Nishiura</name>
</author>
<author>
<name sortKey="Jung, S M" uniqKey="Jung S">S.-M. Jung</name>
</author>
<author>
<name sortKey="Linton, N M" uniqKey="Linton N">N.M. Linton</name>
</author>
<author>
<name sortKey="Kinoshita, R" uniqKey="Kinoshita R">R. Kinoshita</name>
</author>
<author>
<name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name>
</author>
<author>
<name sortKey="Hayashi, K" uniqKey="Hayashi K">K. Hayashi</name>
</author>
<author>
<name sortKey="Kobayashi, T" uniqKey="Kobayashi T">T. Kobayashi</name>
</author>
<author>
<name sortKey="Yuan, B" uniqKey="Yuan B">B. Yuan</name>
</author>
<author>
<name sortKey="Akhmetzhanov, A R" uniqKey="Akhmetzhanov A">A.R. Akhmetzhanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name>
</author>
<author>
<name sortKey="Guan, X" uniqKey="Guan X">X. Guan</name>
</author>
<author>
<name sortKey="Wu, P" uniqKey="Wu P">P. Wu</name>
</author>
<author>
<name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
<author>
<name sortKey="Zhou, L" uniqKey="Zhou L">L. Zhou</name>
</author>
<author>
<name sortKey="Tong, Y" uniqKey="Tong Y">Y. Tong</name>
</author>
<author>
<name sortKey="Ren, R" uniqKey="Ren R">R. Ren</name>
</author>
<author>
<name sortKey="Leung, K S M" uniqKey="Leung K">K.S.M. Leung</name>
</author>
<author>
<name sortKey="Lau, E H Y" uniqKey="Lau E">E.H.Y. Lau</name>
</author>
<author>
<name sortKey="Wong, J Y" uniqKey="Wong J">J.Y. Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Read, J M" uniqKey="Read J">J.M. Read</name>
</author>
<author>
<name sortKey="Bridgen, J R E" uniqKey="Bridgen J">J.R.E. Bridgen</name>
</author>
<author>
<name sortKey="Cummings, D A T" uniqKey="Cummings D">D.A.T. Cummings</name>
</author>
<author>
<name sortKey="Ho, A" uniqKey="Ho A">A. Ho</name>
</author>
<author>
<name sortKey="Jewell, C P" uniqKey="Jewell C">C.P. Jewell</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Jung, S M" uniqKey="Jung S">S.-M. Jung</name>
</author>
<author>
<name sortKey="Akhmetzhanov, A R" uniqKey="Akhmetzhanov A">A.R. Akhmetzhanov</name>
</author>
<author>
<name sortKey="Hayashi, K" uniqKey="Hayashi K">K. Hayashi</name>
</author>
<author>
<name sortKey="Linton, N M" uniqKey="Linton N">N.M. Linton</name>
</author>
<author>
<name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name>
</author>
<author>
<name sortKey="Yuan, B" uniqKey="Yuan B">B. Yuan</name>
</author>
<author>
<name sortKey="Kobayashi, T" uniqKey="Kobayashi T">T. Kobayashi</name>
</author>
<author>
<name sortKey="Kinoshita, R" uniqKey="Kinoshita R">R. Kinoshita</name>
</author>
<author>
<name sortKey="Nishiura, H" uniqKey="Nishiura H">H. Nishiura</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wong, J Y" uniqKey="Wong J">J.Y. Wong</name>
</author>
<author>
<name sortKey="Wu, P" uniqKey="Wu P">P. Wu</name>
</author>
<author>
<name sortKey="Nishiura, H" uniqKey="Nishiura H">H. Nishiura</name>
</author>
<author>
<name sortKey="Goldstein, E" uniqKey="Goldstein E">E. Goldstein</name>
</author>
<author>
<name sortKey="Lau, E H" uniqKey="Lau E">E.H. Lau</name>
</author>
<author>
<name sortKey="Yang, L" uniqKey="Yang L">L. Yang</name>
</author>
<author>
<name sortKey="Chuang, S K" uniqKey="Chuang S">S.K. Chuang</name>
</author>
<author>
<name sortKey="Tsang, T" uniqKey="Tsang T">T. Tsang</name>
</author>
<author>
<name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name>
</author>
<author>
<name sortKey="Wu, J T" uniqKey="Wu J">J.T. Wu</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations>
<list>
<country>
<li>Japon</li>
</country>
</list>
<tree>
<noCountry>
<name sortKey="Akhmetzhanov, Andrei R" sort="Akhmetzhanov, Andrei R" uniqKey="Akhmetzhanov A" first="Andrei R." last="Akhmetzhanov">Andrei R. Akhmetzhanov</name>
<name sortKey="Hayashi, Katsuma" sort="Hayashi, Katsuma" uniqKey="Hayashi K" first="Katsuma" last="Hayashi">Katsuma Hayashi</name>
<name sortKey="Jung, Sung Mok" sort="Jung, Sung Mok" uniqKey="Jung S" first="Sung-Mok" last="Jung">Sung-Mok Jung</name>
<name sortKey="Kinoshita, Ryo" sort="Kinoshita, Ryo" uniqKey="Kinoshita R" first="Ryo" last="Kinoshita">Ryo Kinoshita</name>
<name sortKey="Kobayashi, Tetsuro" sort="Kobayashi, Tetsuro" uniqKey="Kobayashi T" first="Tetsuro" last="Kobayashi">Tetsuro Kobayashi</name>
<name sortKey="Linton, Natalie M" sort="Linton, Natalie M" uniqKey="Linton N" first="Natalie M." last="Linton">Natalie M. Linton</name>
<name sortKey="Miyama, Takeshi" sort="Miyama, Takeshi" uniqKey="Miyama T" first="Takeshi" last="Miyama">Takeshi Miyama</name>
<name sortKey="Suzuki, Ayako" sort="Suzuki, Ayako" uniqKey="Suzuki A" first="Ayako" last="Suzuki">Ayako Suzuki</name>
<name sortKey="Yang, Yichi" sort="Yang, Yichi" uniqKey="Yang Y" first="Yichi" last="Yang">Yichi Yang</name>
<name sortKey="Yuan, Baoyin" sort="Yuan, Baoyin" uniqKey="Yuan B" first="Baoyin" last="Yuan">Baoyin Yuan</name>
</noCountry>
<country name="Japon">
<noRegion>
<name sortKey="Nishiura, Hiroshi" sort="Nishiura, Hiroshi" uniqKey="Nishiura H" first="Hiroshi" last="Nishiura">Hiroshi Nishiura</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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