H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets
Identifieur interne : 001F98 ( Ncbi/Checkpoint ); précédent : 001F97; suivant : 001F99H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets
Auteurs : Lizheng Guan [République populaire de Chine] ; Jianzhong Shi [République populaire de Chine] ; Xingtian Kong [République populaire de Chine] ; Shujie Ma [République populaire de Chine] ; Yaping Zhang [République populaire de Chine] ; Xin Yin [République populaire de Chine] ; Xijun He [République populaire de Chine] ; Liling Liu [République populaire de Chine] ; Yasuo Suzuki [Japon] ; Chengjun Li [République populaire de Chine] ; Guohua Deng [République populaire de Chine] ; Hualan Chen [République populaire de Chine]Source :
- Emerging Microbes & Infections [ 2222-1751 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Attachement viral, Chine, Cochons d'Inde, Furets, Grippe chez les oiseaux (virologie), Humains, Maladies des rongeurs (virologie), Modèles animaux de maladie humaine, Récepteurs viraux (métabolisme), Réplication virale, Souris de lignée BALB C, Sous-type H3N2 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (isolement et purification), Sous-type H3N2 du virus de la grippe A (physiologie), Transmission de maladie infectieuse, Virus recombinants (génétique), Virus recombinants (isolement et purification), Virus recombinants (physiologie), Volaille (virologie).
- MESH :
- génétique : Sous-type H3N2 du virus de la grippe A, Virus recombinants.
- isolement et purification : Sous-type H3N2 du virus de la grippe A, Virus recombinants.
- métabolisme : Récepteurs viraux.
- physiologie : Sous-type H3N2 du virus de la grippe A, Virus recombinants.
- virologie : Grippe chez les oiseaux, Maladies des rongeurs, Volaille.
- Animaux, Attachement viral, Chine, Cochons d'Inde, Furets, Humains, Modèles animaux de maladie humaine, Réplication virale, Souris de lignée BALB C, Transmission de maladie infectieuse.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Animals, China, Disease Models, Animal, Disease Transmission, Infectious, Ferrets, Guinea Pigs, Humans, Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (isolation & purification), Influenza A Virus, H3N2 Subtype (physiology), Influenza in Birds (virology), Mice, Inbred BALB C, Poultry (virology), Reassortant Viruses (genetics), Reassortant Viruses (isolation & purification), Reassortant Viruses (physiology), Receptors, Virus (metabolism), Rodent Diseases (virology), Virus Attachment, Virus Replication.
- MESH :
- chemical , metabolism : Receptors, Virus.
- geographic : China.
- genetics : Influenza A Virus, H3N2 Subtype, Reassortant Viruses.
- isolation & purification : Influenza A Virus, H3N2 Subtype, Reassortant Viruses.
- physiology : Influenza A Virus, H3N2 Subtype, Reassortant Viruses.
- virology : Influenza in Birds, Poultry, Rodent Diseases.
- Animals, Disease Models, Animal, Disease Transmission, Infectious, Ferrets, Guinea Pigs, Humans, Mice, Inbred BALB C, Virus Attachment, Virus Replication.
Abstract
The H3N2 influenza viruses became widespread in humans during the 1968 H3N2 pandemic and have been a major cause of influenza epidemics ever since. Different lineages of H3N2 influenza viruses are also commonly found in animals. If a different lineage of H3N2 virus jumps to humans, a human influenza pandemic could occur with devastating consequences. Here, we studied the genetics, receptor-binding properties, and replication and transmission in mammals of 15 H3N2 avian influenza viruses detected in live poultry markets in China. We found that the H3N2 avian influenza viruses are complicated reassortants with distinct replication phenotypes in mice. Five viruses replicated efficiently in mice and bound to both human-type and avian-type receptors. These viruses transmitted efficiently to direct-contact guinea pigs, and three of them also transmitted among guinea pigs and ferrets via respiratory droplets. Moreover, ferret antiserum induced by human H3N2 viruses did not react with any of the H3N2 avian influenza viruses. Our study demonstrates that the H3N2 avian influenza viruses pose a clear threat to human health and emphasizes the need for continued surveillance and evaluation of the H3N2 influenza viruses circulating in nature.
Url:
DOI: 10.1080/22221751.2019.1660590
PubMed: 31495283
PubMed Central: 6746299
Affiliations:
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PMC:6746299Le document en format XML
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wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yin, Xin" sort="Yin, Xin" uniqKey="Yin X" first="Xin" last="Yin">Xin Yin</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="He, Xijun" sort="He, Xijun" uniqKey="He X" first="Xijun" last="He">Xijun He</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Liling" sort="Liu, Liling" uniqKey="Liu L" first="Liling" last="Liu">Liling Liu</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name><affiliation wicri:level="1"><nlm:aff id="AF2"><institution>College of Life and Health Sciences, Chubu University</institution>, Aichi,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Chengjun" sort="Li, Chengjun" uniqKey="Li C" first="Chengjun" last="Li">Chengjun Li</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deng, Guohua" sort="Deng, Guohua" uniqKey="Deng G" first="Guohua" last="Deng">Guohua Deng</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Hualan" sort="Chen, Hualan" uniqKey="Chen H" first="Hualan" last="Chen">Hualan Chen</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Emerging Microbes & Infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>China</term><term>Disease Models, Animal</term><term>Disease Transmission, Infectious</term><term>Ferrets</term><term>Guinea Pigs</term><term>Humans</term><term>Influenza A Virus, H3N2 Subtype (genetics)</term><term>Influenza A Virus, H3N2 Subtype (isolation & purification)</term><term>Influenza A Virus, H3N2 Subtype (physiology)</term><term>Influenza in Birds (virology)</term><term>Mice, Inbred BALB C</term><term>Poultry (virology)</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (isolation & purification)</term><term>Reassortant Viruses (physiology)</term><term>Receptors, Virus (metabolism)</term><term>Rodent Diseases (virology)</term><term>Virus Attachment</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Attachement viral</term><term>Chine</term><term>Cochons d'Inde</term><term>Furets</term><term>Grippe chez les oiseaux (virologie)</term><term>Humains</term><term>Maladies des rongeurs (virologie)</term><term>Modèles animaux de maladie humaine</term><term>Récepteurs viraux (métabolisme)</term><term>Réplication virale</term><term>Souris de lignée BALB C</term><term>Sous-type H3N2 du virus de la grippe A (génétique)</term><term>Sous-type H3N2 du virus de la grippe A (isolement et purification)</term><term>Sous-type H3N2 du virus de la grippe A (physiologie)</term><term>Transmission de maladie infectieuse</term><term>Virus recombinants (génétique)</term><term>Virus recombinants (isolement et purification)</term><term>Virus recombinants (physiologie)</term><term>Volaille (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Virus</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H3N2 du virus de la grippe A</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H3N2 du virus de la grippe A</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H3N2 du virus de la grippe A</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Maladies des rongeurs</term><term>Volaille</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term><term>Poultry</term><term>Rodent Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Disease Transmission, Infectious</term><term>Ferrets</term><term>Guinea Pigs</term><term>Humans</term><term>Mice, Inbred BALB C</term><term>Virus Attachment</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Attachement viral</term><term>Chine</term><term>Cochons d'Inde</term><term>Furets</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Réplication virale</term><term>Souris de lignée BALB C</term><term>Transmission de maladie infectieuse</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>The H3N2 influenza viruses became widespread in humans during the 1968 H3N2 pandemic and have been a major cause of influenza epidemics ever since. Different lineages of H3N2 influenza viruses are also commonly found in animals. If a different lineage of H3N2 virus jumps to humans, a human influenza pandemic could occur with devastating consequences. Here, we studied the genetics, receptor-binding properties, and replication and transmission in mammals of 15 H3N2 avian influenza viruses detected in live poultry markets in China. We found that the H3N2 avian influenza viruses are complicated reassortants with distinct replication phenotypes in mice. Five viruses replicated efficiently in mice and bound to both human-type and avian-type receptors. These viruses transmitted efficiently to direct-contact guinea pigs, and three of them also transmitted among guinea pigs and ferrets via respiratory droplets. Moreover, ferret antiserum induced by human H3N2 viruses did not react with any of the H3N2 avian influenza viruses. Our study demonstrates that the H3N2 avian influenza viruses pose a clear threat to human health and emphasizes the need for continued surveillance and evaluation of the H3N2 influenza viruses circulating in nature.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name></author><author><name sortKey="Kong, H" uniqKey="Kong H">H Kong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name></author><author><name sortKey="Zhu, W" uniqKey="Zhu W">W Zhu</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name></author><author><name sortKey="Ma, S" uniqKey="Ma S">S Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, X" uniqKey="Zeng X">X Zeng</name></author><author><name sortKey="Tian, G" uniqKey="Tian G">G Tian</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, X" uniqKey="Wei X">X Wei</name></author><author><name sortKey="Cui, J" uniqKey="Cui J">J. 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