H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets
Identifieur interne : 000071 ( Pmc/Checkpoint ); précédent : 000070; suivant : 000072H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets
Auteurs : Lizheng Guan [République populaire de Chine] ; Jianzhong Shi [République populaire de Chine] ; Xingtian Kong [République populaire de Chine] ; Shujie Ma [République populaire de Chine] ; Yaping Zhang [République populaire de Chine] ; Xin Yin [République populaire de Chine] ; Xijun He [République populaire de Chine] ; Liling Liu [République populaire de Chine] ; Yasuo Suzuki [Japon] ; Chengjun Li [République populaire de Chine] ; Guohua Deng [République populaire de Chine] ; Hualan Chen [République populaire de Chine]Source :
- Emerging Microbes & Infections [ 2222-1751 ] ; 2019.
Abstract
The H3N2 influenza viruses became widespread in humans during the 1968 H3N2 pandemic and have been a major cause of influenza epidemics ever since. Different lineages of H3N2 influenza viruses are also commonly found in animals. If a different lineage of H3N2 virus jumps to humans, a human influenza pandemic could occur with devastating consequences. Here, we studied the genetics, receptor-binding properties, and replication and transmission in mammals of 15 H3N2 avian influenza viruses detected in live poultry markets in China. We found that the H3N2 avian influenza viruses are complicated reassortants with distinct replication phenotypes in mice. Five viruses replicated efficiently in mice and bound to both human-type and avian-type receptors. These viruses transmitted efficiently to direct-contact guinea pigs, and three of them also transmitted among guinea pigs and ferrets via respiratory droplets. Moreover, ferret antiserum induced by human H3N2 viruses did not react with any of the H3N2 avian influenza viruses. Our study demonstrates that the H3N2 avian influenza viruses pose a clear threat to human health and emphasizes the need for continued surveillance and evaluation of the H3N2 influenza viruses circulating in nature.
Url:
DOI: 10.1080/22221751.2019.1660590
PubMed: 31495283
PubMed Central: 6746299
Affiliations:
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CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kong, Xingtian" sort="Kong, Xingtian" uniqKey="Kong X" first="Xingtian" last="Kong">Xingtian Kong</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ma, Shujie" sort="Ma, Shujie" uniqKey="Ma S" first="Shujie" last="Ma">Shujie Ma</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Yaping" sort="Zhang, Yaping" uniqKey="Zhang Y" first="Yaping" last="Zhang">Yaping Zhang</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yin, Xin" sort="Yin, Xin" uniqKey="Yin X" first="Xin" last="Yin">Xin Yin</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, 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viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets</title><author><name sortKey="Guan, Lizheng" sort="Guan, Lizheng" uniqKey="Guan L" first="Lizheng" last="Guan">Lizheng Guan</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Jianzhong" sort="Shi, Jianzhong" uniqKey="Shi J" first="Jianzhong" last="Shi">Jianzhong Shi</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kong, Xingtian" sort="Kong, Xingtian" uniqKey="Kong X" first="Xingtian" last="Kong">Xingtian Kong</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ma, Shujie" sort="Ma, Shujie" uniqKey="Ma S" first="Shujie" last="Ma">Shujie Ma</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Yaping" sort="Zhang, Yaping" uniqKey="Zhang Y" first="Yaping" last="Zhang">Yaping Zhang</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yin, Xin" sort="Yin, Xin" uniqKey="Yin X" first="Xin" last="Yin">Xin Yin</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="He, Xijun" sort="He, Xijun" uniqKey="He X" first="Xijun" last="He">Xijun He</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Liling" sort="Liu, Liling" uniqKey="Liu L" first="Liling" last="Liu">Liling Liu</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name><affiliation wicri:level="1"><nlm:aff id="AF2"><institution>College of Life and Health Sciences, Chubu University</institution>, Aichi,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Chengjun" sort="Li, Chengjun" uniqKey="Li C" first="Chengjun" last="Li">Chengjun Li</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deng, Guohua" sort="Deng, Guohua" uniqKey="Deng G" first="Guohua" last="Deng">Guohua Deng</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Hualan" sort="Chen, Hualan" uniqKey="Chen H" first="Hualan" last="Chen">Hualan Chen</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Emerging Microbes & Infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>The H3N2 influenza viruses became widespread in humans during the 1968 H3N2 pandemic and have been a major cause of influenza epidemics ever since. Different lineages of H3N2 influenza viruses are also commonly found in animals. If a different lineage of H3N2 virus jumps to humans, a human influenza pandemic could occur with devastating consequences. Here, we studied the genetics, receptor-binding properties, and replication and transmission in mammals of 15 H3N2 avian influenza viruses detected in live poultry markets in China. We found that the H3N2 avian influenza viruses are complicated reassortants with distinct replication phenotypes in mice. Five viruses replicated efficiently in mice and bound to both human-type and avian-type receptors. These viruses transmitted efficiently to direct-contact guinea pigs, and three of them also transmitted among guinea pigs and ferrets via respiratory droplets. Moreover, ferret antiserum induced by human H3N2 viruses did not react with any of the H3N2 avian influenza viruses. Our study demonstrates that the H3N2 avian influenza viruses pose a clear threat to human health and emphasizes the need for continued surveillance and evaluation of the H3N2 influenza viruses circulating in nature.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name></author><author><name sortKey="Kong, H" uniqKey="Kong H">H Kong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name></author><author><name sortKey="Zhu, W" uniqKey="Zhu W">W Zhu</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name></author><author><name sortKey="Ma, S" uniqKey="Ma S">S Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, X" uniqKey="Zeng X">X Zeng</name></author><author><name sortKey="Tian, G" uniqKey="Tian G">G Tian</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, X" uniqKey="Wei X">X Wei</name></author><author><name sortKey="Cui, J" uniqKey="Cui J">J. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Microbes Infect</journal-id><journal-id journal-id-type="iso-abbrev">Emerg Microbes Infect</journal-id><journal-id journal-id-type="publisher-id">TEMI</journal-id><journal-id journal-id-type="publisher-id">temi20</journal-id><journal-title-group><journal-title>Emerging Microbes & Infections</journal-title></journal-title-group><issn pub-type="epub">2222-1751</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31495283</article-id><article-id pub-id-type="pmc">6746299</article-id><article-id pub-id-type="publisher-id">1660590</article-id><article-id pub-id-type="doi">10.1080/22221751.2019.1660590</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets</article-title><alt-title alt-title-type="running-title">Emerging Microbes & Infections</alt-title><alt-title alt-title-type="running-authors">L. Guan et al.</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Guan</surname><given-names>Lizheng</given-names></name><xref ref-type="aff" rid="AF1"><sup>a</sup></xref><xref ref-type="author-notes" rid="an1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shi</surname><given-names>Jianzhong</given-names></name><xref ref-type="aff" rid="AF1"><sup>a</sup></xref><xref ref-type="author-notes" rid="an1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kong</surname><given-names>Xingtian</given-names></name><xref ref-type="aff" rid="AF1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Shujie</given-names></name><xref ref-type="aff" rid="AF1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Yaping</given-names></name><xref ref-type="aff" rid="AF1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yin</surname><given-names>Xin</given-names></name><xref ref-type="aff" rid="AF1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>He</surname><given-names>Xijun</given-names></name><xref ref-type="aff" rid="AF1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Liling</given-names></name><xref ref-type="aff" rid="AF1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Suzuki</surname><given-names>Yasuo</given-names></name><xref ref-type="aff" rid="AF2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Chengjun</given-names></name><xref ref-type="aff" rid="AF1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Deng</surname><given-names>Guohua</given-names></name><xref ref-type="aff" rid="AF1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor2"></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Hualan</given-names></name><xref ref-type="aff" rid="AF1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1"><sup>CONTACT</sup></xref></contrib><aff id="AF1"><label>a</label><institution>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS</institution>, Harbin,<country>People’s Republic of China</country></aff><aff id="AF2"><label>b</label><institution>College of Life and Health Sciences, Chubu University</institution>, Aichi,<country>Japan</country></aff></contrib-group><author-notes><corresp id="cor1"><label>CONTACT</label> Hualan Chen <email xlink:href="chenhualan@caas.cn">chenhualan@caas.cn</email></corresp><corresp id="cor2">Guohua Deng <email xlink:href="dengguohua01@caas.cn">dengguohua01@caas.cn</email></corresp><fn id="an1"><label>*</label><p>These authors contributed equally to this study.</p></fn><fn><p>Supplemental data for this article can be accessed <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1080/22221751.2019.1660590">https://doi.org/10.1080/22221751.2019.1660590</ext-link></p></fn></author-notes><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>7</day><month>9</month><year>2019</year></pub-date><volume>8</volume><issue>1</issue><fpage seq="125">1280</fpage><lpage>1290</lpage><history><date date-type="received"><day>19</day><month>4</month><year>2019</year></date><date date-type="rev-recd"><day>25</day><month>7</month><year>2019</year></date><date date-type="accepted"><day>20</day><month>8</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>The Author(s)</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="TEMI_8_1660590.pdf"></self-uri><abstract><title>ABSTRACT</title><p>The H3N2 influenza viruses became widespread in humans during the 1968 H3N2 pandemic and have been a major cause of influenza epidemics ever since. Different lineages of H3N2 influenza viruses are also commonly found in animals. If a different lineage of H3N2 virus jumps to humans, a human influenza pandemic could occur with devastating consequences. Here, we studied the genetics, receptor-binding properties, and replication and transmission in mammals of 15 H3N2 avian influenza viruses detected in live poultry markets in China. We found that the H3N2 avian influenza viruses are complicated reassortants with distinct replication phenotypes in mice. Five viruses replicated efficiently in mice and bound to both human-type and avian-type receptors. These viruses transmitted efficiently to direct-contact guinea pigs, and three of them also transmitted among guinea pigs and ferrets via respiratory droplets. Moreover, ferret antiserum induced by human H3N2 viruses did not react with any of the H3N2 avian influenza viruses. Our study demonstrates that the H3N2 avian influenza viruses pose a clear threat to human health and emphasizes the need for continued surveillance and evaluation of the H3N2 influenza viruses circulating in nature.</p></abstract><kwd-group kwd-group-type="author"><title>KEYWORDS</title><kwd>Avian influenza virus</kwd><kwd>H3N2</kwd><kwd>transmission</kwd><kwd>guinea pig</kwd><kwd>ferret</kwd></kwd-group><funding-group><award-group><funding-source><named-content content-type="funder-name">US NIH CEIRS</named-content><named-content content-type="funder-identifier">10.13039/100000002</named-content></funding-source><award-id>HHSN272201400004C</award-id></award-group><award-group><funding-source><named-content content-type="funder-name">National Natural Science Foundation of China</named-content><named-content content-type="funder-identifier">10.13039/501100001809</named-content></funding-source></award-group><award-group><funding-source><named-content content-type="funder-name">National Key R&D Program of China</named-content></funding-source><award-id>2016YFD0500201 and 2016YFD0500203</award-id></award-group><funding-statement>This work was supported by the National Natural Science Foundation of China (31521005 and 31572552), the National Key Research and Development Program of China (2016YFD0500200, 2016YFD0500201 and 2016YFD0500203), and DHHS Contract HHSN272201400004C (NIAID Centers of Excellence for Influenza Research and Surveillance, CEIRS).</funding-statement></funding-group><counts><fig-count count="6"></fig-count><table-count count="1"></table-count><equation-count count="0"></equation-count><ref-count count="30"></ref-count><page-count count="11"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Japon</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Guan, Lizheng" sort="Guan, Lizheng" uniqKey="Guan L" first="Lizheng" last="Guan">Lizheng Guan</name></noRegion><name sortKey="Chen, Hualan" sort="Chen, Hualan" uniqKey="Chen H" first="Hualan" last="Chen">Hualan Chen</name><name sortKey="Deng, Guohua" sort="Deng, Guohua" uniqKey="Deng G" first="Guohua" last="Deng">Guohua Deng</name><name sortKey="He, Xijun" sort="He, Xijun" uniqKey="He X" first="Xijun" last="He">Xijun He</name><name sortKey="Kong, Xingtian" sort="Kong, Xingtian" uniqKey="Kong X" first="Xingtian" last="Kong">Xingtian Kong</name><name sortKey="Li, Chengjun" sort="Li, Chengjun" uniqKey="Li C" first="Chengjun" last="Li">Chengjun Li</name><name sortKey="Liu, Liling" sort="Liu, Liling" uniqKey="Liu L" first="Liling" last="Liu">Liling Liu</name><name sortKey="Ma, Shujie" sort="Ma, Shujie" uniqKey="Ma S" first="Shujie" last="Ma">Shujie Ma</name><name sortKey="Shi, Jianzhong" sort="Shi, Jianzhong" uniqKey="Shi J" first="Jianzhong" last="Shi">Jianzhong Shi</name><name sortKey="Yin, Xin" sort="Yin, Xin" uniqKey="Yin X" first="Xin" last="Yin">Xin Yin</name><name sortKey="Zhang, Yaping" sort="Zhang, Yaping" uniqKey="Zhang Y" first="Yaping" last="Zhang">Yaping Zhang</name></country><country name="Japon"><noRegion><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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