A Single Amino Acid Substitution at Residue 218 of Hemagglutinin Improves the Growth of Influenza A(H7N9) Candidate Vaccine Viruses
Identifieur interne : 001F74 ( Ncbi/Checkpoint ); précédent : 001F73; suivant : 001F75A Single Amino Acid Substitution at Residue 218 of Hemagglutinin Improves the Growth of Influenza A(H7N9) Candidate Vaccine Viruses
Auteurs : Xing Li [États-Unis] ; Yamei Gao [États-Unis] ; Zhiping Ye [États-Unis]Source :
- Journal of Virology [ 0022-538X ] ; 2019.
Descripteurs français
- KwdFr :
- Adaptation biologique, Analyse de survie, Animaux, Attachement viral, Cellules rénales canines Madin-Darby, Chiens, Embryon de poulet, Furets, Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Infections à Orthomyxoviridae (), Modèles animaux de maladie humaine, Protéines mutantes (génétique), Protéines mutantes (métabolisme), Réplication virale, Sous-type H7N9 du virus de la grippe A (croissance et développement), Sous-type H7N9 du virus de la grippe A (génétique), Sous-type H7N9 du virus de la grippe A (immunologie), Substitution d'acide aminé, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (génétique), Vaccins atténués (immunologie), Virus recombinants (croissance et développement), Virus recombinants (génétique).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués.
- croissance et développement : Sous-type H7N9 du virus de la grippe A, Virus recombinants.
- génétique : Glycoprotéine hémagglutinine du virus influenza, Protéines mutantes, Sous-type H7N9 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Virus recombinants.
- immunologie : Sous-type H7N9 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués.
- métabolisme : Glycoprotéine hémagglutinine du virus influenza, Protéines mutantes.
- Adaptation biologique, Analyse de survie, Animaux, Attachement viral, Cellules rénales canines Madin-Darby, Chiens, Embryon de poulet, Furets, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Réplication virale, Substitution d'acide aminé.
English descriptors
- KwdEn :
- Adaptation, Biological, Amino Acid Substitution, Animals, Chick Embryo, Disease Models, Animal, Dogs, Ferrets, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Influenza A Virus, H7N9 Subtype (genetics), Influenza A Virus, H7N9 Subtype (growth & development), Influenza A Virus, H7N9 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Madin Darby Canine Kidney Cells, Mutant Proteins (genetics), Mutant Proteins (metabolism), Orthomyxoviridae Infections (prevention & control), Reassortant Viruses (genetics), Reassortant Viruses (growth & development), Survival Analysis, Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology), Virus Attachment, Virus Replication.
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Mutant Proteins, Vaccines, Attenuated.
- chemical , immunology : Influenza Vaccines, Vaccines, Attenuated.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, Mutant Proteins.
- genetics : Influenza A Virus, H7N9 Subtype, Reassortant Viruses.
- growth & development : Influenza A Virus, H7N9 Subtype, Reassortant Viruses.
- immunology : Influenza A Virus, H7N9 Subtype.
- prevention & control : Orthomyxoviridae Infections.
- Adaptation, Biological, Amino Acid Substitution, Animals, Chick Embryo, Disease Models, Animal, Dogs, Ferrets, Madin Darby Canine Kidney Cells, Survival Analysis, Virus Attachment, Virus Replication.
Abstract
The circulating avian influenza A(H7N9) has caused recurrent epidemic waves with high mortality in China since 2013, in which the alarming fifth wave crossing 2016 and 2017 was highlighted by a large number of human infections and the emergence of highly pathogenic avian influenza (HPAI) A(H7N9) strains in human cases. We generated low-pathogenic reassortant CVVs derived from the emerging A(H7N9) with improved virus replication and protein yield in both MDCK cells and eggs by introducing a single substitution, G218E, into HA, which was associated with reducing HA receptor binding and subsequently balancing HA-NA functions. The
Url:
DOI: 10.1128/JVI.00570-19
PubMed: 31270231
PubMed Central: 6744242
Affiliations:
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PMC:6744242Le document en format XML
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Virus, H7N9 Subtype</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Protéines mutantes</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Biological</term><term>Amino Acid Substitution</term><term>Animals</term><term>Chick Embryo</term><term>Disease Models, Animal</term><term>Dogs</term><term>Ferrets</term><term>Madin Darby Canine Kidney Cells</term><term>Survival Analysis</term><term>Virus Attachment</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adaptation biologique</term><term>Analyse de survie</term><term>Animaux</term><term>Attachement viral</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Embryon de poulet</term><term>Furets</term><term>Infections à Orthomyxoviridae</term><term>Modèles animaux de maladie humaine</term><term>Réplication virale</term><term>Substitution d'acide aminé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The circulating avian influenza A(H7N9) has caused recurrent epidemic waves with high mortality in China since 2013, in which the alarming fifth wave crossing 2016 and 2017 was highlighted by a large number of human infections and the emergence of highly pathogenic avian influenza (HPAI) A(H7N9) strains in human cases. We generated low-pathogenic reassortant CVVs derived from the emerging A(H7N9) with improved virus replication and protein yield in both MDCK cells and eggs by introducing a single substitution, G218E, into HA, which was associated with reducing HA receptor binding and subsequently balancing HA-NA functions. The <italic>in vitro</italic> and <italic>in vivo</italic> experiments demonstrated comparable antigenicity of the G218E CVVs with that of their wild-type (WT) counterparts, and both the WT and the G218E CVVs fully protected ferrets from parental HPAI virus challenge. With high yield traits and the anticipated antigenicity, the G218E CVVs should benefit preparedness against the threat of an A(H7N9) influenza pandemic.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Jiang, H" uniqKey="Jiang H">H Jiang</name></author><author><name sortKey="Wu, P" uniqKey="Wu P">P Wu</name></author><author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name></author><author><name sortKey="Feng, L" uniqKey="Feng L">L Feng</name></author><author><name sortKey="Lai, S" uniqKey="Lai S">S Lai</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Huo, X" uniqKey="Huo X">X Huo</name></author><author><name sortKey="Xu, K" uniqKey="Xu K">K Xu</name></author><author><name sortKey="Chen, E" uniqKey="Chen E">E Chen</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X 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