Antibody Persistence in Adults Two Years after Vaccination with an H1N1 2009 Pandemic Influenza Virus-Like Particle Vaccine
Identifieur interne : 001B37 ( Ncbi/Checkpoint ); précédent : 001B36; suivant : 001B38Antibody Persistence in Adults Two Years after Vaccination with an H1N1 2009 Pandemic Influenza Virus-Like Particle Vaccine
Auteurs : Nuriban Valero-Pacheco [Mexique] ; Marisol Pérez-Toledo [Mexique] ; Miguel Ngel Villasís-Keever [Mexique] ; Adriana Nú Ez-Valencia [Mexique] ; Ilka Bosc Gárate [Mexique] ; Bernardo Lozano-Dubernard [Mexique] ; Horacio Lara-Puente [Mexique] ; Clara Espitia [Mexique] ; Celia Alpuche-Aranda [Mexique] ; Laura C. Bonifaz [Mexique] ; Lourdes Arriaga-Pizano [Mexique] ; Rodolfo Pastelin-Palacios [Mexique] ; Armando Isibasi [Mexique] ; Constantino L Pez-Macías [Mexique, Royaume-Uni]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Facteurs temps, Femelle, Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Jeune adulte, Mexique (épidémiologie), Mâle, Méthode en double aveugle, Pandémies, Rappel de vaccin, Sous-type H1N1 du virus de la grippe A (immunologie), Sujet âgé, Vaccination, Vaccins antigrippaux (immunologie), Vaccins inactivés, Vaccins à pseudo-particules virales (immunologie), Études séroépidémiologiques, Études transversales.
- MESH :
- immunologie : Sous-type H1N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins à pseudo-particules virales.
- sang : Anticorps antiviraux.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine, Mexique.
- Adulte, Adulte d'âge moyen, Facteurs temps, Femelle, Humains, Jeune adulte, Mâle, Méthode en double aveugle, Pandémies, Rappel de vaccin, Sujet âgé, Vaccination, Vaccins inactivés, Études séroépidémiologiques, Études transversales.
- Wicri :
- geographic : Mexique.
English descriptors
- KwdEn :
- Adult, Aged, Antibodies, Viral (blood), Cross-Sectional Studies, Double-Blind Method, Female, Humans, Immunization, Secondary, Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (virology), Male, Mexico (epidemiology), Middle Aged, Pandemics, Seroepidemiologic Studies, Time Factors, Vaccination, Vaccines, Inactivated, Vaccines, Virus-Like Particle (immunology), Young Adult.
- MESH :
- chemical , blood : Antibodies, Viral.
- geographic , epidemiology : Mexico.
- epidemiology : Influenza, Human.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza Vaccines, Vaccines, Virus-Like Particle.
- virology : Influenza, Human.
- Adult, Aged, Cross-Sectional Studies, Double-Blind Method, Female, Humans, Immunization, Secondary, Male, Middle Aged, Pandemics, Seroepidemiologic Studies, Time Factors, Vaccination, Vaccines, Inactivated, Young Adult.
Abstract
The influenza virus is a human pathogen that causes epidemics every year, as well as potential pandemic outbreaks, as occurred in 2009. Vaccination has proven to be sufficient in the prevention and containment of viral spreading. In addition to the current egg-based vaccines, new and promising vaccine platforms, such as cell culture-derived vaccines that include virus-like particles (VLPs), have been developed. VLPs have been shown to be both safe and immunogenic against influenza infections. Although antibody persistence has been studied in traditional egg-based influenza vaccines, studies on antibody response durations induced by VLP influenza vaccines in humans are scarce. Here, we show that subjects vaccinated with an insect cell-derived VLP vaccine, in the midst of the 2009 H1N1 influenza pandemic outbreak in Mexico City, showed antibody persistence up to 24 months post-vaccination. Additionally, we found that subjects that reported being revaccinated with a subsequent inactivated influenza virus vaccine showed higher antibody titres to the pandemic influenza virus than those who were not revaccinated. These findings provide insights into the duration of the antibody responses elicited by an insect cell-derived pandemic influenza VLP vaccine and the possible effects of subsequent influenza vaccination on antibody persistence induced by this VLP vaccine in humans.
Url:
DOI: 10.1371/journal.pone.0150146
PubMed: 26919288
PubMed Central: 4769292
Affiliations:
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Bonifaz</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Arriaga Pizano, Lourdes" sort="Arriaga Pizano, Lourdes" uniqKey="Arriaga Pizano L" first="Lourdes" last="Arriaga-Pizano">Lourdes Arriaga-Pizano</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country 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Isibasi</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Macias, Constantino" sort="L Pez Macias, Constantino" uniqKey="L Pez Macias C" first="Constantino" last="L Pez-Macías">Constantino L Pez-Macías</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country 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Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Perez Toledo, Marisol" sort="Perez Toledo, Marisol" uniqKey="Perez Toledo M" first="Marisol" last="Pérez-Toledo">Marisol Pérez-Toledo</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Villasis Keever, Miguel Ngel" sort="Villasis Keever, Miguel Ngel" uniqKey="Villasis Keever M" first="Miguel Ngel" last="Villasís-Keever">Miguel Ngel Villasís-Keever</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Unidad de Investigación en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional “Siglo XXI”,
Instituto Mexicano del Seguro Social, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Unidad de Investigación en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional “Siglo XXI”,
Instituto Mexicano del Seguro Social, México, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Nu Ez Valencia, Adriana" sort="Nu Ez Valencia, Adriana" uniqKey="Nu Ez Valencia A" first="Adriana" last="Nú Ez-Valencia">Adriana Nú Ez-Valencia</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Bosc Garate, Ilka" sort="Bosc Garate, Ilka" uniqKey="Bosc Garate I" first="Ilka" last="Bosc Gárate">Ilka Bosc Gárate</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Lozano Dubernard, Bernardo" sort="Lozano Dubernard, Bernardo" uniqKey="Lozano Dubernard B" first="Bernardo" last="Lozano-Dubernard">Bernardo Lozano-Dubernard</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Lara Puente, Horacio" sort="Lara Puente, Horacio" uniqKey="Lara Puente H" first="Horacio" last="Lara-Puente">Horacio Lara-Puente</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Espitia, Clara" sort="Espitia, Clara" uniqKey="Espitia C" first="Clara" last="Espitia">Clara Espitia</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Alpuche Aranda, Celia" sort="Alpuche Aranda, Celia" uniqKey="Alpuche Aranda C" first="Celia" last="Alpuche-Aranda">Celia Alpuche-Aranda</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Morelos</wicri:regionArea><wicri:noRegion>Morelos</wicri:noRegion></affiliation></author><author><name sortKey="Bonifaz, Laura C" sort="Bonifaz, Laura C" uniqKey="Bonifaz L" first="Laura C." last="Bonifaz">Laura C. Bonifaz</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Arriaga Pizano, Lourdes" sort="Arriaga Pizano, Lourdes" uniqKey="Arriaga Pizano L" first="Lourdes" last="Arriaga-Pizano">Lourdes Arriaga-Pizano</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Pastelin Palacios, Rodolfo" sort="Pastelin Palacios, Rodolfo" uniqKey="Pastelin Palacios R" first="Rodolfo" last="Pastelin-Palacios">Rodolfo Pastelin-Palacios</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Facultad de Química, Universidad Nacional Autónoma de México, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Facultad de Química, Universidad Nacional Autónoma de México, México, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Isibasi, Armando" sort="Isibasi, Armando" uniqKey="Isibasi A" first="Armando" last="Isibasi">Armando Isibasi</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Macias, Constantino" sort="L Pez Macias, Constantino" uniqKey="L Pez Macias C" first="Constantino" last="L Pez-Macías">Constantino L Pez-Macías</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff008"><addr-line>Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antibodies, Viral (blood)</term><term>Cross-Sectional Studies</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Immunization, Secondary</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Mexico (epidemiology)</term><term>Middle Aged</term><term>Pandemics</term><term>Seroepidemiologic Studies</term><term>Time Factors</term><term>Vaccination</term><term>Vaccines, Inactivated</term><term>Vaccines, Virus-Like Particle (immunology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Facteurs temps</term><term>Femelle</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Jeune adulte</term><term>Mexique (épidémiologie)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Pandémies</term><term>Rappel de vaccin</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sujet âgé</term><term>Vaccination</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins inactivés</term><term>Vaccins à pseudo-particules virales (immunologie)</term><term>Études séroépidémiologiques</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Mexico</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins à pseudo-particules virales</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza Vaccines</term><term>Vaccines, Virus-Like Particle</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Mexique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cross-Sectional Studies</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Immunization, Secondary</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Seroepidemiologic Studies</term><term>Time Factors</term><term>Vaccination</term><term>Vaccines, Inactivated</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Pandémies</term><term>Rappel de vaccin</term><term>Sujet âgé</term><term>Vaccination</term><term>Vaccins inactivés</term><term>Études séroépidémiologiques</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Mexique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The influenza virus is a human pathogen that causes epidemics every year, as well as potential pandemic outbreaks, as occurred in 2009. Vaccination has proven to be sufficient in the prevention and containment of viral spreading. In addition to the current egg-based vaccines, new and promising vaccine platforms, such as cell culture-derived vaccines that include virus-like particles (VLPs), have been developed. VLPs have been shown to be both safe and immunogenic against influenza infections. Although antibody persistence has been studied in traditional egg-based influenza vaccines, studies on antibody response durations induced by VLP influenza vaccines in humans are scarce. Here, we show that subjects vaccinated with an insect cell-derived VLP vaccine, in the midst of the 2009 H1N1 influenza pandemic outbreak in Mexico City, showed antibody persistence up to 24 months post-vaccination. Additionally, we found that subjects that reported being revaccinated with a subsequent inactivated influenza virus vaccine showed higher antibody titres to the pandemic influenza virus than those who were not revaccinated. These findings provide insights into the duration of the antibody responses elicited by an insect cell-derived pandemic influenza VLP vaccine and the possible effects of subsequent influenza vaccination on antibody persistence induced by this VLP vaccine in humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Nicholson, Kg" uniqKey="Nicholson K">KG Nicholson</name></author><author><name sortKey="Wood, Jm" uniqKey="Wood J">JM Wood</name></author><author><name sortKey="Zambon, M" uniqKey="Zambon M">M Zambon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Ss" uniqKey="Wong S">SS Wong</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lopez Macias, C" uniqKey="Lopez Macias C">C Lopez-Macias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plummer, 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Bonifaz</name><name sortKey="Bosc Garate, Ilka" sort="Bosc Garate, Ilka" uniqKey="Bosc Garate I" first="Ilka" last="Bosc Gárate">Ilka Bosc Gárate</name><name sortKey="Espitia, Clara" sort="Espitia, Clara" uniqKey="Espitia C" first="Clara" last="Espitia">Clara Espitia</name><name sortKey="Isibasi, Armando" sort="Isibasi, Armando" uniqKey="Isibasi A" first="Armando" last="Isibasi">Armando Isibasi</name><name sortKey="L Pez Macias, Constantino" sort="L Pez Macias, Constantino" uniqKey="L Pez Macias C" first="Constantino" last="L Pez-Macías">Constantino L Pez-Macías</name><name sortKey="Lara Puente, Horacio" sort="Lara Puente, Horacio" uniqKey="Lara Puente H" first="Horacio" last="Lara-Puente">Horacio Lara-Puente</name><name sortKey="Lozano Dubernard, Bernardo" sort="Lozano Dubernard, Bernardo" uniqKey="Lozano Dubernard B" first="Bernardo" last="Lozano-Dubernard">Bernardo Lozano-Dubernard</name><name sortKey="Nu Ez Valencia, Adriana" sort="Nu Ez Valencia, Adriana" uniqKey="Nu Ez Valencia A" first="Adriana" last="Nú Ez-Valencia">Adriana Nú Ez-Valencia</name><name sortKey="Pastelin Palacios, Rodolfo" sort="Pastelin Palacios, Rodolfo" uniqKey="Pastelin Palacios R" first="Rodolfo" last="Pastelin-Palacios">Rodolfo Pastelin-Palacios</name><name sortKey="Perez Toledo, Marisol" sort="Perez Toledo, Marisol" uniqKey="Perez Toledo M" first="Marisol" last="Pérez-Toledo">Marisol Pérez-Toledo</name><name sortKey="Perez Toledo, Marisol" sort="Perez Toledo, Marisol" uniqKey="Perez Toledo M" first="Marisol" last="Pérez-Toledo">Marisol Pérez-Toledo</name><name sortKey="Valero Pacheco, Nuriban" sort="Valero Pacheco, Nuriban" uniqKey="Valero Pacheco N" first="Nuriban" last="Valero-Pacheco">Nuriban Valero-Pacheco</name><name sortKey="Villasis Keever, Miguel Ngel" sort="Villasis Keever, Miguel Ngel" uniqKey="Villasis Keever M" first="Miguel Ngel" last="Villasís-Keever">Miguel Ngel Villasís-Keever</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="L Pez Macias, Constantino" sort="L Pez Macias, Constantino" uniqKey="L Pez Macias C" first="Constantino" last="L Pez-Macías">Constantino L Pez-Macías</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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