Antibody Persistence in Adults Two Years after Vaccination with an H1N1 2009 Pandemic Influenza Virus-Like Particle Vaccine
Identifieur interne : 000C42 ( Pmc/Curation ); précédent : 000C41; suivant : 000C43Antibody Persistence in Adults Two Years after Vaccination with an H1N1 2009 Pandemic Influenza Virus-Like Particle Vaccine
Auteurs : Nuriban Valero-Pacheco [Mexique] ; Marisol Pérez-Toledo [Mexique] ; Miguel Ngel Villasís-Keever [Mexique] ; Adriana Nú Ez-Valencia [Mexique] ; Ilka Bosc Gárate [Mexique] ; Bernardo Lozano-Dubernard [Mexique] ; Horacio Lara-Puente [Mexique] ; Clara Espitia [Mexique] ; Celia Alpuche-Aranda [Mexique] ; Laura C. Bonifaz [Mexique] ; Lourdes Arriaga-Pizano [Mexique] ; Rodolfo Pastelin-Palacios [Mexique] ; Armando Isibasi [Mexique] ; Constantino L Pez-Macías [Mexique, Royaume-Uni]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
The influenza virus is a human pathogen that causes epidemics every year, as well as potential pandemic outbreaks, as occurred in 2009. Vaccination has proven to be sufficient in the prevention and containment of viral spreading. In addition to the current egg-based vaccines, new and promising vaccine platforms, such as cell culture-derived vaccines that include virus-like particles (VLPs), have been developed. VLPs have been shown to be both safe and immunogenic against influenza infections. Although antibody persistence has been studied in traditional egg-based influenza vaccines, studies on antibody response durations induced by VLP influenza vaccines in humans are scarce. Here, we show that subjects vaccinated with an insect cell-derived VLP vaccine, in the midst of the 2009 H1N1 influenza pandemic outbreak in Mexico City, showed antibody persistence up to 24 months post-vaccination. Additionally, we found that subjects that reported being revaccinated with a subsequent inactivated influenza virus vaccine showed higher antibody titres to the pandemic influenza virus than those who were not revaccinated. These findings provide insights into the duration of the antibody responses elicited by an insect cell-derived pandemic influenza VLP vaccine and the possible effects of subsequent influenza vaccination on antibody persistence induced by this VLP vaccine in humans.
Url:
DOI: 10.1371/journal.pone.0150146
PubMed: 26919288
PubMed Central: 4769292
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antibody Persistence in Adults Two Years after Vaccination with an H1N1 2009 Pandemic Influenza Virus-Like Particle Vaccine</title><author><name sortKey="Valero Pacheco, Nuriban" sort="Valero Pacheco, Nuriban" uniqKey="Valero Pacheco N" first="Nuriban" last="Valero-Pacheco">Nuriban Valero-Pacheco</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Perez Toledo, Marisol" sort="Perez Toledo, Marisol" uniqKey="Perez Toledo M" first="Marisol" last="Pérez-Toledo">Marisol Pérez-Toledo</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Villasis Keever, Miguel Ngel" sort="Villasis Keever, Miguel Ngel" uniqKey="Villasis Keever M" first="Miguel Ngel" last="Villasís-Keever">Miguel Ngel Villasís-Keever</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Unidad de Investigación en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional “Siglo XXI”,
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Instituto Mexicano del Seguro Social, México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Nu Ez Valencia, Adriana" sort="Nu Ez Valencia, Adriana" uniqKey="Nu Ez Valencia A" first="Adriana" last="Nú Ez-Valencia">Adriana Nú Ez-Valencia</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Bosc Garate, Ilka" sort="Bosc Garate, Ilka" uniqKey="Bosc Garate I" first="Ilka" last="Bosc Gárate">Ilka Bosc Gárate</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Lozano Dubernard, Bernardo" sort="Lozano Dubernard, Bernardo" uniqKey="Lozano Dubernard B" first="Bernardo" last="Lozano-Dubernard">Bernardo Lozano-Dubernard</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Lara Puente, Horacio" sort="Lara Puente, Horacio" uniqKey="Lara Puente H" first="Horacio" last="Lara-Puente">Horacio Lara-Puente</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Espitia, Clara" sort="Espitia, Clara" uniqKey="Espitia C" first="Clara" last="Espitia">Clara Espitia</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Alpuche Aranda, Celia" sort="Alpuche Aranda, Celia" uniqKey="Alpuche Aranda C" first="Celia" last="Alpuche-Aranda">Celia Alpuche-Aranda</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Morelos</wicri:regionArea></affiliation></author><author><name sortKey="Bonifaz, Laura C" sort="Bonifaz, Laura C" uniqKey="Bonifaz L" first="Laura C." last="Bonifaz">Laura C. Bonifaz</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Arriaga Pizano, Lourdes" sort="Arriaga Pizano, Lourdes" uniqKey="Arriaga Pizano L" first="Lourdes" last="Arriaga-Pizano">Lourdes Arriaga-Pizano</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Pastelin Palacios, Rodolfo" sort="Pastelin Palacios, Rodolfo" uniqKey="Pastelin Palacios R" first="Rodolfo" last="Pastelin-Palacios">Rodolfo Pastelin-Palacios</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Facultad de Química, Universidad Nacional Autónoma de México, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Facultad de Química, Universidad Nacional Autónoma de México, México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Isibasi, Armando" sort="Isibasi, Armando" uniqKey="Isibasi A" first="Armando" last="Isibasi">Armando Isibasi</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="L Pez Macias, Constantino" sort="L Pez Macias, Constantino" uniqKey="L Pez Macias C" first="Constantino" last="L Pez-Macías">Constantino L Pez-Macías</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Medicine, University of Oxford, Oxford</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26919288</idno><idno type="pmc">4769292</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769292</idno><idno type="RBID">PMC:4769292</idno><idno type="doi">10.1371/journal.pone.0150146</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000C42</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C42</idno><idno type="wicri:Area/Pmc/Curation">000C42</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antibody Persistence in Adults Two Years after Vaccination with an H1N1 2009 Pandemic Influenza Virus-Like Particle Vaccine</title><author><name sortKey="Valero Pacheco, Nuriban" sort="Valero Pacheco, Nuriban" uniqKey="Valero Pacheco N" first="Nuriban" last="Valero-Pacheco">Nuriban Valero-Pacheco</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Perez Toledo, Marisol" sort="Perez Toledo, Marisol" uniqKey="Perez Toledo M" first="Marisol" last="Pérez-Toledo">Marisol Pérez-Toledo</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Villasis Keever, Miguel Ngel" sort="Villasis Keever, Miguel Ngel" uniqKey="Villasis Keever M" first="Miguel Ngel" last="Villasís-Keever">Miguel Ngel Villasís-Keever</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Unidad de Investigación en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional “Siglo XXI”,
Instituto Mexicano del Seguro Social, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Unidad de Investigación en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional “Siglo XXI”,
Instituto Mexicano del Seguro Social, México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Nu Ez Valencia, Adriana" sort="Nu Ez Valencia, Adriana" uniqKey="Nu Ez Valencia A" first="Adriana" last="Nú Ez-Valencia">Adriana Nú Ez-Valencia</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Bosc Garate, Ilka" sort="Bosc Garate, Ilka" uniqKey="Bosc Garate I" first="Ilka" last="Bosc Gárate">Ilka Bosc Gárate</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Lozano Dubernard, Bernardo" sort="Lozano Dubernard, Bernardo" uniqKey="Lozano Dubernard B" first="Bernardo" last="Lozano-Dubernard">Bernardo Lozano-Dubernard</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Lara Puente, Horacio" sort="Lara Puente, Horacio" uniqKey="Lara Puente H" first="Horacio" last="Lara-Puente">Horacio Lara-Puente</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Espitia, Clara" sort="Espitia, Clara" uniqKey="Espitia C" first="Clara" last="Espitia">Clara Espitia</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Alpuche Aranda, Celia" sort="Alpuche Aranda, Celia" uniqKey="Alpuche Aranda C" first="Celia" last="Alpuche-Aranda">Celia Alpuche-Aranda</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Morelos</wicri:regionArea></affiliation></author><author><name sortKey="Bonifaz, Laura C" sort="Bonifaz, Laura C" uniqKey="Bonifaz L" first="Laura C." last="Bonifaz">Laura C. Bonifaz</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Arriaga Pizano, Lourdes" sort="Arriaga Pizano, Lourdes" uniqKey="Arriaga Pizano L" first="Lourdes" last="Arriaga-Pizano">Lourdes Arriaga-Pizano</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Pastelin Palacios, Rodolfo" sort="Pastelin Palacios, Rodolfo" uniqKey="Pastelin Palacios R" first="Rodolfo" last="Pastelin-Palacios">Rodolfo Pastelin-Palacios</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Facultad de Química, Universidad Nacional Autónoma de México, México, D.F., México</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Facultad de Química, Universidad Nacional Autónoma de México, México, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Isibasi, Armando" sort="Isibasi, Armando" uniqKey="Isibasi A" first="Armando" last="Isibasi">Armando Isibasi</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation></author><author><name sortKey="L Pez Macias, Constantino" sort="L Pez Macias, Constantino" uniqKey="L Pez Macias C" first="Constantino" last="L Pez-Macías">Constantino L Pez-Macías</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F.</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Medicine, University of Oxford, Oxford</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The influenza virus is a human pathogen that causes epidemics every year, as well as potential pandemic outbreaks, as occurred in 2009. Vaccination has proven to be sufficient in the prevention and containment of viral spreading. In addition to the current egg-based vaccines, new and promising vaccine platforms, such as cell culture-derived vaccines that include virus-like particles (VLPs), have been developed. VLPs have been shown to be both safe and immunogenic against influenza infections. Although antibody persistence has been studied in traditional egg-based influenza vaccines, studies on antibody response durations induced by VLP influenza vaccines in humans are scarce. Here, we show that subjects vaccinated with an insect cell-derived VLP vaccine, in the midst of the 2009 H1N1 influenza pandemic outbreak in Mexico City, showed antibody persistence up to 24 months post-vaccination. Additionally, we found that subjects that reported being revaccinated with a subsequent inactivated influenza virus vaccine showed higher antibody titres to the pandemic influenza virus than those who were not revaccinated. These findings provide insights into the duration of the antibody responses elicited by an insect cell-derived pandemic influenza VLP vaccine and the possible effects of subsequent influenza vaccination on antibody persistence induced by this VLP vaccine in humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Nicholson, Kg" uniqKey="Nicholson K">KG Nicholson</name></author><author><name sortKey="Wood, Jm" uniqKey="Wood J">JM Wood</name></author><author><name sortKey="Zambon, M" uniqKey="Zambon M">M Zambon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Ss" uniqKey="Wong S">SS Wong</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lopez Macias, C" uniqKey="Lopez Macias C">C Lopez-Macias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plummer, 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26919288</article-id><article-id pub-id-type="pmc">4769292</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0150146</article-id><article-id pub-id-type="publisher-id">PONE-D-15-52652</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Physiology</subject><subj-group><subject>Immune Physiology</subject><subj-group><subject>Antibodies</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Physiology</subject><subj-group><subject>Immune Physiology</subject><subj-group><subject>Antibodies</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Immune System Proteins</subject><subj-group><subject>Antibodies</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Immune System Proteins</subject><subj-group><subject>Antibodies</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Biochemistry</subject><subj-group><subject>Proteins</subject><subj-group><subject>Immune System Proteins</subject><subj-group><subject>Antibodies</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccines</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and 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Health Sciences</subject><subj-group><subject>Public and Occupational Health</subject><subj-group><subject>Preventive Medicine</subject><subj-group><subject>Vaccination and Immunization</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Viral Diseases</subject><subj-group><subject>Influenza</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>RNA viruses</subject><subj-group><subject>Orthomyxoviruses</subject><subj-group><subject>Influenza Viruses</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Microbiology</subject><subj-group><subject>Medical Microbiology</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Orthomyxoviruses</subject><subj-group><subject>Influenza Viruses</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Pathology and Laboratory Medicine</subject><subj-group><subject>Pathogens</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Orthomyxoviruses</subject><subj-group><subject>Influenza Viruses</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Orthomyxoviruses</subject><subj-group><subject>Influenza Viruses</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccines</subject><subj-group><subject>Viral Vaccines</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccines</subject><subj-group><subject>Viral Vaccines</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Public and Occupational Health</subject><subj-group><subject>Preventive Medicine</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccines</subject><subj-group><subject>Viral Vaccines</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Microbiology</subject><subj-group><subject>Virology</subject><subj-group><subject>Viral Vaccines</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Immune Response</subject><subj-group><subject>Antibody Response</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Immune Response</subject><subj-group><subject>Antibody Response</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>RNA viruses</subject><subj-group><subject>Orthomyxoviruses</subject><subj-group><subject>Influenza viruses</subject><subj-group><subject>Influenza A virus</subject><subj-group><subject>H1N1</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Microbiology</subject><subj-group><subject>Medical microbiology</subject><subj-group><subject>Microbial pathogens</subject><subj-group><subject>Viral pathogens</subject><subj-group><subject>Orthomyxoviruses</subject><subj-group><subject>Influenza viruses</subject><subj-group><subject>Influenza A virus</subject><subj-group><subject>H1N1</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and health sciences</subject><subj-group><subject>Pathology and laboratory medicine</subject><subj-group><subject>Pathogens</subject><subj-group><subject>Microbial pathogens</subject><subj-group><subject>Viral pathogens</subject><subj-group><subject>Orthomyxoviruses</subject><subj-group><subject>Influenza viruses</subject><subj-group><subject>Influenza A virus</subject><subj-group><subject>H1N1</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>Viral pathogens</subject><subj-group><subject>Orthomyxoviruses</subject><subj-group><subject>Influenza viruses</subject><subj-group><subject>Influenza A virus</subject><subj-group><subject>H1N1</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Antibody Persistence in Adults Two Years after Vaccination with an H1N1 2009 Pandemic Influenza Virus-Like Particle Vaccine</article-title><alt-title alt-title-type="running-head">Antibody Persistence from an Influenza VLP Vaccine</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Valero-Pacheco</surname><given-names>Nuriban</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Pérez-Toledo</surname><given-names>Marisol</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Villasís-Keever</surname><given-names>Miguel Ángel</given-names></name><xref ref-type="aff" rid="aff003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Núñez-Valencia</surname><given-names>Adriana</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Boscó-Gárate</surname><given-names>Ilka</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lozano-Dubernard</surname><given-names>Bernardo</given-names></name><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lara-Puente</surname><given-names>Horacio</given-names></name><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Espitia</surname><given-names>Clara</given-names></name><xref ref-type="aff" rid="aff005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Alpuche-Aranda</surname><given-names>Celia</given-names></name><xref ref-type="aff" rid="aff006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bonifaz</surname><given-names>Laura C.</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Arriaga-Pizano</surname><given-names>Lourdes</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pastelin-Palacios</surname><given-names>Rodolfo</given-names></name><xref ref-type="aff" rid="aff007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Isibasi</surname><given-names>Armando</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>López-Macías</surname><given-names>Constantino</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff008"><sup>8</sup></xref><xref ref-type="corresp" rid="cor001">*</xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute, Mexico City, D.F., Mexico</addr-line></aff><aff id="aff002"><label>2</label><addr-line>Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., México</addr-line></aff><aff id="aff003"><label>3</label><addr-line>Unidad de Investigación en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional “Siglo XXI”,
Instituto Mexicano del Seguro Social, México, D.F., México</addr-line></aff><aff id="aff004"><label>4</label><addr-line>Departamento de Investigación y Desarrollo, Laboratorio Avi-Mex, S.A. de C.V., México, D.F., México</addr-line></aff><aff id="aff005"><label>5</label><addr-line>Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F., México</addr-line></aff><aff id="aff006"><label>6</label><addr-line>Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México</addr-line></aff><aff id="aff007"><label>7</label><addr-line>Facultad de Química, Universidad Nacional Autónoma de México, México, D.F., México</addr-line></aff><aff id="aff008"><label>8</label><addr-line>Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Krammer</surname><given-names>Florian</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Icahn School of Medicine at Mount Sinai, UNITED STATES</addr-line></aff><author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: CLM AI RPP LCB. Performed the experiments: NVP MPT ANV IBG. Analyzed the data: NVP MPT ANV MAVK HLP LCB LAP RPP AI CLM. Contributed reagents/materials/analysis tools: CE CAA BLD HLP CLM AI. Wrote the paper: NVP MPT CLM.</p></fn><corresp id="cor001">* E-mail: <email>constantino@sminmunologia.org</email></corresp></author-notes><pub-date pub-type="epub"><day>26</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>11</volume><issue>2</issue><elocation-id>e0150146</elocation-id><history><date date-type="received"><day>3</day><month>12</month><year>2015</year></date><date date-type="accepted"><day>9</day><month>2</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 Valero-Pacheco et al</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Valero-Pacheco et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0150146.pdf"></self-uri><abstract><p>The influenza virus is a human pathogen that causes epidemics every year, as well as potential pandemic outbreaks, as occurred in 2009. Vaccination has proven to be sufficient in the prevention and containment of viral spreading. In addition to the current egg-based vaccines, new and promising vaccine platforms, such as cell culture-derived vaccines that include virus-like particles (VLPs), have been developed. VLPs have been shown to be both safe and immunogenic against influenza infections. Although antibody persistence has been studied in traditional egg-based influenza vaccines, studies on antibody response durations induced by VLP influenza vaccines in humans are scarce. Here, we show that subjects vaccinated with an insect cell-derived VLP vaccine, in the midst of the 2009 H1N1 influenza pandemic outbreak in Mexico City, showed antibody persistence up to 24 months post-vaccination. Additionally, we found that subjects that reported being revaccinated with a subsequent inactivated influenza virus vaccine showed higher antibody titres to the pandemic influenza virus than those who were not revaccinated. These findings provide insights into the duration of the antibody responses elicited by an insect cell-derived pandemic influenza VLP vaccine and the possible effects of subsequent influenza vaccination on antibody persistence induced by this VLP vaccine in humans.</p></abstract><funding-group><funding-statement>This work was supported by grants from the Mexican Social Security Institute (IMSS) through the IMSS Fondo de Investigación en Salud projects as follows: FIS/IMSS/PROT/G12/1152 and FIS/IMSS/PROT/PRIO/11/013 awarded to CLM. Funding was also provided by the Mexican National Science and Technology Council (CONACYT), project number CB166946-2011, awarded to RPP. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><fig-count count="1"></fig-count><table-count count="3"></table-count><page-count count="13"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper.</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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