Genetics, Receptor Binding Property, and Transmissibility in Mammals of Naturally Isolated H9N2 Avian Influenza Viruses
Identifieur interne : 001950 ( Ncbi/Checkpoint ); précédent : 001949; suivant : 001951Genetics, Receptor Binding Property, and Transmissibility in Mammals of Naturally Isolated H9N2 Avian Influenza Viruses
Auteurs : Xuyong Li [République populaire de Chine] ; Jianzhong Shi [République populaire de Chine] ; Jing Guo [République populaire de Chine] ; Guohua Deng [République populaire de Chine] ; Qianyi Zhang [République populaire de Chine] ; Jinliang Wang [République populaire de Chine] ; Xijun He [République populaire de Chine] ; Kaicheng Wang [République populaire de Chine] ; Jiming Chen [République populaire de Chine] ; Yuanyuan Li [République populaire de Chine] ; Jun Fan [République populaire de Chine] ; Huiui Kong [République populaire de Chine] ; Chunyang Gu [République populaire de Chine] ; Yuantao Guan [République populaire de Chine] ; Yasuo Suzuki [Japon] ; Yoshihiro Kawaoka [Japon] ; Liling Liu [République populaire de Chine] ; Yongping Jiang [République populaire de Chine] ; Guobin Tian [République populaire de Chine] ; Yanbing Li [République populaire de Chine] ; Zhigao Bu [République populaire de Chine] ; Hualan Chen [République populaire de Chine]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Cellules rénales canines Madin-Darby, Chiens, Chine, Données de séquences moléculaires, Furets, Grippe chez les oiseaux (génétique), Grippe chez les oiseaux (transmission), Grippe humaine (génétique), Grippe humaine (transmission), Humains, Maladies de la volaille (génétique), Maladies de la volaille (transmission), Maladies de la volaille (virologie), Poulets, Sous-type H9N2 du virus de la grippe A (génétique), Sous-type H9N2 du virus de la grippe A (isolement et purification), Sous-type H9N2 du virus de la grippe A (pathogénicité), Séquence nucléotidique, Variation génétique.
- MESH :
- génétique : Grippe chez les oiseaux, Grippe humaine, Maladies de la volaille, Sous-type H9N2 du virus de la grippe A.
- isolement et purification : Sous-type H9N2 du virus de la grippe A.
- pathogénicité : Sous-type H9N2 du virus de la grippe A.
- virologie : Maladies de la volaille.
- Animaux, Cellules rénales canines Madin-Darby, Chiens, Chine, Données de séquences moléculaires, Furets, Grippe chez les oiseaux, Grippe humaine, Humains, Maladies de la volaille, Poulets, Séquence nucléotidique, Variation génétique.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Animals, Base Sequence, Chickens, China, Dogs, Ferrets, Genetic Variation, Humans, Influenza A Virus, H9N2 Subtype (genetics), Influenza A Virus, H9N2 Subtype (isolation & purification), Influenza A Virus, H9N2 Subtype (pathogenicity), Influenza in Birds (genetics), Influenza in Birds (transmission), Influenza, Human (genetics), Influenza, Human (transmission), Madin Darby Canine Kidney Cells, Molecular Sequence Data, Poultry Diseases (genetics), Poultry Diseases (transmission), Poultry Diseases (virology).
- MESH :
- geographic : China.
- genetics : Influenza A Virus, H9N2 Subtype, Influenza in Birds, Influenza, Human, Poultry Diseases.
- isolation & purification : Influenza A Virus, H9N2 Subtype.
- pathogenicity : Influenza A Virus, H9N2 Subtype.
- transmission : Influenza in Birds, Influenza, Human, Poultry Diseases.
- virology : Poultry Diseases.
- Animals, Base Sequence, Chickens, Dogs, Ferrets, Genetic Variation, Humans, Madin Darby Canine Kidney Cells, Molecular Sequence Data.
Abstract
H9N2 subtype influenza viruses have been detected in different species of wild birds and domestic poultry in many countries for several decades. Because these viruses are of low pathogenicity in poultry, their eradication is not a priority for animal disease control in many countries, which has allowed them to continue to evolve and spread. Here, we characterized the genetic variation, receptor-binding specificity, replication capability, and transmission in mammals of a series of H9N2 influenza viruses that were detected in live poultry markets in southern China between 2009 and 2013. Thirty-five viruses represented 17 genotypes on the basis of genomic diversity, and one specific “internal-gene-combination” predominated among the H9N2 viruses. This gene combination was also present in the H7N9 and H10N8 viruses that have infected humans in China. All of the 35 viruses preferentially bound to the human-like receptor, although two also retained the ability to bind to the avian-like receptor. Six of nine viruses tested were transmissible in ferrets by respiratory droplet; two were highly transmissible. Some H9N2 viruses readily acquired the 627K or 701N mutation in their PB2 gene upon infection of ferrets, further enhancing their virulence and transmission in mammals. Our study indicates that the widespread dissemination of H9N2 viruses poses a threat to human health not only because of the potential of these viruses to cause an influenza pandemic, but also because they can function as “vehicles” to deliver different subtypes of influenza viruses from avian species to humans.
Url:
DOI: 10.1371/journal.ppat.1004508
PubMed: 25411973
PubMed Central: 4239090
Affiliations:
- Japon, République populaire de Chine
- Région de Kantō, Wisconsin
- Madison (Wisconsin), Tokyo
- Université de Tokyo, Université du Wisconsin à Madison
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PMC:4239090Le document en format XML
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Kaicheng" sort="Wang, Kaicheng" uniqKey="Wang K" first="Kaicheng" last="Wang">Kaicheng Wang</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Laboratory of Avian Disease Surveillance, China Animal Health and Epidemiology Center, Qingdao, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Avian Disease Surveillance, China Animal Health and Epidemiology Center, Qingdao</wicri:regionArea><wicri:noRegion>Qingdao</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jiming" sort="Chen, Jiming" uniqKey="Chen J" first="Jiming" last="Chen">Jiming Chen</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Laboratory of Avian Disease Surveillance, China Animal Health and Epidemiology Center, Qingdao, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Avian Disease Surveillance, 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first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author><author><name sortKey="Liu, Liling" sort="Liu, Liling" uniqKey="Liu L" first="Liling" last="Liu">Liling Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Yongping" sort="Jiang, Yongping" uniqKey="Jiang Y" first="Yongping" last="Jiang">Yongping Jiang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Tian, Guobin" sort="Tian, Guobin" uniqKey="Tian G" first="Guobin" last="Tian">Guobin Tian</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yanbing" sort="Li, Yanbing" uniqKey="Li Y" first="Yanbing" last="Li">Yanbing Li</name><affiliation wicri:level="1"><nlm:aff 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Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hualan" sort="Chen, Hualan" uniqKey="Chen H" first="Hualan" last="Chen">Hualan Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25411973</idno><idno type="pmc">4239090</idno><idno 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Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou</wicri:regionArea><wicri:noRegion>Lanzhou</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Jianzhong" sort="Shi, Jianzhong" uniqKey="Shi J" first="Jianzhong" last="Shi">Jianzhong Shi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Jing" sort="Guo, Jing" uniqKey="Guo J" first="Jing" last="Guo">Jing Guo</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou</wicri:regionArea><wicri:noRegion>Lanzhou</wicri:noRegion></affiliation></author><author><name sortKey="Deng, Guohua" sort="Deng, Guohua" uniqKey="Deng G" first="Guohua" last="Deng">Guohua Deng</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Qianyi" sort="Zhang, Qianyi" uniqKey="Zhang Q" first="Qianyi" last="Zhang">Qianyi Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jinliang" sort="Wang, Jinliang" uniqKey="Wang J" first="Jinliang" last="Wang">Jinliang Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="He, Xijun" sort="He, Xijun" uniqKey="He X" first="Xijun" last="He">Xijun He</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Kaicheng" sort="Wang, Kaicheng" uniqKey="Wang K" first="Kaicheng" last="Wang">Kaicheng Wang</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Laboratory of Avian Disease Surveillance, China Animal Health and Epidemiology Center, Qingdao, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Avian Disease Surveillance, China Animal Health and Epidemiology Center, Qingdao</wicri:regionArea><wicri:noRegion>Qingdao</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jiming" sort="Chen, Jiming" uniqKey="Chen J" first="Jiming" last="Chen">Jiming Chen</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Laboratory of Avian Disease Surveillance, China Animal Health and Epidemiology Center, Qingdao, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Avian Disease Surveillance, China Animal Health and Epidemiology Center, Qingdao</wicri:regionArea><wicri:noRegion>Qingdao</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yuanyuan" sort="Li, Yuanyuan" uniqKey="Li Y" first="Yuanyuan" last="Li">Yuanyuan Li</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Jun" sort="Fan, Jun" uniqKey="Fan J" first="Jun" last="Fan">Jun Fan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Kong, Huiui" sort="Kong, Huiui" uniqKey="Kong H" first="Huiui" last="Kong">Huiui Kong</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Gu, Chunyang" sort="Gu, Chunyang" uniqKey="Gu C" first="Chunyang" last="Gu">Chunyang Gu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Yuantao" sort="Guan, Yuantao" uniqKey="Guan Y" first="Yuantao" last="Guan">Yuantao Guan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>College of Life and Health Sciences, Chubu University, Aichi, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>College of Life and Health Sciences, Chubu University, Aichi</wicri:regionArea><wicri:noRegion>Aichi</wicri:noRegion></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author><author><name sortKey="Liu, Liling" sort="Liu, Liling" uniqKey="Liu L" first="Liling" last="Liu">Liling Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Yongping" sort="Jiang, Yongping" uniqKey="Jiang Y" first="Yongping" last="Jiang">Yongping Jiang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Tian, Guobin" sort="Tian, Guobin" uniqKey="Tian G" first="Guobin" last="Tian">Guobin Tian</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yanbing" sort="Li, Yanbing" uniqKey="Li Y" first="Yanbing" last="Li">Yanbing Li</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Bu, Zhigao" sort="Bu, Zhigao" uniqKey="Bu Z" first="Zhigao" last="Bu">Zhigao Bu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hualan" sort="Chen, Hualan" uniqKey="Chen H" first="Hualan" last="Chen">Hualan Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Chickens</term><term>China</term><term>Dogs</term><term>Ferrets</term><term>Genetic Variation</term><term>Humans</term><term>Influenza A Virus, H9N2 Subtype (genetics)</term><term>Influenza A Virus, H9N2 Subtype (isolation & purification)</term><term>Influenza A Virus, H9N2 Subtype (pathogenicity)</term><term>Influenza in Birds (genetics)</term><term>Influenza in Birds (transmission)</term><term>Influenza, Human (genetics)</term><term>Influenza, Human (transmission)</term><term>Madin Darby Canine Kidney Cells</term><term>Molecular Sequence Data</term><term>Poultry Diseases (genetics)</term><term>Poultry Diseases (transmission)</term><term>Poultry Diseases (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Chine</term><term>Données de séquences moléculaires</term><term>Furets</term><term>Grippe chez les oiseaux (génétique)</term><term>Grippe chez les oiseaux (transmission)</term><term>Grippe humaine (génétique)</term><term>Grippe humaine (transmission)</term><term>Humains</term><term>Maladies de la volaille (génétique)</term><term>Maladies de la volaille (transmission)</term><term>Maladies de la volaille (virologie)</term><term>Poulets</term><term>Sous-type H9N2 du virus de la grippe A (génétique)</term><term>Sous-type H9N2 du virus de la grippe A (isolement et purification)</term><term>Sous-type H9N2 du virus de la grippe A (pathogénicité)</term><term>Séquence nucléotidique</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H9N2 Subtype</term><term>Influenza in Birds</term><term>Influenza, Human</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Grippe humaine</term><term>Maladies de la volaille</term><term>Sous-type H9N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H9N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H9N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H9N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H9N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies de la volaille</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Poultry Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Chickens</term><term>Dogs</term><term>Ferrets</term><term>Genetic Variation</term><term>Humans</term><term>Madin Darby Canine Kidney Cells</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Chine</term><term>Données de séquences moléculaires</term><term>Furets</term><term>Grippe chez les oiseaux</term><term>Grippe humaine</term><term>Humains</term><term>Maladies de la volaille</term><term>Poulets</term><term>Séquence nucléotidique</term><term>Variation génétique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>H9N2 subtype influenza viruses have been detected in different species of wild birds and domestic poultry in many countries for several decades. Because these viruses are of low pathogenicity in poultry, their eradication is not a priority for animal disease control in many countries, which has allowed them to continue to evolve and spread. Here, we characterized the genetic variation, receptor-binding specificity, replication capability, and transmission in mammals of a series of H9N2 influenza viruses that were detected in live poultry markets in southern China between 2009 and 2013. Thirty-five viruses represented 17 genotypes on the basis of genomic diversity, and one specific “internal-gene-combination” predominated among the H9N2 viruses. This gene combination was also present in the H7N9 and H10N8 viruses that have infected humans in China. All of the 35 viruses preferentially bound to the human-like receptor, although two also retained the ability to bind to the avian-like receptor. Six of nine viruses tested were transmissible in ferrets by respiratory droplet; two were highly transmissible. Some H9N2 viruses readily acquired the 627K or 701N mutation in their PB2 gene upon infection of ferrets, further enhancing their virulence and transmission in mammals. Our study indicates that the widespread dissemination of H9N2 viruses poses a threat to human health not only because of the potential of these viruses to cause an influenza pandemic, but also because they can function as “vehicles” to deliver different subtypes of influenza viruses from avian species to humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Kong, H" uniqKey="Kong H">H Kong</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name></author><author><name sortKey="Schrauwen, Ej" uniqKey="Schrauwen E">EJ 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last="Li">Xuyong Li</name></noRegion><name sortKey="Bu, Zhigao" sort="Bu, Zhigao" uniqKey="Bu Z" first="Zhigao" last="Bu">Zhigao Bu</name><name sortKey="Chen, Hualan" sort="Chen, Hualan" uniqKey="Chen H" first="Hualan" last="Chen">Hualan Chen</name><name sortKey="Chen, Jiming" sort="Chen, Jiming" uniqKey="Chen J" first="Jiming" last="Chen">Jiming Chen</name><name sortKey="Deng, Guohua" sort="Deng, Guohua" uniqKey="Deng G" first="Guohua" last="Deng">Guohua Deng</name><name sortKey="Fan, Jun" sort="Fan, Jun" uniqKey="Fan J" first="Jun" last="Fan">Jun Fan</name><name sortKey="Gu, Chunyang" sort="Gu, Chunyang" uniqKey="Gu C" first="Chunyang" last="Gu">Chunyang Gu</name><name sortKey="Guan, Yuantao" sort="Guan, Yuantao" uniqKey="Guan Y" first="Yuantao" last="Guan">Yuantao Guan</name><name sortKey="Guo, Jing" sort="Guo, Jing" uniqKey="Guo J" first="Jing" last="Guo">Jing Guo</name><name sortKey="Guo, Jing" sort="Guo, Jing" uniqKey="Guo J" first="Jing" last="Guo">Jing Guo</name><name 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Jinliang" sort="Wang, Jinliang" uniqKey="Wang J" first="Jinliang" last="Wang">Jinliang Wang</name><name sortKey="Wang, Kaicheng" sort="Wang, Kaicheng" uniqKey="Wang K" first="Kaicheng" last="Wang">Kaicheng Wang</name><name sortKey="Zhang, Qianyi" sort="Zhang, Qianyi" uniqKey="Zhang Q" first="Qianyi" last="Zhang">Qianyi Zhang</name></country><country name="Japon"><noRegion><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name></noRegion><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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