A cell culture-derived whole-virus H9N2 vaccine induces high titer antibodies against hemagglutinin and neuraminidase and protects mice from severe lung pathology and weight loss after challenge with a highly virulent H9N2 isolate.
Identifieur interne : 001376 ( Ncbi/Checkpoint ); précédent : 001375; suivant : 001377A cell culture-derived whole-virus H9N2 vaccine induces high titer antibodies against hemagglutinin and neuraminidase and protects mice from severe lung pathology and weight loss after challenge with a highly virulent H9N2 isolate.
Auteurs : Walter Wodal [Autriche] ; Falko G. Falkner ; Astrid Kerschbaum ; Claudia Gaiswinkler ; Richard Fritz ; Stefan Kiermayr ; Daniel Portsmouth ; Helga Savidis-Dacho ; Sogue Coulibaly ; Christina Piskernik ; Christine Hohenadl ; M Keith Howard ; Otfried Kistner ; P Noel Barrett ; Thomas R. KreilSource :
- Vaccine [ 1873-2518 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Cochons d'Inde, Femelle, Glycoprotéine hémagglutinine du virus influenza (immunologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Perte de poids, Poumon (anatomopathologie), Poumon (virologie), Relation dose-réponse (immunologie), Sialidase (immunologie), Souris, Souris de lignée BALB C, Sous-type H9N2 du virus de la grippe A (immunologie), Tests d'inhibition de l'hémagglutination, Tests de neutralisation, Vaccins antigrippaux (immunologie).
- MESH :
- anatomopathologie : Poumon.
- immunologie : Glycoprotéine hémagglutinine du virus influenza, Infections à Orthomyxoviridae, Sialidase, Sous-type H9N2 du virus de la grippe A, Vaccins antigrippaux.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- virologie : Poumon.
- Animaux, Cochons d'Inde, Femelle, Infections à Orthomyxoviridae, Perte de poids, Relation dose-réponse (immunologie), Souris, Souris de lignée BALB C, Tests d'inhibition de l'hémagglutination, Tests de neutralisation.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Dose-Response Relationship, Immunologic, Female, Guinea Pigs, Hemagglutination Inhibition Tests, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Influenza A Virus, H9N2 Subtype (immunology), Influenza Vaccines (immunology), Lung (pathology), Lung (virology), Mice, Mice, Inbred BALB C, Neuraminidase (immunology), Neutralization Tests, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Weight Loss.
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , immunology : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Neuraminidase.
- immunology : Influenza A Virus, H9N2 Subtype, Orthomyxoviridae Infections.
- pathology : Lung.
- prevention & control : Orthomyxoviridae Infections.
- virology : Lung.
- Animals, Dose-Response Relationship, Immunologic, Female, Guinea Pigs, Hemagglutination Inhibition Tests, Mice, Mice, Inbred BALB C, Neutralization Tests, Weight Loss.
Abstract
Influenza viruses of subtype A/H9N2 are enzootic in poultry across Asia and the Middle East and are considered to have pandemic potential. The development of new vaccine manufacturing technologies is a cornerstone of influenza pandemic preparedness.
DOI: 10.1016/j.vaccine.2012.04.102
PubMed: 22580355
Affiliations:
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The development of new vaccine manufacturing technologies is a cornerstone of influenza pandemic preparedness.</div></front></TEI><affiliations><list><country><li>Autriche</li></country></list><tree><noCountry><name sortKey="Barrett, P Noel" sort="Barrett, P Noel" uniqKey="Barrett P" first="P Noel" last="Barrett">P Noel Barrett</name><name sortKey="Coulibaly, Sogue" sort="Coulibaly, Sogue" uniqKey="Coulibaly S" first="Sogue" last="Coulibaly">Sogue Coulibaly</name><name sortKey="Falkner, Falko G" sort="Falkner, Falko G" uniqKey="Falkner F" first="Falko G" last="Falkner">Falko G. Falkner</name><name sortKey="Fritz, Richard" sort="Fritz, Richard" uniqKey="Fritz R" first="Richard" last="Fritz">Richard Fritz</name><name sortKey="Gaiswinkler, Claudia" sort="Gaiswinkler, Claudia" uniqKey="Gaiswinkler C" first="Claudia" last="Gaiswinkler">Claudia Gaiswinkler</name><name sortKey="Hohenadl, Christine" sort="Hohenadl, Christine" uniqKey="Hohenadl C" first="Christine" last="Hohenadl">Christine Hohenadl</name><name sortKey="Howard, M Keith" sort="Howard, M Keith" uniqKey="Howard M" first="M Keith" last="Howard">M Keith Howard</name><name sortKey="Kerschbaum, Astrid" sort="Kerschbaum, Astrid" uniqKey="Kerschbaum A" first="Astrid" last="Kerschbaum">Astrid Kerschbaum</name><name sortKey="Kiermayr, Stefan" sort="Kiermayr, Stefan" uniqKey="Kiermayr S" first="Stefan" last="Kiermayr">Stefan Kiermayr</name><name sortKey="Kistner, Otfried" sort="Kistner, Otfried" uniqKey="Kistner O" first="Otfried" last="Kistner">Otfried Kistner</name><name sortKey="Kreil, Thomas R" sort="Kreil, Thomas R" uniqKey="Kreil T" first="Thomas R" last="Kreil">Thomas R. Kreil</name><name sortKey="Piskernik, Christina" sort="Piskernik, Christina" uniqKey="Piskernik C" first="Christina" last="Piskernik">Christina Piskernik</name><name sortKey="Portsmouth, Daniel" sort="Portsmouth, Daniel" uniqKey="Portsmouth D" first="Daniel" last="Portsmouth">Daniel Portsmouth</name><name sortKey="Savidis Dacho, Helga" sort="Savidis Dacho, Helga" uniqKey="Savidis Dacho H" first="Helga" last="Savidis-Dacho">Helga Savidis-Dacho</name></noCountry><country name="Autriche"><noRegion><name sortKey="Wodal, Walter" sort="Wodal, Walter" uniqKey="Wodal W" first="Walter" last="Wodal">Walter Wodal</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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