A cell culture-derived whole-virus H9N2 vaccine induces high titer antibodies against hemagglutinin and neuraminidase and protects mice from severe lung pathology and weight loss after challenge with a highly virulent H9N2 isolate.
Identifieur interne : 001376 ( Ncbi/Curation ); précédent : 001375; suivant : 001377A cell culture-derived whole-virus H9N2 vaccine induces high titer antibodies against hemagglutinin and neuraminidase and protects mice from severe lung pathology and weight loss after challenge with a highly virulent H9N2 isolate.
Auteurs : Walter Wodal [Autriche] ; Falko G. Falkner ; Astrid Kerschbaum ; Claudia Gaiswinkler ; Richard Fritz ; Stefan Kiermayr ; Daniel Portsmouth ; Helga Savidis-Dacho ; Sogue Coulibaly ; Christina Piskernik ; Christine Hohenadl ; M Keith Howard ; Otfried Kistner ; P Noel Barrett ; Thomas R. KreilSource :
- Vaccine [ 1873-2518 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Cochons d'Inde, Femelle, Glycoprotéine hémagglutinine du virus influenza (immunologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Perte de poids, Poumon (anatomopathologie), Poumon (virologie), Relation dose-réponse (immunologie), Sialidase (immunologie), Souris, Souris de lignée BALB C, Sous-type H9N2 du virus de la grippe A (immunologie), Tests d'inhibition de l'hémagglutination, Tests de neutralisation, Vaccins antigrippaux (immunologie).
- MESH :
- anatomopathologie : Poumon.
- immunologie : Glycoprotéine hémagglutinine du virus influenza, Infections à Orthomyxoviridae, Sialidase, Sous-type H9N2 du virus de la grippe A, Vaccins antigrippaux.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- virologie : Poumon.
- Animaux, Cochons d'Inde, Femelle, Infections à Orthomyxoviridae, Perte de poids, Relation dose-réponse (immunologie), Souris, Souris de lignée BALB C, Tests d'inhibition de l'hémagglutination, Tests de neutralisation.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Dose-Response Relationship, Immunologic, Female, Guinea Pigs, Hemagglutination Inhibition Tests, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Influenza A Virus, H9N2 Subtype (immunology), Influenza Vaccines (immunology), Lung (pathology), Lung (virology), Mice, Mice, Inbred BALB C, Neuraminidase (immunology), Neutralization Tests, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Weight Loss.
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , immunology : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Neuraminidase.
- immunology : Influenza A Virus, H9N2 Subtype, Orthomyxoviridae Infections.
- pathology : Lung.
- prevention & control : Orthomyxoviridae Infections.
- virology : Lung.
- Animals, Dose-Response Relationship, Immunologic, Female, Guinea Pigs, Hemagglutination Inhibition Tests, Mice, Mice, Inbred BALB C, Neutralization Tests, Weight Loss.
Abstract
Influenza viruses of subtype A/H9N2 are enzootic in poultry across Asia and the Middle East and are considered to have pandemic potential. The development of new vaccine manufacturing technologies is a cornerstone of influenza pandemic preparedness.
DOI: 10.1016/j.vaccine.2012.04.102
PubMed: 22580355
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000C96
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000C96
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000D62
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001376
Links to Exploration step
pubmed:22580355Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A cell culture-derived whole-virus H9N2 vaccine induces high titer antibodies against hemagglutinin and neuraminidase and protects mice from severe lung pathology and weight loss after challenge with a highly virulent H9N2 isolate.</title>
<author><name sortKey="Wodal, Walter" sort="Wodal, Walter" uniqKey="Wodal W" first="Walter" last="Wodal">Walter Wodal</name>
<affiliation wicri:level="1"><nlm:affiliation>Vaccine R&D, Baxter BioScience, Biomedical Research Centre, Orth/Donau, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Vaccine R&D, Baxter BioScience, Biomedical Research Centre, Orth/Donau</wicri:regionArea>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Falkner, Falko G" sort="Falkner, Falko G" uniqKey="Falkner F" first="Falko G" last="Falkner">Falko G. Falkner</name>
</author>
<author><name sortKey="Kerschbaum, Astrid" sort="Kerschbaum, Astrid" uniqKey="Kerschbaum A" first="Astrid" last="Kerschbaum">Astrid Kerschbaum</name>
</author>
<author><name sortKey="Gaiswinkler, Claudia" sort="Gaiswinkler, Claudia" uniqKey="Gaiswinkler C" first="Claudia" last="Gaiswinkler">Claudia Gaiswinkler</name>
</author>
<author><name sortKey="Fritz, Richard" sort="Fritz, Richard" uniqKey="Fritz R" first="Richard" last="Fritz">Richard Fritz</name>
</author>
<author><name sortKey="Kiermayr, Stefan" sort="Kiermayr, Stefan" uniqKey="Kiermayr S" first="Stefan" last="Kiermayr">Stefan Kiermayr</name>
</author>
<author><name sortKey="Portsmouth, Daniel" sort="Portsmouth, Daniel" uniqKey="Portsmouth D" first="Daniel" last="Portsmouth">Daniel Portsmouth</name>
</author>
<author><name sortKey="Savidis Dacho, Helga" sort="Savidis Dacho, Helga" uniqKey="Savidis Dacho H" first="Helga" last="Savidis-Dacho">Helga Savidis-Dacho</name>
</author>
<author><name sortKey="Coulibaly, Sogue" sort="Coulibaly, Sogue" uniqKey="Coulibaly S" first="Sogue" last="Coulibaly">Sogue Coulibaly</name>
</author>
<author><name sortKey="Piskernik, Christina" sort="Piskernik, Christina" uniqKey="Piskernik C" first="Christina" last="Piskernik">Christina Piskernik</name>
</author>
<author><name sortKey="Hohenadl, Christine" sort="Hohenadl, Christine" uniqKey="Hohenadl C" first="Christine" last="Hohenadl">Christine Hohenadl</name>
</author>
<author><name sortKey="Howard, M Keith" sort="Howard, M Keith" uniqKey="Howard M" first="M Keith" last="Howard">M Keith Howard</name>
</author>
<author><name sortKey="Kistner, Otfried" sort="Kistner, Otfried" uniqKey="Kistner O" first="Otfried" last="Kistner">Otfried Kistner</name>
</author>
<author><name sortKey="Barrett, P Noel" sort="Barrett, P Noel" uniqKey="Barrett P" first="P Noel" last="Barrett">P Noel Barrett</name>
</author>
<author><name sortKey="Kreil, Thomas R" sort="Kreil, Thomas R" uniqKey="Kreil T" first="Thomas R" last="Kreil">Thomas R. Kreil</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="RBID">pubmed:22580355</idno>
<idno type="pmid">22580355</idno>
<idno type="doi">10.1016/j.vaccine.2012.04.102</idno>
<idno type="wicri:Area/PubMed/Corpus">000C96</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C96</idno>
<idno type="wicri:Area/PubMed/Curation">000C96</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C96</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D62</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D62</idno>
<idno type="wicri:Area/Ncbi/Merge">001376</idno>
<idno type="wicri:Area/Ncbi/Curation">001376</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">A cell culture-derived whole-virus H9N2 vaccine induces high titer antibodies against hemagglutinin and neuraminidase and protects mice from severe lung pathology and weight loss after challenge with a highly virulent H9N2 isolate.</title>
<author><name sortKey="Wodal, Walter" sort="Wodal, Walter" uniqKey="Wodal W" first="Walter" last="Wodal">Walter Wodal</name>
<affiliation wicri:level="1"><nlm:affiliation>Vaccine R&D, Baxter BioScience, Biomedical Research Centre, Orth/Donau, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Vaccine R&D, Baxter BioScience, Biomedical Research Centre, Orth/Donau</wicri:regionArea>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Falkner, Falko G" sort="Falkner, Falko G" uniqKey="Falkner F" first="Falko G" last="Falkner">Falko G. Falkner</name>
</author>
<author><name sortKey="Kerschbaum, Astrid" sort="Kerschbaum, Astrid" uniqKey="Kerschbaum A" first="Astrid" last="Kerschbaum">Astrid Kerschbaum</name>
</author>
<author><name sortKey="Gaiswinkler, Claudia" sort="Gaiswinkler, Claudia" uniqKey="Gaiswinkler C" first="Claudia" last="Gaiswinkler">Claudia Gaiswinkler</name>
</author>
<author><name sortKey="Fritz, Richard" sort="Fritz, Richard" uniqKey="Fritz R" first="Richard" last="Fritz">Richard Fritz</name>
</author>
<author><name sortKey="Kiermayr, Stefan" sort="Kiermayr, Stefan" uniqKey="Kiermayr S" first="Stefan" last="Kiermayr">Stefan Kiermayr</name>
</author>
<author><name sortKey="Portsmouth, Daniel" sort="Portsmouth, Daniel" uniqKey="Portsmouth D" first="Daniel" last="Portsmouth">Daniel Portsmouth</name>
</author>
<author><name sortKey="Savidis Dacho, Helga" sort="Savidis Dacho, Helga" uniqKey="Savidis Dacho H" first="Helga" last="Savidis-Dacho">Helga Savidis-Dacho</name>
</author>
<author><name sortKey="Coulibaly, Sogue" sort="Coulibaly, Sogue" uniqKey="Coulibaly S" first="Sogue" last="Coulibaly">Sogue Coulibaly</name>
</author>
<author><name sortKey="Piskernik, Christina" sort="Piskernik, Christina" uniqKey="Piskernik C" first="Christina" last="Piskernik">Christina Piskernik</name>
</author>
<author><name sortKey="Hohenadl, Christine" sort="Hohenadl, Christine" uniqKey="Hohenadl C" first="Christine" last="Hohenadl">Christine Hohenadl</name>
</author>
<author><name sortKey="Howard, M Keith" sort="Howard, M Keith" uniqKey="Howard M" first="M Keith" last="Howard">M Keith Howard</name>
</author>
<author><name sortKey="Kistner, Otfried" sort="Kistner, Otfried" uniqKey="Kistner O" first="Otfried" last="Kistner">Otfried Kistner</name>
</author>
<author><name sortKey="Barrett, P Noel" sort="Barrett, P Noel" uniqKey="Barrett P" first="P Noel" last="Barrett">P Noel Barrett</name>
</author>
<author><name sortKey="Kreil, Thomas R" sort="Kreil, Thomas R" uniqKey="Kreil T" first="Thomas R" last="Kreil">Thomas R. Kreil</name>
</author>
</analytic>
<series><title level="j">Vaccine</title>
<idno type="eISSN">1873-2518</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Neutralizing (blood)</term>
<term>Antibodies, Viral (blood)</term>
<term>Dose-Response Relationship, Immunologic</term>
<term>Female</term>
<term>Guinea Pigs</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Influenza A Virus, H9N2 Subtype (immunology)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Neuraminidase (immunology)</term>
<term>Neutralization Tests</term>
<term>Orthomyxoviridae Infections (immunology)</term>
<term>Orthomyxoviridae Infections (prevention & control)</term>
<term>Weight Loss</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Anticorps neutralisants (sang)</term>
<term>Cochons d'Inde</term>
<term>Femelle</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Perte de poids</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (virologie)</term>
<term>Relation dose-réponse (immunologie)</term>
<term>Sialidase (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sous-type H9N2 du virus de la grippe A (immunologie)</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
<term>Vaccins antigrippaux (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Influenza Vaccines</term>
<term>Neuraminidase</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Infections à Orthomyxoviridae</term>
<term>Sialidase</term>
<term>Sous-type H9N2 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H9N2 Subtype</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps neutralisants</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Dose-Response Relationship, Immunologic</term>
<term>Female</term>
<term>Guinea Pigs</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Neutralization Tests</term>
<term>Weight Loss</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cochons d'Inde</term>
<term>Femelle</term>
<term>Infections à Orthomyxoviridae</term>
<term>Perte de poids</term>
<term>Relation dose-réponse (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Influenza viruses of subtype A/H9N2 are enzootic in poultry across Asia and the Middle East and are considered to have pandemic potential. The development of new vaccine manufacturing technologies is a cornerstone of influenza pandemic preparedness.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001376 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001376 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:22580355 |texte= A cell culture-derived whole-virus H9N2 vaccine induces high titer antibodies against hemagglutinin and neuraminidase and protects mice from severe lung pathology and weight loss after challenge with a highly virulent H9N2 isolate. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:22580355" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a PandemieGrippaleV1
![]() | This area was generated with Dilib version V0.6.34. | ![]() |