Immunopathology in influenza virus infection: Uncoupling the friend from foe
Identifieur interne : 002132 ( Main/Merge ); précédent : 002131; suivant : 002133Immunopathology in influenza virus infection: Uncoupling the friend from foe
Auteurs : Daniela Damjanovic [Canada] ; Cherrie-Lee Small ; Mangalakumari Jeyananthan ; Sarah Mccormick ; ZHOU XINGSource :
- Clinical immunology : (Orlando, Fla. Print) [ 1521-6616 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Immunologie.
English descriptors
- KwdEn :
Abstract
Influenza epidemics and pandemics cause significant morbidity and mortality worldwide associated with severe immunopathology in the lung, and the mechanisms of such immunopathogenesis still remain poorly understood. While human studies help to understand influenza immunopathology, they provide only limited mechanistic information. On the other hand, recent studies using experimental animal models have significantly enhanced our understanding of the complex mechanisms involved in the immunopathogenesis during primary influenza or influenza-associated bacterial superinfection. This includes the involvement of acute inflammatory responses (macrophages, neutrophils, dendritic cells, toll-like receptors, cytokines, chemokines), CD4 and CD8 T cells, tissue remodeling processes, and contribution of bacterial superinfection. In particular, progress has been made in uncoupling the mechanisms that are involved in both antiviral host defense and in immunopathogenesis from those that solely contribute to lung immunopathology. Uncoupling such events will facilitate the discovery of new intervention strategies to treat pulmonary immunopathology associated with influenza infection.
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Pascal:12-0274820Le document en format XML
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DeGroote Institute for Infectious Disease Research, McMaster University</s1><s2>Hamilton, Ontario</s2><s3>CAN</s3></inist:fA14><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université McMaster</orgName></affiliation></author><author><name sortKey="Small, Cherrie Lee" sort="Small, Cherrie Lee" uniqKey="Small C" first="Cherrie-Lee" last="Small">Cherrie-Lee Small</name></author><author><name sortKey="Jeyananthan, Mangalakumari" sort="Jeyananthan, Mangalakumari" uniqKey="Jeyananthan M" first="Mangalakumari" last="Jeyananthan">Mangalakumari Jeyananthan</name></author><author><name sortKey="Mccormick, Sarah" sort="Mccormick, Sarah" uniqKey="Mccormick S" first="Sarah" last="Mccormick">Sarah Mccormick</name></author><author><name sortKey="Zhou Xing" sort="Zhou Xing" uniqKey="Zhou Xing" last="Zhou Xing">ZHOU XING</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0274820</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0274820 INIST</idno><idno type="RBID">Pascal:12-0274820</idno><idno type="wicri:Area/PascalFrancis/Corpus">000606</idno><idno type="wicri:Area/PascalFrancis/Curation">001832</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000596</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000596</idno><idno type="wicri:doubleKey">1521-6616:2012:Damjanovic D:immunopathology:in:influenza</idno><idno type="wicri:Area/Main/Merge">002132</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Immunopathology in influenza virus infection: Uncoupling the friend from foe</title><author><name sortKey="Damjanovic, Daniela" sort="Damjanovic, Daniela" uniqKey="Damjanovic D" first="Daniela" last="Damjanovic">Daniela Damjanovic</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>McMaster Immunology Research Centre, Department of Pathology & Molecular Medicine, McMaster University</s1><s2>Hamilton, Ontario</s2><s3>CAN</s3></inist:fA14><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université McMaster</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>M.G. DeGroote Institute for Infectious Disease Research, McMaster University</s1><s2>Hamilton, Ontario</s2><s3>CAN</s3></inist:fA14><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université McMaster</orgName></affiliation></author><author><name sortKey="Small, Cherrie Lee" sort="Small, Cherrie Lee" uniqKey="Small C" first="Cherrie-Lee" last="Small">Cherrie-Lee Small</name></author><author><name sortKey="Jeyananthan, Mangalakumari" sort="Jeyananthan, Mangalakumari" uniqKey="Jeyananthan M" first="Mangalakumari" last="Jeyananthan">Mangalakumari Jeyananthan</name></author><author><name sortKey="Mccormick, Sarah" sort="Mccormick, Sarah" uniqKey="Mccormick S" first="Sarah" last="Mccormick">Sarah Mccormick</name></author><author><name sortKey="Zhou Xing" sort="Zhou Xing" uniqKey="Zhou Xing" last="Zhou Xing">ZHOU XING</name></author></analytic><series><title level="j" type="main">Clinical immunology : (Orlando, Fla. Print)</title><title level="j" type="abbreviated">Clin. immunol. : (Orlando, Fla., Print)</title><idno type="ISSN">1521-6616</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical immunology : (Orlando, Fla. Print)</title><title level="j" type="abbreviated">Clin. immunol. : (Orlando, Fla., Print)</title><idno type="ISSN">1521-6616</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bacteria</term><term>Bacteriosis</term><term>Immunology</term><term>Immunopathology</term><term>Influenza</term><term>Influenzavirus</term><term>Mechanism</term><term>Superinfection</term><term>Viral disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virose</term><term>Bactériose</term><term>Immunopathologie</term><term>Influenzavirus</term><term>Grippe</term><term>Bactérie</term><term>Surinfection</term><term>Mécanisme</term><term>Immunologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Immunologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza epidemics and pandemics cause significant morbidity and mortality worldwide associated with severe immunopathology in the lung, and the mechanisms of such immunopathogenesis still remain poorly understood. While human studies help to understand influenza immunopathology, they provide only limited mechanistic information. On the other hand, recent studies using experimental animal models have significantly enhanced our understanding of the complex mechanisms involved in the immunopathogenesis during primary influenza or influenza-associated bacterial superinfection. This includes the involvement of acute inflammatory responses (macrophages, neutrophils, dendritic cells, toll-like receptors, cytokines, chemokines), CD4 and CD8 T cells, tissue remodeling processes, and contribution of bacterial superinfection. In particular, progress has been made in uncoupling the mechanisms that are involved in both antiviral host defense and in immunopathogenesis from those that solely contribute to lung immunopathology. Uncoupling such events will facilitate the discovery of new intervention strategies to treat pulmonary immunopathology associated with influenza infection.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Hamilton (Ontario)</li></settlement><orgName><li>Université McMaster</li></orgName></list><tree><noCountry><name sortKey="Jeyananthan, Mangalakumari" sort="Jeyananthan, Mangalakumari" uniqKey="Jeyananthan M" first="Mangalakumari" last="Jeyananthan">Mangalakumari Jeyananthan</name><name sortKey="Mccormick, Sarah" sort="Mccormick, Sarah" uniqKey="Mccormick S" first="Sarah" last="Mccormick">Sarah Mccormick</name><name sortKey="Small, Cherrie Lee" sort="Small, Cherrie Lee" uniqKey="Small C" first="Cherrie-Lee" last="Small">Cherrie-Lee Small</name><name sortKey="Zhou Xing" sort="Zhou Xing" uniqKey="Zhou Xing" last="Zhou Xing">ZHOU XING</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Damjanovic, Daniela" sort="Damjanovic, Daniela" uniqKey="Damjanovic D" first="Daniela" last="Damjanovic">Daniela Damjanovic</name></region><name sortKey="Damjanovic, Daniela" sort="Damjanovic, Daniela" uniqKey="Damjanovic D" first="Daniela" last="Damjanovic">Daniela Damjanovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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