Immunosuppressed patients with pandemic influenza A 2009 (H1N1) virus infection
Identifieur interne : 002131 ( Main/Merge ); précédent : 002130; suivant : 002132Immunosuppressed patients with pandemic influenza A 2009 (H1N1) virus infection
Auteurs : E. Cordero [Espagne] ; T. Aydillo [Espagne] ; M. C. Farinas [Espagne] ; J. R. Pano-Pardo [Espagne] ; J. Pachon [Espagne] ; D. Viasus [Espagne] ; M. Riera [Espagne] ; F. Lopez-Medrano [Espagne] ; A. Payeras [Espagne] ; A. Moreno [Espagne] ; J. Rodriguez-Bano [Espagne] ; J. A. Oteo [Espagne] ; J. Martinez-Montauti [Espagne] ; J. Torre-Cisneros [Espagne] ; F. Segura [Espagne] ; J. Carratala [Espagne]Source :
- European journal of clinical microbiology & infectious diseases : (Print) [ 0934-9723 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
The purpose of this paper was to prospectively characterize the clinical manifestations and outcomes of confirmed influenza A 2009 (H1N1) virus infection in immunosuppressed patients with hospital admission and compare them with those of a general population. A multicenter prospective cohort study was carried out. All adult patients admitted to 13 hospitals in Spain with confirmed influenza A 2009 (H1N1) virus infection from June 12, 2009 to November 11, 2009 were included. Risk factors for complicated influenza infection were studied in immunosuppressed patients. Overall, 559 patients were included, of which 56 were immunosuppressed, nine with solid or hematological malignancies, 18 with solid-organ transplant recipients, 13 with corticosteroid therapy, and six with other types of immunosuppression. Clinical findings at diagnosis were similar in both groups. Nineteen immunosuppressed patients had pneumonia (33.9%). Immunosuppressed patients with pandemic influenza had bacterial co-infection more frequently (17.9% vs. 6.4%,p=0.02), specifically, gram-negative bacilli and Staphylococcus aureus infections. Mortality was higher in immunosuppressed patients (7.1% vs. 1.8%, p<0.05). The only modifiable risk factor of complicated influenza A 2009 (H1N1) was delayed antiviral therapy. In immunosuppressed patients, influenza A 2009 (H1N1) virus infection has higher mortality than in non-immunosuppressed individuals. Bacterial co-infection is common in complicated cases.
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Pascal:12-0182430Le document en format XML
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<author><name sortKey="Carratala, J" sort="Carratala, J" uniqKey="Carratala J" first="J." last="Carratala">J. Carratala</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Immunosuppressed patients with pandemic influenza A 2009 (H1N1) virus infection</title>
<author><name sortKey="Cordero, E" sort="Cordero, E" uniqKey="Cordero E" first="E." last="Cordero">E. Cordero</name>
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<author><name sortKey="Aydillo, T" sort="Aydillo, T" uniqKey="Aydillo T" first="T." last="Aydillo">T. Aydillo</name>
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<author><name sortKey="Pano Pardo, J R" sort="Pano Pardo, J R" uniqKey="Pano Pardo J" first="J. R." last="Pano-Pardo">J. R. Pano-Pardo</name>
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<author><name sortKey="Viasus, D" sort="Viasus, D" uniqKey="Viasus D" first="D." last="Viasus">D. Viasus</name>
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<author><name sortKey="Riera, M" sort="Riera, M" uniqKey="Riera M" first="M." last="Riera">M. Riera</name>
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<author><name sortKey="Lopez Medrano, F" sort="Lopez Medrano, F" uniqKey="Lopez Medrano F" first="F." last="Lopez-Medrano">F. Lopez-Medrano</name>
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<author><name sortKey="Moreno, A" sort="Moreno, A" uniqKey="Moreno A" first="A." last="Moreno">A. Moreno</name>
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<author><name sortKey="Rodriguez Bano, J" sort="Rodriguez Bano, J" uniqKey="Rodriguez Bano J" first="J." last="Rodriguez-Bano">J. Rodriguez-Bano</name>
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<s2>Seville</s2>
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<author><name sortKey="Oteo, J A" sort="Oteo, J A" uniqKey="Oteo J" first="J. A." last="Oteo">J. A. Oteo</name>
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<author><name sortKey="Martinez Montauti, J" sort="Martinez Montauti, J" uniqKey="Martinez Montauti J" first="J." last="Martinez-Montauti">J. Martinez-Montauti</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>SCIAS-Hospital de Barcelona</s1>
<s2>Barcelona</s2>
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<author><name sortKey="Torre Cisneros, J" sort="Torre Cisneros, J" uniqKey="Torre Cisneros J" first="J." last="Torre-Cisneros">J. Torre-Cisneros</name>
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<s2>Barcelona</s2>
<s3>ESP</s3>
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<author><name sortKey="Segura, F" sort="Segura, F" uniqKey="Segura F" first="F." last="Segura">F. Segura</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>University Hospital Reina Sofia-IMIBIC, University of Cordoba</s1>
<s2>Cordoba</s2>
<s3>ESP</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Cordoba</wicri:noRegion>
</affiliation>
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<author><name sortKey="Carratala, J" sort="Carratala, J" uniqKey="Carratala J" first="J." last="Carratala">J. Carratala</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>University Hospital Bellvitge-IDIBELL, Barcelona, University of Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>6 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
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<term>Influenza A (H1N1)</term>
<term>Influenza A virus</term>
<term>Microbiology</term>
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<term>Grippe H1N1</term>
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<front><div type="abstract" xml:lang="en">The purpose of this paper was to prospectively characterize the clinical manifestations and outcomes of confirmed influenza A 2009 (H1N1) virus infection in immunosuppressed patients with hospital admission and compare them with those of a general population. A multicenter prospective cohort study was carried out. All adult patients admitted to 13 hospitals in Spain with confirmed influenza A 2009 (H1N1) virus infection from June 12, 2009 to November 11, 2009 were included. Risk factors for complicated influenza infection were studied in immunosuppressed patients. Overall, 559 patients were included, of which 56 were immunosuppressed, nine with solid or hematological malignancies, 18 with solid-organ transplant recipients, 13 with corticosteroid therapy, and six with other types of immunosuppression. Clinical findings at diagnosis were similar in both groups. Nineteen immunosuppressed patients had pneumonia (33.9%). Immunosuppressed patients with pandemic influenza had bacterial co-infection more frequently (17.9% vs. 6.4%,p=0.02), specifically, gram-negative bacilli and Staphylococcus aureus infections. Mortality was higher in immunosuppressed patients (7.1% vs. 1.8%, p<0.05). The only modifiable risk factor of complicated influenza A 2009 (H1N1) was delayed antiviral therapy. In immunosuppressed patients, influenza A 2009 (H1N1) virus infection has higher mortality than in non-immunosuppressed individuals. Bacterial co-infection is common in complicated cases.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Andalousie</li>
<li>Catalogne</li>
<li>Communauté de Madrid</li>
</region>
<settlement><li>Barcelone</li>
<li>Madrid</li>
</settlement>
</list>
<tree><country name="Espagne"><region name="Andalousie"><name sortKey="Cordero, E" sort="Cordero, E" uniqKey="Cordero E" first="E." last="Cordero">E. Cordero</name>
</region>
<name sortKey="Aydillo, T" sort="Aydillo, T" uniqKey="Aydillo T" first="T." last="Aydillo">T. Aydillo</name>
<name sortKey="Carratala, J" sort="Carratala, J" uniqKey="Carratala J" first="J." last="Carratala">J. Carratala</name>
<name sortKey="Farinas, M C" sort="Farinas, M C" uniqKey="Farinas M" first="M. C." last="Farinas">M. C. Farinas</name>
<name sortKey="Lopez Medrano, F" sort="Lopez Medrano, F" uniqKey="Lopez Medrano F" first="F." last="Lopez-Medrano">F. Lopez-Medrano</name>
<name sortKey="Martinez Montauti, J" sort="Martinez Montauti, J" uniqKey="Martinez Montauti J" first="J." last="Martinez-Montauti">J. Martinez-Montauti</name>
<name sortKey="Moreno, A" sort="Moreno, A" uniqKey="Moreno A" first="A." last="Moreno">A. Moreno</name>
<name sortKey="Oteo, J A" sort="Oteo, J A" uniqKey="Oteo J" first="J. A." last="Oteo">J. A. Oteo</name>
<name sortKey="Pachon, J" sort="Pachon, J" uniqKey="Pachon J" first="J." last="Pachon">J. Pachon</name>
<name sortKey="Pano Pardo, J R" sort="Pano Pardo, J R" uniqKey="Pano Pardo J" first="J. R." last="Pano-Pardo">J. R. Pano-Pardo</name>
<name sortKey="Payeras, A" sort="Payeras, A" uniqKey="Payeras A" first="A." last="Payeras">A. Payeras</name>
<name sortKey="Riera, M" sort="Riera, M" uniqKey="Riera M" first="M." last="Riera">M. Riera</name>
<name sortKey="Rodriguez Bano, J" sort="Rodriguez Bano, J" uniqKey="Rodriguez Bano J" first="J." last="Rodriguez-Bano">J. Rodriguez-Bano</name>
<name sortKey="Segura, F" sort="Segura, F" uniqKey="Segura F" first="F." last="Segura">F. Segura</name>
<name sortKey="Torre Cisneros, J" sort="Torre Cisneros, J" uniqKey="Torre Cisneros J" first="J." last="Torre-Cisneros">J. Torre-Cisneros</name>
<name sortKey="Viasus, D" sort="Viasus, D" uniqKey="Viasus D" first="D." last="Viasus">D. Viasus</name>
</country>
</tree>
</affiliations>
</record>
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