Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission
Identifieur interne : 001083 ( Main/Merge ); précédent : 001082; suivant : 001084Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission
Auteurs : J. Rebolledo [Irlande (pays), Suède] ; D. Igoe [Irlande (pays)] ; J. O'Donnell [Irlande (pays)] ; L. Domegan [Irlande (pays)] ; M. Boland [Irlande (pays)] ; B. Freyne [Irlande (pays)] ; A. Mcnamara [Irlande (pays)] ; E. Molloy [Irlande (pays)] ; M. Callaghan [Irlande (pays)] ; A. Ryan [Irlande (pays)] ; D. O'Flanagan [Irlande (pays)]Source :
- Epidemiology and infection [ 0950-2688 ] ; 2014.
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- Pascal (Inist)
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- topic : Enfant.
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Abstract
Influenza causes significant morbidity and mortality in children. This study's objectives were to describe influenza A(H1N1)pdm09 during the pandemic, to compare it with circulating influenza in 2010/2011, and to identify risk factors for severe influenza defined as requiring admission to a paediatric intensive care unit (PICU). Children hospitalized with influenza during the pandemic were older, and more likely to have received antiviral therapy than children hospitalized during the 2010/2011 season. In 2010/2011, only one child admitted to a PICU with underlying medical conditions had been vaccinated. The risk of severe illness in the pandemic was higher in females and those with underlying conditions. In 2010/2011, infection with influenza A(H1N1)pdm09 compared to other influenza viruses was a significant risk factor for severe disease. An incremental relationship was found between the number of underlying conditions and PICU admission. These findings highlight the importance of improving low vaccination uptake and increasing the use of antivirals in vulnerable children.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission</title><author><name sortKey="Rebolledo, J" sort="Rebolledo, J" uniqKey="Rebolledo J" first="J." last="Rebolledo">J. Rebolledo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Health Protection Surveillance Centre, Health Service Executive</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC)</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>1 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Igoe, D" sort="Igoe, D" uniqKey="Igoe D" first="D." last="Igoe">D. 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Freyne</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Maternity Hospital, Holies Street</s1><s2>Dublin</s2><s3>IRL</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mcnamara, A" sort="Mcnamara, A" uniqKey="Mcnamara A" first="A." last="Mcnamara">A. Mcnamara</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Public Health, Health Service Executive Tullamore</s1><s3>IRL</s3><sZ>7 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Department of Public Health, Health Service Executive Tullamore</wicri:noRegion></affiliation></author><author><name sortKey="Molloy, E" sort="Molloy, E" uniqKey="Molloy E" first="E." last="Molloy">E. Molloy</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Maternity Hospital, Holies Street</s1><s2>Dublin</s2><s3>IRL</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Our Lady's Children's Hospital</s1><s2>Crumlin, Dublin</s2><s3>IRL</s3><sZ>8 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Our Lady's Children's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Callaghan, M" sort="Callaghan, M" uniqKey="Callaghan M" first="M." last="Callaghan">M. Callaghan</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Anaesthesia and Intensive Care Medicine, Our Lady's Children's Hospital</s1><s2>Crumlin, Dublin</s2><s3>IRL</s3><sZ>9 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Crumlin, Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Ryan, A" sort="Ryan, A" uniqKey="Ryan A" first="A." last="Ryan">A. Ryan</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Public Health, Health Service Executive Sligo</s1><s3>IRL</s3><sZ>10 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Department of Public Health, Health Service Executive Sligo</wicri:noRegion></affiliation></author><author><name sortKey="O Flanagan, D" sort="O Flanagan, D" uniqKey="O Flanagan D" first="D." last="O'Flanagan">D. O'Flanagan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Health Protection Surveillance Centre, Health Service Executive</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0277467</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0277467 INIST</idno><idno type="RBID">Pascal:14-0277467</idno><idno type="wicri:Area/PascalFrancis/Corpus">000020</idno><idno type="wicri:Area/PascalFrancis/Curation">001D99</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000082</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000082</idno><idno type="wicri:doubleKey">0950-2688:2014:Rebolledo J:influenza:in:hospitalized</idno><idno type="wicri:Area/Main/Merge">001083</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission</title><author><name sortKey="Rebolledo, J" sort="Rebolledo, J" uniqKey="Rebolledo J" first="J." last="Rebolledo">J. Rebolledo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Health Protection Surveillance Centre, Health Service Executive</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC)</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>1 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Igoe, D" sort="Igoe, D" uniqKey="Igoe D" first="D." last="Igoe">D. Igoe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Health Protection Surveillance Centre, Health Service Executive</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="O Donnell, J" sort="O Donnell, J" uniqKey="O Donnell J" first="J." last="O'Donnell">J. O'Donnell</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Health Protection Surveillance Centre, Health Service Executive</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Domegan, L" sort="Domegan, L" uniqKey="Domegan L" first="L." last="Domegan">L. Domegan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Health Protection Surveillance Centre, Health Service Executive</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Boland, M" sort="Boland, M" uniqKey="Boland M" first="M." last="Boland">M. Boland</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Public Health, Health Service Executive Dublin</s1><s3>IRL</s3><sZ>5 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Department of Public Health, Health Service Executive Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Freyne, B" sort="Freyne, B" uniqKey="Freyne B" first="B." last="Freyne">B. Freyne</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Maternity Hospital, Holies Street</s1><s2>Dublin</s2><s3>IRL</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mcnamara, A" sort="Mcnamara, A" uniqKey="Mcnamara A" first="A." last="Mcnamara">A. Mcnamara</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Public Health, Health Service Executive Tullamore</s1><s3>IRL</s3><sZ>7 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Department of Public Health, Health Service Executive Tullamore</wicri:noRegion></affiliation></author><author><name sortKey="Molloy, E" sort="Molloy, E" uniqKey="Molloy E" first="E." last="Molloy">E. Molloy</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Maternity Hospital, Holies Street</s1><s2>Dublin</s2><s3>IRL</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Our Lady's Children's Hospital</s1><s2>Crumlin, Dublin</s2><s3>IRL</s3><sZ>8 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Our Lady's Children's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Callaghan, M" sort="Callaghan, M" uniqKey="Callaghan M" first="M." last="Callaghan">M. Callaghan</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Anaesthesia and Intensive Care Medicine, Our Lady's Children's Hospital</s1><s2>Crumlin, Dublin</s2><s3>IRL</s3><sZ>9 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Crumlin, Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Ryan, A" sort="Ryan, A" uniqKey="Ryan A" first="A." last="Ryan">A. Ryan</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Public Health, Health Service Executive Sligo</s1><s3>IRL</s3><sZ>10 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Department of Public Health, Health Service Executive Sligo</wicri:noRegion></affiliation></author><author><name sortKey="O Flanagan, D" sort="O Flanagan, D" uniqKey="O Flanagan D" first="D." last="O'Flanagan">D. O'Flanagan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Health Protection Surveillance Centre, Health Service Executive</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Epidemiology and infection</title><title level="j" type="abbreviated">Epidemiol. infect.</title><idno type="ISSN">0950-2688</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Epidemiology and infection</title><title level="j" type="abbreviated">Epidemiol. infect.</title><idno type="ISSN">0950-2688</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Epidemiology</term><term>Influenza</term><term>Ireland</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Enfant</term><term>Irlande</term><term>Facteur risque</term><term>Epidémiologie</term><term>Grippe</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza causes significant morbidity and mortality in children. This study's objectives were to describe influenza A(H1N1)pdm09 during the pandemic, to compare it with circulating influenza in 2010/2011, and to identify risk factors for severe influenza defined as requiring admission to a paediatric intensive care unit (PICU). Children hospitalized with influenza during the pandemic were older, and more likely to have received antiviral therapy than children hospitalized during the 2010/2011 season. In 2010/2011, only one child admitted to a PICU with underlying medical conditions had been vaccinated. The risk of severe illness in the pandemic was higher in females and those with underlying conditions. In 2010/2011, infection with influenza A(H1N1)pdm09 compared to other influenza viruses was a significant risk factor for severe disease. An incremental relationship was found between the number of underlying conditions and PICU admission. These findings highlight the importance of improving low vaccination uptake and increasing the use of antivirals in vulnerable children.</div></front></TEI><affiliations><list><country><li>Irlande (pays)</li><li>Suède</li></country><region><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><country name="Irlande (pays)"><noRegion><name sortKey="Rebolledo, J" sort="Rebolledo, J" uniqKey="Rebolledo J" first="J." last="Rebolledo">J. Rebolledo</name></noRegion><name sortKey="Boland, M" sort="Boland, M" uniqKey="Boland M" first="M." last="Boland">M. Boland</name><name sortKey="Callaghan, M" sort="Callaghan, M" uniqKey="Callaghan M" first="M." last="Callaghan">M. Callaghan</name><name sortKey="Domegan, L" sort="Domegan, L" uniqKey="Domegan L" first="L." last="Domegan">L. Domegan</name><name sortKey="Freyne, B" sort="Freyne, B" uniqKey="Freyne B" first="B." last="Freyne">B. Freyne</name><name sortKey="Igoe, D" sort="Igoe, D" uniqKey="Igoe D" first="D." last="Igoe">D. Igoe</name><name sortKey="Mcnamara, A" sort="Mcnamara, A" uniqKey="Mcnamara A" first="A." last="Mcnamara">A. Mcnamara</name><name sortKey="Molloy, E" sort="Molloy, E" uniqKey="Molloy E" first="E." last="Molloy">E. Molloy</name><name sortKey="Molloy, E" sort="Molloy, E" uniqKey="Molloy E" first="E." last="Molloy">E. Molloy</name><name sortKey="O Donnell, J" sort="O Donnell, J" uniqKey="O Donnell J" first="J." last="O'Donnell">J. O'Donnell</name><name sortKey="O Flanagan, D" sort="O Flanagan, D" uniqKey="O Flanagan D" first="D." last="O'Flanagan">D. O'Flanagan</name><name sortKey="Ryan, A" sort="Ryan, A" uniqKey="Ryan A" first="A." last="Ryan">A. Ryan</name></country><country name="Suède"><region name="Svealand"><name sortKey="Rebolledo, J" sort="Rebolledo, J" uniqKey="Rebolledo J" first="J." last="Rebolledo">J. Rebolledo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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