Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
Identifieur interne : 000318 ( Main/Merge ); précédent : 000317; suivant : 000319Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
Auteurs : David M. Morens [États-Unis] ; Jeffery K. Taubenberger [États-Unis]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2019.
Descripteurs français
- KwdFr :
- Adulte, Animaux, Anticorps antiviraux (immunologie), Antigènes viraux (génétique), Antigènes viraux (immunologie), Comportement de recherche d'hôte, Dérive génétique, Enfant d'âge préscolaire, Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (), Grippe humaine (histoire), Grippe humaine (épidémiologie), Histoire du 20ème siècle, Humains, Infections à Orthomyxoviridae (virologie), Jeune adulte, Pandémies (), Pandémies (histoire), Pneumopathie bactérienne (mortalité), Pneumopathie bactérienne (étiologie), Prédisposition génétique à une maladie, Sialidase (génétique), Sialidase (immunologie), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (immunologie), Suidae (virologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Vaccins antigrippaux (immunologie), Épitopes (immunologie).
- MESH :
- génétique : Antigènes viraux, Glycoprotéine hémagglutinine du virus influenza, Sialidase, Sous-type H1N1 du virus de la grippe A.
- histoire : Grippe humaine, Pandémies.
- immunologie : Anticorps antiviraux, Antigènes viraux, Glycoprotéine hémagglutinine du virus influenza, Sialidase, Sous-type H1N1 du virus de la grippe A, Vaccins antigrippaux, Épitopes.
- mortalité : Pneumopathie bactérienne.
- virologie : Infections à Orthomyxoviridae, Suidae.
- épidémiologie : Grippe humaine.
- étiologie : Pneumopathie bactérienne.
- Adulte, Animaux, Comportement de recherche d'hôte, Dérive génétique, Enfant d'âge préscolaire, Grippe humaine, Histoire du 20ème siècle, Humains, Jeune adulte, Pandémies, Prédisposition génétique à une maladie, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Animals, Antibodies, Viral (immunology), Antigens, Viral (genetics), Antigens, Viral (immunology), Child, Preschool, Epitopes (immunology), Genetic Drift, Genetic Predisposition to Disease, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), History, 20th Century, Host-Seeking Behavior, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines (immunology), Influenza, Human (complications), Influenza, Human (epidemiology), Influenza, Human (history), Influenza, Human (prevention & control), Neuraminidase (genetics), Neuraminidase (immunology), Orthomyxoviridae Infections (virology), Pandemics (history), Pandemics (prevention & control), Pneumonia, Bacterial (etiology), Pneumonia, Bacterial (mortality), Swine (virology), Young Adult.
- MESH :
- chemical , genetics : Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Neuraminidase.
- chemical , immunology : Antibodies, Viral, Antigens, Viral, Epitopes, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Neuraminidase.
- complications : Influenza, Human.
- epidemiology : Influenza, Human.
- etiology : Pneumonia, Bacterial.
- genetics : Influenza A Virus, H1N1 Subtype.
- history : Influenza, Human, Pandemics.
- immunology : Influenza A Virus, H1N1 Subtype.
- mortality : Pneumonia, Bacterial.
- prevention & control : Influenza, Human, Pandemics.
- virology : Orthomyxoviridae Infections, Swine.
- Adult, Aged, Aged, 80 and over, Animals, Child, Preschool, Genetic Drift, Genetic Predisposition to Disease, History, 20th Century, Host-Seeking Behavior, Humans, Young Adult.
Abstract
The year 2018 marked the 100th anniversary of the deadliest event in human history. In 1918–1919, pandemic influenza spread globally and caused an estimated 50–100 million deaths associated with unexpected clinical and epidemiological features. The descendants of the 1918 virus continue to circulate as annual epidemic viruses causing significant mortality each year. The 1918 influenza pandemic serves as a benchmark for the development of universal influenza vaccines. Challenges to producing a truly universal influenza vaccine include eliciting broad protection against antigenically different influenza viruses that can prevent or significantly downregulate viral replication and reduce morbidity by preventing development of viral and secondary bacterial pneumonia. Perhaps the most important goal of such vaccines is not to prevent influenza, but to prevent influenza deaths.
Url:
DOI: 10.1093/infdis/jiy728
PubMed: 30715352
PubMed Central: 6452324
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PMC:6452324Le document en format XML
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<term>Antigens, Viral (genetics)</term>
<term>Antigens, Viral (immunology)</term>
<term>Child, Preschool</term>
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<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
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<term>Host-Seeking Behavior</term>
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<term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Antigènes viraux (génétique)</term>
<term>Antigènes viraux (immunologie)</term>
<term>Comportement de recherche d'hôte</term>
<term>Dérive génétique</term>
<term>Enfant d'âge préscolaire</term>
<term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (histoire)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Histoire du 20ème siècle</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae (virologie)</term>
<term>Jeune adulte</term>
<term>Pandémies ()</term>
<term>Pandémies (histoire)</term>
<term>Pneumopathie bactérienne (mortalité)</term>
<term>Pneumopathie bactérienne (étiologie)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Sialidase (génétique)</term>
<term>Sialidase (immunologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
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<term>Sous-type H1N1 du virus de la grippe A</term>
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<term>Enfant d'âge préscolaire</term>
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<term>Histoire du 20ème siècle</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>The year 2018 marked the 100th anniversary of the deadliest event in human history. In 1918–1919, pandemic influenza spread globally and caused an estimated 50–100 million deaths associated with unexpected clinical and epidemiological features. The descendants of the 1918 virus continue to circulate as annual epidemic viruses causing significant mortality each year. The 1918 influenza pandemic serves as a benchmark for the development of universal influenza vaccines. Challenges to producing a truly universal influenza vaccine include eliciting broad protection against antigenically different influenza viruses that can prevent or significantly downregulate viral replication and reduce morbidity by preventing development of viral and secondary bacterial pneumonia. Perhaps the most important goal of such vaccines is not to prevent influenza, but to prevent influenza deaths.</p>
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