Serveur d'exploration sur les pandémies grippales

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic

Identifieur interne : 000318 ( Main/Merge ); précédent : 000317; suivant : 000319

Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic

Auteurs : David M. Morens [États-Unis] ; Jeffery K. Taubenberger [États-Unis]

Source :

RBID : PMC:6452324

Descripteurs français

English descriptors

Abstract

Abstract

The year 2018 marked the 100th anniversary of the deadliest event in human history. In 1918–1919, pandemic influenza spread globally and caused an estimated 50–100 million deaths associated with unexpected clinical and epidemiological features. The descendants of the 1918 virus continue to circulate as annual epidemic viruses causing significant mortality each year. The 1918 influenza pandemic serves as a benchmark for the development of universal influenza vaccines. Challenges to producing a truly universal influenza vaccine include eliciting broad protection against antigenically different influenza viruses that can prevent or significantly downregulate viral replication and reduce morbidity by preventing development of viral and secondary bacterial pneumonia. Perhaps the most important goal of such vaccines is not to prevent influenza, but to prevent influenza deaths.


Url:
DOI: 10.1093/infdis/jiy728
PubMed: 30715352
PubMed Central: 6452324

Links toward previous steps (curation, corpus...)


Links to Exploration step

PMC:6452324

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic</title>
<author>
<name sortKey="Morens, David M" sort="Morens, David M" uniqKey="Morens D" first="David M" last="Morens">David M. Morens</name>
<affiliation wicri:level="2">
<nlm:aff id="AF0001">Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name>
<affiliation wicri:level="2">
<nlm:aff id="AF0002">Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">30715352</idno>
<idno type="pmc">6452324</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452324</idno>
<idno type="RBID">PMC:6452324</idno>
<idno type="doi">10.1093/infdis/jiy728</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000723</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000723</idno>
<idno type="wicri:Area/Pmc/Curation">000723</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000723</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000058</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000058</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:30715352</idno>
<idno type="wicri:Area/PubMed/Corpus">000174</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000174</idno>
<idno type="wicri:Area/PubMed/Curation">000174</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000174</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000125</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000125</idno>
<idno type="wicri:Area/Ncbi/Merge">001F20</idno>
<idno type="wicri:Area/Ncbi/Curation">001F20</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001F20</idno>
<idno type="wicri:doubleKey">0022-1899:2019:Morens D:making:universal:influenza</idno>
<idno type="wicri:Area/Main/Merge">000318</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic</title>
<author>
<name sortKey="Morens, David M" sort="Morens, David M" uniqKey="Morens D" first="David M" last="Morens">David M. Morens</name>
<affiliation wicri:level="2">
<nlm:aff id="AF0001">Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name>
<affiliation wicri:level="2">
<nlm:aff id="AF0002">Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint>
<date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antigens, Viral (genetics)</term>
<term>Antigens, Viral (immunology)</term>
<term>Child, Preschool</term>
<term>Epitopes (immunology)</term>
<term>Genetic Drift</term>
<term>Genetic Predisposition to Disease</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>History, 20th Century</term>
<term>Host-Seeking Behavior</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (complications)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (history)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Neuraminidase (genetics)</term>
<term>Neuraminidase (immunology)</term>
<term>Orthomyxoviridae Infections (virology)</term>
<term>Pandemics (history)</term>
<term>Pandemics (prevention & control)</term>
<term>Pneumonia, Bacterial (etiology)</term>
<term>Pneumonia, Bacterial (mortality)</term>
<term>Swine (virology)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte</term>
<term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Antigènes viraux (génétique)</term>
<term>Antigènes viraux (immunologie)</term>
<term>Comportement de recherche d'hôte</term>
<term>Dérive génétique</term>
<term>Enfant d'âge préscolaire</term>
<term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (histoire)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Histoire du 20ème siècle</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae (virologie)</term>
<term>Jeune adulte</term>
<term>Pandémies ()</term>
<term>Pandémies (histoire)</term>
<term>Pneumopathie bactérienne (mortalité)</term>
<term>Pneumopathie bactérienne (étiologie)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Sialidase (génétique)</term>
<term>Sialidase (immunologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Suidae (virologie)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Épitopes (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Antigens, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Neuraminidase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en">
<term>Antibodies, Viral</term>
<term>Antigens, Viral</term>
<term>Epitopes</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Influenza Vaccines</term>
<term>Neuraminidase</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en">
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Pneumonia, Bacterial</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Antigènes viraux</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Sialidase</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="histoire" xml:lang="fr">
<term>Grippe humaine</term>
<term>Pandémies</term>
</keywords>
<keywords scheme="MESH" qualifier="history" xml:lang="en">
<term>Influenza, Human</term>
<term>Pandemics</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Anticorps antiviraux</term>
<term>Antigènes viraux</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Sialidase</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Épitopes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en">
<term>Pneumonia, Bacterial</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr">
<term>Pneumopathie bactérienne</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en">
<term>Influenza, Human</term>
<term>Pandemics</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr">
<term>Infections à Orthomyxoviridae</term>
<term>Suidae</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Orthomyxoviridae Infections</term>
<term>Swine</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr">
<term>Pneumopathie bactérienne</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Child, Preschool</term>
<term>Genetic Drift</term>
<term>Genetic Predisposition to Disease</term>
<term>History, 20th Century</term>
<term>Host-Seeking Behavior</term>
<term>Humans</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Animaux</term>
<term>Comportement de recherche d'hôte</term>
<term>Dérive génétique</term>
<term>Enfant d'âge préscolaire</term>
<term>Grippe humaine</term>
<term>Histoire du 20ème siècle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Pandémies</term>
<term>Prédisposition génétique à une maladie</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<title>Abstract</title>
<p>The year 2018 marked the 100th anniversary of the deadliest event in human history. In 1918–1919, pandemic influenza spread globally and caused an estimated 50–100 million deaths associated with unexpected clinical and epidemiological features. The descendants of the 1918 virus continue to circulate as annual epidemic viruses causing significant mortality each year. The 1918 influenza pandemic serves as a benchmark for the development of universal influenza vaccines. Challenges to producing a truly universal influenza vaccine include eliciting broad protection against antigenically different influenza viruses that can prevent or significantly downregulate viral replication and reduce morbidity by preventing development of viral and secondary bacterial pneumonia. Perhaps the most important goal of such vaccines is not to prevent influenza, but to prevent influenza deaths.</p>
</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000318 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000318 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    PandemieGrippaleV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:6452324
   |texte=   Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i   -Sk "pubmed:30715352" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a PandemieGrippaleV1 

Wicri

This area was generated with Dilib version V0.6.34.
Data generation: Wed Jun 10 11:04:28 2020. Site generation: Sun Mar 28 09:10:28 2021