Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
Identifieur interne : 000723 ( Pmc/Corpus ); précédent : 000722; suivant : 000724Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
Auteurs : David M. Morens ; Jeffery K. TaubenbergerSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2019.
Abstract
The year 2018 marked the 100th anniversary of the deadliest event in human history. In 1918–1919, pandemic influenza spread globally and caused an estimated 50–100 million deaths associated with unexpected clinical and epidemiological features. The descendants of the 1918 virus continue to circulate as annual epidemic viruses causing significant mortality each year. The 1918 influenza pandemic serves as a benchmark for the development of universal influenza vaccines. Challenges to producing a truly universal influenza vaccine include eliciting broad protection against antigenically different influenza viruses that can prevent or significantly downregulate viral replication and reduce morbidity by preventing development of viral and secondary bacterial pneumonia. Perhaps the most important goal of such vaccines is not to prevent influenza, but to prevent influenza deaths.
Url:
DOI: 10.1093/infdis/jiy728
PubMed: 30715352
PubMed Central: 6452324
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic</title><author><name sortKey="Morens, David M" sort="Morens, David M" uniqKey="Morens D" first="David M" last="Morens">David M. Morens</name><affiliation><nlm:aff id="AF0001">Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</nlm:aff></affiliation></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name><affiliation><nlm:aff id="AF0002">Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30715352</idno><idno type="pmc">6452324</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452324</idno><idno type="RBID">PMC:6452324</idno><idno type="doi">10.1093/infdis/jiy728</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000723</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000723</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic</title><author><name sortKey="Morens, David M" sort="Morens, David M" uniqKey="Morens D" first="David M" last="Morens">David M. Morens</name><affiliation><nlm:aff id="AF0001">Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</nlm:aff></affiliation></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name><affiliation><nlm:aff id="AF0002">Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>The year 2018 marked the 100th anniversary of the deadliest event in human history. In 1918–1919, pandemic influenza spread globally and caused an estimated 50–100 million deaths associated with unexpected clinical and epidemiological features. The descendants of the 1918 virus continue to circulate as annual epidemic viruses causing significant mortality each year. The 1918 influenza pandemic serves as a benchmark for the development of universal influenza vaccines. Challenges to producing a truly universal influenza vaccine include eliciting broad protection against antigenically different influenza viruses that can prevent or significantly downregulate viral replication and reduce morbidity by preventing development of viral and secondary bacterial pneumonia. Perhaps the most important goal of such vaccines is not to prevent influenza, but to prevent influenza deaths.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">jid</journal-id><journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">0022-1899</issn><issn pub-type="epub">1537-6613</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>US</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">30715352</article-id><article-id pub-id-type="pmc">6452324</article-id><article-id pub-id-type="doi">10.1093/infdis/jiy728</article-id><article-id pub-id-type="publisher-id">jiy728</article-id><article-categories><subj-group subj-group-type="heading"><subject>Supplement Articles</subject></subj-group></article-categories><title-group><article-title>Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Morens</surname><given-names>David M</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Taubenberger</surname><given-names>Jeffery K</given-names></name><xref ref-type="aff" rid="AF0002">2</xref><xref ref-type="corresp" rid="c1"></xref><pmc-comment>taubenbergerj@niaid.nih.gov </pmc-comment>
</contrib></contrib-group><aff id="AF0001"><label>1</label>Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</aff><aff id="AF0002"><label>2</label>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</aff><author-notes><corresp id="c1">Correspondence: J. K. Taubenberger, MD, PhD, Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203 (<email>taubenbergerj@niaid.nih.gov</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>4</month><year>2019</year></pub-date><pub-date pub-type="epub" iso-8601-date="2019-04-08"><day>08</day><month>4</month><year>2019</year></pub-date><pub-date pub-type="pmc-release"><day>08</day><month>4</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>219</volume><issue>Suppl 1</issue><issue-title>100 Years of Fighting Pandemic Influenza 1918/19–2018/19</issue-title><fpage>S5</fpage><lpage>S13</lpage><permissions><copyright-statement>Published by Oxford University Press for the Infectious Diseases Society of America 2019.</copyright-statement><copyright-year>2019</copyright-year><license license-type="us-gov"><license-p>This work is written by (a) US Government employee(s) and is in the public domain in the US.</license-p></license></permissions><self-uri xlink:href="jiy728.pdf"></self-uri><abstract><title>Abstract</title><p>The year 2018 marked the 100th anniversary of the deadliest event in human history. In 1918–1919, pandemic influenza spread globally and caused an estimated 50–100 million deaths associated with unexpected clinical and epidemiological features. The descendants of the 1918 virus continue to circulate as annual epidemic viruses causing significant mortality each year. The 1918 influenza pandemic serves as a benchmark for the development of universal influenza vaccines. Challenges to producing a truly universal influenza vaccine include eliciting broad protection against antigenically different influenza viruses that can prevent or significantly downregulate viral replication and reduce morbidity by preventing development of viral and secondary bacterial pneumonia. Perhaps the most important goal of such vaccines is not to prevent influenza, but to prevent influenza deaths.</p></abstract><kwd-group><kwd>influenza</kwd><kwd>pandemic</kwd><kwd>pathogenesis</kwd><kwd>vaccine</kwd></kwd-group><funding-group><award-group award-type="grant"><funding-source><named-content content-type="funder-name">National Institute of Allergy and Infectious Diseases</named-content><named-content content-type="funder-identifier">10.13039/100000060</named-content></funding-source></award-group><award-group award-type="grant"><funding-source><named-content content-type="funder-name">National Institutes of Health</named-content><named-content content-type="funder-identifier">10.13039/100000002</named-content></funding-source></award-group></funding-group><counts><page-count count="9"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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