Constrained optimal control applied to vaccination for influenza
Identifieur interne : 000900 ( Main/Exploration ); précédent : 000899; suivant : 000901Constrained optimal control applied to vaccination for influenza
Auteurs : Jungeun Kim [Corée du Sud] ; Hee-Dae Kwon [Corée du Sud] ; Jeehyun Lee [Corée du Sud]Source :
- Computers & Mathematics with Applications [ 0898-1221 ] ; 2016.
Abstract
The efficient time schedule and prioritization of vaccine supplies are important in mitigating impact of an influenza pandemic. In practice, there are restrictions associated with limited vaccination coverage and the maximum daily vaccine administration. We extend previous work on optimal control for influenza to reflect these realistic restrictions using mixed constraints on state and control variables. An optimal control problem is formulated with the aim of minimizing the number of infected individuals while considering intervention costs. Time-dependent vaccination is computed and analysed using a model incorporating heterogeneity in population structure under different settings of transmissibility levels, vaccine coverages, and time delays.
Url:
DOI: 10.1016/j.camwa.2015.12.044
PubMed: NONE
PubMed Central: 7125829
Affiliations:
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Le document en format XML
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