Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus
Identifieur interne : 000714 ( Main/Exploration ); précédent : 000713; suivant : 000715Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus
Auteurs : Amali E. Samarasinghe [États-Unis] ; Rossana C. N. Melo [Brésil] ; Susu Duan [États-Unis] ; Kim S. Lemessurier [États-Unis] ; Swantje Liedmann [États-Unis] ; Sherri L. Surman [États-Unis] ; James J. Lee [États-Unis] ; Julia L. Hurwitz [États-Unis] ; Paul G. Thomas [États-Unis] ; Jonathan A. Mccullers [États-Unis]Source :
- The Journal of Immunology Author Choice [ 0022-1767 ] ; 2017.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Animaux, Asthme (), Asthme (immunologie), Cytométrie en flux, Granulocytes éosinophiles (immunologie), Hypersensibilité (), Hypersensibilité (immunologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Lymphocytes T CD8+ (immunologie), Microscopie confocale, Microscopie électronique à transmission, Modèles animaux de maladie humaine, Poumon éosinophile (immunologie), Souris, Virus de la grippe A (immunologie).
- MESH :
- immunologie : Activation des lymphocytes, Asthme, Granulocytes éosinophiles, Hypersensibilité, Infections à Orthomyxoviridae, Lymphocytes T CD8+, Poumon éosinophile, Virus de la grippe A.
- Animaux, Asthme, Cytométrie en flux, Hypersensibilité, Infections à Orthomyxoviridae, Microscopie confocale, Microscopie électronique à transmission, Modèles animaux de maladie humaine, Souris.
English descriptors
- KwdEn :
- Animals, Asthma (complications), Asthma (immunology), CD8-Positive T-Lymphocytes (immunology), Disease Models, Animal, Eosinophils (immunology), Flow Cytometry, Hypersensitivity (complications), Hypersensitivity (immunology), Influenza A virus (immunology), Lymphocyte Activation (immunology), Mice, Microscopy, Confocal, Microscopy, Electron, Transmission, Orthomyxoviridae Infections (complications), Orthomyxoviridae Infections (immunology), Pulmonary Eosinophilia (immunology).
- MESH :
- complications : Asthma, Hypersensitivity, Orthomyxoviridae Infections.
- immunology : Asthma, CD8-Positive T-Lymphocytes, Eosinophils, Hypersensitivity, Influenza A virus, Lymphocyte Activation, Orthomyxoviridae Infections, Pulmonary Eosinophilia.
- Animals, Disease Models, Animal, Flow Cytometry, Mice, Microscopy, Confocal, Microscopy, Electron, Transmission.
Abstract
Eosinophils are multifunctional cells of the innate immune system linked to allergic inflammation. Asthmatics were more likely to be hospitalized but less likely to suffer severe morbidity and mortality during the 2009 influenza pandemic. These epidemiologic findings were recapitulated in a mouse model of fungal asthma wherein infection during heightened allergic inflammation was protective against influenza A virus (IAV) infection and disease. Our goal was to delineate a mechanism(s) by which allergic asthma may alleviate influenza disease outcome, focused on the hypothesis that pulmonary eosinophilia linked with allergic respiratory disease is able to promote antiviral host defenses against the influenza virus. The transfer of eosinophils from the lungs of allergen-sensitized and challenged mice into influenza virus–infected mice resulted in reduced morbidity and viral burden, improved lung compliance, and increased CD8+ T cell numbers in the airways. In vitro assays with primary or bone marrow–derived eosinophils were used to determine eosinophil responses to the virus using the laboratory strain (A/PR/08/1934) or the pandemic strain (A/CA/04/2009) of IAV. Eosinophils were susceptible to IAV infection and responded by activation, piecemeal degranulation, and upregulation of Ag presentation markers. Virus- or viral peptide–exposed eosinophils induced CD8+ T cell proliferation, activation, and effector functions. Our data suggest that eosinophils promote host cellular immunity to reduce influenza virus replication in lungs, thereby providing a novel mechanism by which hosts with allergic asthma may be protected from influenza morbidity.
Url:
DOI: 10.4049/jimmunol.1600787
PubMed: 28283567
PubMed Central: 5384374
Affiliations:
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Le document en format XML
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<term>Asthma (immunology)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>Disease Models, Animal</term>
<term>Eosinophils (immunology)</term>
<term>Flow Cytometry</term>
<term>Hypersensitivity (complications)</term>
<term>Hypersensitivity (immunology)</term>
<term>Influenza A virus (immunology)</term>
<term>Lymphocyte Activation (immunology)</term>
<term>Mice</term>
<term>Microscopy, Confocal</term>
<term>Microscopy, Electron, Transmission</term>
<term>Orthomyxoviridae Infections (complications)</term>
<term>Orthomyxoviridae Infections (immunology)</term>
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</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (immunologie)</term>
<term>Animaux</term>
<term>Asthme ()</term>
<term>Asthme (immunologie)</term>
<term>Cytométrie en flux</term>
<term>Granulocytes éosinophiles (immunologie)</term>
<term>Hypersensibilité ()</term>
<term>Hypersensibilité (immunologie)</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
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<term>Microscopie confocale</term>
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<term>Modèles animaux de maladie humaine</term>
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<term>Souris</term>
<term>Virus de la grippe A (immunologie)</term>
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<term>Hypersensitivity</term>
<term>Orthomyxoviridae Infections</term>
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<term>Asthme</term>
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<term>Hypersensibilité</term>
<term>Infections à Orthomyxoviridae</term>
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<term>Poumon éosinophile</term>
<term>Virus de la grippe A</term>
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<term>Hypersensitivity</term>
<term>Influenza A virus</term>
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<term>Orthomyxoviridae Infections</term>
<term>Pulmonary Eosinophilia</term>
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<term>Cytométrie en flux</term>
<term>Hypersensibilité</term>
<term>Infections à Orthomyxoviridae</term>
<term>Microscopie confocale</term>
<term>Microscopie électronique à transmission</term>
<term>Modèles animaux de maladie humaine</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Eosinophils are multifunctional cells of the innate immune system linked to allergic inflammation. Asthmatics were more likely to be hospitalized but less likely to suffer severe morbidity and mortality during the 2009 influenza pandemic. These epidemiologic findings were recapitulated in a mouse model of fungal asthma wherein infection during heightened allergic inflammation was protective against influenza A virus (IAV) infection and disease. Our goal was to delineate a mechanism(s) by which allergic asthma may alleviate influenza disease outcome, focused on the hypothesis that pulmonary eosinophilia linked with allergic respiratory disease is able to promote antiviral host defenses against the influenza virus. The transfer of eosinophils from the lungs of allergen-sensitized and challenged mice into influenza virus–infected mice resulted in reduced morbidity and viral burden, improved lung compliance, and increased CD8<sup>+</sup>
T cell numbers in the airways. In vitro assays with primary or bone marrow–derived eosinophils were used to determine eosinophil responses to the virus using the laboratory strain (A/PR/08/1934) or the pandemic strain (A/CA/04/2009) of IAV. Eosinophils were susceptible to IAV infection and responded by activation, piecemeal degranulation, and upregulation of Ag presentation markers. Virus- or viral peptide–exposed eosinophils induced CD8<sup>+</sup>
T cell proliferation, activation, and effector functions. Our data suggest that eosinophils promote host cellular immunity to reduce influenza virus replication in lungs, thereby providing a novel mechanism by which hosts with allergic asthma may be protected from influenza morbidity.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Brésil</li>
<li>États-Unis</li>
</country>
<region><li>Arizona</li>
<li>Tennessee</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Samarasinghe, Amali E" sort="Samarasinghe, Amali E" uniqKey="Samarasinghe A" first="Amali E." last="Samarasinghe">Amali E. Samarasinghe</name>
</region>
<name sortKey="Duan, Susu" sort="Duan, Susu" uniqKey="Duan S" first="Susu" last="Duan">Susu Duan</name>
<name sortKey="Hurwitz, Julia L" sort="Hurwitz, Julia L" uniqKey="Hurwitz J" first="Julia L." last="Hurwitz">Julia L. Hurwitz</name>
<name sortKey="Lee, James J" sort="Lee, James J" uniqKey="Lee J" first="James J." last="Lee">James J. Lee</name>
<name sortKey="Lemessurier, Kim S" sort="Lemessurier, Kim S" uniqKey="Lemessurier K" first="Kim S." last="Lemessurier">Kim S. Lemessurier</name>
<name sortKey="Lemessurier, Kim S" sort="Lemessurier, Kim S" uniqKey="Lemessurier K" first="Kim S." last="Lemessurier">Kim S. Lemessurier</name>
<name sortKey="Liedmann, Swantje" sort="Liedmann, Swantje" uniqKey="Liedmann S" first="Swantje" last="Liedmann">Swantje Liedmann</name>
<name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name>
<name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name>
<name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name>
<name sortKey="Samarasinghe, Amali E" sort="Samarasinghe, Amali E" uniqKey="Samarasinghe A" first="Amali E." last="Samarasinghe">Amali E. Samarasinghe</name>
<name sortKey="Samarasinghe, Amali E" sort="Samarasinghe, Amali E" uniqKey="Samarasinghe A" first="Amali E." last="Samarasinghe">Amali E. Samarasinghe</name>
<name sortKey="Surman, Sherri L" sort="Surman, Sherri L" uniqKey="Surman S" first="Sherri L." last="Surman">Sherri L. Surman</name>
<name sortKey="Thomas, Paul G" sort="Thomas, Paul G" uniqKey="Thomas P" first="Paul G." last="Thomas">Paul G. Thomas</name>
</country>
<country name="Brésil"><noRegion><name sortKey="Melo, Rossana C N" sort="Melo, Rossana C N" uniqKey="Melo R" first="Rossana C. N." last="Melo">Rossana C. N. Melo</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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