Peramivir: A Novel Intravenous Neuraminidase Inhibitor for Treatment of Acute Influenza Infections
Identifieur interne : 000852 ( Main/Exploration ); précédent : 000851; suivant : 000853Peramivir: A Novel Intravenous Neuraminidase Inhibitor for Treatment of Acute Influenza Infections
Auteurs : Malak M. Alame [Liban] ; Elie Massaad [Liban] ; Hassan Zaraket [Liban]Source :
- Frontiers in Microbiology [ 1664-302X ] ; 2016.
Abstract
Peramivir is a novel cyclopentane neuraminidase inhibitor of influenza virus. It was approved by the Food and Drug Administration in December 2014 for treatment of acute uncomplicated influenza in patients 18 years and older. For several months prior to approval, the drug was made clinically available under Emergency Use authorization during the 2009 H1N1 influenza pandemic. Peramivir is highly effective against human influenza A and B isolates as well as emerging influenza virus strains with pandemic potential. Clinical trials demonstrated that the drug is well-tolerated in adult and pediatric populations. Adverse events are generally mild to moderate and similar in frequency to patients receiving placebo. Common side effects include gastrointestinal disorders and decreased neutrophil counts but are self-limiting. Peramivir is administered as a single-dose via the intravenous route providing a valuable therapeutic alternative for critically ill patients or those unable to tolerate other administration routes. Successful clinical trials and post-marketing data in pediatric populations in Japan support the safety and efficacy of peramivir in this population where administration of other antivirals might not be feasible.
Url:
DOI: 10.3389/fmicb.2016.00450
PubMed: 27065996
PubMed Central: 4815007
Affiliations:
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Alame</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>The School of Pharmacy, Lebanese International University</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Massaad, Elie" sort="Massaad, Elie" uniqKey="Massaad E" first="Elie" last="Massaad">Elie Massaad</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Zaraket, Hassan" sort="Zaraket, Hassan" uniqKey="Zaraket H" first="Hassan" last="Zaraket">Hassan Zaraket</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Center for Infectious Diseases Research, Faculty of Medicine, American University of Beirut</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Microbiology</title><idno type="eISSN">1664-302X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Peramivir is a novel cyclopentane neuraminidase inhibitor of influenza virus. It was approved by the Food and Drug Administration in December 2014 for treatment of acute uncomplicated influenza in patients 18 years and older. For several months prior to approval, the drug was made clinically available under Emergency Use authorization during the 2009 H1N1 influenza pandemic. Peramivir is highly effective against human influenza A and B isolates as well as emerging influenza virus strains with pandemic potential. Clinical trials demonstrated that the drug is well-tolerated in adult and pediatric populations. Adverse events are generally mild to moderate and similar in frequency to patients receiving placebo. Common side effects include gastrointestinal disorders and decreased neutrophil counts but are self-limiting. Peramivir is administered as a single-dose via the intravenous route providing a valuable therapeutic alternative for critically ill patients or those unable to tolerate other administration routes. Successful clinical trials and post-marketing data in pediatric populations in Japan support the safety and efficacy of peramivir in this population where administration of other antivirals might not be feasible.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abdelwhab, E M" uniqKey="Abdelwhab E">E. M. Abdelwhab</name></author><author><name sortKey="Hafez, H M" uniqKey="Hafez H">H. M. Hafez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abed, Y" uniqKey="Abed Y">Y. Abed</name></author><author><name sortKey="Boivin, G" uniqKey="Boivin G">G. Boivin</name></author><author><name sortKey="Yoshida, R" uniqKey="Yoshida R">R. Yoshida</name></author><author><name sortKey="Kodama, M" uniqKey="Kodama M">M. Kodama</name></author><author><name sortKey="Hernandez, J E" uniqKey="Hernandez J">J. E. 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Lee</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Liban</li></country></list><tree><country name="Liban"><noRegion><name sortKey="Alame, Malak M" sort="Alame, Malak M" uniqKey="Alame M" first="Malak M." last="Alame">Malak M. Alame</name></noRegion><name sortKey="Massaad, Elie" sort="Massaad, Elie" uniqKey="Massaad E" first="Elie" last="Massaad">Elie Massaad</name><name sortKey="Zaraket, Hassan" sort="Zaraket, Hassan" uniqKey="Zaraket H" first="Hassan" last="Zaraket">Hassan Zaraket</name><name sortKey="Zaraket, Hassan" sort="Zaraket, Hassan" uniqKey="Zaraket H" first="Hassan" last="Zaraket">Hassan Zaraket</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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