Peramivir: A Novel Intravenous Neuraminidase Inhibitor for Treatment of Acute Influenza Infections
Identifieur interne : 000092 ( Pmc/Curation ); précédent : 000091; suivant : 000093Peramivir: A Novel Intravenous Neuraminidase Inhibitor for Treatment of Acute Influenza Infections
Auteurs : Malak M. Alame [Liban] ; Elie Massaad [Liban] ; Hassan Zaraket [Liban]Source :
- Frontiers in Microbiology [ 1664-302X ] ; 2016.
Abstract
Peramivir is a novel cyclopentane neuraminidase inhibitor of influenza virus. It was approved by the Food and Drug Administration in December 2014 for treatment of acute uncomplicated influenza in patients 18 years and older. For several months prior to approval, the drug was made clinically available under Emergency Use authorization during the 2009 H1N1 influenza pandemic. Peramivir is highly effective against human influenza A and B isolates as well as emerging influenza virus strains with pandemic potential. Clinical trials demonstrated that the drug is well-tolerated in adult and pediatric populations. Adverse events are generally mild to moderate and similar in frequency to patients receiving placebo. Common side effects include gastrointestinal disorders and decreased neutrophil counts but are self-limiting. Peramivir is administered as a single-dose via the intravenous route providing a valuable therapeutic alternative for critically ill patients or those unable to tolerate other administration routes. Successful clinical trials and post-marketing data in pediatric populations in Japan support the safety and efficacy of peramivir in this population where administration of other antivirals might not be feasible.
Url:
DOI: 10.3389/fmicb.2016.00450
PubMed: 27065996
PubMed Central: 4815007
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Alame</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>The School of Pharmacy, Lebanese International University</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Massaad, Elie" sort="Massaad, Elie" uniqKey="Massaad E" first="Elie" last="Massaad">Elie Massaad</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Zaraket, Hassan" sort="Zaraket, Hassan" uniqKey="Zaraket H" first="Hassan" last="Zaraket">Hassan Zaraket</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Center for Infectious Diseases Research, Faculty of Medicine, American University of Beirut</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27065996</idno><idno type="pmc">4815007</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815007</idno><idno type="RBID">PMC:4815007</idno><idno type="doi">10.3389/fmicb.2016.00450</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000092</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000092</idno><idno type="wicri:Area/Pmc/Curation">000092</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000092</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Peramivir: A Novel Intravenous Neuraminidase Inhibitor for Treatment of Acute Influenza Infections</title><author><name sortKey="Alame, Malak M" sort="Alame, Malak M" uniqKey="Alame M" first="Malak M." last="Alame">Malak M. Alame</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>The School of Pharmacy, Lebanese International University</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Massaad, Elie" sort="Massaad, Elie" uniqKey="Massaad E" first="Elie" last="Massaad">Elie Massaad</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Zaraket, Hassan" sort="Zaraket, Hassan" uniqKey="Zaraket H" first="Hassan" last="Zaraket">Hassan Zaraket</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Center for Infectious Diseases Research, Faculty of Medicine, American University of Beirut</institution><country>Beirut, Lebanon</country></nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Microbiology</title><idno type="eISSN">1664-302X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Peramivir is a novel cyclopentane neuraminidase inhibitor of influenza virus. It was approved by the Food and Drug Administration in December 2014 for treatment of acute uncomplicated influenza in patients 18 years and older. For several months prior to approval, the drug was made clinically available under Emergency Use authorization during the 2009 H1N1 influenza pandemic. Peramivir is highly effective against human influenza A and B isolates as well as emerging influenza virus strains with pandemic potential. Clinical trials demonstrated that the drug is well-tolerated in adult and pediatric populations. Adverse events are generally mild to moderate and similar in frequency to patients receiving placebo. Common side effects include gastrointestinal disorders and decreased neutrophil counts but are self-limiting. Peramivir is administered as a single-dose via the intravenous route providing a valuable therapeutic alternative for critically ill patients or those unable to tolerate other administration routes. Successful clinical trials and post-marketing data in pediatric populations in Japan support the safety and efficacy of peramivir in this population where administration of other antivirals might not be feasible.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abdelwhab, E M" uniqKey="Abdelwhab E">E. M. Abdelwhab</name></author><author><name sortKey="Hafez, H M" uniqKey="Hafez H">H. M. Hafez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abed, Y" uniqKey="Abed Y">Y. Abed</name></author><author><name sortKey="Boivin, G" uniqKey="Boivin G">G. Boivin</name></author><author><name sortKey="Yoshida, R" uniqKey="Yoshida R">R. Yoshida</name></author><author><name sortKey="Kodama, M" uniqKey="Kodama M">M. Kodama</name></author><author><name sortKey="Hernandez, J E" uniqKey="Hernandez J">J. E. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Microbiol</journal-id><journal-id journal-id-type="iso-abbrev">Front Microbiol</journal-id><journal-id journal-id-type="publisher-id">Front. Microbiol.</journal-id><journal-title-group><journal-title>Frontiers in Microbiology</journal-title></journal-title-group><issn pub-type="epub">1664-302X</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27065996</article-id><article-id pub-id-type="pmc">4815007</article-id><article-id pub-id-type="doi">10.3389/fmicb.2016.00450</article-id><article-categories><subj-group subj-group-type="heading"><subject>Microbiology</subject><subj-group><subject>Review</subject></subj-group></subj-group></article-categories><title-group><article-title>Peramivir: A Novel Intravenous Neuraminidase Inhibitor for Treatment of Acute Influenza Infections</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Alame</surname><given-names>Malak M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Massaad</surname><given-names>Elie</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/314719/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Zaraket</surname><given-names>Hassan</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/289783/overview"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>The School of Pharmacy, Lebanese International University</institution><country>Beirut, Lebanon</country></aff><aff id="aff2"><sup>2</sup><institution>Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut</institution><country>Beirut, Lebanon</country></aff><aff id="aff3"><sup>3</sup><institution>Center for Infectious Diseases Research, Faculty of Medicine, American University of Beirut</institution><country>Beirut, Lebanon</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: <italic>Saleh AlGhamdi, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia</italic></p></fn><fn fn-type="edited-by"><p>Reviewed by: <italic>Julie McAuley, University of Melbourne – The Peter Doherty Institute for Infection and Immunity, Australia; Sergey P. Morzunov, University of Nevada, Reno, USA</italic></p></fn><corresp id="fn001">*Correspondence: <italic>Hassan Zaraket, <email xlink:type="simple">hassan.zaraket@aub.edu.lb</email></italic></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to Infectious Diseases, a section of the journal Frontiers in Microbiology</p></fn></author-notes><pub-date pub-type="epub"><day>31</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>7</volume><elocation-id>450</elocation-id><history><date date-type="received"><day>14</day><month>1</month><year>2016</year></date><date date-type="accepted"><day>21</day><month>3</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016 Alame, Massaad and Zaraket.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Alame, Massaad and Zaraket</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Peramivir is a novel cyclopentane neuraminidase inhibitor of influenza virus. It was approved by the Food and Drug Administration in December 2014 for treatment of acute uncomplicated influenza in patients 18 years and older. For several months prior to approval, the drug was made clinically available under Emergency Use authorization during the 2009 H1N1 influenza pandemic. Peramivir is highly effective against human influenza A and B isolates as well as emerging influenza virus strains with pandemic potential. Clinical trials demonstrated that the drug is well-tolerated in adult and pediatric populations. Adverse events are generally mild to moderate and similar in frequency to patients receiving placebo. Common side effects include gastrointestinal disorders and decreased neutrophil counts but are self-limiting. Peramivir is administered as a single-dose via the intravenous route providing a valuable therapeutic alternative for critically ill patients or those unable to tolerate other administration routes. Successful clinical trials and post-marketing data in pediatric populations in Japan support the safety and efficacy of peramivir in this population where administration of other antivirals might not be feasible.</p></abstract><kwd-group><kwd>influenza</kwd><kwd>neuraminidase inhibitors</kwd><kwd>peramivir</kwd><kwd>efficacy</kwd><kwd>safety</kwd></kwd-group><counts><fig-count count="2"></fig-count><table-count count="2"></table-count><equation-count count="0"></equation-count><ref-count count="148"></ref-count><page-count count="14"></page-count><word-count count="0"></word-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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