Benefit of Conjugate Pneumococcal Vaccination in Preventing Influenza Hospitalization in Children: A Case-control Study
Identifieur interne : 001890 ( Main/Exploration ); précédent : 001889; suivant : 001891Benefit of Conjugate Pneumococcal Vaccination in Preventing Influenza Hospitalization in Children: A Case-control Study
Auteurs : Angela Dominguez [Espagne] ; Jesús Castilla [Espagne] ; Pere Godoy [Espagne] ; Miguel Delgado-Rodriguez [Espagne] ; Marc Saez [Espagne] ; Núria Soldevila [Espagne] ; Jenaro Astray [Espagne] ; José María Mayoral [Espagne] ; Vicente Martin [Espagne] ; José María Quintana [Espagne] ; Fernando Gonzalez-Candelas [Espagne] ; Juan Carlos Galan [Espagne] ; Sonia Tamames [Espagne] ; Ady Castro Acosta [Espagne] ; Maretva Baricot [Espagne] ; Olatz Garin [Espagne] ; Juan Jose Garcia [Espagne] ; Fernando Moraga [Espagne] ; Tomás Pumarola [Espagne]Source :
- The Pediatric infectious disease journal [ 0891-3668 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccination, Hospitalisation, Enfant, Pédiatrie.
English descriptors
- KwdEn :
Abstract
Background: The pneumococcal conjugate vaccine (PCV) might prevent hospitalizations in children because of the role of Streptococcus pneumoniae in the complications of influenza infection. We investigated the benefit of PCV vaccination in preventing influenza hospitalization in children <5 years of age during the 2009 to 2010 pandemic wave and the 2010 to 2011 influenza epidemic in Spain. Methods: A multicenter matched case-control study was undertaken in 27 hospitals from 7 Spanish regions between July 2009 and April 2011. A case was defined as a hospitalized patient between 6 months and 5 years of age with influenza virus infection confirmed by real-time reverse-transcription polymerase chain reaction. We selected 2 matched controls for each case from patients with unplanned hospital admission for reasons other than acute respiratory infection or influenza-like illness. Cases and controls were matched according to age, date of hospitalization and province of residence. Crude and adjusted odds ratios were calculated for associations between influenza hospitalization and PCV vaccination. Results: One hundred ninety-four cases and 342 controls were included in the study. In the 2009 to 2010 pandemic wave, the adjusted benefit in preventing hospitalization was 48% (95% confidence interval: 1 to 76) in fully vaccinated children compared with -79% (95% confidence interval: -341 to 27) in the 2010 to 2011 influenza season. Conclusions: The results obtained suggest that, in children <5 years of age, PCV vaccination reduced hospitalization during the 2009 to 2010 pandemic wave. By contrast, there was no observed benefit of vaccination in the 2010 to 2011 influenza season.
Affiliations:
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sort="Baricot, Maretva" uniqKey="Baricot M" first="Maretva" last="Baricot">Maretva Baricot</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CIBER Epidemiologia y Salud Pública</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Garin, Olatz" sort="Garin, Olatz" uniqKey="Garin O" first="Olatz" last="Garin">Olatz Garin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CIBER Epidemiologia y Salud Pública</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 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aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Soldevila, Nuria" sort="Soldevila, Nuria" uniqKey="Soldevila N" first="Núria" last="Soldevila">Núria Soldevila</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CIBER Epidemiologia y Salud Pública</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Area de Epidemiologia, Comunidad de Madrid</s1><s2>Madrid</s2><s3>ESP</s3><sZ>7 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Mayoral, Jose Maria" sort="Mayoral, Jose Maria" uniqKey="Mayoral J" first="José María" last="Mayoral">José María Mayoral</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Servicio de Vigilancia de Andalucia</s1><s3>ESP</s3><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Servicio de Vigilancia de Andalucia</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martin">Vicente Martin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CIBER Epidemiologia y Salud Pública</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Instituto de Biomedicina, Universidad de Leon</s1><s2>León</s2><s3>ESP</s3><sZ>9 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>León</wicri:noRegion></affiliation></author><author><name sortKey="Quintana, Jose Maria" sort="Quintana, Jose Maria" uniqKey="Quintana J" first="José María" last="Quintana">José María Quintana</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CIBER Epidemiologia y Salud Pública</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Unidad de Investigación, Hospital Galdakao-Usansolo</s1><s2>San Sebastian</s2><s3>ESP</s3><sZ>10 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>San Sebastian</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Candelas, Fernando" sort="Gonzalez Candelas, Fernando" uniqKey="Gonzalez Candelas F" first="Fernando" last="Gonzalez-Candelas">Fernando Gonzalez-Candelas</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CIBER Epidemiologia y Salud Pública</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centro Superior de Investigación en Salud Pública, Universidad de Valencia</s1><s3>ESP</s3><sZ>11 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Centro Superior de Investigación en Salud Pública, Universidad de Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Carlos Galan, Juan" sort="Carlos Galan, Juan" uniqKey="Carlos Galan J" first="Juan" last="Carlos Galan">Juan Carlos Galan</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CIBER Epidemiologia y Salud Pública</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Hospital Universitario Ramón y Cajal</s1><s2>Madrid</s2><s3>ESP</s3><sZ>12 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Tamames, Sonia" sort="Tamames, Sonia" uniqKey="Tamames S" first="Sonia" last="Tamames">Sonia Tamames</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Dirección General de Salud Pública e Investigación, Desarrollo e Innovación, Junta de Castilla y León</s1><s3>ESP</s3><sZ>13 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Dirección General de Salud Pública e Investigación, Desarrollo e Innovación, Junta de Castilla y León</wicri:noRegion></affiliation></author><author><name sortKey="Castro Acosta, Ady" sort="Castro Acosta, Ady" uniqKey="Castro Acosta A" first="Ady" last="Castro Acosta">Ady Castro Acosta</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>CIBER Enfermedades Respiratorias</s1><s3>ESP</s3><sZ>14 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>CIBER Enfermedades Respiratorias</wicri:noRegion></affiliation></author><author><name sortKey="Baricot, Maretva" sort="Baricot, Maretva" uniqKey="Baricot M" first="Maretva" last="Baricot">Maretva Baricot</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CIBER Epidemiologia y Salud Pública</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Garin, Olatz" sort="Garin, Olatz" uniqKey="Garin O" first="Olatz" last="Garin">Olatz Garin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CIBER Epidemiologia y Salud Pública</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Institut Municipal d' Investigació Mèdica</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>16 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Jose Garcia, Juan" sort="Jose Garcia, Juan" uniqKey="Jose Garcia J" first="Juan" last="Jose Garcia">Juan Jose Garcia</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Hospital Universitari San Joan de Déu</s1><s2>Esplugues</s2><s3>ESP</s3><sZ>17 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Hospital Universitari San Joan de Déu</wicri:noRegion></affiliation></author><author><name sortKey="Moraga, Fernando" sort="Moraga, Fernando" uniqKey="Moraga F" first="Fernando" last="Moraga">Fernando Moraga</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Hospital Universitari Vall d' Hebrón</s1><s3>ESP</s3><sZ>18 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Hospital Universitari Vall d' Hebrón</wicri:noRegion></affiliation></author><author><name sortKey="Pumarola, Tomas" sort="Pumarola, Tomas" uniqKey="Pumarola T" first="Tomás" last="Pumarola">Tomás Pumarola</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Red Española de Investigación en Patologia Infecciosa</s1><s3>ESP</s3><sZ>19 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Red Española de Investigación en Patologia Infecciosa</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">The Pediatric infectious disease journal</title><title level="j" type="abbreviated">Pediatr. infect. dis. j.</title><idno type="ISSN">0891-3668</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Pediatric infectious disease journal</title><title level="j" type="abbreviated">Pediatr. infect. dis. j.</title><idno type="ISSN">0891-3668</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case control study</term><term>Child</term><term>Hospitalization</term><term>Immunoprophylaxis</term><term>Influenza A</term><term>Mixed vaccine</term><term>Pediatrics</term><term>Pneumococcal infection</term><term>Prevention</term><term>Seasonal variation</term><term>Streptococcus pneumoniae</term><term>Vaccination</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pneumococcie</term><term>Grippe A</term><term>Immunoprophylaxie</term><term>Vaccination</term><term>Prévention</term><term>Hospitalisation</term><term>Streptococcus pneumoniae</term><term>Enfant</term><term>Etude cas témoin</term><term>Vaccin associé</term><term>Variation saisonnière</term><term>Pédiatrie</term><term>Pandémie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccination</term><term>Hospitalisation</term><term>Enfant</term><term>Pédiatrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: The pneumococcal conjugate vaccine (PCV) might prevent hospitalizations in children because of the role of Streptococcus pneumoniae in the complications of influenza infection. We investigated the benefit of PCV vaccination in preventing influenza hospitalization in children <5 years of age during the 2009 to 2010 pandemic wave and the 2010 to 2011 influenza epidemic in Spain. Methods: A multicenter matched case-control study was undertaken in 27 hospitals from 7 Spanish regions between July 2009 and April 2011. A case was defined as a hospitalized patient between 6 months and 5 years of age with influenza virus infection confirmed by real-time reverse-transcription polymerase chain reaction. We selected 2 matched controls for each case from patients with unplanned hospital admission for reasons other than acute respiratory infection or influenza-like illness. Cases and controls were matched according to age, date of hospitalization and province of residence. Crude and adjusted odds ratios were calculated for associations between influenza hospitalization and PCV vaccination. Results: One hundred ninety-four cases and 342 controls were included in the study. In the 2009 to 2010 pandemic wave, the adjusted benefit in preventing hospitalization was 48% (95% confidence interval: 1 to 76) in fully vaccinated children compared with -79% (95% confidence interval: -341 to 27) in the 2010 to 2011 influenza season. Conclusions: The results obtained suggest that, in children <5 years of age, PCV vaccination reduced hospitalization during the 2009 to 2010 pandemic wave. By contrast, there was no observed benefit of vaccination in the 2010 to 2011 influenza season.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li><li>Communauté de Madrid</li></region><settlement><li>Barcelone</li><li>Madrid</li></settlement><orgName><li>Université de Barcelone</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Angela" last="Dominguez">Angela Dominguez</name></region><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name><name sortKey="Baricot, Maretva" sort="Baricot, Maretva" uniqKey="Baricot M" first="Maretva" last="Baricot">Maretva Baricot</name><name sortKey="Carlos Galan, Juan" sort="Carlos Galan, Juan" uniqKey="Carlos Galan J" first="Juan" last="Carlos Galan">Juan Carlos Galan</name><name sortKey="Carlos Galan, Juan" sort="Carlos Galan, Juan" uniqKey="Carlos Galan J" first="Juan" last="Carlos Galan">Juan Carlos Galan</name><name sortKey="Castilla, Jesus" sort="Castilla, Jesus" uniqKey="Castilla J" first="Jesús" last="Castilla">Jesús Castilla</name><name sortKey="Castilla, Jesus" sort="Castilla, Jesus" uniqKey="Castilla J" first="Jesús" last="Castilla">Jesús Castilla</name><name sortKey="Castro Acosta, Ady" sort="Castro Acosta, Ady" uniqKey="Castro Acosta A" first="Ady" last="Castro Acosta">Ady Castro Acosta</name><name sortKey="Delgado Rodriguez, Miguel" sort="Delgado Rodriguez, Miguel" uniqKey="Delgado Rodriguez M" first="Miguel" last="Delgado-Rodriguez">Miguel Delgado-Rodriguez</name><name sortKey="Delgado Rodriguez, Miguel" sort="Delgado Rodriguez, Miguel" uniqKey="Delgado Rodriguez M" first="Miguel" last="Delgado-Rodriguez">Miguel Delgado-Rodriguez</name><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Angela" last="Dominguez">Angela Dominguez</name><name sortKey="Garin, Olatz" sort="Garin, Olatz" uniqKey="Garin O" first="Olatz" last="Garin">Olatz Garin</name><name sortKey="Garin, Olatz" sort="Garin, Olatz" uniqKey="Garin O" first="Olatz" last="Garin">Olatz Garin</name><name sortKey="Godoy, Pere" sort="Godoy, Pere" uniqKey="Godoy P" first="Pere" last="Godoy">Pere Godoy</name><name sortKey="Godoy, Pere" sort="Godoy, Pere" uniqKey="Godoy P" first="Pere" last="Godoy">Pere Godoy</name><name sortKey="Gonzalez Candelas, Fernando" sort="Gonzalez Candelas, Fernando" uniqKey="Gonzalez Candelas F" first="Fernando" last="Gonzalez-Candelas">Fernando Gonzalez-Candelas</name><name sortKey="Gonzalez Candelas, Fernando" sort="Gonzalez Candelas, Fernando" uniqKey="Gonzalez Candelas F" first="Fernando" last="Gonzalez-Candelas">Fernando Gonzalez-Candelas</name><name sortKey="Jose Garcia, Juan" sort="Jose Garcia, Juan" uniqKey="Jose Garcia J" first="Juan" last="Jose Garcia">Juan Jose Garcia</name><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martin">Vicente Martin</name><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martin">Vicente Martin</name><name sortKey="Mayoral, Jose Maria" sort="Mayoral, Jose Maria" uniqKey="Mayoral J" first="José María" last="Mayoral">José María Mayoral</name><name sortKey="Moraga, Fernando" sort="Moraga, Fernando" uniqKey="Moraga F" first="Fernando" last="Moraga">Fernando Moraga</name><name sortKey="Pumarola, Tomas" sort="Pumarola, Tomas" uniqKey="Pumarola T" first="Tomás" last="Pumarola">Tomás Pumarola</name><name sortKey="Quintana, Jose Maria" sort="Quintana, Jose Maria" uniqKey="Quintana J" first="José María" last="Quintana">José María Quintana</name><name sortKey="Quintana, Jose Maria" sort="Quintana, Jose Maria" uniqKey="Quintana J" first="José María" last="Quintana">José María Quintana</name><name sortKey="Saez, Marc" sort="Saez, Marc" uniqKey="Saez M" first="Marc" last="Saez">Marc Saez</name><name sortKey="Soldevila, Nuria" sort="Soldevila, Nuria" uniqKey="Soldevila N" first="Núria" last="Soldevila">Núria Soldevila</name><name sortKey="Tamames, Sonia" sort="Tamames, Sonia" uniqKey="Tamames S" first="Sonia" last="Tamames">Sonia Tamames</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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