PandemieGrippaleV1, Main, Exploration, bibRecordById, Pascal:08-0315805

Cellular and Humoral Responses to Influenza in Gabonese Children Living in Rural and Semi-Urban Areas

Identifieur interne : 004E80 ( Main/Exploration ); précédent : 004E79; suivant : 004E81

Cellular and Humoral Responses to Influenza in Gabonese Children Living in Rural and Semi-Urban Areas

Auteurs : E. Van Riet [Pays-Bas] ; A. A. Adegnika [Pays-Bas, Gabon, Allemagne] ; K. Retra [Pays-Bas] ; R. Vieira [Pays-Bas] ; A. G. M. Tielens [Pays-Bas] ; B. Lell [Gabon, Allemagne] ; S. Issifou [Gabon] ; F. C. Hangers [Pays-Bas] ; G. F. Rimmelzwaan [Pays-Bas] ; P. G. Kremsner [Gabon, Allemagne] ; M. Yazdanbakhsh [Pays-Bas, Gabon]

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 2007.

RBID : Pascal:08-0315805

Descripteurs français

Pascal (Inist)
- Immunité humorale, Enfant, Gabon, Milieu rural, Réponse immune, Sérologie, Grippe.
Wicri :
- geographic : Gabon.
- topic : Enfant.

English descriptors

KwdEn :
- Child, Gabon, Humoral immunity, Immune response, Influenza, Rural environment, Serology.

Abstract

Background. With the current attention to the pandemic threat of avian influenza viruses, it is recognized that there is little information on influenza in Africa. In addition, the effects of influenza vaccination in African countries could be very different from the effects in regions with less exposure to microorganisms and parasites. Methods. To monitor the presence of influenza viruses and investigate the immunological responses to influenza vaccination, schoolchildren in semi-urban and rural regions of Gabon were studied. Influenza-specific antibody responses to the 3 strains represented in the vaccine were determined in the serum. Furthermore, cytokine responses were measured after in vitro stimulation of whole blood by influenza antigens, before and after vaccination. Results. Prevaccination titers of antibody against H3N2 were high. At vaccination, the titers of antibody against the 3 influenza strains increased significantly. The anti-H1N1 and anti-B responses after vaccination were weaker in rural schoolchildren than in semi-urban schoolchildren. Influenza-specific cytokine responses were induced within a week, showing significantly lower interferon-y and significantly higher interleukin-5 in the children from rural areas. Conclusions. Prevaccination antibody levels indicated that influenza viruses circulate in Gabon. Altogether, influenza vaccination induces weaker immune responses in a rural population than in a semi-urban population of Gabonese schoolchildren.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001971
to stream PascalFrancis, to step Curation: 000527
to stream PascalFrancis, to step Checkpoint: 001A51
to stream Main, to step Merge: 005201
to stream Main, to step Curation: 004E80

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Cellular and Humoral Responses to Influenza in Gabonese Children Living in Rural and Semi-Urban Areas</title>
<author><name sortKey="Van Riet, E" sort="Van Riet, E" uniqKey="Van Riet E" first="E." last="Van Riet">E. Van Riet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Adegnika, A A" sort="Adegnika, A A" uniqKey="Adegnika A" first="A. A." last="Adegnika">A. A. Adegnika</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Research Unit, Albert Schweitzer Hospital</s1>
<s2>Lambaréné</s2>
<s3>GAB</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Gabon</country>
<wicri:noRegion>Lambaréné</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Human Parasitology, Institute for Tropical Medicine, Tübingen University</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Retra, K" sort="Retra, K" uniqKey="Retra K" first="K." last="Retra">K. Retra</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author><name sortKey="Vieira, R" sort="Vieira, R" uniqKey="Vieira R" first="R." last="Vieira">R. Vieira</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tielens, A G M" sort="Tielens, A G M" uniqKey="Tielens A" first="A. G. M." last="Tielens">A. G. M. Tielens</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author><name sortKey="Lell, B" sort="Lell, B" uniqKey="Lell B" first="B." last="Lell">B. Lell</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Research Unit, Albert Schweitzer Hospital</s1>
<s2>Lambaréné</s2>
<s3>GAB</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Gabon</country>
<wicri:noRegion>Lambaréné</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Human Parasitology, Institute for Tropical Medicine, Tübingen University</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Issifou, S" sort="Issifou, S" uniqKey="Issifou S" first="S." last="Issifou">S. Issifou</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Research Unit, Albert Schweitzer Hospital</s1>
<s2>Lambaréné</s2>
<s3>GAB</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Gabon</country>
<wicri:noRegion>Lambaréné</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hangers, F C" sort="Hangers, F C" uniqKey="Hangers F" first="F. C." last="Hangers">F. C. Hangers</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rimmelzwaan, G F" sort="Rimmelzwaan, G F" uniqKey="Rimmelzwaan G" first="G. F." last="Rimmelzwaan">G. F. Rimmelzwaan</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Virology and National Influenza Center, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kremsner, P G" sort="Kremsner, P G" uniqKey="Kremsner P" first="P. G." last="Kremsner">P. G. Kremsner</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Research Unit, Albert Schweitzer Hospital</s1>
<s2>Lambaréné</s2>
<s3>GAB</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Gabon</country>
<wicri:noRegion>Lambaréné</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Human Parasitology, Institute for Tropical Medicine, Tübingen University</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yazdanbakhsh, M" sort="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M" first="M." last="Yazdanbakhsh">M. Yazdanbakhsh</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Research Unit, Albert Schweitzer Hospital</s1>
<s2>Lambaréné</s2>
<s3>GAB</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Gabon</country>
<wicri:noRegion>Lambaréné</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0315805</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 08-0315805 INIST</idno>
<idno type="RBID">Pascal:08-0315805</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001971</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000527</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001A51</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001A51</idno>
<idno type="wicri:doubleKey">0022-1899:2007:Van Riet E:cellular:and:humoral</idno>
<idno type="wicri:Area/Main/Merge">005201</idno>
<idno type="wicri:Area/Main/Curation">004E80</idno>
<idno type="wicri:Area/Main/Exploration">004E80</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cellular and Humoral Responses to Influenza in Gabonese Children Living in Rural and Semi-Urban Areas</title>
<author><name sortKey="Van Riet, E" sort="Van Riet, E" uniqKey="Van Riet E" first="E." last="Van Riet">E. Van Riet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Adegnika, A A" sort="Adegnika, A A" uniqKey="Adegnika A" first="A. A." last="Adegnika">A. A. Adegnika</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Research Unit, Albert Schweitzer Hospital</s1>
<s2>Lambaréné</s2>
<s3>GAB</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Gabon</country>
<wicri:noRegion>Lambaréné</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Human Parasitology, Institute for Tropical Medicine, Tübingen University</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Retra, K" sort="Retra, K" uniqKey="Retra K" first="K." last="Retra">K. Retra</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author><name sortKey="Vieira, R" sort="Vieira, R" uniqKey="Vieira R" first="R." last="Vieira">R. Vieira</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tielens, A G M" sort="Tielens, A G M" uniqKey="Tielens A" first="A. G. M." last="Tielens">A. G. M. Tielens</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author><name sortKey="Lell, B" sort="Lell, B" uniqKey="Lell B" first="B." last="Lell">B. Lell</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Research Unit, Albert Schweitzer Hospital</s1>
<s2>Lambaréné</s2>
<s3>GAB</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Gabon</country>
<wicri:noRegion>Lambaréné</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Human Parasitology, Institute for Tropical Medicine, Tübingen University</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Issifou, S" sort="Issifou, S" uniqKey="Issifou S" first="S." last="Issifou">S. Issifou</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Research Unit, Albert Schweitzer Hospital</s1>
<s2>Lambaréné</s2>
<s3>GAB</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Gabon</country>
<wicri:noRegion>Lambaréné</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hangers, F C" sort="Hangers, F C" uniqKey="Hangers F" first="F. C." last="Hangers">F. C. Hangers</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rimmelzwaan, G F" sort="Rimmelzwaan, G F" uniqKey="Rimmelzwaan G" first="G. F." last="Rimmelzwaan">G. F. Rimmelzwaan</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Virology and National Influenza Center, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kremsner, P G" sort="Kremsner, P G" uniqKey="Kremsner P" first="P. G." last="Kremsner">P. G. Kremsner</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Research Unit, Albert Schweitzer Hospital</s1>
<s2>Lambaréné</s2>
<s3>GAB</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Gabon</country>
<wicri:noRegion>Lambaréné</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Human Parasitology, Institute for Tropical Medicine, Tübingen University</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yazdanbakhsh, M" sort="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M" first="M." last="Yazdanbakhsh">M. Yazdanbakhsh</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Parasitology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Research Unit, Albert Schweitzer Hospital</s1>
<s2>Lambaréné</s2>
<s3>GAB</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Gabon</country>
<wicri:noRegion>Lambaréné</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term>
<term>Gabon</term>
<term>Humoral immunity</term>
<term>Immune response</term>
<term>Influenza</term>
<term>Rural environment</term>
<term>Serology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Immunité humorale</term>
<term>Enfant</term>
<term>Gabon</term>
<term>Milieu rural</term>
<term>Réponse immune</term>
<term>Sérologie</term>
<term>Grippe</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Gabon</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background. With the current attention to the pandemic threat of avian influenza viruses, it is recognized that there is little information on influenza in Africa. In addition, the effects of influenza vaccination in African countries could be very different from the effects in regions with less exposure to microorganisms and parasites. Methods. To monitor the presence of influenza viruses and investigate the immunological responses to influenza vaccination, schoolchildren in semi-urban and rural regions of Gabon were studied. Influenza-specific antibody responses to the 3 strains represented in the vaccine were determined in the serum. Furthermore, cytokine responses were measured after in vitro stimulation of whole blood by influenza antigens, before and after vaccination. Results. Prevaccination titers of antibody against H3N2 were high. At vaccination, the titers of antibody against the 3 influenza strains increased significantly. The anti-H1N1 and anti-B responses after vaccination were weaker in rural schoolchildren than in semi-urban schoolchildren. Influenza-specific cytokine responses were induced within a week, showing significantly lower interferon-y and significantly higher interleukin-5 in the children from rural areas. Conclusions. Prevaccination antibody levels indicated that influenza viruses circulate in Gabon. Altogether, influenza vaccination induces weaker immune responses in a rural population than in a semi-urban population of Gabonese schoolchildren.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Gabon</li>
<li>Pays-Bas</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>District de Tübingen</li>
<li>Hollande-Méridionale</li>
<li>Utrecht (province)</li>
</region>
<settlement><li>Leyde</li>
<li>Rotterdam</li>
<li>Tübingen</li>
<li>Utrecht</li>
</settlement>
<orgName><li>Université d'Utrecht</li>
</orgName>
</list>
<tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Riet, E" sort="Van Riet, E" uniqKey="Van Riet E" first="E." last="Van Riet">E. Van Riet</name>
</region>
<name sortKey="Adegnika, A A" sort="Adegnika, A A" uniqKey="Adegnika A" first="A. A." last="Adegnika">A. A. Adegnika</name>
<name sortKey="Hangers, F C" sort="Hangers, F C" uniqKey="Hangers F" first="F. C." last="Hangers">F. C. Hangers</name>
<name sortKey="Retra, K" sort="Retra, K" uniqKey="Retra K" first="K." last="Retra">K. Retra</name>
<name sortKey="Retra, K" sort="Retra, K" uniqKey="Retra K" first="K." last="Retra">K. Retra</name>
<name sortKey="Rimmelzwaan, G F" sort="Rimmelzwaan, G F" uniqKey="Rimmelzwaan G" first="G. F." last="Rimmelzwaan">G. F. Rimmelzwaan</name>
<name sortKey="Tielens, A G M" sort="Tielens, A G M" uniqKey="Tielens A" first="A. G. M." last="Tielens">A. G. M. Tielens</name>
<name sortKey="Vieira, R" sort="Vieira, R" uniqKey="Vieira R" first="R." last="Vieira">R. Vieira</name>
<name sortKey="Yazdanbakhsh, M" sort="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M" first="M." last="Yazdanbakhsh">M. Yazdanbakhsh</name>
</country>
<country name="Gabon"><noRegion><name sortKey="Adegnika, A A" sort="Adegnika, A A" uniqKey="Adegnika A" first="A. A." last="Adegnika">A. A. Adegnika</name>
</noRegion>
<name sortKey="Issifou, S" sort="Issifou, S" uniqKey="Issifou S" first="S." last="Issifou">S. Issifou</name>
<name sortKey="Kremsner, P G" sort="Kremsner, P G" uniqKey="Kremsner P" first="P. G." last="Kremsner">P. G. Kremsner</name>
<name sortKey="Lell, B" sort="Lell, B" uniqKey="Lell B" first="B." last="Lell">B. Lell</name>
<name sortKey="Yazdanbakhsh, M" sort="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M" first="M." last="Yazdanbakhsh">M. Yazdanbakhsh</name>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Adegnika, A A" sort="Adegnika, A A" uniqKey="Adegnika A" first="A. A." last="Adegnika">A. A. Adegnika</name>
</region>
<name sortKey="Kremsner, P G" sort="Kremsner, P G" uniqKey="Kremsner P" first="P. G." last="Kremsner">P. G. Kremsner</name>
<name sortKey="Lell, B" sort="Lell, B" uniqKey="Lell B" first="B." last="Lell">B. Lell</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004E80 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004E80 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    PandemieGrippaleV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:08-0315805
   |texte=   Cellular and Humoral Responses to Influenza in Gabonese Children Living in Rural and Semi-Urban Areas
}}

This area was generated with Dilib version V0.6.34.
Data generation: Wed Jun 10 11:04:28 2020. Site generation: Sun Mar 28 09:10:28 2021

	Serveur d'exploration sur les pandémies grippales
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les pandémies grippales

Cellular and Humoral Responses to Influenza in Gabonese Children Living in Rural and Semi-Urban Areas

Cellular and Humoral Responses to Influenza in Gabonese Children Living in Rural and Semi-Urban Areas

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri