A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic
Identifieur interne : 004478 ( Main/Exploration ); précédent : 004477; suivant : 004479A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic
Auteurs : Yuk-Fai Lau [Singapour] ; Lay-Hoon Tang [Singapour] ; Eng-Eong Ooi [Singapour]Source :
- Vaccine [ 0264-410X ] ; 2009.
Descripteurs français
- KwdFr :
- ARN double brin (génétique), ARN viral (génétique), Administration par voie nasale, Animaux, Anticorps antiviraux (génétique), Anticorps antiviraux (immunologie), Flambées de maladies, Grippe chez les oiseaux (génétique), Grippe chez les oiseaux (immunologie), Grippe chez les oiseaux (virologie), Grippe humaine (immunologie), Grippe humaine (épidémiologie), Humains, Mâle, Oiseaux, Récepteur de type Toll-3 (génétique), Réplication virale, Souris, Souris de lignée BALB C, Sous-type H5N1 du virus de la grippe A (génétique), Sous-type H5N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (pathogénicité), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins antigrippaux (usage thérapeutique), Vaccins inactivés (génétique), Vaccins inactivés (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- génétique : ARN double brin, ARN viral, Anticorps antiviraux, Grippe chez les oiseaux, Récepteur de type Toll-3, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins inactivés.
- immunologie : Anticorps antiviraux, Grippe chez les oiseaux, Grippe humaine, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins inactivés.
- pathogénicité : Sous-type H5N1 du virus de la grippe A.
- usage thérapeutique : Vaccins antigrippaux.
- virologie : Grippe chez les oiseaux.
- épidémiologie : Grippe humaine.
- Pascal (Inist)
English descriptors
- KwdEn :
- Administration, Intranasal, Animals, Antibodies, Viral (genetics), Antibodies, Viral (immunology), Birds, Disease Outbreaks, Humans, Immunological adjuvant, Immunoprophylaxis, Influenza, Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza Vaccines (therapeutic use), Influenza in Birds (genetics), Influenza in Birds (immunology), Influenza in Birds (virology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenzavirus, Male, Mice, Mice, Inbred BALB C, RNA, Double-Stranded (genetics), RNA, Viral (genetics), Replication, Toll-Like Receptor 3 (genetics), Vaccines, Inactivated (genetics), Vaccines, Inactivated (immunology), Virus Replication.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , genetics : Antibodies, Viral, Influenza Vaccines, RNA, Double-Stranded, RNA, Viral, Toll-Like Receptor 3, Vaccines, Inactivated.
- chemical , immunology : Antibodies, Viral, Influenza Vaccines, Vaccines, Inactivated.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H5N1 Subtype, Influenza in Birds.
- immunology : Influenza A Virus, H5N1 Subtype, Influenza in Birds, Influenza, Human.
- pathogenicity : Influenza A Virus, H5N1 Subtype.
- chemical , therapeutic use : Influenza Vaccines.
- virology : Influenza in Birds.
- Administration, Intranasal, Animals, Birds, Disease Outbreaks, Humans, Male, Mice, Mice, Inbred BALB C, Virus Replication.
Abstract
The appearance and spread of the H5N1 highly pathogenic avian influenza (HPAI) raise concern of a possible pandemic. Current preventive measures include the development of a pre-pandemic influenza vaccine and stockpiling ofneuraminidase inhibitors. However, their benefits can be significantly reduced by mutations in the hemagglutinin or neuraminidase resulting in antigenic changes and the appearance of drug-resistance, respectively. Drugs that target the innate immune system to achieve a 'heightened antiviral' state represent another class of antiviral agents that could contribute to the control and treatment of influenza infection. In this study, PIKA (a stabilized dsRNA) provides broad-spectrum prophylaxis against a number of influenza A viruses. In addition, when PIKA was admixed with influenza vaccine preparations, including a formalin-inactivated whole-virion H5 vaccine, significant adjuvanting effect leading to accelerated viral clearance was observed in a murine model. These biological effects appear to be mediated by the ability of PIKA to promote the maturation of dendritic cells, including up-regulation of co-stimulatory molecules, such as CD80 and CD86, and the induction of various cytokines and chemokines. Toll-like receptor 3 (TLR3) was shown to recognize PIKA in a concentration-dependent manner. The potency and versatility in its activities make PIKA an attractive candidate for use in an influenza pandemic.
Url:
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001849
- to stream PascalFrancis, to step Curation: 000650
- to stream PascalFrancis, to step Checkpoint: 001769
- to stream Main, to step Merge: 004726
- to stream Pmc, to step Corpus: 000E30
- to stream Pmc, to step Curation: 000E30
- to stream Pmc, to step Checkpoint: 000C58
- to stream PubMed, to step Corpus: 001827
- to stream PubMed, to step Curation: 001827
- to stream PubMed, to step Checkpoint: 001697
- to stream Ncbi, to step Merge: 000813
- to stream Ncbi, to step Curation: 000813
- to stream Ncbi, to step Checkpoint: 000813
- to stream Main, to step Merge: 004086
- to stream Main, to step Curation: 004478
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic</title>
<author><name sortKey="Lau, Yuk Fai" sort="Lau, Yuk Fai" uniqKey="Lau Y" first="Yuk-Fai" last="Lau">Yuk-Fai Lau</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Countermeasures (Biological) Laboratory, Defense Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive #13-00</s1>
<s2>117510</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>117510</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tang, Lay Hoon" sort="Tang, Lay Hoon" uniqKey="Tang L" first="Lay-Hoon" last="Tang">Lay-Hoon Tang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Countermeasures (Biological) Laboratory, Defense Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive #13-00</s1>
<s2>117510</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>117510</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ooi, Eng Eong" sort="Ooi, Eng Eong" uniqKey="Ooi E" first="Eng-Eong" last="Ooi">Eng-Eong Ooi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Countermeasures (Biological) Laboratory, Defense Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive #13-00</s1>
<s2>117510</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>117510</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0167946</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0167946 INIST</idno>
<idno type="RBID">Pascal:09-0167946</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001849</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000650</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001769</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001769</idno>
<idno type="wicri:doubleKey">0264-410X:2009:Lau Y:a:tlr:ligand</idno>
<idno type="wicri:Area/Main/Merge">004726</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115584</idno>
<idno type="RBID">PMC:7115584</idno>
<idno type="wicri:Area/Pmc/Corpus">000E30</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E30</idno>
<idno type="wicri:Area/Pmc/Curation">000E30</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E30</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C58</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C58</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:19150474</idno>
<idno type="wicri:Area/PubMed/Corpus">001827</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001827</idno>
<idno type="wicri:Area/PubMed/Curation">001827</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001827</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001697</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001697</idno>
<idno type="wicri:Area/Ncbi/Merge">000813</idno>
<idno type="wicri:Area/Ncbi/Curation">000813</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000813</idno>
<idno type="wicri:doubleKey">0264-410X:2009:Lau Y:a:tlr:ligand</idno>
<idno type="wicri:Area/Main/Merge">004086</idno>
<idno type="wicri:Area/Main/Curation">004478</idno>
<idno type="wicri:Area/Main/Exploration">004478</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic</title>
<author><name sortKey="Lau, Yuk Fai" sort="Lau, Yuk Fai" uniqKey="Lau Y" first="Yuk-Fai" last="Lau">Yuk-Fai Lau</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Countermeasures (Biological) Laboratory, Defense Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive #13-00</s1>
<s2>117510</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>117510</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tang, Lay Hoon" sort="Tang, Lay Hoon" uniqKey="Tang L" first="Lay-Hoon" last="Tang">Lay-Hoon Tang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Countermeasures (Biological) Laboratory, Defense Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive #13-00</s1>
<s2>117510</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>117510</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ooi, Eng Eong" sort="Ooi, Eng Eong" uniqKey="Ooi E" first="Eng-Eong" last="Ooi">Eng-Eong Ooi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Countermeasures (Biological) Laboratory, Defense Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive #13-00</s1>
<s2>117510</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>117510</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intranasal</term>
<term>Animals</term>
<term>Antibodies, Viral (genetics)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Birds</term>
<term>Disease Outbreaks</term>
<term>Humans</term>
<term>Immunological adjuvant</term>
<term>Immunoprophylaxis</term>
<term>Influenza</term>
<term>Influenza A Virus, H5N1 Subtype (genetics)</term>
<term>Influenza A Virus, H5N1 Subtype (immunology)</term>
<term>Influenza A Virus, H5N1 Subtype (pathogenicity)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (genetics)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza Vaccines (therapeutic use)</term>
<term>Influenza in Birds (genetics)</term>
<term>Influenza in Birds (immunology)</term>
<term>Influenza in Birds (virology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenzavirus</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>RNA, Double-Stranded (genetics)</term>
<term>RNA, Viral (genetics)</term>
<term>Replication</term>
<term>Toll-Like Receptor 3 (genetics)</term>
<term>Vaccines, Inactivated (genetics)</term>
<term>Vaccines, Inactivated (immunology)</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN double brin (génétique)</term>
<term>ARN viral (génétique)</term>
<term>Administration par voie nasale</term>
<term>Animaux</term>
<term>Anticorps antiviraux (génétique)</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Flambées de maladies</term>
<term>Grippe chez les oiseaux (génétique)</term>
<term>Grippe chez les oiseaux (immunologie)</term>
<term>Grippe chez les oiseaux (virologie)</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Mâle</term>
<term>Oiseaux</term>
<term>Récepteur de type Toll-3 (génétique)</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sous-type H5N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H5N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H5N1 du virus de la grippe A (pathogénicité)</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (génétique)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins antigrippaux (usage thérapeutique)</term>
<term>Vaccins inactivés (génétique)</term>
<term>Vaccins inactivés (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antibodies, Viral</term>
<term>Influenza Vaccines</term>
<term>RNA, Double-Stranded</term>
<term>RNA, Viral</term>
<term>Toll-Like Receptor 3</term>
<term>Vaccines, Inactivated</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term>
<term>Influenza Vaccines</term>
<term>Vaccines, Inactivated</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza in Birds</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN double brin</term>
<term>ARN viral</term>
<term>Anticorps antiviraux</term>
<term>Grippe chez les oiseaux</term>
<term>Récepteur de type Toll-3</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins inactivés</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Grippe chez les oiseaux</term>
<term>Grippe humaine</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins inactivés</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza in Birds</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term>
<term>Animals</term>
<term>Birds</term>
<term>Disease Outbreaks</term>
<term>Humans</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Administration par voie nasale</term>
<term>Animaux</term>
<term>Flambées de maladies</term>
<term>Humains</term>
<term>Influenzavirus</term>
<term>Mâle</term>
<term>Oiseaux</term>
<term>Réplication</term>
<term>Adjuvant immunologique</term>
<term>Immunoprophylaxie</term>
<term>Grippe</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The appearance and spread of the H5N1 highly pathogenic avian influenza (HPAI) raise concern of a possible pandemic. Current preventive measures include the development of a pre-pandemic influenza vaccine and stockpiling ofneuraminidase inhibitors. However, their benefits can be significantly reduced by mutations in the hemagglutinin or neuraminidase resulting in antigenic changes and the appearance of drug-resistance, respectively. Drugs that target the innate immune system to achieve a 'heightened antiviral' state represent another class of antiviral agents that could contribute to the control and treatment of influenza infection. In this study, PIKA (a stabilized dsRNA) provides broad-spectrum prophylaxis against a number of influenza A viruses. In addition, when PIKA was admixed with influenza vaccine preparations, including a formalin-inactivated whole-virion H5 vaccine, significant adjuvanting effect leading to accelerated viral clearance was observed in a murine model. These biological effects appear to be mediated by the ability of PIKA to promote the maturation of dendritic cells, including up-regulation of co-stimulatory molecules, such as CD80 and CD86, and the induction of various cytokines and chemokines. Toll-like receptor 3 (TLR3) was shown to recognize PIKA in a concentration-dependent manner. The potency and versatility in its activities make PIKA an attractive candidate for use in an influenza pandemic.</div>
</front>
</TEI>
<affiliations><list><country><li>Singapour</li>
</country>
</list>
<tree><country name="Singapour"><noRegion><name sortKey="Lau, Yuk Fai" sort="Lau, Yuk Fai" uniqKey="Lau Y" first="Yuk-Fai" last="Lau">Yuk-Fai Lau</name>
</noRegion>
<name sortKey="Ooi, Eng Eong" sort="Ooi, Eng Eong" uniqKey="Ooi E" first="Eng-Eong" last="Ooi">Eng-Eong Ooi</name>
<name sortKey="Tang, Lay Hoon" sort="Tang, Lay Hoon" uniqKey="Tang L" first="Lay-Hoon" last="Tang">Lay-Hoon Tang</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004478 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004478 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:09-0167946 |texte= A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic }}
This area was generated with Dilib version V0.6.34. |