Severity of Pneumonia Due to New H1N1 Influenza Virus in Ferrets Is Intermediate between That Due to Seasonal H1N1 Virus and Highly Pathogenic Avian Influenza H5N1 Virus
Identifieur interne : 003306 ( Main/Exploration ); précédent : 003305; suivant : 003307Severity of Pneumonia Due to New H1N1 Influenza Virus in Ferrets Is Intermediate between That Due to Seasonal H1N1 Virus and Highly Pathogenic Avian Influenza H5N1 Virus
Auteurs : Judith M. A. Van Den Brand [Pays-Bas] ; Koert J. Stittelaar [Pays-Bas] ; Geert Van Amerongen [Pays-Bas] ; Guus F. Rimmelzwaan [Pays-Bas] ; James Simon [Pays-Bas] ; Emmie De Wit [Pays-Bas] ; Vincent Munster [Pays-Bas] ; Theo Bestebroer [Pays-Bas] ; Ron A. M. Fouchier [Pays-Bas] ; Thijs Kuiken [Pays-Bas] ; Albert D. M. E. Osterhaus [Pays-Bas]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2010.
Descripteurs français
- KwdFr :
- Analyse de variance, Animaux, Charge virale, Femelle, Furets (virologie), Immunohistochimie, Indice de gravité médicale, Infections à Orthomyxoviridae (médecine vétérinaire), Infections à Orthomyxoviridae (virologie), Lignée cellulaire, Mâle, Pneumopathie virale (médecine vétérinaire), Pneumopathie virale (virologie), Poids du corps, Poumon (anatomopathologie), Poumon (virologie), Sous-type H1N1 du virus de la grippe A (pathogénicité), Sous-type H5N1 du virus de la grippe A (pathogénicité), Taille d'organe, Température du corps.
- MESH :
- anatomopathologie : Poumon.
- médecine vétérinaire : Infections à Orthomyxoviridae, Pneumopathie virale.
- pathogénicité : Sous-type H1N1 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A.
- virologie : Furets, Infections à Orthomyxoviridae, Pneumopathie virale, Poumon.
- Analyse de variance, Animaux, Charge virale, Femelle, Immunohistochimie, Indice de gravité médicale, Lignée cellulaire, Mâle, Poids du corps, Taille d'organe, Température du corps.
- Pascal (Inist)
English descriptors
- KwdEn :
- Analysis of Variance, Animals, Avian influenzavirus, Body Temperature, Body Weight, Cell Line, Female, Ferret, Ferrets (virology), Immunohistochemistry, Infection, Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza A virus, Lung (pathology), Lung (virology), Male, Organ Size, Orthomyxoviridae Infections (veterinary), Orthomyxoviridae Infections (virology), Pneumonia, Pneumonia, Viral (veterinary), Pneumonia, Viral (virology), Severity of Illness Index, Viral Load.
- MESH :
- pathogenicity : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype.
- pathology : Lung.
- veterinary : Orthomyxoviridae Infections, Pneumonia, Viral.
- virology : Ferrets, Lung, Orthomyxoviridae Infections, Pneumonia, Viral.
- Analysis of Variance, Animals, Body Temperature, Body Weight, Cell Line, Female, Immunohistochemistry, Male, Organ Size, Severity of Illness Index, Viral Load.
Abstract
Background. The newly emerged influenza A(H1N1) virus (new H1N1 virus) is causing the first influenza pandemic of this century. Three influenza pandemics of the previous century caused variable mortality, which largely depended on the development of severe pneumonia. However, the ability of the new H1N1 virus to cause pneumonia is poorly understood. Methods. The new H1N1 virus was inoculated intratracheally into ferrets. Its ability to cause pneumonia was compared with that of seasonal influenza H1N1 virus and highly pathogenic avian influenza (HPAI) H5N1 virus by using clinical, virological, and pathological analyses. Results. Our results showed that the new H1N1 virus causes pneumonia in ferrets intermediate in severity between that caused by seasonal H1N1 virus and by HPAI H5N1 virus. The new H1N1 virus replicated well throughout the lower respiratory tract and more extensively than did both seasonal H1N1 virus (which replicated mainly in the bronchi) and HPAI H5N1 virus (which replicated mainly in the alveoli). High loads of new H1N1 virus in lung tissue were associated with diffuse alveolar damage and mortality. Conclusions. The new H1N1 virus may be intrinsically more pathogenic for humans than is seasonal H1N1 virus.
Url:
- https://api.istex.fr/ark:/67375/HXZ-8LFSMRKL-T/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110095
DOI: 10.1086/651132
Affiliations:
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M." last="Fouchier">Ron A. M. Fouchier</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ViroClinics Biosciences BV, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Pays-Bas</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Pays-Bas</country><wicri:regionArea>Reprints or correspondence: Dr A. D. M. E. Osterhaus, Dr Molewaterplein 50, 3015 GE Rotterdam</wicri:regionArea><wicri:noRegion>3015 GE Rotterdam</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2010</date><biblScope unit="vol">201</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="993">993</biblScope><biblScope unit="page" to="999">999</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Avian influenzavirus</term><term>Body Temperature</term><term>Body Weight</term><term>Cell Line</term><term>Female</term><term>Ferret</term><term>Ferrets (virology)</term><term>Immunohistochemistry</term><term>Infection</term><term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term><term>Influenza A Virus, H5N1 Subtype (pathogenicity)</term><term>Influenza A virus</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Male</term><term>Organ Size</term><term>Orthomyxoviridae Infections (veterinary)</term><term>Orthomyxoviridae Infections (virology)</term><term>Pneumonia</term><term>Pneumonia, Viral (veterinary)</term><term>Pneumonia, Viral (virology)</term><term>Severity of Illness Index</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de variance</term><term>Animaux</term><term>Charge virale</term><term>Femelle</term><term>Furets (virologie)</term><term>Immunohistochimie</term><term>Indice de gravité médicale</term><term>Infections à Orthomyxoviridae (médecine vétérinaire)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Lignée cellulaire</term><term>Mâle</term><term>Pneumopathie virale (médecine vétérinaire)</term><term>Pneumopathie virale (virologie)</term><term>Poids du corps</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term><term>Sous-type H5N1 du virus de la grippe A (pathogénicité)</term><term>Taille d'organe</term><term>Température du corps</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Orthomyxoviridae Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Furets</term><term>Infections à Orthomyxoviridae</term><term>Pneumopathie virale</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Ferrets</term><term>Lung</term><term>Orthomyxoviridae Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Body Temperature</term><term>Body Weight</term><term>Cell Line</term><term>Female</term><term>Immunohistochemistry</term><term>Male</term><term>Organ Size</term><term>Severity of Illness Index</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de variance</term><term>Animaux</term><term>Charge virale</term><term>Femelle</term><term>Immunohistochimie</term><term>Indice de gravité médicale</term><term>Lignée cellulaire</term><term>Mâle</term><term>Poids du corps</term><term>Taille d'organe</term><term>Température du corps</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Furet</term><term>Infection</term><term>Influenzavirus aviaire</term><term>Pneumonie</term><term>Virus grippal A</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background. The newly emerged influenza A(H1N1) virus (new H1N1 virus) is causing the first influenza pandemic of this century. Three influenza pandemics of the previous century caused variable mortality, which largely depended on the development of severe pneumonia. However, the ability of the new H1N1 virus to cause pneumonia is poorly understood. Methods. The new H1N1 virus was inoculated intratracheally into ferrets. Its ability to cause pneumonia was compared with that of seasonal influenza H1N1 virus and highly pathogenic avian influenza (HPAI) H5N1 virus by using clinical, virological, and pathological analyses. Results. Our results showed that the new H1N1 virus causes pneumonia in ferrets intermediate in severity between that caused by seasonal H1N1 virus and by HPAI H5N1 virus. The new H1N1 virus replicated well throughout the lower respiratory tract and more extensively than did both seasonal H1N1 virus (which replicated mainly in the bronchi) and HPAI H5N1 virus (which replicated mainly in the alveoli). High loads of new H1N1 virus in lung tissue were associated with diffuse alveolar damage and mortality. Conclusions. The new H1N1 virus may be intrinsically more pathogenic for humans than is seasonal H1N1 virus.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Rotterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Den Brand, Judith M A" sort="Van Den Brand, Judith M A" uniqKey="Van Den Brand J" first="Judith M. A." last="Van Den Brand">Judith M. A. Van Den Brand</name></region><name sortKey="Bestebroer, Theo" sort="Bestebroer, Theo" uniqKey="Bestebroer T" first="Theo" last="Bestebroer">Theo Bestebroer</name><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><name sortKey="Munster, Vincent" sort="Munster, Vincent" uniqKey="Munster V" first="Vincent" last="Munster">Vincent Munster</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name><name sortKey="Simon, James" sort="Simon, James" uniqKey="Simon J" first="James" last="Simon">James Simon</name><name sortKey="Stittelaar, Koert J" sort="Stittelaar, Koert J" uniqKey="Stittelaar K" first="Koert J." last="Stittelaar">Koert J. Stittelaar</name><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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