A review of epidemic preparedness for influenza through local vaccine production: national security for Thailand
Identifieur interne : 000384 ( Main/Exploration ); précédent : 000383; suivant : 000385A review of epidemic preparedness for influenza through local vaccine production: national security for Thailand
Auteurs : Punnee Pitisuttithum [Thaïlande] ; Ponthip Wirachwong [Thaïlande]Source :
- Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Thaïlande.
English descriptors
- KwdEn :
- Antibodies, Viral (immunology), Epidemics (prevention & control), Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N2 Subtype, Influenza Vaccines (immunology), Influenza, Human (prevention & control), Security Measures, Thailand, Vaccines, Attenuated (immunology), Vaccines, Inactivated (immunology).
- MESH :
- chemical , immunology : Antibodies, Viral, Influenza Vaccines, Vaccines, Attenuated, Vaccines, Inactivated.
- geographic : Thailand.
- prevention & control : Epidemics, Influenza, Human.
- Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N2 Subtype, Security Measures.
Abstract
Being vigilant of the potential for an influenza pandemic, the Global Action Plan for Influenza Vaccines (GAP) promoted the establishment and maintenance of local vaccine manufacturing capacity. In accordance with this, the Thai government has developed its national strategic plan for influenza pandemic preparedness including the plan for manufacturing influenza vaccine in Thailand. With the support of WHO, the Thai Government Pharmaceutical Organization (GPO) as the developed local production capacity of influenza vaccines. The H1N1 live attenuated influenza vaccine (LAIV) and H5N2 LAIV produced by GPO have been proven to be safe and immunogenic through clinical trials, followed by Thai FDA licensure for pandemic use. The GPO-produced H5N2 LAIV has been proven to have priming effects on an inactivated subunit H5N1 booster vaccine. This Thai local manufacturer is now expanding its capacity to Inactivated Influenza Vaccine (IIV), aiming for sustainable influenza vaccine production for national coverage.
Url:
DOI: 10.1080/21645515.2019.1638205
PubMed: 31335234
PubMed Central: 6816430
Affiliations:
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Le document en format XML
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<term>Epidemics (prevention & control)</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H5N2 Subtype</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Security Measures</term>
<term>Thailand</term>
<term>Vaccines, Attenuated (immunology)</term>
<term>Vaccines, Inactivated (immunology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (immunologie)</term>
<term>Grippe humaine ()</term>
<term>Humains</term>
<term>Mesures de sécurité</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H5N2 du virus de la grippe A</term>
<term>Thaïlande</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins atténués (immunologie)</term>
<term>Vaccins inactivés (immunologie)</term>
<term>Épidémies ()</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term>
<term>Influenza Vaccines</term>
<term>Vaccines, Attenuated</term>
<term>Vaccines, Inactivated</term>
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<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Thailand</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Vaccins inactivés</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Epidemics</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H5N2 Subtype</term>
<term>Security Measures</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Grippe humaine</term>
<term>Humains</term>
<term>Mesures de sécurité</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H5N2 du virus de la grippe A</term>
<term>Thaïlande</term>
<term>Épidémies</term>
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Thaïlande</term>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>Being vigilant of the potential for an influenza pandemic, the Global Action Plan for Influenza Vaccines (GAP) promoted the establishment and maintenance of local vaccine manufacturing capacity. In accordance with this, the Thai government has developed its national strategic plan for influenza pandemic preparedness including the plan for manufacturing influenza vaccine in Thailand. With the support of WHO, the Thai Government Pharmaceutical Organization (GPO) as the developed local production capacity of influenza vaccines. The H1N1 live attenuated influenza vaccine (LAIV) and H5N2 LAIV produced by GPO have been proven to be safe and immunogenic through clinical trials, followed by Thai FDA licensure for pandemic use. The GPO-produced H5N2 LAIV has been proven to have priming effects on an inactivated subunit H5N1 booster vaccine. This Thai local manufacturer is now expanding its capacity to Inactivated Influenza Vaccine (IIV), aiming for sustainable influenza vaccine production for national coverage.</p>
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