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Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.

Identifieur interne : 001926 ( Main/Exploration ); précédent : 001925; suivant : 001927

Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.

Auteurs : L. Wiltzer [Australie] ; Florence Larrous [France] ; S. Oksayan [Australie] ; N. Ito [Japon] ; G A Marsh ; L F Wang [Canada] ; D. Blondel [France] ; Hervé Bourhy [France] ; D A Jans [Australie] ; G W Moseley [Australie]

Source :

RBID : Hal:pasteur-01481638

English descriptors

Abstract

The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.


Url:
DOI: 10.1128/JVI.01249-12


Affiliations:


Links toward previous steps (curation, corpus...)


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<p>The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.</p>
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