PandemieGrippaleV1, Hal, Curation, bibRecord, 000121

Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.

Identifieur interne : 000121 ( Hal/Curation ); précédent : 000120; suivant : 000122

Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.

Auteurs : L. Wiltzer [Australie] ; Florence Larrous [France] ; S. Oksayan [Australie] ; N. Ito [Japon] ; G A Marsh ; L F Wang [Canada] ; D. Blondel [France] ; Hervé Bourhy [France] ; D A Jans [Australie] ; G W Moseley [Australie]

Source :

Journal of Virology [ 0022-538X ] ; 2012-09.

RBID : Hal:pasteur-01481638

English descriptors

mix :
- Amino Acid, Animals, Conserved Sequence, Host-Pathogen Interactions/immunology, Humans, Immunity, Innate, Interferon Type I/metabolism, Lyssavirus/classification/*genetics/*immunology/pathogenicity, Molecular Sequence Data, Rabies virus/genetics/immunology/pathogenicity, STAT Transcription Factors/immunology, Sequence Homology, Signal Transduction/immunology, Species Specificity, Viral Proteins/genetics/immunology, Amino Acid Sequence.

Abstract

The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.

Url:

https://hal-pasteur.archives-ouvertes.fr/pasteur-01481638

DOI: 10.1128/JVI.01249-12

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000121

Links to Exploration step

Hal:pasteur-01481638

Le document en format XML

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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term> Amino Acid</term>
<term> Animals</term>
<term> Conserved Sequence</term>
<term> Host-Pathogen Interactions/immunology</term>
<term> Humans</term>
<term> Immunity</term>
<term> Innate</term>
<term> Interferon Type I/metabolism</term>
<term> Lyssavirus/classification/*genetics/*immunology/pathogenicity</term>
<term> Molecular Sequence Data</term>
<term> Rabies virus/genetics/immunology/pathogenicity</term>
<term> STAT Transcription Factors/immunology</term>
<term> Sequence Homology</term>
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<front><div type="abstract" xml:lang="en">              <p>The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.</p>
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            <funder ref="#projeurop-89460"></funder>
            <funder>This research was supported by the National Health and Medical Research Council Australia project grant 1003244 to G.W.M., Senior Principal Research Fellowship 1002486 to D.A.J., Australian Research Council discovery project grant DP110101749 to G.W.M., D.A.J., and L.F.W., and European Union Seventh Framework Programme (FP7/2007-2013) PREDEMICS grant 278433 to F.L. and H.B. </funder>
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            <idno type="halRefHtml">Journal of Virology, American Society for Microbiology, 2012, 86 (18), pp.10194-9. ⟨10.1128/JVI.01249-12⟩</idno>
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            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="OPENAIRE">OpenAIRE</idno>
            <idno type="stamp" n="I2BC">I2BC</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="UNIV-PARIS">Université de Paris</idno>
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          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.</title>
                <author role="aut">                  <persName>                    <forename type="first">L.</forename>
                    <surname>Wiltzer</surname>
                  </persName>
                  <idno type="halauthorid">1503561</idno>
                  <affiliation ref="#struct-306322"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Florence</forename>
                    <surname>Larrous</surname>
                  </persName>
                  <idno type="halauthorid">466243</idno>
                  <affiliation ref="#struct-415981"></affiliation>
                  <affiliation ref="#struct-31472"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">S</forename>
                    <surname>Oksayan</surname>
                  </persName>
                  <idno type="halauthorid">1504694</idno>
                  <affiliation ref="#struct-306322"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">N</forename>
                    <surname>Ito</surname>
                  </persName>
                  <idno type="halauthorid">1504695</idno>
                  <affiliation ref="#struct-307656"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">G A</forename>
                    <surname>Marsh</surname>
                  </persName>
                  <idno type="halauthorid">1504696</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">L F</forename>
                    <surname>Wang</surname>
                  </persName>
                  <idno type="halauthorid">1504697</idno>
                  <affiliation ref="#struct-355894"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">D</forename>
                    <surname>Blondel</surname>
                  </persName>
                  <idno type="halauthorid">1504698</idno>
                  <affiliation ref="#struct-526"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Hervé</forename>
                    <surname>Bourhy</surname>
                  </persName>
                  <email type="md5">5c042ae4dc70a704d897924d6bd2e227</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">herve-bourhy</idno>
                  <idno type="idhal" notation="numeric">11293</idno>
                  <idno type="halauthorid">612301</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2608-5589</idno>
                  <affiliation ref="#struct-169670"></affiliation>
                  <affiliation ref="#struct-462779"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">D A</forename>
                    <surname>Jans</surname>
                  </persName>
                  <idno type="halauthorid">1504699</idno>
                  <affiliation ref="#struct-306322"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">G W</forename>
                    <surname>Moseley</surname>
                  </persName>
                  <idno type="halauthorid">1504700</idno>
                  <affiliation ref="#struct-306322"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">6614</idno>
                <idno type="issn">0022-538X</idno>
                <idno type="eissn">1098-5514</idno>
                <title level="j">Journal of Virology</title>
                <imprint>                  <publisher>American Society for Microbiology</publisher>
                  <biblScope unit="volume">86</biblScope>
                  <biblScope unit="issue">18</biblScope>
                  <biblScope unit="pp">10194-9</biblScope>
                  <date type="datePub">2012-09</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1128/JVI.01249-12</idno>
              <idno type="pubmed">22740405</idno>
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            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <keywords scheme="author">                <term xml:lang="en"> Signal Transduction/immunology</term>
                <term xml:lang="en"> Sequence Homology</term>
                <term xml:lang="en"> Amino Acid</term>
                <term xml:lang="en"> Host-Pathogen Interactions/immunology</term>
                <term xml:lang="en"> Humans</term>
                <term xml:lang="en"> Immunity</term>
                <term xml:lang="en"> Innate</term>
                <term xml:lang="en"> Interferon Type I/metabolism</term>
                <term xml:lang="en"> Lyssavirus/classification/*genetics/*immunology/pathogenicity</term>
                <term xml:lang="en"> Molecular Sequence Data</term>
                <term xml:lang="en"> Rabies virus/genetics/immunology/pathogenicity</term>
                <term xml:lang="en"> Conserved Sequence</term>
                <term xml:lang="en"> Animals</term>
                <term xml:lang="en">Amino Acid Sequence</term>
                <term xml:lang="en"> Species Specificity</term>
                <term xml:lang="en"> STAT Transcription Factors/immunology</term>
                <term xml:lang="en"> Viral Proteins/genetics/immunology</term>
              </keywords>
              <classCode scheme="mesh">Amino Acid Sequence</classCode>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Immunity, Innate</classCode>
              <classCode scheme="mesh">Interferon Type I</classCode>
              <classCode scheme="mesh">Lyssavirus</classCode>
              <classCode scheme="mesh">Molecular Sequence Data</classCode>
              <classCode scheme="mesh">Rabies virus</classCode>
              <classCode scheme="mesh">STAT Transcription Factors</classCode>
              <classCode scheme="mesh">Sequence Homology, Amino Acid</classCode>
              <classCode scheme="mesh">Signal Transduction</classCode>
              <classCode scheme="mesh">Species Specificity</classCode>
              <classCode scheme="mesh">Viral Proteins</classCode>
              <classCode scheme="mesh">Conserved Sequence</classCode>
              <classCode scheme="mesh">Host-Pathogen Interactions</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="halDomain" n="sdv.mp.vir">Life Sciences [q-bio]/Microbiology and Parasitology/Virology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">              <p>The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.</p>
            </abstract>
          </profileDesc>
        </hal>
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Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.

Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.

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