Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy
Identifieur interne : 002D92 ( Main/Exploration ); précédent : 002D91; suivant : 002D93Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy
Auteurs : Madoka Horiya [Japon] ; Michi Hisano [Japon] ; Yoko Iwasaki [Japon] ; Masachi Hanaoka [Japon] ; Noriyoshi Watanabe [Japon] ; Yushi Ito [Japon] ; Jun Kojima [Japon] ; Haruhiko Sago [Japon] ; Atsuko Murashima [Japon] ; Tatsuo Kato [Japon] ; Koushi Yamaguchi [Japon]Source :
- Obstetrics and gynecology : (New York. 1953) [ 0029-7844 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccination, Vaccin, Gynécologie.
English descriptors
- KwdEn :
Abstract
OBJECTIVE: To evaluate the efficacy of double vaccination with the 2009 pandemic influenza A (H1N1) vaccine during pregnancy. METHODS: A study of the 2009 H1N1 vaccine was conducted in 128 pregnant women, who were between 8 and 32 weeks of gestation in October 2009, to monitor the immune response to vaccination and the change in antibody positivity rate and to assess the immune response. Furthermore, the study aimed to assess the changes in these parameters after the first and second vaccination, monitor the maintenance of antibody titers in maternal blood, assess antibody transfer to umbilical cord blood, and evaluate the vaccine. RESULTS: The antibody positivity rate increased from 7.2% before vaccination to 89.5% after the second vaccination. The vaccine was efficacious, producing a sufficient immune response in 90% of patients, regardless of the stage of gestation. The antibody titers were maintained until delivery, and were higher in umbilical cord blood at delivery than in maternal blood. Although the second vaccination increased the antibody titers in 27% of patients, and the antibody titers in maternal and umbilical cord blood at delivery tended to be higher in the double vaccination group than in the single, the differences were not statistically significant. CONCLUSION: Single vaccination induces sufficient immune response and transfer of immunity to the fetus in pregnant women with no pre-existing antibodies.
Affiliations:
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Watanabe</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Ito, Yushi" sort="Ito, Yushi" uniqKey="Ito Y" first="Yushi" last="Ito">Yushi Ito</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 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type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Hisano, Michi" sort="Hisano, Michi" uniqKey="Hisano M" first="Michi" last="Hisano">Michi Hisano</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Iwasaki, Yoko" sort="Iwasaki, Yoko" uniqKey="Iwasaki Y" first="Yoko" last="Iwasaki">Yoko Iwasaki</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Hanaoka, Masachi" sort="Hanaoka, Masachi" uniqKey="Hanaoka M" first="Masachi" last="Hanaoka">Masachi Hanaoka</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Watanabe, Noriyoshi" sort="Watanabe, Noriyoshi" uniqKey="Watanabe N" first="Noriyoshi" last="Watanabe">Noriyoshi Watanabe</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Ito, Yushi" sort="Ito, Yushi" uniqKey="Ito Y" first="Yushi" last="Ito">Yushi Ito</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kojima, Jun" sort="Kojima, Jun" uniqKey="Kojima J" first="Jun" last="Kojima">Jun Kojima</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Sago, Haruhiko" sort="Sago, Haruhiko" uniqKey="Sago H" first="Haruhiko" last="Sago">Haruhiko Sago</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Murashima, Atsuko" sort="Murashima, Atsuko" uniqKey="Murashima A" first="Atsuko" last="Murashima">Atsuko Murashima</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kato, Tatsuo" sort="Kato, Tatsuo" uniqKey="Kato T" first="Tatsuo" last="Kato">Tatsuo Kato</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Yamaguchi, Koushi" sort="Yamaguchi, Koushi" uniqKey="Yamaguchi K" first="Koushi" last="Yamaguchi">Koushi Yamaguchi</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Obstetrics and gynecology : (New York. 1953)</title><title level="j" type="abbreviated">Obstet. gynecol. : (N. Y., 1953)</title><idno type="ISSN">0029-7844</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Obstetrics and gynecology : (New York. 1953)</title><title level="j" type="abbreviated">Obstet. gynecol. : (N. Y., 1953)</title><idno type="ISSN">0029-7844</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Double</term><term>Gynecology</term><term>H1N1 influenza</term><term>Immunoprophylaxis</term><term>Influenza A (H1N1)</term><term>Obstetrics</term><term>Pregnancy</term><term>Prevention</term><term>Vaccination</term><term>Vaccine</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Immunoprophylaxie</term><term>Dédoublement</term><term>Vaccination</term><term>Prévention</term><term>Vaccin</term><term>Gestation</term><term>Gynécologie</term><term>Obstétrique</term><term>Grippe H1N1</term><term>Virus grippal A(H1N1)</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccination</term><term>Vaccin</term><term>Gynécologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVE: To evaluate the efficacy of double vaccination with the 2009 pandemic influenza A (H1N1) vaccine during pregnancy. METHODS: A study of the 2009 H1N1 vaccine was conducted in 128 pregnant women, who were between 8 and 32 weeks of gestation in October 2009, to monitor the immune response to vaccination and the change in antibody positivity rate and to assess the immune response. Furthermore, the study aimed to assess the changes in these parameters after the first and second vaccination, monitor the maintenance of antibody titers in maternal blood, assess antibody transfer to umbilical cord blood, and evaluate the vaccine. RESULTS: The antibody positivity rate increased from 7.2% before vaccination to 89.5% after the second vaccination. The vaccine was efficacious, producing a sufficient immune response in 90% of patients, regardless of the stage of gestation. The antibody titers were maintained until delivery, and were higher in umbilical cord blood at delivery than in maternal blood. Although the second vaccination increased the antibody titers in 27% of patients, and the antibody titers in maternal and umbilical cord blood at delivery tended to be higher in the double vaccination group than in the single, the differences were not statistically significant. CONCLUSION: Single vaccination induces sufficient immune response and transfer of immunity to the fetus in pregnant women with no pre-existing antibodies.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Horiya, Madoka" sort="Horiya, Madoka" uniqKey="Horiya M" first="Madoka" last="Horiya">Madoka Horiya</name></region><name sortKey="Hanaoka, Masachi" sort="Hanaoka, Masachi" uniqKey="Hanaoka M" first="Masachi" last="Hanaoka">Masachi Hanaoka</name><name sortKey="Hisano, Michi" sort="Hisano, Michi" uniqKey="Hisano M" first="Michi" last="Hisano">Michi Hisano</name><name sortKey="Ito, Yushi" sort="Ito, Yushi" uniqKey="Ito Y" first="Yushi" last="Ito">Yushi Ito</name><name sortKey="Iwasaki, Yoko" sort="Iwasaki, Yoko" uniqKey="Iwasaki Y" first="Yoko" last="Iwasaki">Yoko Iwasaki</name><name sortKey="Kato, Tatsuo" sort="Kato, Tatsuo" uniqKey="Kato T" first="Tatsuo" last="Kato">Tatsuo Kato</name><name sortKey="Kojima, Jun" sort="Kojima, Jun" uniqKey="Kojima J" first="Jun" last="Kojima">Jun Kojima</name><name sortKey="Murashima, Atsuko" sort="Murashima, Atsuko" uniqKey="Murashima A" first="Atsuko" last="Murashima">Atsuko Murashima</name><name sortKey="Sago, Haruhiko" sort="Sago, Haruhiko" uniqKey="Sago H" first="Haruhiko" last="Sago">Haruhiko Sago</name><name sortKey="Watanabe, Noriyoshi" sort="Watanabe, Noriyoshi" uniqKey="Watanabe N" first="Noriyoshi" last="Watanabe">Noriyoshi Watanabe</name><name sortKey="Yamaguchi, Koushi" sort="Yamaguchi, Koushi" uniqKey="Yamaguchi K" first="Koushi" last="Yamaguchi">Koushi Yamaguchi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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