PandemieGrippaleV1, PascalFrancis, Corpus, bibRecord, 000975

Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy

Identifieur interne : 000975 ( PascalFrancis/Corpus ); précédent : 000974; suivant : 000976

Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy

Auteurs : Madoka Horiya ; Michi Hisano ; Yoko Iwasaki ; Masachi Hanaoka ; Noriyoshi Watanabe ; Yushi Ito ; Jun Kojima ; Haruhiko Sago ; Atsuko Murashima ; Tatsuo Kato ; Koushi Yamaguchi

Source :

Obstetrics and gynecology : (New York. 1953) [ 0029-7844 ] ; 2011.

RBID : Pascal:11-0444320

Descripteurs français

Pascal (Inist)
- Immunoprophylaxie, Dédoublement, Vaccination, Prévention, Vaccin, Gestation, Gynécologie, Obstétrique, Grippe H1N1, Virus grippal A(H1N1).

English descriptors

KwdEn :
- Double, Gynecology, H1N1 influenza, Immunoprophylaxis, Influenza A (H1N1), Obstetrics, Pregnancy, Prevention, Vaccination, Vaccine.

Abstract

OBJECTIVE: To evaluate the efficacy of double vaccination with the 2009 pandemic influenza A (H1N1) vaccine during pregnancy. METHODS: A study of the 2009 H1N1 vaccine was conducted in 128 pregnant women, who were between 8 and 32 weeks of gestation in October 2009, to monitor the immune response to vaccination and the change in antibody positivity rate and to assess the immune response. Furthermore, the study aimed to assess the changes in these parameters after the first and second vaccination, monitor the maintenance of antibody titers in maternal blood, assess antibody transfer to umbilical cord blood, and evaluate the vaccine. RESULTS: The antibody positivity rate increased from 7.2% before vaccination to 89.5% after the second vaccination. The vaccine was efficacious, producing a sufficient immune response in 90% of patients, regardless of the stage of gestation. The antibody titers were maintained until delivery, and were higher in umbilical cord blood at delivery than in maternal blood. Although the second vaccination increased the antibody titers in 27% of patients, and the antibody titers in maternal and umbilical cord blood at delivery tended to be higher in the double vaccination group than in the single, the differences were not statistically significant. CONCLUSION: Single vaccination induces sufficient immune response and transfer of immunity to the fetus in pregnant women with no pre-existing antibodies.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0029-7844`
A02	`01`			`@0 OBGNAS`
A03		`1`		`@0 Obstet. gynecol. : (N. Y., 1953)`
A05				`@2 118`
A06				`@2 4`
A08	`01`	`1`	`ENG`	`@1 Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy`
A11	`01`	`1`		`@1 HORIYA (Madoka)`
A11	`02`	`1`		`@1 HISANO (Michi)`
A11	`03`	`1`		`@1 IWASAKI (Yoko)`
A11	`04`	`1`		`@1 HANAOKA (Masachi)`
A11	`05`	`1`		`@1 WATANABE (Noriyoshi)`
A11	`06`	`1`		`@1 ITO (Yushi)`
A11	`07`	`1`		`@1 KOJIMA (Jun)`
A11	`08`	`1`		`@1 SAGO (Haruhiko)`
A11	`09`	`1`		`@1 MURASHIMA (Atsuko)`
A11	`10`	`1`		`@1 KATO (Tatsuo)`
A11	`11`	`1`		`@1 YAMAGUCHI (Koushi)`
A14	`01`			`@1 National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy @2 Tokyo @3 JPN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut. @Z 10 aut. @Z 11 aut.`
A20				`@1 887-894`
A21				`@1 2011`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 7207 @5 354000509934100170`
A44				`@0 0000 @1 © 2011 INIST-CNRS. All rights reserved.`
A45				`@0 30 ref.`
A47	`01`	`1`		`@0 11-0444320`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Obstetrics and gynecology : (New York. 1953)`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 OBJECTIVE: To evaluate the efficacy of double vaccination with the 2009 pandemic influenza A (H1N1) vaccine during pregnancy. METHODS: A study of the 2009 H1N1 vaccine was conducted in 128 pregnant women, who were between 8 and 32 weeks of gestation in October 2009, to monitor the immune response to vaccination and the change in antibody positivity rate and to assess the immune response. Furthermore, the study aimed to assess the changes in these parameters after the first and second vaccination, monitor the maintenance of antibody titers in maternal blood, assess antibody transfer to umbilical cord blood, and evaluate the vaccine. RESULTS: The antibody positivity rate increased from 7.2% before vaccination to 89.5% after the second vaccination. The vaccine was efficacious, producing a sufficient immune response in 90% of patients, regardless of the stage of gestation. The antibody titers were maintained until delivery, and were higher in umbilical cord blood at delivery than in maternal blood. Although the second vaccination increased the antibody titers in 27% of patients, and the antibody titers in maternal and umbilical cord blood at delivery tended to be higher in the double vaccination group than in the single, the differences were not statistically significant. CONCLUSION: Single vaccination induces sufficient immune response and transfer of immunity to the fetus in pregnant women with no pre-existing antibodies.
C02	`01`	`X`		`@0 002B20`
C02	`02`	`X`		`@0 002B05C02C`
C03	`01`	`X`	`FRE`	`@0 Immunoprophylaxie @5 01`
C03	`01`	`X`	`ENG`	`@0 Immunoprophylaxis @5 01`
C03	`01`	`X`	`SPA`	`@0 Inmunoprofilaxia @5 01`
C03	`02`	`X`	`FRE`	`@0 Dédoublement @5 02`
C03	`02`	`X`	`ENG`	`@0 Double @5 02`
C03	`02`	`X`	`SPA`	`@0 Desdoblamiento @5 02`
C03	`03`	`X`	`FRE`	`@0 Vaccination @5 03`
C03	`03`	`X`	`ENG`	`@0 Vaccination @5 03`
C03	`03`	`X`	`SPA`	`@0 Vacunación @5 03`
C03	`04`	`X`	`FRE`	`@0 Prévention @5 05`
C03	`04`	`X`	`ENG`	`@0 Prevention @5 05`
C03	`04`	`X`	`SPA`	`@0 Prevención @5 05`
C03	`05`	`X`	`FRE`	`@0 Vaccin @5 06`
C03	`05`	`X`	`ENG`	`@0 Vaccine @5 06`
C03	`05`	`X`	`SPA`	`@0 Vacuna @5 06`
C03	`06`	`X`	`FRE`	`@0 Gestation @5 08`
C03	`06`	`X`	`ENG`	`@0 Pregnancy @5 08`
C03	`06`	`X`	`SPA`	`@0 Gestación @5 08`
C03	`07`	`X`	`FRE`	`@0 Gynécologie @5 09`
C03	`07`	`X`	`ENG`	`@0 Gynecology @5 09`
C03	`07`	`X`	`SPA`	`@0 Ginecología @5 09`
C03	`08`	`X`	`FRE`	`@0 Obstétrique @5 11`
C03	`08`	`X`	`ENG`	`@0 Obstetrics @5 11`
C03	`08`	`X`	`SPA`	`@0 Obstétrico @5 11`
C03	`09`	`X`	`FRE`	`@0 Grippe H1N1 @4 CD @5 96`
C03	`09`	`X`	`ENG`	`@0 H1N1 influenza @4 CD @5 96`
C03	`09`	`X`	`SPA`	`@0 Gripe H1N1 @4 CD @5 96`
C03	`10`	`X`	`FRE`	`@0 Virus grippal A(H1N1) @4 CD @5 97`
C03	`10`	`X`	`ENG`	`@0 Influenza A (H1N1) @4 CD @5 97`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'appareil respiratoire @5 37`
C07	`01`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`01`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Virose @5 38`
C07	`02`	`X`	`ENG`	`@0 Viral disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Virosis @5 38`
C07	`03`	`X`	`FRE`	`@0 Infection`
C07	`03`	`X`	`ENG`	`@0 Infection`
C07	`03`	`X`	`SPA`	`@0 Infección`
N21				`@1 305`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 11-0444320 INIST
ET :	Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy
AU :	HORIYA (Madoka); HISANO (Michi); IWASAKI (Yoko); HANAOKA (Masachi); WATANABE (Noriyoshi); ITO (Yushi); KOJIMA (Jun); SAGO (Haruhiko); MURASHIMA (Atsuko); KATO (Tatsuo); YAMAGUCHI (Koushi)
AF :	National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy/Tokyo/Japon (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 10 aut., 11 aut.)
DT :	Publication en série; Niveau analytique
SO :	Obstetrics and gynecology : (New York. 1953); ISSN 0029-7844; Coden OBGNAS; Etats-Unis; Da. 2011; Vol. 118; No. 4; Pp. 887-894; Bibl. 30 ref.
LA :	Anglais
EA :	OBJECTIVE: To evaluate the efficacy of double vaccination with the 2009 pandemic influenza A (H1N1) vaccine during pregnancy. METHODS: A study of the 2009 H1N1 vaccine was conducted in 128 pregnant women, who were between 8 and 32 weeks of gestation in October 2009, to monitor the immune response to vaccination and the change in antibody positivity rate and to assess the immune response. Furthermore, the study aimed to assess the changes in these parameters after the first and second vaccination, monitor the maintenance of antibody titers in maternal blood, assess antibody transfer to umbilical cord blood, and evaluate the vaccine. RESULTS: The antibody positivity rate increased from 7.2% before vaccination to 89.5% after the second vaccination. The vaccine was efficacious, producing a sufficient immune response in 90% of patients, regardless of the stage of gestation. The antibody titers were maintained until delivery, and were higher in umbilical cord blood at delivery than in maternal blood. Although the second vaccination increased the antibody titers in 27% of patients, and the antibody titers in maternal and umbilical cord blood at delivery tended to be higher in the double vaccination group than in the single, the differences were not statistically significant. CONCLUSION: Single vaccination induces sufficient immune response and transfer of immunity to the fetus in pregnant women with no pre-existing antibodies.
CC :	002B20; 002B05C02C
FD :	Immunoprophylaxie; Dédoublement; Vaccination; Prévention; Vaccin; Gestation; Gynécologie; Obstétrique; Grippe H1N1; Virus grippal A(H1N1)
FG :	Pathologie de l'appareil respiratoire; Virose; Infection
ED :	Immunoprophylaxis; Double; Vaccination; Prevention; Vaccine; Pregnancy; Gynecology; Obstetrics; H1N1 influenza; Influenza A (H1N1)
EG :	Respiratory disease; Viral disease; Infection
SD :	Inmunoprofilaxia; Desdoblamiento; Vacunación; Prevención; Vacuna; Gestación; Ginecología; Obstétrico; Gripe H1N1
LO :	INIST-7207.354000509934100170
ID :	11-0444320

Links to Exploration step

Pascal:11-0444320

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy</title>
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<author><name sortKey="Iwasaki, Yoko" sort="Iwasaki, Yoko" uniqKey="Iwasaki Y" first="Yoko" last="Iwasaki">Yoko Iwasaki</name>
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<author><name sortKey="Watanabe, Noriyoshi" sort="Watanabe, Noriyoshi" uniqKey="Watanabe N" first="Noriyoshi" last="Watanabe">Noriyoshi Watanabe</name>
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<author><name sortKey="Ito, Yushi" sort="Ito, Yushi" uniqKey="Ito Y" first="Yushi" last="Ito">Yushi Ito</name>
<affiliation><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<author><name sortKey="Kojima, Jun" sort="Kojima, Jun" uniqKey="Kojima J" first="Jun" last="Kojima">Jun Kojima</name>
<affiliation><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1>
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<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Sago, Haruhiko" sort="Sago, Haruhiko" uniqKey="Sago H" first="Haruhiko" last="Sago">Haruhiko Sago</name>
<affiliation><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<author><name sortKey="Murashima, Atsuko" sort="Murashima, Atsuko" uniqKey="Murashima A" first="Atsuko" last="Murashima">Atsuko Murashima</name>
<affiliation><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kato, Tatsuo" sort="Kato, Tatsuo" uniqKey="Kato T" first="Tatsuo" last="Kato">Tatsuo Kato</name>
<affiliation><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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</author>
<author><name sortKey="Yamaguchi, Koushi" sort="Yamaguchi, Koushi" uniqKey="Yamaguchi K" first="Koushi" last="Yamaguchi">Koushi Yamaguchi</name>
<affiliation><inist:fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<series><title level="j" type="main">Obstetrics and gynecology : (New York. 1953)</title>
<title level="j" type="abbreviated">Obstet. gynecol. : (N. Y., 1953)</title>
<idno type="ISSN">0029-7844</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Obstetrics and gynecology : (New York. 1953)</title>
<title level="j" type="abbreviated">Obstet. gynecol. : (N. Y., 1953)</title>
<idno type="ISSN">0029-7844</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Double</term>
<term>Gynecology</term>
<term>H1N1 influenza</term>
<term>Immunoprophylaxis</term>
<term>Influenza A (H1N1)</term>
<term>Obstetrics</term>
<term>Pregnancy</term>
<term>Prevention</term>
<term>Vaccination</term>
<term>Vaccine</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Immunoprophylaxie</term>
<term>Dédoublement</term>
<term>Vaccination</term>
<term>Prévention</term>
<term>Vaccin</term>
<term>Gestation</term>
<term>Gynécologie</term>
<term>Obstétrique</term>
<term>Grippe H1N1</term>
<term>Virus grippal A(H1N1)</term>
</keywords>
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<front><div type="abstract" xml:lang="en">OBJECTIVE: To evaluate the efficacy of double vaccination with the 2009 pandemic influenza A (H1N1) vaccine during pregnancy. METHODS: A study of the 2009 H1N1 vaccine was conducted in 128 pregnant women, who were between 8 and 32 weeks of gestation in October 2009, to monitor the immune response to vaccination and the change in antibody positivity rate and to assess the immune response. Furthermore, the study aimed to assess the changes in these parameters after the first and second vaccination, monitor the maintenance of antibody titers in maternal blood, assess antibody transfer to umbilical cord blood, and evaluate the vaccine. RESULTS: The antibody positivity rate increased from 7.2% before vaccination to 89.5% after the second vaccination. The vaccine was efficacious, producing a sufficient immune response in 90% of patients, regardless of the stage of gestation. The antibody titers were maintained until delivery, and were higher in umbilical cord blood at delivery than in maternal blood. Although the second vaccination increased the antibody titers in 27% of patients, and the antibody titers in maternal and umbilical cord blood at delivery tended to be higher in the double vaccination group than in the single, the differences were not statistically significant. CONCLUSION: Single vaccination induces sufficient immune response and transfer of immunity to the fetus in pregnant women with no pre-existing antibodies.</div>
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<fA05><s2>118</s2>
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<fA06><s2>4</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>HORIYA (Madoka)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>HISANO (Michi)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>IWASAKI (Yoko)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>HANAOKA (Masachi)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>WATANABE (Noriyoshi)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>ITO (Yushi)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>KOJIMA (Jun)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>SAGO (Haruhiko)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>MURASHIMA (Atsuko)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>KATO (Tatsuo)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>YAMAGUCHI (Koushi)</s1>
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<fA14 i1="01"><s1>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy</s1>
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<s3>JPN</s3>
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<sZ>2 aut.</sZ>
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<s1>© 2011 INIST-CNRS. All rights reserved.</s1>
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<fA60><s1>P</s1>
</fA60>
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<fC01 i1="01" l="ENG"><s0>OBJECTIVE: To evaluate the efficacy of double vaccination with the 2009 pandemic influenza A (H1N1) vaccine during pregnancy. METHODS: A study of the 2009 H1N1 vaccine was conducted in 128 pregnant women, who were between 8 and 32 weeks of gestation in October 2009, to monitor the immune response to vaccination and the change in antibody positivity rate and to assess the immune response. Furthermore, the study aimed to assess the changes in these parameters after the first and second vaccination, monitor the maintenance of antibody titers in maternal blood, assess antibody transfer to umbilical cord blood, and evaluate the vaccine. RESULTS: The antibody positivity rate increased from 7.2% before vaccination to 89.5% after the second vaccination. The vaccine was efficacious, producing a sufficient immune response in 90% of patients, regardless of the stage of gestation. The antibody titers were maintained until delivery, and were higher in umbilical cord blood at delivery than in maternal blood. Although the second vaccination increased the antibody titers in 27% of patients, and the antibody titers in maternal and umbilical cord blood at delivery tended to be higher in the double vaccination group than in the single, the differences were not statistically significant. CONCLUSION: Single vaccination induces sufficient immune response and transfer of immunity to the fetus in pregnant women with no pre-existing antibodies.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B20</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05C02C</s0>
</fC02>
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<s5>01</s5>
</fC03>
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<s5>03</s5>
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<s5>05</s5>
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<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Prevención</s0>
<s5>05</s5>
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<s5>06</s5>
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<s5>08</s5>
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<s5>08</s5>
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<s5>09</s5>
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<s5>11</s5>
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<s5>11</s5>
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<fC03 i1="09" i2="X" l="FRE"><s0>Grippe H1N1</s0>
<s4>CD</s4>
<s5>96</s5>
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<s4>CD</s4>
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</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Gripe H1N1</s0>
<s4>CD</s4>
<s5>96</s5>
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<s5>97</s5>
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<s4>CD</s4>
<s5>97</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Virose</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Viral disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Virosis</s0>
<s5>38</s5>
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<fC07 i1="03" i2="X" l="FRE"><s0>Infection</s0>
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<fC07 i1="03" i2="X" l="ENG"><s0>Infection</s0>
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</fC07>
<fN21><s1>305</s1>
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<server><NO>PASCAL 11-0444320 INIST</NO>
<ET>Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy</ET>
<AU>HORIYA (Madoka); HISANO (Michi); IWASAKI (Yoko); HANAOKA (Masachi); WATANABE (Noriyoshi); ITO (Yushi); KOJIMA (Jun); SAGO (Haruhiko); MURASHIMA (Atsuko); KATO (Tatsuo); YAMAGUCHI (Koushi)</AU>
<AF>National Center for Child Health and Development and the Japan Drug Information Institute in Pregnancy/Tokyo/Japon (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 10 aut., 11 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Obstetrics and gynecology : (New York. 1953); ISSN 0029-7844; Coden OBGNAS; Etats-Unis; Da. 2011; Vol. 118; No. 4; Pp. 887-894; Bibl. 30 ref.</SO>
<LA>Anglais</LA>
<EA>OBJECTIVE: To evaluate the efficacy of double vaccination with the 2009 pandemic influenza A (H1N1) vaccine during pregnancy. METHODS: A study of the 2009 H1N1 vaccine was conducted in 128 pregnant women, who were between 8 and 32 weeks of gestation in October 2009, to monitor the immune response to vaccination and the change in antibody positivity rate and to assess the immune response. Furthermore, the study aimed to assess the changes in these parameters after the first and second vaccination, monitor the maintenance of antibody titers in maternal blood, assess antibody transfer to umbilical cord blood, and evaluate the vaccine. RESULTS: The antibody positivity rate increased from 7.2% before vaccination to 89.5% after the second vaccination. The vaccine was efficacious, producing a sufficient immune response in 90% of patients, regardless of the stage of gestation. The antibody titers were maintained until delivery, and were higher in umbilical cord blood at delivery than in maternal blood. Although the second vaccination increased the antibody titers in 27% of patients, and the antibody titers in maternal and umbilical cord blood at delivery tended to be higher in the double vaccination group than in the single, the differences were not statistically significant. CONCLUSION: Single vaccination induces sufficient immune response and transfer of immunity to the fetus in pregnant women with no pre-existing antibodies.</EA>
<CC>002B20; 002B05C02C</CC>
<FD>Immunoprophylaxie; Dédoublement; Vaccination; Prévention; Vaccin; Gestation; Gynécologie; Obstétrique; Grippe H1N1; Virus grippal A(H1N1)</FD>
<FG>Pathologie de l'appareil respiratoire; Virose; Infection</FG>
<ED>Immunoprophylaxis; Double; Vaccination; Prevention; Vaccine; Pregnancy; Gynecology; Obstetrics; H1N1 influenza; Influenza A (H1N1)</ED>
<EG>Respiratory disease; Viral disease; Infection</EG>
<SD>Inmunoprofilaxia; Desdoblamiento; Vacunación; Prevención; Vacuna; Gestación; Ginecología; Obstétrico; Gripe H1N1</SD>
<LO>INIST-7207.354000509934100170</LO>
<ID>11-0444320</ID>
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Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy

Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy

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