Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs.
Identifieur interne : 001A59 ( Main/Exploration ); précédent : 001A58; suivant : 001A60Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs.
Auteurs : Hyun-Mi Pyo [Canada] ; Aleksandar Masic ; Nizihti Woldeab ; Carissa Embury-Hyatt ; Li Lin ; Yeun-Kyung Shin ; Jae-Young Song ; Shawn Babiuk ; Yan ZhouSource :
- Vaccine [ 1873-2518 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (biosynthèse), Anticorps antiviraux (immunologie), Grippe humaine (virologie), Humains, Hémagglutinines virales (génétique), Hémagglutinines virales (immunologie), Immunoglobuline A (biosynthèse), Immunoglobuline A (immunologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (médecine vétérinaire), Maladies des porcs (), Maladies des porcs (immunologie), Pandémies, Protéines de la matrice virale (génétique), Protéines de la matrice virale (immunologie), Sialidase (génétique), Sialidase (immunologie), Sous-type H1N1 du virus de la grippe A (immunologie), Suidae, Vaccination, Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins à pseudo-particules virales (génétique), Vaccins à pseudo-particules virales (immunologie), Virus de la grippe A (immunologie).
- MESH :
- biosynthèse : Anticorps antiviraux, Immunoglobuline A.
- génétique : Hémagglutinines virales, Protéines de la matrice virale, Sialidase, Vaccins antigrippaux, Vaccins à pseudo-particules virales.
- immunologie : Anticorps antiviraux, Hémagglutinines virales, Immunoglobuline A, Infections à Orthomyxoviridae, Maladies des porcs, Protéines de la matrice virale, Sialidase, Sous-type H1N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins à pseudo-particules virales, Virus de la grippe A.
- médecine vétérinaire : Infections à Orthomyxoviridae.
- virologie : Grippe humaine.
- Animaux, Humains, Infections à Orthomyxoviridae, Maladies des porcs, Pandémies, Suidae, Vaccination.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (biosynthesis), Antibodies, Viral (immunology), Hemagglutinins, Viral (genetics), Hemagglutinins, Viral (immunology), Humans, Immunoglobulin A (biosynthesis), Immunoglobulin A (immunology), Influenza A Virus, H1N1 Subtype (immunology), Influenza A virus (immunology), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza, Human (virology), Neuraminidase (genetics), Neuraminidase (immunology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (veterinary), Pandemics, Swine, Swine Diseases (immunology), Swine Diseases (prevention & control), Vaccination, Vaccines, Virus-Like Particle (genetics), Vaccines, Virus-Like Particle (immunology), Viral Matrix Proteins (genetics), Viral Matrix Proteins (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Viral, Immunoglobulin A.
- chemical , genetics : Hemagglutinins, Viral, Influenza Vaccines, Neuraminidase, Vaccines, Virus-Like Particle, Viral Matrix Proteins.
- chemical , immunology : Antibodies, Viral, Hemagglutinins, Viral, Immunoglobulin A, Influenza Vaccines, Neuraminidase, Vaccines, Virus-Like Particle, Viral Matrix Proteins.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A virus, Orthomyxoviridae Infections, Swine Diseases.
- prevention & control : Orthomyxoviridae Infections, Swine Diseases.
- veterinary : Orthomyxoviridae Infections.
- virology : Influenza, Human.
- Animals, Humans, Pandemics, Swine, Vaccination.
Abstract
The outbreak of the 2009 influenza pandemic underscored the important role of swine in influenza virus evolution and the emergence of novel viruses with pandemic potential. Vaccination is the most common practice to control swine influenza in swine industry. Influenza virus-like particle (VLP) vaccines are an alternative approach and have been demonstrated to be immunogenic and confer protection against influenza virus challenge in chickens, mice and ferrets. In this study, we generated VLPs consisting of HA, NA and M1 proteins derived from pandemic virus A/California/04/2009 in insect cells. The immunogenicity and efficacy following vaccination of VLPs were evaluated in swine. Our data showed that vaccination using VLPs elicited robust levels of serum IgG, mucosal IgA, and viral neutralizing antibodies against A/Sw/Manitoba/MAFRI32/2009 H1N1. Following challenge with pandemic H1N1 2009, vaccinated pigs were protected, displaying reduced lung lesions, virus shedding and inhibition of virus replication in the lungs compared to non-vaccinated control pigs. Thus, VLPs can serve as a promising vaccination strategy to control influenza in swine.
DOI: 10.1016/j.vaccine.2011.12.083
PubMed: 22207090
Affiliations:
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Le document en format XML
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Woldeab</name></author><author><name sortKey="Embury Hyatt, Carissa" sort="Embury Hyatt, Carissa" uniqKey="Embury Hyatt C" first="Carissa" last="Embury-Hyatt">Carissa Embury-Hyatt</name></author><author><name sortKey="Lin, Li" sort="Lin, Li" uniqKey="Lin L" first="Li" last="Lin">Li Lin</name></author><author><name sortKey="Shin, Yeun Kyung" sort="Shin, Yeun Kyung" uniqKey="Shin Y" first="Yeun-Kyung" last="Shin">Yeun-Kyung Shin</name></author><author><name sortKey="Song, Jae Young" sort="Song, Jae Young" uniqKey="Song J" first="Jae-Young" last="Song">Jae-Young Song</name></author><author><name sortKey="Babiuk, Shawn" sort="Babiuk, Shawn" uniqKey="Babiuk S" first="Shawn" last="Babiuk">Shawn Babiuk</name></author><author><name sortKey="Zhou, Yan" sort="Zhou, Yan" uniqKey="Zhou Y" first="Yan" last="Zhou">Yan Zhou</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22207090</idno><idno 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pigs.</title><author><name sortKey="Pyo, Hyun Mi" sort="Pyo, Hyun Mi" uniqKey="Pyo H" first="Hyun-Mi" last="Pyo">Hyun-Mi Pyo</name><affiliation wicri:level="1"><nlm:affiliation>Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3</wicri:regionArea><wicri:noRegion>SK S7N 5E3</wicri:noRegion></affiliation></author><author><name sortKey="Masic, Aleksandar" sort="Masic, Aleksandar" uniqKey="Masic A" first="Aleksandar" last="Masic">Aleksandar Masic</name></author><author><name sortKey="Woldeab, Nizihti" sort="Woldeab, Nizihti" uniqKey="Woldeab N" first="Nizihti" last="Woldeab">Nizihti Woldeab</name></author><author><name sortKey="Embury Hyatt, Carissa" sort="Embury Hyatt, Carissa" uniqKey="Embury Hyatt C" first="Carissa" last="Embury-Hyatt">Carissa 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Orthomyxoviridae</term><term>Maladies des porcs</term><term>Pandémies</term><term>Suidae</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The outbreak of the 2009 influenza pandemic underscored the important role of swine in influenza virus evolution and the emergence of novel viruses with pandemic potential. Vaccination is the most common practice to control swine influenza in swine industry. Influenza virus-like particle (VLP) vaccines are an alternative approach and have been demonstrated to be immunogenic and confer protection against influenza virus challenge in chickens, mice and ferrets. In this study, we generated VLPs consisting of HA, NA and M1 proteins derived from pandemic virus A/California/04/2009 in insect cells. The immunogenicity and efficacy following vaccination of VLPs were evaluated in swine. Our data showed that vaccination using VLPs elicited robust levels of serum IgG, mucosal IgA, and viral neutralizing antibodies against A/Sw/Manitoba/MAFRI32/2009 H1N1. Following challenge with pandemic H1N1 2009, vaccinated pigs were protected, displaying reduced lung lesions, virus shedding and inhibition of virus replication in the lungs compared to non-vaccinated control pigs. Thus, VLPs can serve as a promising vaccination strategy to control influenza in swine.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Babiuk, Shawn" sort="Babiuk, Shawn" uniqKey="Babiuk S" first="Shawn" last="Babiuk">Shawn Babiuk</name><name sortKey="Embury Hyatt, Carissa" sort="Embury Hyatt, Carissa" uniqKey="Embury Hyatt C" first="Carissa" last="Embury-Hyatt">Carissa Embury-Hyatt</name><name sortKey="Lin, Li" sort="Lin, Li" uniqKey="Lin L" first="Li" last="Lin">Li Lin</name><name sortKey="Masic, Aleksandar" sort="Masic, Aleksandar" uniqKey="Masic A" first="Aleksandar" last="Masic">Aleksandar Masic</name><name sortKey="Shin, Yeun Kyung" sort="Shin, Yeun Kyung" uniqKey="Shin Y" first="Yeun-Kyung" last="Shin">Yeun-Kyung Shin</name><name sortKey="Song, Jae Young" sort="Song, Jae Young" uniqKey="Song J" first="Jae-Young" last="Song">Jae-Young Song</name><name sortKey="Woldeab, Nizihti" sort="Woldeab, Nizihti" uniqKey="Woldeab N" first="Nizihti" last="Woldeab">Nizihti Woldeab</name><name sortKey="Zhou, Yan" sort="Zhou, Yan" uniqKey="Zhou Y" first="Yan" last="Zhou">Yan Zhou</name></noCountry><country name="Canada"><noRegion><name sortKey="Pyo, Hyun Mi" sort="Pyo, Hyun Mi" uniqKey="Pyo H" first="Hyun-Mi" last="Pyo">Hyun-Mi Pyo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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