Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs.
Identifieur interne : 000D94 ( PubMed/Corpus ); précédent : 000D93; suivant : 000D95Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs.
Auteurs : Hyun-Mi Pyo ; Aleksandar Masic ; Nizihti Woldeab ; Carissa Embury-Hyatt ; Li Lin ; Yeun-Kyung Shin ; Jae-Young Song ; Shawn Babiuk ; Yan ZhouSource :
- Vaccine [ 1873-2518 ] ; 2012.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (biosynthesis), Antibodies, Viral (immunology), Hemagglutinins, Viral (genetics), Hemagglutinins, Viral (immunology), Humans, Immunoglobulin A (biosynthesis), Immunoglobulin A (immunology), Influenza A Virus, H1N1 Subtype (immunology), Influenza A virus (immunology), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza, Human (virology), Neuraminidase (genetics), Neuraminidase (immunology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (veterinary), Pandemics, Swine, Swine Diseases (immunology), Swine Diseases (prevention & control), Vaccination, Vaccines, Virus-Like Particle (genetics), Vaccines, Virus-Like Particle (immunology), Viral Matrix Proteins (genetics), Viral Matrix Proteins (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Viral, Immunoglobulin A.
- chemical , genetics : Hemagglutinins, Viral, Influenza Vaccines, Neuraminidase, Vaccines, Virus-Like Particle, Viral Matrix Proteins.
- chemical , immunology : Antibodies, Viral, Hemagglutinins, Viral, Immunoglobulin A, Influenza Vaccines, Neuraminidase, Vaccines, Virus-Like Particle, Viral Matrix Proteins.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A virus, Orthomyxoviridae Infections, Swine Diseases.
- prevention & control : Orthomyxoviridae Infections, Swine Diseases.
- veterinary : Orthomyxoviridae Infections.
- virology : Influenza, Human.
- Animals, Humans, Pandemics, Swine, Vaccination.
Abstract
The outbreak of the 2009 influenza pandemic underscored the important role of swine in influenza virus evolution and the emergence of novel viruses with pandemic potential. Vaccination is the most common practice to control swine influenza in swine industry. Influenza virus-like particle (VLP) vaccines are an alternative approach and have been demonstrated to be immunogenic and confer protection against influenza virus challenge in chickens, mice and ferrets. In this study, we generated VLPs consisting of HA, NA and M1 proteins derived from pandemic virus A/California/04/2009 in insect cells. The immunogenicity and efficacy following vaccination of VLPs were evaluated in swine. Our data showed that vaccination using VLPs elicited robust levels of serum IgG, mucosal IgA, and viral neutralizing antibodies against A/Sw/Manitoba/MAFRI32/2009 H1N1. Following challenge with pandemic H1N1 2009, vaccinated pigs were protected, displaying reduced lung lesions, virus shedding and inhibition of virus replication in the lungs compared to non-vaccinated control pigs. Thus, VLPs can serve as a promising vaccination strategy to control influenza in swine.
DOI: 10.1016/j.vaccine.2011.12.083
PubMed: 22207090
Links to Exploration step
pubmed:22207090Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs.</title><author><name sortKey="Pyo, Hyun Mi" sort="Pyo, Hyun Mi" uniqKey="Pyo H" first="Hyun-Mi" last="Pyo">Hyun-Mi Pyo</name><affiliation><nlm:affiliation>Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Masic, Aleksandar" sort="Masic, Aleksandar" uniqKey="Masic A" first="Aleksandar" last="Masic">Aleksandar Masic</name></author><author><name sortKey="Woldeab, Nizihti" sort="Woldeab, Nizihti" uniqKey="Woldeab N" first="Nizihti" last="Woldeab">Nizihti Woldeab</name></author><author><name sortKey="Embury Hyatt, Carissa" sort="Embury Hyatt, Carissa" uniqKey="Embury Hyatt C" first="Carissa" last="Embury-Hyatt">Carissa Embury-Hyatt</name></author><author><name sortKey="Lin, Li" sort="Lin, Li" uniqKey="Lin L" first="Li" last="Lin">Li Lin</name></author><author><name sortKey="Shin, Yeun Kyung" sort="Shin, Yeun Kyung" uniqKey="Shin Y" first="Yeun-Kyung" last="Shin">Yeun-Kyung Shin</name></author><author><name sortKey="Song, Jae Young" sort="Song, Jae Young" uniqKey="Song J" first="Jae-Young" last="Song">Jae-Young Song</name></author><author><name sortKey="Babiuk, Shawn" sort="Babiuk, Shawn" uniqKey="Babiuk S" first="Shawn" last="Babiuk">Shawn Babiuk</name></author><author><name sortKey="Zhou, Yan" sort="Zhou, Yan" uniqKey="Zhou Y" first="Yan" last="Zhou">Yan Zhou</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22207090</idno><idno type="pmid">22207090</idno><idno type="doi">10.1016/j.vaccine.2011.12.083</idno><idno type="wicri:Area/PubMed/Corpus">000D94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs.</title><author><name sortKey="Pyo, Hyun Mi" sort="Pyo, Hyun Mi" uniqKey="Pyo H" first="Hyun-Mi" last="Pyo">Hyun-Mi Pyo</name><affiliation><nlm:affiliation>Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Masic, Aleksandar" sort="Masic, Aleksandar" uniqKey="Masic A" first="Aleksandar" last="Masic">Aleksandar Masic</name></author><author><name sortKey="Woldeab, Nizihti" sort="Woldeab, Nizihti" uniqKey="Woldeab N" first="Nizihti" last="Woldeab">Nizihti Woldeab</name></author><author><name sortKey="Embury Hyatt, Carissa" sort="Embury Hyatt, Carissa" uniqKey="Embury Hyatt C" first="Carissa" last="Embury-Hyatt">Carissa Embury-Hyatt</name></author><author><name sortKey="Lin, Li" sort="Lin, Li" uniqKey="Lin L" first="Li" last="Lin">Li Lin</name></author><author><name sortKey="Shin, Yeun Kyung" sort="Shin, Yeun Kyung" uniqKey="Shin Y" first="Yeun-Kyung" last="Shin">Yeun-Kyung Shin</name></author><author><name sortKey="Song, Jae Young" sort="Song, Jae Young" uniqKey="Song J" first="Jae-Young" last="Song">Jae-Young Song</name></author><author><name sortKey="Babiuk, Shawn" sort="Babiuk, Shawn" uniqKey="Babiuk S" first="Shawn" last="Babiuk">Shawn Babiuk</name></author><author><name sortKey="Zhou, Yan" sort="Zhou, Yan" uniqKey="Zhou Y" first="Yan" last="Zhou">Yan Zhou</name></author></analytic><series><title level="j">Vaccine</title><idno type="eISSN">1873-2518</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (biosynthesis)</term><term>Antibodies, Viral (immunology)</term><term>Hemagglutinins, Viral (genetics)</term><term>Hemagglutinins, Viral (immunology)</term><term>Humans</term><term>Immunoglobulin A (biosynthesis)</term><term>Immunoglobulin A (immunology)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (virology)</term><term>Neuraminidase (genetics)</term><term>Neuraminidase (immunology)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Orthomyxoviridae Infections (veterinary)</term><term>Pandemics</term><term>Swine</term><term>Swine Diseases (immunology)</term><term>Swine Diseases (prevention & control)</term><term>Vaccination</term><term>Vaccines, Virus-Like Particle (genetics)</term><term>Vaccines, Virus-Like Particle (immunology)</term><term>Viral Matrix Proteins (genetics)</term><term>Viral Matrix Proteins (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinins, Viral</term><term>Influenza Vaccines</term><term>Neuraminidase</term><term>Vaccines, Virus-Like Particle</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Hemagglutinins, Viral</term><term>Immunoglobulin A</term><term>Influenza Vaccines</term><term>Neuraminidase</term><term>Vaccines, Virus-Like Particle</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A virus</term><term>Orthomyxoviridae Infections</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Pandemics</term><term>Swine</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The outbreak of the 2009 influenza pandemic underscored the important role of swine in influenza virus evolution and the emergence of novel viruses with pandemic potential. Vaccination is the most common practice to control swine influenza in swine industry. Influenza virus-like particle (VLP) vaccines are an alternative approach and have been demonstrated to be immunogenic and confer protection against influenza virus challenge in chickens, mice and ferrets. In this study, we generated VLPs consisting of HA, NA and M1 proteins derived from pandemic virus A/California/04/2009 in insect cells. The immunogenicity and efficacy following vaccination of VLPs were evaluated in swine. Our data showed that vaccination using VLPs elicited robust levels of serum IgG, mucosal IgA, and viral neutralizing antibodies against A/Sw/Manitoba/MAFRI32/2009 H1N1. Following challenge with pandemic H1N1 2009, vaccinated pigs were protected, displaying reduced lung lesions, virus shedding and inhibition of virus replication in the lungs compared to non-vaccinated control pigs. Thus, VLPs can serve as a promising vaccination strategy to control influenza in swine.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22207090</PMID><DateCompleted><Year>2013</Year><Month>03</Month><Day>01</Day></DateCompleted><DateRevised><Year>2012</Year><Month>02</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2518</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>7</Issue><PubDate><Year>2012</Year><Month>Feb</Month><Day>08</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs.</ArticleTitle><Pagination><MedlinePgn>1297-304</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2011.12.083</ELocationID><Abstract><AbstractText>The outbreak of the 2009 influenza pandemic underscored the important role of swine in influenza virus evolution and the emergence of novel viruses with pandemic potential. Vaccination is the most common practice to control swine influenza in swine industry. Influenza virus-like particle (VLP) vaccines are an alternative approach and have been demonstrated to be immunogenic and confer protection against influenza virus challenge in chickens, mice and ferrets. In this study, we generated VLPs consisting of HA, NA and M1 proteins derived from pandemic virus A/California/04/2009 in insect cells. The immunogenicity and efficacy following vaccination of VLPs were evaluated in swine. Our data showed that vaccination using VLPs elicited robust levels of serum IgG, mucosal IgA, and viral neutralizing antibodies against A/Sw/Manitoba/MAFRI32/2009 H1N1. Following challenge with pandemic H1N1 2009, vaccinated pigs were protected, displaying reduced lung lesions, virus shedding and inhibition of virus replication in the lungs compared to non-vaccinated control pigs. Thus, VLPs can serve as a promising vaccination strategy to control influenza in swine.</AbstractText><CopyrightInformation>Copyright © 2011 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pyo</LastName><ForeName>Hyun-Mi</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masic</LastName><ForeName>Aleksandar</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Woldeab</LastName><ForeName>Nizihti</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Embury-Hyatt</LastName><ForeName>Carissa</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Li</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Shin</LastName><ForeName>Yeun-Kyung</ForeName><Initials>YK</Initials></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Jae-Young</ForeName><Initials>JY</Initials></Author><Author ValidYN="Y"><LastName>Babiuk</LastName><ForeName>Shawn</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Yan</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>12</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006389">Hemagglutinins, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007070">Immunoglobulin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C488936">M1 protein, Influenza A virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D058425">Vaccines, Virus-Like Particle</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014763">Viral Matrix Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber><NameOfSubstance UI="D009439">Neuraminidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006389" MajorTopicYN="N">Hemagglutinins, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007070" MajorTopicYN="N">Immunoglobulin A</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009439" MajorTopicYN="N">Neuraminidase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013553" MajorTopicYN="N">Swine Diseases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058425" MajorTopicYN="N">Vaccines, Virus-Like Particle</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014763" MajorTopicYN="N">Viral Matrix Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>09</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>11</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>12</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>12</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>12</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>3</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22207090</ArticleId><ArticleId IdType="pii">S0264-410X(11)02032-9</ArticleId><ArticleId IdType="doi">10.1016/j.vaccine.2011.12.083</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D94 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000D94 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= PandemieGrippaleV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:22207090
|texte= Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:22207090" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a PandemieGrippaleV1
| This area was generated with Dilib version V0.6.34. |  |