Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine
Identifieur interne : 001580 ( Main/Exploration ); précédent : 001579; suivant : 001581Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine
Auteurs : Fenghua Zhang [République populaire de Chine] ; Fang Fang [République populaire de Chine, Niger] ; Haiyan Chang [République populaire de Chine] ; Bo Peng [République populaire de Chine] ; Jian Wu [République populaire de Chine] ; Jianjun Chen [République populaire de Chine] ; Hanzhong Wang [République populaire de Chine] ; Ze Chen [République populaire de Chine]Source :
- Archives of Virology [ 0304-8608 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Facteurs de l'âge, Femelle, Immunité acquise d'origine maternelle (immunologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Relation dose-réponse (immunologie), Souris, Souris de lignée BALB C, Sous-type H5N1 du virus de la grippe A (immunologie), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Vaccins antigrippaux (usage thérapeutique), Vaccins inactivés (immunologie), Vaccins inactivés (usage thérapeutique).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- immunologie : Immunité acquise d'origine maternelle, Infections à Orthomyxoviridae, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins inactivés.
- sang : Anticorps antiviraux.
- usage thérapeutique : Vaccins antigrippaux, Vaccins inactivés.
- Animaux, Facteurs de l'âge, Femelle, Infections à Orthomyxoviridae, Relation dose-réponse (immunologie), Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Age Factors, Animals, Antibodies, Viral (blood), Dose-Response Relationship, Immunologic, Female, Immunity, Maternally-Acquired (immunology), Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza Vaccines (therapeutic use), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Vaccines, Inactivated (immunology), Vaccines, Inactivated (therapeutic use).
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , blood : Antibodies, Viral.
- immunology : Immunity, Maternally-Acquired, Influenza A Virus, H5N1 Subtype, Influenza Vaccines, Orthomyxoviridae Infections, Vaccines, Inactivated.
- prevention & control : Orthomyxoviridae Infections.
- chemical , therapeutic use : Influenza Vaccines, Vaccines, Inactivated.
- Age Factors, Animals, Dose-Response Relationship, Immunologic, Female, Mice, Mice, Inbred BALB C.
Abstract
Abstract: H5N1 influenza virus is one of the viruses that can potentially cause an influenza pandemic. Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. In this study, female mice were immunized with H5N1 HA DNA vaccine or inactivated whole-virion vaccine, and the protection provided by maternal antibodies in their offspring against a lethal homologous influenza virus challenge was compared. The results showed that maternal antibodies, whether induced by a DNA vaccine or an inactivated vaccine, could completely protect offspring aged 1-4 weeks from a lethal influenza virus challenge. Breast-feeding was the major route of transfer for maternal antibodies. Milk-derived antibodies were able to effectively protect the offspring aged 1-4 weeks from lethal influenza virus infection, whereas maternal antibodies transferred through the placenta only partially protected the offspring 1-2 weeks of age. The milk- and placenta-transferred IgG2a antibody levels in offspring from their mothers, whether vaccinated with DNA vaccine or inactivated vaccine, were higher than the IgG1 levels. Our results indicated that maternal vaccination with HA DNA, as well as with whole-virion inactivated vaccine, could offer effective protection to offspring against H5N1 influenza virus infection.
Url:
DOI: 10.1007/s00705-013-1621-y
Affiliations:
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Le document en format XML
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<term>Animals</term>
<term>Antibodies, Viral (blood)</term>
<term>Dose-Response Relationship, Immunologic</term>
<term>Female</term>
<term>Immunity, Maternally-Acquired (immunology)</term>
<term>Influenza A Virus, H5N1 Subtype (immunology)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza Vaccines (therapeutic use)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
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<term>Orthomyxoviridae Infections (prevention & control)</term>
<term>Vaccines, Inactivated (immunology)</term>
<term>Vaccines, Inactivated (therapeutic use)</term>
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<term>Anticorps antiviraux (sang)</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Immunité acquise d'origine maternelle (immunologie)</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Relation dose-réponse (immunologie)</term>
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<term>Souris de lignée BALB C</term>
<term>Sous-type H5N1 du virus de la grippe A (immunologie)</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins antigrippaux (usage thérapeutique)</term>
<term>Vaccins inactivés (immunologie)</term>
<term>Vaccins inactivés (usage thérapeutique)</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Immunité acquise d'origine maternelle</term>
<term>Infections à Orthomyxoviridae</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins inactivés</term>
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<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza Vaccines</term>
<term>Orthomyxoviridae Infections</term>
<term>Vaccines, Inactivated</term>
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<term>Vaccines, Inactivated</term>
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<term>Vaccins inactivés</term>
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<term>Femelle</term>
<term>Infections à Orthomyxoviridae</term>
<term>Relation dose-réponse (immunologie)</term>
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<front><div type="abstract" xml:lang="en">Abstract: H5N1 influenza virus is one of the viruses that can potentially cause an influenza pandemic. Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. In this study, female mice were immunized with H5N1 HA DNA vaccine or inactivated whole-virion vaccine, and the protection provided by maternal antibodies in their offspring against a lethal homologous influenza virus challenge was compared. The results showed that maternal antibodies, whether induced by a DNA vaccine or an inactivated vaccine, could completely protect offspring aged 1-4 weeks from a lethal influenza virus challenge. Breast-feeding was the major route of transfer for maternal antibodies. Milk-derived antibodies were able to effectively protect the offspring aged 1-4 weeks from lethal influenza virus infection, whereas maternal antibodies transferred through the placenta only partially protected the offspring 1-2 weeks of age. The milk- and placenta-transferred IgG2a antibody levels in offspring from their mothers, whether vaccinated with DNA vaccine or inactivated vaccine, were higher than the IgG1 levels. Our results indicated that maternal vaccination with HA DNA, as well as with whole-virion inactivated vaccine, could offer effective protection to offspring against H5N1 influenza virus infection.</div>
</front>
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<affiliations><list><country><li>Niger</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Fenghua" sort="Zhang, Fenghua" uniqKey="Zhang F" first="Fenghua" last="Zhang">Fenghua Zhang</name>
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<name sortKey="Chang, Haiyan" sort="Chang, Haiyan" uniqKey="Chang H" first="Haiyan" last="Chang">Haiyan Chang</name>
<name sortKey="Chen, Jianjun" sort="Chen, Jianjun" uniqKey="Chen J" first="Jianjun" last="Chen">Jianjun Chen</name>
<name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name>
<name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name>
<name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name>
<name sortKey="Fang, Fang" sort="Fang, Fang" uniqKey="Fang F" first="Fang" last="Fang">Fang Fang</name>
<name sortKey="Peng, Bo" sort="Peng, Bo" uniqKey="Peng B" first="Bo" last="Peng">Bo Peng</name>
<name sortKey="Wang, Hanzhong" sort="Wang, Hanzhong" uniqKey="Wang H" first="Hanzhong" last="Wang">Hanzhong Wang</name>
<name sortKey="Wu, Jian" sort="Wu, Jian" uniqKey="Wu J" first="Jian" last="Wu">Jian Wu</name>
</country>
<country name="Niger"><noRegion><name sortKey="Fang, Fang" sort="Fang, Fang" uniqKey="Fang F" first="Fang" last="Fang">Fang Fang</name>
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